JP7053783B2 - 肝疾患予測又は診断用組成物及びこれを用いた肝疾患予測又は診断方法 - Google Patents

肝疾患予測又は診断用組成物及びこれを用いた肝疾患予測又は診断方法 Download PDF

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JP7053783B2
JP7053783B2 JP2020501172A JP2020501172A JP7053783B2 JP 7053783 B2 JP7053783 B2 JP 7053783B2 JP 2020501172 A JP2020501172 A JP 2020501172A JP 2020501172 A JP2020501172 A JP 2020501172A JP 7053783 B2 JP7053783 B2 JP 7053783B2
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gdf15
protein
fibrosis
liver
liver disease
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JP2020528138A (ja
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ウォン・キム
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Seoul National University Hospital
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

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  • Biomedical Technology (AREA)
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  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • General Engineering & Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020501172A 2017-08-21 2018-08-20 肝疾患予測又は診断用組成物及びこれを用いた肝疾患予測又は診断方法 Active JP7053783B2 (ja)

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KR1020170105714A KR102010652B1 (ko) 2017-08-21 2017-08-21 간질환 예측 또는 진단용 조성물 및 이를 이용한 간질환 예측 또는 진단 방법
KR10-2017-0105714 2017-08-21
PCT/KR2018/009548 WO2019039817A2 (ko) 2017-08-21 2018-08-20 간질환 예측 또는 진단용 조성물 및 이를 이용한 간질환 예측 또는 진단 방법

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JP2020528138A5 JP2020528138A5 (enExample) 2021-04-08
JP7053783B2 true JP7053783B2 (ja) 2022-04-12

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US (1) US20200292553A1 (enExample)
EP (1) EP3674710B1 (enExample)
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US12372530B2 (en) * 2017-11-15 2025-07-29 Beth Israel Deaconess Medical Center, Inc. Markers for the diagnosis and treatment of non-alcoholic steatohepatitis (NASH) and advanced liver fibrosis
KR102569644B1 (ko) 2020-10-30 2023-08-23 가톨릭대학교 산학협력단 Gdf15를 유효성분으로 함유하는 면역질환의 예방 및 치료용 조성물
CN113160983A (zh) * 2021-04-09 2021-07-23 南京医科大学附属逸夫医院 一种代谢相关脂肪性肝病临床预测模型
US20240344134A1 (en) * 2021-07-26 2024-10-17 Osaka University Diagnostic marker for hepatic cancer development in chronic hepatic disease
WO2023008673A1 (ko) * 2021-07-30 2023-02-02 숙명여자대학교산학협력단 머신러닝 기반 비알코올성 지방간염 판별용 복합 마커 및 이의 용도
CN115948563A (zh) * 2023-03-13 2023-04-11 中国医学科学院北京协和医院 蛋白标志物的检测试剂在制备诊断肝癌的产品中的应用
KR20250071598A (ko) 2023-11-15 2025-05-22 주식회사 아이도트 장내미생물 중 전체 레벨의 데이터를 이용하는 간 질환 진단 시스템 및 방법
KR20250074386A (ko) 2023-11-20 2025-05-27 주식회사 아이도트 장내 미생물 중 전체 레벨의 데이터를 이용하는 간 질환 진단을 위한 학습 시스템 및 방법
KR20250075910A (ko) 2023-11-22 2025-05-29 주식회사 아이도트 장내 미생물 중 종 레벨의 데이터를 이용하는 간 질환 진단 시스템 및 방법
KR20250077720A (ko) 2023-11-24 2025-06-02 주식회사 아이도트 장내 미생물 중 종 레벨의 데이터를 이용하는 간 질환 진단 위한 학습 시스템 및 방법

Citations (5)

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US20030232385A1 (en) 2002-06-17 2003-12-18 Breit Samuel N. Methods of diagnoisis, prognosis and treatment of cardiovascular disease
US20070237713A1 (en) 2006-04-04 2007-10-11 Fan Rong A PCan065 Antibody Compositions and Methods of Use
WO2012049874A1 (ja) 2010-10-13 2012-04-19 ヒューマン・メタボローム・テクノロジーズ株式会社 脂肪性肝疾患を診断するためのバイオマーカー、その測定方法、コンピュータプログラム、および、記憶媒体
JP2012515336A (ja) 2009-01-16 2012-07-05 エフ．ホフマン−ラ ロシュ アーゲー 肝硬変の重症度の評価方法
JP2015532271A (ja) 2012-09-26 2015-11-09 ユリウス・マクシミリアンス−ウニヴェルジテート・ヴュルツブルクＪｕｌｉｕｓ Ｍａｘｉｍｉｌｉａｎｓ−Ｕｎｉｖｅｒｓｉｔａｅｔ Ｗｕｅｒｚｂｕｒｇ 増殖分化因子１５（ｇｄｆ−１５）に対するモノクローナル抗体

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US9862752B2 (en) * 2013-07-31 2018-01-09 Amgen Inc. Growth differentiation factor 15 (GDF-15) constructs
EP4006049A1 (en) * 2016-01-29 2022-06-01 Washington University Gdf15 in glaucoma and methods of use thereof
KR102266627B1 (ko) 2016-03-10 2021-06-17 엘에스엠트론 주식회사 플랫 케이블용 커넥터

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US20030232385A1 (en) 2002-06-17 2003-12-18 Breit Samuel N. Methods of diagnoisis, prognosis and treatment of cardiovascular disease
US20070237713A1 (en) 2006-04-04 2007-10-11 Fan Rong A PCan065 Antibody Compositions and Methods of Use
JP2012515336A (ja) 2009-01-16 2012-07-05 エフ．ホフマン−ラ ロシュ アーゲー 肝硬変の重症度の評価方法
WO2012049874A1 (ja) 2010-10-13 2012-04-19 ヒューマン・メタボローム・テクノロジーズ株式会社 脂肪性肝疾患を診断するためのバイオマーカー、その測定方法、コンピュータプログラム、および、記憶媒体
JP2015532271A (ja) 2012-09-26 2015-11-09 ユリウス・マクシミリアンス−ウニヴェルジテート・ヴュルツブルクＪｕｌｉｕｓ Ｍａｘｉｍｉｌｉａｎｓ−Ｕｎｉｖｅｒｓｉｔａｅｔ Ｗｕｅｒｚｂｕｒｇ 増殖分化因子１５（ｇｄｆ−１５）に対するモノクローナル抗体

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CN111316103B (zh) 2023-12-26
WO2019039817A2 (ko) 2019-02-28
EP3674710A4 (en) 2020-08-05
KR20190020581A (ko) 2019-03-04
US20200292553A1 (en) 2020-09-17
EP3674710A2 (en) 2020-07-01
KR102010652B1 (ko) 2019-08-13
EP3674710C0 (en) 2024-02-28
WO2019039817A3 (ko) 2019-06-06
CN111316103A (zh) 2020-06-19
EP3674710B1 (en) 2024-02-28
WO2019039817A9 (ko) 2019-07-18
JP2020528138A (ja) 2020-09-17

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