JP7027026B2 - 眼疾患を処置するためのａｂｃｂ５（＋）幹細胞 - Google Patents

眼疾患を処置するためのａｂｃｂ５（＋）幹細胞 Download PDF

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JP7027026B2
JP7027026B2 JP2015558916A JP2015558916A JP7027026B2 JP 7027026 B2 JP7027026 B2 JP 7027026B2 JP 2015558916 A JP2015558916 A JP 2015558916A JP 2015558916 A JP2015558916 A JP 2015558916A JP 7027026 B2 JP7027026 B2 JP 7027026B2
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abcb5
stem cells
cells
corneal
isolated
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JP2016510727A (ja
JP2016510727A5 (https=
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フランク，マルクス，エイチ．
フランク，ナターシャ，ワイ．
クサンダー，ブルース
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Schepens Eye Research Institute Inc
Government of the United States of America
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Schepens Eye Research Institute Inc
Government of the United States of America
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
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JP2015558916A 2013-02-19 2014-02-19 眼疾患を処置するためのａｂｃｂ５（＋）幹細胞 Active JP7027026B2 (ja)

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Application Number Priority Date Filing Date Title
US201361766424P 2013-02-19 2013-02-19
US61/766,424 2013-02-19
PCT/US2014/017076 WO2014130518A1 (en) 2013-02-19 2014-02-19 Abcb5(+) stem cells for treating ocular disease

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JP2019036040A Division JP2019189600A (ja) 2013-02-19 2019-02-28 眼疾患を処置するためのａｂｃｂ５（＋）幹細胞

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JP2016510727A JP2016510727A (ja) 2016-04-11
JP2016510727A5 JP2016510727A5 (https=) 2017-03-30
JP7027026B2 true JP7027026B2 (ja) 2022-03-01

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JP2019036040A Pending JP2019189600A (ja) 2013-02-19 2019-02-28 眼疾患を処置するためのａｂｃｂ５（＋）幹細胞

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US (3) US9801912B2 (https=)
EP (2) EP3865573A1 (https=)
JP (2) JP7027026B2 (https=)
KR (2) KR102385934B1 (https=)
AU (1) AU2014219026B2 (https=)
CA (1) CA2901931C (https=)
DK (1) DK2964238T3 (https=)
ES (1) ES2860573T3 (https=)
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Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2411101C (en) 2000-06-05 2018-01-16 Brigham And Women's Hospital, Inc. A gene encoding a multidrug resistance human p-glycoprotein homologue on chromosome 7p15-21 and uses thereof
SI2772535T1 (sl) 2006-05-31 2022-08-31 Children's Medical Center Corporation ABC5 pozitivne mezenhimske matične celice kot imunomodulatorji
EP2155248B1 (en) 2007-04-12 2015-06-10 The Brigham and Women's Hospital, Inc. Targeting abcb5 for cancer therapy
EP3978928A1 (en) 2008-11-14 2022-04-06 The Brigham and Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
US11542328B2 (en) 2008-11-14 2023-01-03 The Brigham And Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
WO2014130518A1 (en) 2013-02-19 2014-08-28 Children's Medical Center Corporation Abcb5(+) stem cells for treating ocular disease
AU2014262590B2 (en) * 2013-05-10 2018-05-10 Children's Medical Center Corporation Wound healing and tissue engineering
ES2905558T3 (es) * 2015-11-13 2022-04-11 Avellino Lab Usa Inc Procedimientos para el tratamiento de las distrofias corneales
MX2020011297A (es) 2018-04-25 2020-11-18 Childrens Medical Center Ligandos y substratos de abcb5.
US12329781B2 (en) 2018-07-22 2025-06-17 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of renal diseases
JP2021531288A (ja) * 2018-07-22 2021-11-18 ミノヴィア セラピューティクス リミテッド 眼疾患のミトコンドリア増強療法
WO2020021536A1 (en) 2018-07-22 2020-01-30 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy for primary mitochondrial diseases
JP7524157B2 (ja) 2018-07-22 2024-07-29 ミノヴィア セラピューティクス リミテッド 脳疾患のミトコンドリア増強療法
US12551504B2 (en) 2018-07-22 2026-02-17 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of pancreatic diseases
EP3947651A1 (en) * 2019-04-01 2022-02-09 Stemsight Oy Method for obtaining or maintaining abcg2-positive corneal limbal stem cells
WO2021092564A1 (en) * 2019-11-07 2021-05-14 Massachusetts Eye And Ear Infirmary Cultivated autologous limbal epithelial cell (calec) transplantation
EP3842079A1 (en) * 2019-12-24 2021-06-30 Universiteit Antwerpen Ophthalmological device for the treatment of lscd and substrate for use in same
EP4125960A4 (en) * 2020-03-30 2024-04-03 Children's Medical Center Corporation USING STEM CELLS TO TREAT EXCESSIVE INFLAMMATION
CA3172402A1 (en) 2020-03-31 2021-10-07 Minovia Therapeutics Ltd. Mitochondria-enriched genetically engineered cells and uses thereof
US20240335562A1 (en) * 2021-08-04 2024-10-10 Alpine Biotherapeutics Corporation Sustainable ocular cell-mediated intraocular delivery of cellular therapeutics for treatment of ocular diseases or disorders
KR20230129828A (ko) 2022-03-02 2023-09-11 포항공과대학교 산학협력단 안구 후방 질환 또는 손상의 예방 또는 치료용 조성물
KR102913194B1 (ko) 2022-03-03 2026-01-19 서울대학교병원 안구건조증 또는 마이봄샘 기능장애의 예방, 개선, 또는 치료용 조성물
CN115074368B (zh) * 2022-06-09 2023-08-08 澳门科技大学 一种耐药型类风湿性关节炎动物模型的构建及其应用
WO2025090565A1 (en) * 2023-10-23 2025-05-01 The Children's Medical Center Corporation Abcb5-targeted stem cell reprogramming and anti-aging strategies

