JP7077335B2 - プロテインキナーゼ阻害剤 - Google Patents

プロテインキナーゼ阻害剤 Download PDF

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JP7077335B2
JP7077335B2 JP2019551918A JP2019551918A JP7077335B2 JP 7077335 B2 JP7077335 B2 JP 7077335B2 JP 2019551918 A JP2019551918 A JP 2019551918A JP 2019551918 A JP2019551918 A JP 2019551918A JP 7077335 B2 JP7077335 B2 JP 7077335B2
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compound
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enantiomer
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JP2020503376A (ja
JP2020503376A5 (enExample
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ホー、カン
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プリンストン ドラッグ ディスカバリー インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019551918A 2016-12-13 2017-12-12 プロテインキナーゼ阻害剤 Active JP7077335B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662433410P 2016-12-13 2016-12-13
US62/433,410 2016-12-13
US201762539785P 2017-08-01 2017-08-01
US62/539,785 2017-08-01
PCT/US2017/065847 WO2018111893A1 (en) 2016-12-13 2017-12-12 Protein kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2020503376A JP2020503376A (ja) 2020-01-30
JP2020503376A5 JP2020503376A5 (enExample) 2020-11-12
JP7077335B2 true JP7077335B2 (ja) 2022-05-30

Family

ID=61829613

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019551918A Active JP7077335B2 (ja) 2016-12-13 2017-12-12 プロテインキナーゼ阻害剤

Country Status (8)

Country Link
US (5) US10174018B2 (enExample)
EP (1) EP3555092A4 (enExample)
JP (1) JP7077335B2 (enExample)
KR (1) KR102582752B1 (enExample)
CN (1) CN108473487B (enExample)
AU (1) AU2017375949B2 (enExample)
CA (1) CA3044066A1 (enExample)
WO (1) WO2018111893A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108473487B (zh) * 2016-12-13 2021-08-03 普林斯顿药物研发公司 一种蛋白激酶抑制剂
EP3846793B1 (en) 2018-09-07 2024-01-24 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
WO2020123277A1 (en) * 2018-12-10 2020-06-18 Princeton Drug Discovery Inc. Protein kinase inhibitor prodrugs
KR102256804B1 (ko) * 2019-02-26 2021-05-26 한국화학연구원 N-페닐-2-(피리미딘-4-일아미노)티아졸-5-카복사미드 유도체, 이의 약학적으로 허용 가능한 염 및 이를 유효성분으로 함유하는 미백 소재 조성물
AR121506A1 (es) 2020-03-03 2022-06-08 Pic Therapeutics Inc Inhibidores del eif4e y sus usos
US12157732B2 (en) 2021-08-25 2024-12-03 PIC Therapeutics, Inc. eIF4E inhibitors and uses thereof
IL310924A (en) 2021-08-25 2024-04-01 Pic Therapeutics Inc Eif4e inhibitors and uses thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006503866A (ja) 2002-10-02 2006-02-02 ブリストル−マイヤーズ　スクイブ　カンパニー 癌を処置するための相乗的な方法および組成物
WO2006099474A1 (en) 2005-03-15 2006-09-21 Bristol-Myers Squibb Company 'n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamides metabolites
JP2006523216A (ja) 2003-03-24 2006-10-12 ブリストル−マイヤーズ　スクイブ　カンパニー 環状プロテインチロシンキナーゼインヒビター
WO2008150446A1 (en) 2007-05-30 2008-12-11 Congxin Liang Inhibitors of protein kinases
US20090076025A1 (en) 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched dasatinib
JP2010502742A (ja) 2006-09-11 2010-01-28 キュリス，インコーポレイテッド 亜鉛結合部分を含むチロシンキナーゼインヒビター
JP2012529511A (ja) 2009-06-08 2012-11-22 アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー トリアジン誘導体類及びそれらの治療応用
CN104151321A (zh) 2013-05-15 2014-11-19 复旦大学 N-(2-氯-6-甲基苯基)-2[(2-甲基嘧啶-4-基)氨基]噻唑-5-甲酰胺化合物及其制备方法和用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2366932C (en) 1999-04-15 2009-08-25 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
ES2257461T3 (es) 2000-12-21 2006-08-01 Bristol-Myers Squibb Company Inhibidores de tiazolilo de tirosina quinasas de la familia tec.
US20040209930A1 (en) * 2002-10-02 2004-10-21 Carboni Joan M. Synergistic methods and compositions for treating cancer
US7491725B2 (en) 2004-02-06 2009-02-17 Bristol-Myers Squibb Company Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
US20060021105A1 (en) * 2004-07-29 2006-02-02 Wilson Nick L Ergonomic hand protection apparatus
WO2009076373A1 (en) 2007-12-10 2009-06-18 Concert Pharmaceuticals Inc. Heterocyclic kinase inhibitors
WO2010107791A2 (en) 2009-03-17 2010-09-23 Concert Pharmaceuticals, Inc. Pyrazinoisoquinoline compounds
CN102665756A (zh) * 2009-10-01 2012-09-12 Csl有限公司 费城染色体阳性白血病的治疗方法
CN101891738B (zh) 2010-02-08 2011-09-28 南京卡文迪许生物工程技术有限公司 达沙替尼多晶型物及其制备方法和药用组合物
MX380504B (es) 2010-06-03 2025-03-12 Pharmacyclics Llc El uso de inhibidores de la tirosina quinasa de bruton (btk).
EP2872159A2 (en) 2012-07-13 2015-05-20 Concert Pharmaceuticals Inc. Deuterated carfilzomib
CA2904148A1 (en) 2013-03-14 2014-10-02 Concert Pharmaceuticals, Inc. Deuterated pacritinib
CN104130250B (zh) 2013-05-07 2016-06-22 郑州泰基鸿诺药物科技有限公司 氘代达沙替尼及其制备方法和应用
US9993472B2 (en) 2014-01-28 2018-06-12 Unity Biotechnology, Inc. Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2
US20170224688A1 (en) 2016-02-04 2017-08-10 Acerta Pharma B.V. Methods of Using BTK Inhibitors to Treat Dermatoses
WO2017168454A2 (en) * 2016-04-02 2017-10-05 Sun Pharma Advanced Research Company Limited Novel compounds as btk inhibitors
CN108473487B (zh) 2016-12-13 2021-08-03 普林斯顿药物研发公司 一种蛋白激酶抑制剂

