JP7072519B2 - Ｂｅｔタンパク質分解剤 - Google Patents

Ｂｅｔタンパク質分解剤 Download PDF

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JP7072519B2
JP7072519B2 JP2018553365A JP2018553365A JP7072519B2 JP 7072519 B2 JP7072519 B2 JP 7072519B2 JP 2018553365 A JP2018553365 A JP 2018553365A JP 2018553365 A JP2018553365 A JP 2018553365A JP 7072519 B2 JP7072519 B2 JP 7072519B2
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compound
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pharmaceutically acceptable
solvate
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JP2019511528A (ja
JP2019511528A5 (enExample
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シャオメン ワン
ビン チョウ
フーミン スー
ジャンタオ フー
ロンチュアン バイ
チャオ－イエ ヤン
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ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
JP2018553365A 2016-04-12 2017-04-06 Ｂｅｔタンパク質分解剤 Expired - Fee Related JP7072519B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662321499P 2016-04-12 2016-04-12
US62/321,499 2016-04-12
US201662393888P 2016-09-13 2016-09-13
US62/393,888 2016-09-13
PCT/US2017/026278 WO2017180417A1 (en) 2016-04-12 2017-04-06 Bet protein degraders

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JP2019511528A JP2019511528A (ja) 2019-04-25
JP2019511528A5 JP2019511528A5 (enExample) 2020-05-14
JP7072519B2 true JP7072519B2 (ja) 2022-05-20

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US (1) US10633386B2 (enExample)
EP (1) EP3442976B1 (enExample)
JP (1) JP7072519B2 (enExample)
KR (1) KR20180132861A (enExample)
CN (1) CN109311890B (enExample)
AU (1) AU2017250076B2 (enExample)
BR (1) BR112018070859A2 (enExample)
CA (1) CA3020541A1 (enExample)
IL (1) IL262139B (enExample)
MX (1) MX384905B (enExample)
RU (1) RU2752677C2 (enExample)
SG (1) SG11201808729WA (enExample)
UA (1) UA123168C2 (enExample)
WO (1) WO2017180417A1 (enExample)
ZA (1) ZA201806969B (enExample)

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JP2019511528A (ja) 2019-04-25
MX384905B (es) 2025-03-14
CN109311890A (zh) 2019-02-05
AU2017250076B2 (en) 2021-07-22
IL262139A (en) 2018-11-29
ZA201806969B (en) 2019-12-18
US10633386B2 (en) 2020-04-28
UA123168C2 (uk) 2021-02-24
BR112018070859A2 (pt) 2019-02-05
CN109311890B (zh) 2021-08-31
IL262139B (en) 2021-05-31
US20190169195A1 (en) 2019-06-06
MX2018012379A (es) 2019-07-04
RU2752677C2 (ru) 2021-07-29
RU2018139537A (ru) 2020-05-14
SG11201808729WA (en) 2018-11-29
EP3442976A1 (en) 2019-02-20
RU2018139537A3 (enExample) 2020-08-11
AU2017250076A1 (en) 2018-11-08
WO2017180417A1 (en) 2017-10-19
KR20180132861A (ko) 2018-12-12
CA3020541A1 (en) 2017-10-19
EP3442976B1 (en) 2022-07-20

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