AU2017250076B2 - Bet protein degraders - Google Patents

Bet protein degraders Download PDF

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Publication number
AU2017250076B2
AU2017250076B2 AU2017250076A AU2017250076A AU2017250076B2 AU 2017250076 B2 AU2017250076 B2 AU 2017250076B2 AU 2017250076 A AU2017250076 A AU 2017250076A AU 2017250076 A AU2017250076 A AU 2017250076A AU 2017250076 B2 AU2017250076 B2 AU 2017250076B2
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AU
Australia
Prior art keywords
meo
group
compound
pharmaceutically acceptable
another embodiment
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Ceased
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AU2017250076A
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English (en)
Other versions
AU2017250076A1 (en
Inventor
Longchuan Bai
Jiantao HU
Shaomeng Wang
Fuming XU
Chao-Yie Yang
Bing Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan System
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University of Michigan System
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Publication of AU2017250076A1 publication Critical patent/AU2017250076A1/en
Application granted granted Critical
Publication of AU2017250076B2 publication Critical patent/AU2017250076B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
AU2017250076A 2016-04-12 2017-04-06 Bet protein degraders Ceased AU2017250076B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662321499P 2016-04-12 2016-04-12
US62/321,499 2016-04-12
US201662393888P 2016-09-13 2016-09-13
US62/393,888 2016-09-13
PCT/US2017/026278 WO2017180417A1 (en) 2016-04-12 2017-04-06 Bet protein degraders

Publications (2)

Publication Number Publication Date
AU2017250076A1 AU2017250076A1 (en) 2018-11-08
AU2017250076B2 true AU2017250076B2 (en) 2021-07-22

Family

ID=58548921

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017250076A Ceased AU2017250076B2 (en) 2016-04-12 2017-04-06 Bet protein degraders

Country Status (15)

Country Link
US (1) US10633386B2 (enExample)
EP (1) EP3442976B1 (enExample)
JP (1) JP7072519B2 (enExample)
KR (1) KR20180132861A (enExample)
CN (1) CN109311890B (enExample)
AU (1) AU2017250076B2 (enExample)
BR (1) BR112018070859A2 (enExample)
CA (1) CA3020541A1 (enExample)
IL (1) IL262139B (enExample)
MX (1) MX384905B (enExample)
RU (1) RU2752677C2 (enExample)
SG (1) SG11201808729WA (enExample)
UA (1) UA123168C2 (enExample)
WO (1) WO2017180417A1 (enExample)
ZA (1) ZA201806969B (enExample)

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Publication number Publication date
RU2018139537A (ru) 2020-05-14
JP2019511528A (ja) 2019-04-25
RU2018139537A3 (enExample) 2020-08-11
CN109311890B (zh) 2021-08-31
IL262139B (en) 2021-05-31
CA3020541A1 (en) 2017-10-19
WO2017180417A1 (en) 2017-10-19
US10633386B2 (en) 2020-04-28
CN109311890A (zh) 2019-02-05
KR20180132861A (ko) 2018-12-12
AU2017250076A1 (en) 2018-11-08
IL262139A (en) 2018-11-29
ZA201806969B (en) 2019-12-18
MX384905B (es) 2025-03-14
US20190169195A1 (en) 2019-06-06
UA123168C2 (uk) 2021-02-24
RU2752677C2 (ru) 2021-07-29
MX2018012379A (es) 2019-07-04
SG11201808729WA (en) 2018-11-29
BR112018070859A2 (pt) 2019-02-05
JP7072519B2 (ja) 2022-05-20
EP3442976B1 (en) 2022-07-20
EP3442976A1 (en) 2019-02-20

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