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006503866A (ja) 2002-10-02 2006-02-02 ブリストル−マイヤーズ　スクイブ　カンパニー 癌を処置するための相乗的な方法および組成物
JP2006523216A (ja) 2003-03-24 2006-10-12 ブリストル−マイヤーズ　スクイブ　カンパニー 環状プロテインチロシンキナーゼインヒビター
WO2006099474A1 (en) 2005-03-15 2006-09-21 Bristol-Myers Squibb Company 'n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamides metabolites
JP2010502742A (ja) 2006-09-11 2010-01-28 キュリス，インコーポレイテッド 亜鉛結合部分を含むチロシンキナーゼインヒビター
WO2008150446A1 (en) 2007-05-30 2008-12-11 Congxin Liang Inhibitors of protein kinases
US20090076025A1 (en) 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched dasatinib
JP2012529511A (ja) 2009-06-08 2012-11-22 アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー トリアジン誘導体類及びそれらの治療応用
CN104151321A (zh) 2013-05-15 2014-11-19 复旦大学 N-(2-氯-6-甲基苯基)-2[(2-甲基嘧啶-4-基)氨基]噻唑-5-甲酰胺化合物及其制备方法和用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Drug Metabolism and Disposition，2009年，Vol. 37, No. 6，pp. 1242-1250

Also Published As

Publication number Publication date
CA3044066A1 (en) 2018-06-21
JP2020503376A (ja) 2020-01-30
US20180099961A1 (en) 2018-04-12
WO2018111893A1 (en) 2018-06-21
KR20190091312A (ko) 2019-08-05
US20180099960A1 (en) 2018-04-12
US10479786B2 (en) 2019-11-19
CN108473487A (zh) 2018-08-31
US10174018B2 (en) 2019-01-08
US11236080B2 (en) 2022-02-01
US20200123148A1 (en) 2020-04-23
US20190071437A1 (en) 2019-03-07
CN108473487B (zh) 2021-08-03
AU2017375949B2 (en) 2021-09-09
EP3555092A1 (en) 2019-10-23
US20180099959A1 (en) 2018-04-12
EP3555092A4 (en) 2020-05-13
US10556897B2 (en) 2020-02-11
AU2017375949A1 (en) 2019-05-23
KR102582752B1 (ko) 2023-09-22

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