JP7033591B2 - 治療用オリゴヌクレオチドの捕捉および検出 - Google Patents

治療用オリゴヌクレオチドの捕捉および検出 Download PDF

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JP7033591B2
JP7033591B2 JP2019524385A JP2019524385A JP7033591B2 JP 7033591 B2 JP7033591 B2 JP 7033591B2 JP 2019524385 A JP2019524385 A JP 2019524385A JP 2019524385 A JP2019524385 A JP 2019524385A JP 7033591 B2 JP7033591 B2 JP 7033591B2
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nucleoside
oligonucleotide
modified
capture probe
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JP2019534025A (ja
JP2019534025A5 (https=
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マス オーボー イェンスン
ラース ヨーンソン
ルカス キールピンスキ
モーデン リンドウ
ヨーナス ヴィケソー
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ロシュ イノベーション センター コペンハーゲン エーエス
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    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855—Ligating adaptors
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    • C12Q1/6869—Methods for sequencing
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    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/50—Other enzymatic activities
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    • C—CHEMISTRY; METALLURGY
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/117—Modifications characterised by incorporating modified base
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/155—Modifications characterised by incorporating/generating a new priming site
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/30—Oligonucleotides characterised by their secondary structure
    • C12Q2525/301—Hairpin oligonucleotides
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    • C12Q2545/00—Reactions characterised by their quantitative nature
    • C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
    • C12Q2545/114—Reactions characterised by their quantitative nature the purpose being quantitative analysis involving a quantitation step

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  • Chemical & Material Sciences (AREA)
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  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2019524385A 2016-11-11 2017-11-09 治療用オリゴヌクレオチドの捕捉および検出 Expired - Fee Related JP7033591B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16198340 2016-11-11
EP16198340.8 2016-11-11
PCT/EP2017/078695 WO2018087200A1 (en) 2016-11-11 2017-11-09 Therapeutic oligonucleotides capture and detection

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JP2019534025A JP2019534025A (ja) 2019-11-28
JP2019534025A5 JP2019534025A5 (https=) 2020-01-16
JP7033591B2 true JP7033591B2 (ja) 2022-03-10

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US (1) US20190284621A1 (https=)
EP (1) EP3538671A1 (https=)
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WO (1) WO2018087200A1 (https=)

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AU2017289204A1 (en) 2016-07-01 2019-01-17 F. Hoffmann-La Roche Ag Antisense oligonucleotides for modulating HTRA1 expression
WO2018130585A1 (en) * 2017-01-13 2018-07-19 Roche Innovation Center Copenhagen A/S Antisense oligonucleotides for modulating relb expression
US20190055564A1 (en) * 2017-06-01 2019-02-21 F. Hoffmann-La Roche Ag Antisense oligonucleotides for modulating htra1 expression
US20240175077A1 (en) * 2019-11-14 2024-05-30 Sekisui Medical Co., Ltd. Method for detecting or quantifying oligonucleotide
CN121344163A (zh) * 2020-01-16 2026-01-16 Dnae诊断有限公司 用于分离靶多核苷酸的组合物、试剂盒和方法
US20230407374A1 (en) * 2020-11-09 2023-12-21 Children's Medical Center Corporation Systems and methods for high throughput screening of molecular interactions
GB202217984D0 (en) * 2022-11-30 2023-01-11 Qbiotix Ltd Assays

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JP2003533971A (ja) 1999-11-12 2003-11-18 アイシス・ファーマシューティカルス・インコーポレーテッド オリゴヌクレオチドを定量するための方法
JP2008545430A (ja) 2005-05-31 2008-12-18 アプレラ コーポレイション 短い核酸のマルチプレックス増幅
JP2009509565A (ja) 2005-10-03 2009-03-12 アプレラ コーポレイション 核酸を増幅するための組成物、方法およびキット
WO2013153911A1 (ja) 2012-04-12 2013-10-17 国立大学法人東京大学 核酸の定量方法、検出プローブ、検出プローブセット、及び核酸の検出方法
WO2014110272A1 (en) 2013-01-09 2014-07-17 The Penn State Research Foundation Low sequence bias single-stranded dna ligation
JP2015511819A (ja) 2012-02-27 2015-04-23 セルラー リサーチ， インコーポレイテッド 分子計数のための組成物およびキット

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AU9063398A (en) 1997-09-12 1999-04-05 Exiqon A/S Oligonucleotide analogues
CZ296576B6 (cs) 1999-02-12 2006-04-12 Sankyo Company Limited Nukleosidový analog a oligonukleotidový analog a farmaceutický prostredek, sonda a primer s jeho obsahem
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ATE532878T1 (de) * 2005-08-24 2011-11-15 Life Technologies Corp Verfahren zur quantifizierung von sirnas, mirnas und polymorphen mirnas
JP5342881B2 (ja) 2006-01-27 2013-11-13 アイシス ファーマシューティカルズ， インコーポレーテッド ６−修飾された二環式核酸類似体
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JP2003533971A (ja) 1999-11-12 2003-11-18 アイシス・ファーマシューティカルス・インコーポレーテッド オリゴヌクレオチドを定量するための方法
JP2008545430A (ja) 2005-05-31 2008-12-18 アプレラ コーポレイション 短い核酸のマルチプレックス増幅
JP2009509565A (ja) 2005-10-03 2009-03-12 アプレラ コーポレイション 核酸を増幅するための組成物、方法およびキット
JP2015511819A (ja) 2012-02-27 2015-04-23 セルラー リサーチ， インコーポレイテッド 分子計数のための組成物およびキット
WO2013153911A1 (ja) 2012-04-12 2013-10-17 国立大学法人東京大学 核酸の定量方法、検出プローブ、検出プローブセット、及び核酸の検出方法
WO2014110272A1 (en) 2013-01-09 2014-07-17 The Penn State Research Foundation Low sequence bias single-stranded dna ligation

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JP2019534025A (ja) 2019-11-28
US20190284621A1 (en) 2019-09-19
WO2018087200A1 (en) 2018-05-17
EP3538671A1 (en) 2019-09-18

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