JP7025094B2 - ヘテロシクリデンアセトアミド誘導体含有医薬 - Google Patents

ヘテロシクリデンアセトアミド誘導体含有医薬 Download PDF

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Publication number
JP7025094B2
JP7025094B2 JP2021541679A JP2021541679A JP7025094B2 JP 7025094 B2 JP7025094 B2 JP 7025094B2 JP 2021541679 A JP2021541679 A JP 2021541679A JP 2021541679 A JP2021541679 A JP 2021541679A JP 7025094 B2 JP7025094 B2 JP 7025094B2
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dry eye
item
eye
compound
present disclosure
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Japanese (ja)
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JPWO2021066144A1 (ja
Inventor
毅 樽井
真也 小林
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Senju Pharmaceutical Co Ltd
Mochida Pharmaceutical Co Ltd
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Senju Pharmaceutical Co Ltd
Mochida Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
JP2021541679A 2019-10-04 2020-10-02 ヘテロシクリデンアセトアミド誘導体含有医薬 Active JP7025094B2 (ja)

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JP2022017196A JP7248836B2 (ja) 2019-10-04 2022-02-07 ヘテロシクリデンアセトアミド誘導体含有医薬

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JP2019184053 2019-10-04
JP2019184053 2019-10-04
PCT/JP2020/037548 WO2021066144A1 (ja) 2019-10-04 2020-10-02 ヘテロシクリデンアセトアミド誘導体含有医薬

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JP2022017196A Division JP7248836B2 (ja) 2019-10-04 2022-02-07 ヘテロシクリデンアセトアミド誘導体含有医薬

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JPWO2021066144A1 JPWO2021066144A1 (ja) 2021-12-02
JP7025094B2 true JP7025094B2 (ja) 2022-02-24

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JP2021541679A Active JP7025094B2 (ja) 2019-10-04 2020-10-02 ヘテロシクリデンアセトアミド誘導体含有医薬
JP2022017196A Active JP7248836B2 (ja) 2019-10-04 2022-02-07 ヘテロシクリデンアセトアミド誘導体含有医薬
JP2022171542A Pending JP2023011735A (ja) 2019-10-04 2022-10-26 ヘテロシクリデンアセトアミド誘導体含有医薬

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JP2022017196A Active JP7248836B2 (ja) 2019-10-04 2022-02-07 ヘテロシクリデンアセトアミド誘導体含有医薬
JP2022171542A Pending JP2023011735A (ja) 2019-10-04 2022-10-26 ヘテロシクリデンアセトアミド誘導体含有医薬

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US (1) US20220370404A1 (enExample)
EP (2) EP4043014B1 (enExample)
JP (3) JP7025094B2 (enExample)
KR (1) KR20220078604A (enExample)
CN (1) CN114585357A (enExample)
AU (1) AU2020361093A1 (enExample)
BR (1) BR112022005992A2 (enExample)
CA (1) CA3156484A1 (enExample)
DK (1) DK4043014T3 (enExample)
ES (1) ES3031607T3 (enExample)
HU (1) HUE072085T2 (enExample)
MX (2) MX2022004027A (enExample)
MY (1) MY207759A (enExample)
PH (1) PH12022550805A1 (enExample)
PL (1) PL4043014T3 (enExample)
PT (1) PT4043014T (enExample)
WO (1) WO2021066144A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023011735A (ja) * 2019-10-04 2023-01-24 千寿製薬株式会社 ヘテロシクリデンアセトアミド誘導体含有医薬
US12502375B2 (en) 2019-10-04 2025-12-23 Senju Pharmaceutical Co., Ltd. Pharmaceutical drug containing heterocyclidene acetamide derivative

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7175431B1 (ja) * 2021-03-30 2022-11-18 千寿製薬株式会社 ヘテロシクリデンアセトアミド誘導体含有懸濁液
KR20250065723A (ko) 2022-09-29 2025-05-13 센주 세이야꾸 가부시키가이샤 멸균 처리한 헤테로시클리덴아세트아미드 유도체 함유 현탁액
AU2023352013A1 (en) 2022-09-29 2025-04-03 Mochida Pharmaceutical Co., Ltd. Combination preparation containing heterocyclidene acetamide derivative

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007010383A1 (ja) 2005-07-22 2007-01-25 Mochida Pharmaceutical Co., Ltd. 新規なヘテロシクリデンアセトアミド誘導体
US20090131449A1 (en) 2007-11-19 2009-05-21 Alcon Research, Ltd. Use of trpv1 receptor antagonists for treating dry eye and ocular pain
WO2018221543A1 (ja) 2017-05-31 2018-12-06 持田製薬株式会社 ヘテロシクリデンアセトアミド誘導体の結晶

