JP7017509B2 - がんを治療するための四環式キノロン類似体の併用療法 - Google Patents

がんを治療するための四環式キノロン類似体の併用療法 Download PDF

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JP7017509B2
JP7017509B2 JP2018526088A JP2018526088A JP7017509B2 JP 7017509 B2 JP7017509 B2 JP 7017509B2 JP 2018526088 A JP2018526088 A JP 2018526088A JP 2018526088 A JP2018526088 A JP 2018526088A JP 7017509 B2 JP7017509 B2 JP 7017509B2
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cancer
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ジョン ソーン，
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センワ バイオサイエンシズ インコーポレイテッド
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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JP2018526088A 2015-11-20 2016-11-09 がんを治療するための四環式キノロン類似体の併用療法 Active JP7017509B2 (ja)

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JP2021197736A JP2022020003A (ja) 2015-11-20 2021-12-06 がんを治療するための四環式キノロン類似体の併用療法

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US201562258211P 2015-11-20 2015-11-20
US62/258,211 2015-11-20
PCT/US2016/061176 WO2017087235A1 (en) 2015-11-20 2016-11-09 Combination therapy of tetracyclic quinolone analogs for treating cancer

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JP2021197736A Withdrawn JP2022020003A (ja) 2015-11-20 2021-12-06 がんを治療するための四環式キノロン類似体の併用療法

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US (4) US10857156B2 (cg-RX-API-DMAC7.html)
EP (1) EP3377068B1 (cg-RX-API-DMAC7.html)
JP (2) JP7017509B2 (cg-RX-API-DMAC7.html)
KR (2) KR20250065935A (cg-RX-API-DMAC7.html)
CN (2) CN108601789A (cg-RX-API-DMAC7.html)
AU (3) AU2016355268B2 (cg-RX-API-DMAC7.html)
CA (1) CA3005730A1 (cg-RX-API-DMAC7.html)
IL (1) IL259423A (cg-RX-API-DMAC7.html)
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Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9758518B2 (en) 2015-03-04 2017-09-12 Pimera, Inc. Compositions, uses and methods for making them
KR20250065935A (ko) 2015-11-20 2025-05-13 센화 바이오사이언시즈 인코포레이티드 암을 치료하기 위한 테트라사이클릭 퀴놀론 유사체의 병행 요법
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
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US12303508B2 (en) * 2016-09-23 2025-05-20 The Johns Hopkins University Combinatory treatment strategies of cancer based on RNA polymerase I inhibition
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WO2018200571A1 (en) 2017-04-25 2018-11-01 Arbutus Biopharma Corporation Substituted 2,3-dihydro-1h-indene analogs and methods using same
MX2020008258A (es) * 2018-02-05 2020-11-13 Tesaro Inc Formulaciones pediátricas de niraparib y métodos de tratamiento pediátricos.
JP7445597B2 (ja) * 2018-02-15 2024-03-07 センワ バイオサイエンシズ インコーポレイテッド キノロン類似体及びそれらの塩、組成物、ならびにそれらの使用方法
CN111867598A (zh) * 2018-03-13 2020-10-30 国立大学法人大阪大学 肿瘤免疫赋活剂
US12083118B2 (en) 2018-03-29 2024-09-10 Arbutus Biopharma Corporation Substituted 1,1′-biphenyl compounds, analogues thereof, and methods using same
GB201816825D0 (en) * 2018-10-16 2018-11-28 Phoremost Ltd Target for anti-cancer therapy
EP3892333A4 (en) * 2018-12-07 2022-11-30 CRAGE medical Co., Limited Tumor combined immunotherapy
ES2973104T3 (es) 2019-02-18 2024-06-18 Medivir Ab Combinación de fármacos para su uso en un método de tratamiento de cáncer de hígado
CN110075061A (zh) * 2019-03-13 2019-08-02 安庆瑄宇医药科技有限公司 一种尼拉帕尼口服液及其制备方法
EP4013421A4 (en) 2019-08-14 2023-08-23 Senhwa Biosciences, Inc. Tetracyclic compounds and their salts, compositions, and methods for their use
CA3166741A1 (en) * 2020-01-09 2021-07-15 Astrazeneca Ab Combination therapy for treating cancer
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AR123227A1 (es) * 2020-08-12 2022-11-09 Servier Pharmaceuticals Llc Terapias combinadas para su uso en el tratamiento del cáncer
CN114409681A (zh) * 2022-03-18 2022-04-29 信义核新(北京)生物科技有限公司 用于治疗dna损伤修复缺陷肿瘤的喹诺酮类似物及其应用
CN115160341B (zh) * 2022-07-18 2023-07-18 中国医学科学院医学实验动物研究所 苯并噁嗪类化合物及其药物用途
KR20250054778A (ko) * 2022-08-30 2025-04-23 도레이 카부시키가이샤 암의 치료 및/또는 예방을 위한 의약품
CN116063328B (zh) * 2023-03-29 2023-06-20 信义核新(北京)生物科技有限公司 一种四环喹诺酮化合物、药学上可接受的盐及其应用
WO2024222630A1 (zh) * 2023-04-23 2024-10-31 信义核新(北京)生物科技有限公司 喹诺酮衍生物及其在抗肿瘤中的应用
WO2024242545A1 (ko) * 2023-05-23 2024-11-28 (주) 메티메디제약 칼슘 락테이트를 활성 성분으로 포함하는 암 백신 조성물 및 그 용도
WO2025101688A1 (en) * 2023-11-08 2025-05-15 Mary Hitchcock Memorial Hospital For Itself And On Behalf Of Dartmouth-Hitchcock Clinic (Collectively Doing Business As Dartmouth-Hitchcock) Combination therapy using tetrathiomolybdate