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007524411A (ja) 2004-01-27 2007-08-30 リライアンス ライフ サイエンシーズ ピーヴィーティー． リミテッド 角膜輪部由来の未分化幹細胞を有する組織系
WO2007143139A1 (en) 2006-05-31 2007-12-13 The Brigham And Women's Hospital, Inc. Abcb5 positive mesenchymal stem cells as immunomodulators

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5434075A (en) 1992-03-20 1995-07-18 Board Of Trustees Of The University Of Illinois Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses
US5837258A (en) 1991-08-30 1998-11-17 University Of South Florida Induction of tissue, bone or cartilage formation using connective tissue growth factor
US6231881B1 (en) 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
US5906934A (en) 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair
ES2329953T3 (es) 1996-04-19 2009-12-02 Osiris Therapeutics, Inc. Regeneracion e incremento de hueso utilizando celulas madre mesenquimales.
US6152142A (en) 1997-02-28 2000-11-28 Tseng; Scheffer C. G. Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries
DE19722075C1 (de) 1997-05-27 1998-10-01 Wilhelm Dr Med Fleischmann Vorrichtung zur Applikation von Wirkstoffen an einer Wundoberfläche
AU749675B2 (en) 1998-03-13 2002-07-04 Mesoblast International Sarl Uses for human non-autologous mesenchymal stem cells
US6368636B1 (en) 1998-03-18 2002-04-09 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
AU2999199A (en) 1998-04-03 1999-10-25 Osiris Therapeutics, Inc. Mesenchymal stem cells as immunosuppressants
PT1082410E (pt) 1998-05-29 2007-11-09 Osiris Therapeutics Inc Células estaminais mesenquimatosas humanas cd45+ e/ou fibroblastos+
DE60039451D1 (de) 1999-11-29 2008-08-21 Hill Rom Services Inc Vorrichtung zur behandlung einer wunde
CA2411101C (en) 2000-06-05 2018-01-16 Brigham And Women's Hospital, Inc. A gene encoding a multidrug resistance human p-glycoprotein homologue on chromosome 7p15-21 and uses thereof
EP1322936A2 (en) 2000-10-03 2003-07-02 California Institute Of Technology Microfluidic devices and methods of use
WO2002083046A1 (en) 2001-04-16 2002-10-24 Pamela Howard Wound dressing system
US6905678B2 (en) 2001-07-07 2005-06-14 Crucell Holland B.V. Gene delivery vectors with cell type specificity for mesenchymal stem cells
US8034904B2 (en) 2002-06-14 2011-10-11 Immunogen Inc. Anti-IGF-I receptor antibody
WO2006103685A2 (en) * 2005-03-28 2006-10-05 Vision Research Foundation A method for cultivating cells derived from corneal limbal tissue and cells deived from corneal limbal tissue
