JP7043082B2 - 眼疾患を処置するオリゴヌクレオチド - Google Patents

眼疾患を処置するオリゴヌクレオチド Download PDF

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JP7043082B2
JP7043082B2 JP2019506546A JP2019506546A JP7043082B2 JP 7043082 B2 JP7043082 B2 JP 7043082B2 JP 2019506546 A JP2019506546 A JP 2019506546A JP 2019506546 A JP2019506546 A JP 2019506546A JP 7043082 B2 JP7043082 B2 JP 7043082B2
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ush2a
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JP2019515688A (ja
JP2019515688A5 (OSRAM
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ディエペン，ヘスター カタリナ ファン
ラム チャン，ヒー
ユハ トュルネン，ヤンネ
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プロキューアール セラピューティクス ツー ベスローテン フェンノートシャップ
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JP2019506546A 2016-04-25 2017-04-25 眼疾患を処置するオリゴヌクレオチド Expired - Fee Related JP7043082B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1607141.7 2016-04-25
GB201607141 2016-04-25
PCT/EP2017/059830 WO2017186739A1 (en) 2016-04-25 2017-04-25 Oligonucleotides to treat eye disease

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JP2019515688A JP2019515688A (ja) 2019-06-13
JP2019515688A5 JP2019515688A5 (OSRAM) 2020-06-11
JP7043082B2 true JP7043082B2 (ja) 2022-03-29

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US (3) US10617707B2 (OSRAM)
EP (1) EP3448999B1 (OSRAM)
JP (1) JP7043082B2 (OSRAM)
KR (1) KR102368920B1 (OSRAM)
CN (1) CN109072239A (OSRAM)
AU (1) AU2017257292A1 (OSRAM)
CA (1) CA3021899A1 (OSRAM)
DK (1) DK3448999T3 (OSRAM)
EA (1) EA201892431A1 (OSRAM)
ES (1) ES2801823T3 (OSRAM)
IL (1) IL262199B (OSRAM)
MX (1) MX2018013003A (OSRAM)
PL (1) PL3448999T3 (OSRAM)
WO (1) WO2017186739A1 (OSRAM)
ZA (1) ZA201806628B (OSRAM)

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NZ751483A (en) 2016-09-01 2022-07-01 Proqr Therapeutics Ii Bv Chemically modified single-stranded rna-editing oligonucleotides
GB201706009D0 (en) 2017-04-13 2017-05-31 Proqr Therapeutics Ii Bv Antisense oligonucleotides for the treatment of stargardt disease
CA3084633A1 (en) 2017-12-21 2019-06-27 Crispr Therapeutics Ag Materials and methods for treatment of usher syndrome type 2a and/or non-syndromic autosomal recessive retinitis pigmentosa (arrp)
AU2018393050A1 (en) 2017-12-21 2020-06-18 Bayer Healthcare Llc Materials and methods for treatment of Usher Syndrome Type 2A
GB201808146D0 (en) 2018-05-18 2018-07-11 Proqr Therapeutics Ii Bv Stereospecific Linkages in RNA Editing Oligonucleotides
CA3124493A1 (en) 2019-01-28 2020-08-06 Proqr Therapeutics Ii B.V. Rna-editing oligonucleotides for the treatment of usher syndrome
CA3127527A1 (en) * 2019-02-12 2020-08-20 Universita Degli Studi Di Trento Cas12a guide rna molecules and uses thereof
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CR20210572A (es) 2019-04-15 2022-04-07 Univ Beijing Métodos y composiciones para editar ácido ribonucleicos (arn)
AU2020259856A1 (en) 2019-04-18 2021-11-18 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of usher syndrome
WO2020254249A1 (en) 2019-06-21 2020-12-24 Proqr Therapeutics Ii B.V. Delivery of nucleic acids for the treatment of auditory disorders
MX2022000497A (es) 2019-07-12 2022-02-03 Univ Beijing Edicion de acido ribonucleico (arn) dirigido aprovechando la adenosina desaminasa que actua sobre acido ribonucleico endogeno (adar) utilizando acidos ribonucleicos (arn) modificados geneticamente.
US20220265695A1 (en) 2019-07-26 2022-08-25 Proqr Therapeutics Ii B.V. Opthalmic compositions comprising viscosifying polymers and nucleic acids
EP4010475A1 (en) * 2019-08-08 2022-06-15 UCL Business Ltd Antisense oligonucleotides rescue aberrant splicing of abca4
WO2021130313A1 (en) 2019-12-23 2021-07-01 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for nucleotide deamination in the treatment of stargardt disease
IL294260A (en) * 2019-12-30 2022-08-01 Edigene Therapeutics Beijing Inc Method for treating usher syndrome and composition thereof
CN113122577A (zh) * 2019-12-30 2021-07-16 博雅辑因（北京）生物科技有限公司 一种治疗Usher综合征的方法和其组合物
WO2021175904A1 (en) 2020-03-04 2021-09-10 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for use in the treatment of usher syndrome
WO2022184888A2 (en) 2021-03-05 2022-09-09 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for use in the treatment of corneal dystrophies
TR2022001648A2 (tr) * 2022-02-09 2022-02-21 T C Ueskuedar Ueniversitesi Ush2a kaynaklı retinitis pigmentosa hastalığının genetik tedavisi için ekzon 13 atlama işlevi gören kseno nükleik asit antisens-oligonükleotit (xna-aso) dizileri.
EP4479535A1 (en) 2022-02-14 2024-12-25 ProQR Therapeutics II B.V. Guide oligonucleotides for nucleic acid editing in the treatment of hypercholesterolemia
EP4599061A1 (en) * 2022-10-06 2025-08-13 Stichting Radboud universitair medisch centrum Antisense oligonucleotides for treatment of usher 2a. exon 68
WO2024074668A1 (en) * 2022-10-06 2024-04-11 Stichting Radboud Universitair Medisch Centrum Antisense oligonucleotides for treatment of usher 2a. exons 30-31
CN120129747A (zh) * 2022-10-11 2025-06-10 广州瑞风生物科技有限公司 snRNA核酸分子及其应用
WO2024105063A1 (en) * 2022-11-15 2024-05-23 Stichting Radboud Universitair Medisch Centrum Antisense oligonucleotides for treatment of usher 2a. exons 39-40
WO2025007937A1 (zh) * 2023-07-04 2025-01-09 广州瑞风生物科技有限公司 靶向USH2A pre-mRNA假外显子PE40的snRNA及其应用

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KR102368920B1 (ko) 2022-02-28
US20200237802A1 (en) 2020-07-30
CA3021899A1 (en) 2017-11-02
US20190381089A1 (en) 2019-12-19
EA201892431A1 (ru) 2019-04-30
JP2019515688A (ja) 2019-06-13
ES2801823T3 (es) 2021-01-14
DK3448999T3 (da) 2020-06-08
AU2017257292A1 (en) 2018-12-06
IL262199B (en) 2022-03-01
CN109072239A (zh) 2018-12-21
MX2018013003A (es) 2019-01-28
IL262199A (en) 2018-12-31
KR20180134931A (ko) 2018-12-19
US11123360B2 (en) 2021-09-21
US20210401871A1 (en) 2021-12-30
EP3448999B1 (en) 2020-05-13
EP3448999A1 (en) 2019-03-06
US10617707B2 (en) 2020-04-14
PL3448999T3 (pl) 2020-11-30
WO2017186739A1 (en) 2017-11-02
ZA201806628B (en) 2019-07-31

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