CN114585357A - 含有杂环亚基乙酰胺衍生物的药物 - Google Patents

含有杂环亚基乙酰胺衍生物的药物 Download PDF

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Publication number
CN114585357A
CN114585357A CN202080069192.5A CN202080069192A CN114585357A CN 114585357 A CN114585357 A CN 114585357A CN 202080069192 A CN202080069192 A CN 202080069192A CN 114585357 A CN114585357 A CN 114585357A
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CN
China
Prior art keywords
dry eye
eye
composition
acetamide
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080069192.5A
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English (en)
Chinese (zh)
Inventor
樽井毅
小林真也
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senju Pharmaceutical Co Ltd
Mochida Pharmaceutical Co Ltd
Original Assignee
Senju Pharmaceutical Co Ltd
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharmaceutical Co Ltd, Mochida Pharmaceutical Co Ltd filed Critical Senju Pharmaceutical Co Ltd
Publication of CN114585357A publication Critical patent/CN114585357A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CN202080069192.5A 2019-10-04 2020-10-02 含有杂环亚基乙酰胺衍生物的药物 Pending CN114585357A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019184053 2019-10-04
JP2019-184053 2019-10-04
PCT/JP2020/037548 WO2021066144A1 (ja) 2019-10-04 2020-10-02 ヘテロシクリデンアセトアミド誘導体含有医薬

Publications (1)

Publication Number Publication Date
CN114585357A true CN114585357A (zh) 2022-06-03

Family

ID=75338162

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080069192.5A Pending CN114585357A (zh) 2019-10-04 2020-10-02 含有杂环亚基乙酰胺衍生物的药物

Country Status (17)

Country Link
US (1) US20220370404A1 (enExample)
EP (2) EP4043014B1 (enExample)
JP (3) JP7025094B2 (enExample)
KR (1) KR20220078604A (enExample)
CN (1) CN114585357A (enExample)
AU (1) AU2020361093A1 (enExample)
BR (1) BR112022005992A2 (enExample)
CA (1) CA3156484A1 (enExample)
DK (1) DK4043014T3 (enExample)
ES (1) ES3031607T3 (enExample)
HU (1) HUE072085T2 (enExample)
MX (2) MX2022004027A (enExample)
MY (1) MY207759A (enExample)
PH (1) PH12022550805A1 (enExample)
PL (1) PL4043014T3 (enExample)
PT (1) PT4043014T (enExample)
WO (1) WO2021066144A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK4043014T3 (da) * 2019-10-04 2025-06-23 Senju Pharma Co Farmaceutisk sammensætning indeholdende heterocyklidenacetamid-derivat til brug til behandling af tørre øjne
JP7175431B1 (ja) * 2021-03-30 2022-11-18 千寿製薬株式会社 ヘテロシクリデンアセトアミド誘導体含有懸濁液
KR20250065723A (ko) 2022-09-29 2025-05-13 센주 세이야꾸 가부시키가이샤 멸균 처리한 헤테로시클리덴아세트아미드 유도체 함유 현탁액
AU2023352013A1 (en) 2022-09-29 2025-04-03 Mochida Pharmaceutical Co., Ltd. Combination preparation containing heterocyclidene acetamide derivative

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101228131A (zh) * 2005-07-22 2008-07-23 持田制药株式会社 新的杂环亚基乙酰胺衍生物
US20090131449A1 (en) * 2007-11-19 2009-05-21 Alcon Research, Ltd. Use of trpv1 receptor antagonists for treating dry eye and ocular pain
US20100210682A1 (en) * 2009-02-19 2010-08-19 Abbott Laboratories Repeated Dosing of TRPV1 Antagonists
WO2012045729A1 (en) * 2010-10-05 2012-04-12 Glaxo Group Limited Imidazo [1, 2 -a] pyridine and pyrazolo [1, 5 -a] pyridine derivatives as trpv1 antagonists
US20130079339A1 (en) * 2010-03-30 2013-03-28 Pharmeste S.R.L. Trpv1 vanilloid receptor antagonists with a bicyclic portion
CN104640988A (zh) * 2012-09-05 2015-05-20 西伦蒂斯私人股份公司 siRNA及其在用于治疗和/或预防眼部病症的方法和组合物中的应用
WO2018221543A1 (ja) * 2017-05-31 2018-12-06 持田製薬株式会社 ヘテロシクリデンアセトアミド誘導体の結晶

