JP7030113B2 - 無機-有機複合医科材料、および、無機-有機複合医科材料の製造方法 - Google Patents
無機-有機複合医科材料、および、無機-有機複合医科材料の製造方法 Download PDFInfo
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- JP7030113B2 JP7030113B2 JP2019518885A JP2019518885A JP7030113B2 JP 7030113 B2 JP7030113 B2 JP 7030113B2 JP 2019518885 A JP2019518885 A JP 2019518885A JP 2019518885 A JP2019518885 A JP 2019518885A JP 7030113 B2 JP7030113 B2 JP 7030113B2
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/15—Compositions characterised by their physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C5/00—Filling or capping teeth
- A61C5/70—Tooth crowns; Making thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/70—Preparations for dentistry comprising inorganic additives
- A61K6/71—Fillers
- A61K6/77—Glass
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/802—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/84—Preparations for artificial teeth, for filling teeth or for capping teeth comprising metals or alloys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
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Description
図1を参照して、本発明の無機-有機複合医科材料の一実施形態としてのナノコンポジットレジン1を説明する。
無機物2は、モノリス型構造を有する多孔質体であり、3次元網目状に連続する骨格21と、その骨格21により区画される連通孔22とを備えている。
有機高分子3は、連通孔22内に空隙が生じないように、連通孔22内に密に充填されている。有機高分子3は、3次元網目状に連続しており、無機物2の骨格21と互いに絡み合っている。有機高分子3は、原料単量体の重合体である。
このようなナノコンポジットレジン1は、補綴物として好適な硬さを有する。
次に、図2A~図2Dを参照して、本発明の無機-有機複合医科材料の製造方法の一実施形態としてのナノコンポジットレジン1の製造方法を説明する。
図2Aに示すように、ナノコンポジットレジン1の製造方法では、まず、無機ナノ粒子23を分散媒中に分散させて、無機粒子分散液25を調製する。
次いで、図2Bに示すように、無機粒子分散液25(好ましくは、高分子配合分散液26)を乾燥して、ナノポア27を有する多孔質前駆体24を形成する。なお、本実施形態では、高分子配合分散液26を乾燥する場合について詳述する。
次に、図2Cに示すように、多孔質前駆体24を、例えば、大気中において焼成し、無機焼成体として無機物2を形成する。
次いで、無機物2の連通孔22に有機高分子3を充填する。
このようなナノコンポジットレジン1は、各種医療分野における補綴物として好適に利用できる。ナノコンポジットレジン1の用途として、例えば、医療用人工骨、骨補てん剤、歯科材料、医療用教材などが挙げられ、好ましくは、歯科材料(無機-有機複合歯科材料)が挙げられ、さらに好ましくは、CAD/CAM用歯科修復材料が挙げられる。
図1に示すように、ナノコンポジットレジン1では、連通孔22の平均孔径が上記下限以上である。そのため、無機物2の連通孔22に有機高分子3を十分に充填することができ、無機物2と有機高分子3との2相共連続構造を確保することができる。その結果、ナノコンポジットレジン1が脆くなることを抑制できる。
そのため、多孔質前駆体24において、水溶性高分子41に起因するナノポア27を確実に形成することができる。
(実施例1~4および比較例1、2)
平均一次粒子径が7nmのシリカ粒子(無機ナノ粒子、フュームドシリカ、商品名:Aerosil300、日本アエロジル社製)を、蒸留水(分散媒)に、超音波分散により分散させた。
平均一次粒子径が7nmのシリカ粒子を平均一次粒子径が200nmのシリカ粒子に変更したこと以外は、実施例2と同様にして、連通孔を有するシリカガラスの焼結体(無機物)を調製した。
実施例1のシリカガラスの焼結体(焼成時間:3時間)と、実施例3のシリカガラスの焼結体(焼成時間:5時間)とを、FE-SEM(電界放射型走査電子顕微鏡:Field Emission-Scanning Electron Microscope)により撮影した。実施例1のシリカガラスの焼結体のFE-SEM画像を図3Aに示し、実施例3のシリカガラスの焼結体のFE-SEM画像を図3Bに示す。図3Aおよび図3Bでは、シリカガラスの焼結体に連通孔が形成されていることが確認された。
メチルメタクリレート(MMA、原料単量体)10gを準備し、そのMMAに、過酸化ベンゾイル(BPO、重合開始剤)0.05gを溶解した。
2 無機物
3 有機高分子
22 連通孔
23 無機ナノ粒子
24 多孔質前駆体
31 原料単量体
41 水溶性高分子
Claims (8)
- 連通孔を有する無機物と、前記連通孔内に充填される有機高分子との2相共連続構造を有し、
前記無機物は、複数の金属酸化物の粒子が互いに接合した骨格を有し、
前記連通孔は、前記骨格の間にできた空間であり、
前記連通孔の平均孔径が、1nm以上50nm以下であり、
前記無機物の比表面積が、100m2/g以下であることを特徴とする、無機-有機複合医科材料。 - 前記骨格は、3次元網目状に連続する前記金属酸化物のガラスであり、
前記連通孔は、3次元網目状であることを特徴とする、請求項1に記載の無機-有機複合医科材料。 - 前記有機高分子が、エチレン性不飽和二重結合を有する原料単量体の重合体であることを特徴とする、請求項1または2に記載の無機-有機複合医科材料。
- 金属酸化物の粒子である無機ナノ粒子を分散媒中に分散させる工程、
前記分散媒を乾燥して、前記無機ナノ粒子からナノポアを有する多孔質前駆体を形成する工程、
前記多孔質前駆体を焼成して、複数の前記無機ナノ粒子が互いに接合した骨格と、前記骨格の間にできた空間である連通孔であって、平均孔径が1nm以上50nm以下の連通孔とを有し、比表面積が100m2/g以下である無機焼成体を形成する工程、
前記無機焼成体の前記連通孔に有機高分子を充填して、前記連通孔を有する無機物と、前記連通孔内に充填される有機高分子との2相共連続構造を有する無機-有機複合医科材料を製造する工程、
を備えることを特徴とする、無機-有機複合医科材料の製造方法。 - 前記無機ナノ粒子を前記分散媒中に分散させる工程では、
前記無機ナノ粒子とともに水溶性高分子を前記分散媒中に配合して、前記無機ナノ粒子を前記分散媒中に分散させ、
前記多孔質前駆体を形成する工程では、
前記分散媒を乾燥して、前記無機ナノ粒子および前記水溶性高分子から、前記水溶性高分子に起因するナノポアを有する前記多孔質前駆体を形成することを特徴とする、請求項4に記載の無機-有機複合医科材料の製造方法。 - 前記無機焼成体を形成する工程では、
前記無機焼成体が、前記連通孔を有さない緻密な無機焼成体となる条件よりも、緩和された条件にて、前記多孔質前駆体を焼成することを特徴とする、請求項4または5に記載の無機-有機複合医科材料の製造方法。 - 前記緩和された条件により、前記連通孔の平均孔径を、1nm以上50nm以下の範囲で調整することを特徴とする、請求項6に記載の無機-有機複合医科材料の製造方法。
- 前記無機焼成体の前記連通孔に前記有機高分子を充填する工程では、
前記有機高分子の原料単量体を、前記連通孔に導入する工程と、
前記連通孔に導入された前記原料単量体を重合して、前記有機高分子を形成する工程と、を備えていることを特徴とする、請求項4~7のいずれか一項に記載の無機-有機複合医科材料の製造方法。
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電子情報通信学会技術研究報告,2016年,Vol.116,No.169,pp.1-2 |
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