KR101441843B1 (ko) 2005-10-18 2014-09-17 내셔날 쥬이쉬 헬스 조건부 불멸화 장기 줄기 세포 및 상기 세포의 제조 및 사용 방법
GB0610778D0 (en) 2006-05-31 2006-07-12 Het Nl Kanker I Phosphatidylinositol phospahte and apoptosis
EP2155248B1 (en) 2007-04-12 2015-06-10 The Brigham and Women's Hospital, Inc. Targeting abcb5 for cancer therapy
US9011840B2 (en) 2008-03-14 2015-04-21 The Board Of Trustees Of The University Of Illinois Activated mesenchymal stem cells for wound healing and impaired tissue regeneration
EP3978928A1 (en) 2008-11-14 2022-04-06 The Brigham and Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
WO2010065711A1 (en) 2008-12-04 2010-06-10 Adimab, Inc. An abcb5 epitope and antibodies thereto for the treatment of cancer
GB0908927D0 (en) * 2009-05-22 2009-07-01 Univ Reading The Synthetic graft
US20140309738A1 (en) 2011-06-01 2014-10-16 The Board Of Trustees Of The University Of Illinois Membrane-Scaffold Composites for Tissue Engineering Applications
WO2014130518A1 (en) * 2013-02-19 2014-08-28 Children's Medical Center Corporation Abcb5(+) stem cells for treating ocular disease
AU2014262590B2 (en) 2013-05-10 2018-05-10 Children's Medical Center Corporation Wound healing and tissue engineering
WO2016179576A1 (en) 2015-05-07 2016-11-10 Bioxcel Corporation Novel immunomodulatory therapeutic strategies targeting tumors in cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007524411A (ja) 2004-01-27 2007-08-30 リライアンス ライフ サイエンシーズ ピーヴィーティー． リミテッド 角膜輪部由来の未分化幹細胞を有する組織系
WO2007143139A1 (en) 2006-05-31 2007-12-13 The Brigham And Women's Hospital, Inc. Abcb5 positive mesenchymal stem cells as immunomodulators

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ＰＮＡＳ，２００１年，Ｖｏｌ．９８，Ｎｏ．６，ｐｐ．３１５６－３１６１
Ｔｈｅ Ｎｅｗ Ｅｎｇｌａｎｄ Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎｅ，２０１０年，Ｖｏｌ．３６３，Ｎｏ．２，ｐｐ．１４

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JP2019189600A (ja) 2019-10-31
US20180064762A1 (en) 2018-03-08
CA2901931A1 (en) 2014-08-28
ES2860573T3 (es) 2021-10-05
EP2964238A4 (en) 2016-09-07
AU2014219026A1 (en) 2015-09-17
JP2016510727A (ja) 2016-04-11
US9801912B2 (en) 2017-10-31
US11129854B2 (en) 2021-09-28
AU2014219026B2 (en) 2018-11-29
US20220118024A1 (en) 2022-04-21
KR102474489B1 (ko) 2022-12-06
US20150374756A1 (en) 2015-12-31
CA2901931C (en) 2023-03-07
DK2964238T3 (da) 2021-03-22
KR20220048048A (ko) 2022-04-19
KR102385934B1 (ko) 2022-04-13
EP2964238B1 (en) 2021-01-13
WO2014130518A1 (en) 2014-08-28
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KR20160033068A (ko) 2016-03-25
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