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5621566A (en) 1979-08-01 1981-02-28 Alpha- Shokuhin Kk Preparation of bifun from homegrown rice and apparatus used for it
CA2616079C (en) 2005-07-22 2012-09-25 Mochida Pharmaceutical Co., Ltd. Novel heterocyclidene acetamide derivative
JP7373909B2 (ja) 2018-04-06 2023-11-06 株式会社シマノ 変速制御装置および変速システム
DK4043014T3 (da) * 2019-10-04 2025-06-23 Senju Pharma Co Farmaceutisk sammensætning indeholdende heterocyklidenacetamid-derivat til brug til behandling af tørre øjne

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101228131A (zh) * 2005-07-22 2008-07-23 持田制药株式会社 新的杂环亚基乙酰胺衍生物
US20090131449A1 (en) * 2007-11-19 2009-05-21 Alcon Research, Ltd. Use of trpv1 receptor antagonists for treating dry eye and ocular pain
US20100210682A1 (en) * 2009-02-19 2010-08-19 Abbott Laboratories Repeated Dosing of TRPV1 Antagonists
US20130079339A1 (en) * 2010-03-30 2013-03-28 Pharmeste S.R.L. Trpv1 vanilloid receptor antagonists with a bicyclic portion
WO2012045729A1 (en) * 2010-10-05 2012-04-12 Glaxo Group Limited Imidazo [1, 2 -a] pyridine and pyrazolo [1, 5 -a] pyridine derivatives as trpv1 antagonists
CN104640988A (zh) * 2012-09-05 2015-05-20 西伦蒂斯私人股份公司 siRNA及其在用于治疗和/或预防眼部病症的方法和组合物中的应用
WO2018221543A1 (ja) * 2017-05-31 2018-12-06 持田製薬株式会社 ヘテロシクリデンアセトアミド誘導体の結晶

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
"TRPM8 channels and dry eye", 《PHARMACEUTICALS》, vol. 11, no. 4, 1 December 2018 (2018-12-01), pages 1 - 7 *
BEREITER, DAVID A: "TRPV1 and TRPM8 Channels and Nocifensive Behavior in a Rat Model for Dry Eye", 《INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE》, vol. 59, no. 8, 8 August 2018 (2018-08-08), pages 3739 - 3746 *
HATTA, AZUSA: "Dry eye sensitizes cool cells to capsaicin-induced changes in activity via TRPV1", 《JOURNAL OF NEUROPHYSIOLOGY》, vol. 121, no. 6, 2 July 2019 (2019-07-02), pages 2191 - 2201 *
KATAGIRI, A: "EVIDENCE FOR TRPA1 INVOLVEMENT IN CENTRAL NEURAL MECHANISMS IN A RAT MODEL OF DRY EYE", 《NEUROSCIENCE》, vol. 290, 15 April 2015 (2015-04-15), pages 204 - 213, XP029144692, DOI: 10.1016/j.neuroscience.2015.01.046 *
ZAN PAN: "TRPV1 Activation Is Required for Hypertonicity-Stimulated Inflammatory Cytokine Release in Human Corneal Epithelial Cells", 《INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE》, vol. 52, no. 1, 21 January 2011 (2011-01-21), pages 485 - 493 *
张燕: "东莨菪碱建立干眼动物模型研究综述", 《中国畜牧兽医文摘》, vol. 29, no. 02, 26 February 2013 (2013-02-26), pages 48 *

Also Published As

Publication number Publication date
DK4043014T3 (da) 2025-06-23
EP4545095A3 (en) 2025-07-02
WO2021066144A1 (ja) 2021-04-08
MX2025005474A (es) 2025-06-02
CA3156484A1 (en) 2021-04-08
JP7025094B2 (ja) 2022-02-24
US20250134854A1 (en) 2025-05-01
EP4545095A2 (en) 2025-04-30
MY207759A (en) 2025-03-17
US20220370404A1 (en) 2022-11-24
ES3031607T3 (en) 2025-07-09
HUE072085T2 (hu) 2025-10-28
JP7248836B2 (ja) 2023-03-29
JP2022065024A (ja) 2022-04-26
AU2020361093A1 (en) 2022-05-19
JP2023011735A (ja) 2023-01-24
MX2022004027A (es) 2022-07-19
EP4043014A4 (en) 2023-10-11
EP4043014B1 (en) 2025-03-19
PL4043014T3 (pl) 2025-08-11
PT4043014T (pt) 2025-06-09
PH12022550805A1 (en) 2023-10-02
BR112022005992A2 (pt) 2022-06-21
JPWO2021066144A1 (ja) 2021-12-02
KR20220078604A (ko) 2022-06-10
EP4043014A1 (en) 2022-08-17

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