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5621566A (en) 1979-08-01 1981-02-28 Alpha- Shokuhin Kk Preparation of bifun from homegrown rice and apparatus used for it
ZA200800959B (en) * 2005-07-22 2009-10-28 Mochida Pharmaceutical Company Novel heterocyclidene acetamide derivative
US20100210682A1 (en) * 2009-02-19 2010-08-19 Abbott Laboratories Repeated Dosing of TRPV1 Antagonists
EP2377850A1 (en) * 2010-03-30 2011-10-19 Pharmeste S.r.l. TRPV1 vanilloid receptor antagonists with a bicyclic portion
WO2012045729A1 (en) * 2010-10-05 2012-04-12 Glaxo Group Limited Imidazo [1, 2 -a] pyridine and pyrazolo [1, 5 -a] pyridine derivatives as trpv1 antagonists
GB201215857D0 (en) * 2012-09-05 2012-10-24 Sylentis Sau siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions
JP7373909B2 (ja) 2018-04-06 2023-11-06 株式会社シマノ 変速制御装置および変速システム
DK4043014T3 (da) * 2019-10-04 2025-06-23 Senju Pharma Co Farmaceutisk sammensætning indeholdende heterocyklidenacetamid-derivat til brug til behandling af tørre øjne

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007010383A1 (ja) 2005-07-22 2007-01-25 Mochida Pharmaceutical Co., Ltd. 新規なヘテロシクリデンアセトアミド誘導体
US20090131449A1 (en) 2007-11-19 2009-05-21 Alcon Research, Ltd. Use of trpv1 receptor antagonists for treating dry eye and ocular pain
WO2018221543A1 (ja) 2017-05-31 2018-12-06 持田製薬株式会社 ヘテロシクリデンアセトアミド誘導体の結晶

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ARVO Annual Meeting Abstract，2017年，57，458
BELMONTE Carlos，TFOS DEWS II pain and sensation report，The Ocular Surface，2017年12月31日，Vol.15, No.3，p.404-437
IOVS，2016年，57(14)，6447-6454
海道美奈子ほか，低濃度カプサイシン刺激に対し感受性低下を示したBUT短縮型ドライアイの3症例，角膜カンファランス2019 第43回日本角膜学会総会・第35回日本角膜移植学会 プログラム・抄録集，2019年02月07日，p.88
田川 義晃ほか，痛みをターゲットとしたドライアイ治療，あたらしい眼科，2017年03月30日，第34巻, 第3号，p.341-346
益岡 尚由，ドライアイの角膜知覚異常における神経栄養因子の役割，平成28年度 金沢医科大学 共同研究成果報告書・奨励研究成果報告書，2018年10月30日，p.35-37

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023011735A (ja) * 2019-10-04 2023-01-24 千寿製薬株式会社 ヘテロシクリデンアセトアミド誘導体含有医薬
US12502375B2 (en) 2019-10-04 2025-12-23 Senju Pharmaceutical Co., Ltd. Pharmaceutical drug containing heterocyclidene acetamide derivative

Also Published As

Publication number Publication date
DK4043014T3 (da) 2025-06-23
EP4545095A3 (en) 2025-07-02
WO2021066144A1 (ja) 2021-04-08
MX2025005474A (es) 2025-06-02
CA3156484A1 (en) 2021-04-08
US20250134854A1 (en) 2025-05-01
CN114585357A (zh) 2022-06-03
EP4545095A2 (en) 2025-04-30
MY207759A (en) 2025-03-17
US20220370404A1 (en) 2022-11-24
ES3031607T3 (en) 2025-07-09
HUE072085T2 (hu) 2025-10-28
JP7248836B2 (ja) 2023-03-29
JP2022065024A (ja) 2022-04-26
AU2020361093A1 (en) 2022-05-19
JP2023011735A (ja) 2023-01-24
MX2022004027A (es) 2022-07-19
EP4043014A4 (en) 2023-10-11
EP4043014B1 (en) 2025-03-19
PL4043014T3 (pl) 2025-08-11
PT4043014T (pt) 2025-06-09
PH12022550805A1 (en) 2023-10-02
BR112022005992A2 (pt) 2022-06-21
JPWO2021066144A1 (ja) 2021-12-02
KR20220078604A (ko) 2022-06-10
EP4043014A1 (en) 2022-08-17

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