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006519827A (ja) 2003-03-12 2006-08-31 クドス ファーマシューティカルズ リミテッド フタラジノン誘導体
JP2007537291A (ja) 2004-05-13 2007-12-20 イコス・コーポレイション ヒトホスファチジルイノシトール３−キナーゼデルタの阻害剤としてのキナゾリノン
JP2010540663A (ja) 2007-10-05 2010-12-24 サイリーン ファーマシューティカルズ インコーポレーティッド キノロン類似体およびそれに関連する方法
JP2015518826A (ja) 2012-05-15 2015-07-06 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔ Ｐｄ−１／ｐｄ−ｌ１シグナル伝達を破壊することによる癌免疫療法

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
DE60011755T2 (de) 1999-04-07 2005-06-30 The University Of Virginia Patent Foundation Calciumkanalblocker als antikrebsmittel
JP2005511743A (ja) 2001-12-13 2005-04-28 ウォックハート・リミテッド 新世代の三重標的化したキラルな広域スペクトラム抗菌性の７位置換ピペリジノ−キノロンカルボン酸誘導体、その調製方法、組成物、および医薬としての使用
US6900224B2 (en) 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
DK1660095T3 (da) 2003-07-25 2010-05-25 Cancer Rec Tech Ltd Tricykliske PARP-inhibitorer
PT1675852E (pt) 2003-09-22 2009-03-25 Janssen Pharmaceutica Nv Quinolonas e naftiridonas heterocíclicas de 7-aminoalquilidenilo
PT2305221E (pt) 2003-12-01 2015-09-03 Cancer Res Inst Inibidores de reparação de danos no adn para tratamento de cancro
US7816406B2 (en) 2004-09-17 2010-10-19 Cylene Pharmaceuticals, Inc. Quinolone analogs
EP1928887B1 (en) 2005-08-05 2014-12-17 Senhwa Biosciences, Inc. Methods of preparing quinolone analogs
CA2619663A1 (en) 2005-08-19 2007-02-22 Cylene Pharmaceuticals, Inc. Human ribosomal dna(rdna) and ribosomal rna (rrna) nucleic acids and uses thereof
AR057555A1 (es) 2005-10-27 2007-12-05 Merck Frosst Canada Ltd Un inhibidor de fosfodiesterasa-4 4-oxo-1-(3-sustituido fenil-1,4-dihidro-1,8-naftiridin-3-carboxamida y un procedimiento de preparacion del mismo
US20090291437A1 (en) 2005-11-02 2009-11-26 O'brien Sean Methods for targeting quadruplex sequences
US20100063046A1 (en) 2006-05-17 2010-03-11 Whitten Jeffrey P Tetracyclic imidazole analogs
US20110112086A1 (en) 2006-06-08 2011-05-12 Cylene Pharmaceuticals, Inc. Pyridinone analogs
WO2007146831A2 (en) 2006-06-08 2007-12-21 Cylene Pharmaceuticals, Inc. Quinolone analogs derivatized with sulfonic acid, sulfonate or sulfonamide
GB0701992D0 (en) 2007-02-02 2007-03-14 7Tm Pharma As Grehlin Receptor Modulators
WO2008131134A1 (en) 2007-04-17 2008-10-30 Cylene Pharmaceuticals, Inc. Hydrazide compounds and uses thereof
AU2008201871A1 (en) * 2008-04-16 2009-11-26 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts Inhibition of angiogenesis and tumor metastasis
CL2009001156A1 (es) 2008-05-14 2010-08-27 Canbas Co Ltd Acetato de un peptido de 12 aminoacidos; metodo de preparacion; composicion farmaceutica y agente que lo contiene, solo o conjuntamente con un principio activo que dana el acido nucleico; util para el tratamiento o profilaxis de trastornos proliferativos celulares.
US9359605B2 (en) * 2011-03-11 2016-06-07 Sarissa Inc. Method of treating cancer by inhibition of DNA repair proteins
CN103533934B (zh) 2011-03-17 2016-03-30 特尔汗什莫尔医学基础设施研究和服务公司 用于治疗自身免疫性疾病的喹诺酮类似物
CA2892371C (en) * 2011-12-01 2021-01-19 The Brigham And Women's Hospital, Inc. Anti-ceacam1 recombinant antibodies for cancer therapy
WO2013133876A1 (en) * 2011-12-07 2013-09-12 The Regents Of The University Of California Biomarkers for prediction of response to parp inhibition in breast cancer
US9044421B2 (en) * 2012-03-28 2015-06-02 Genus Oncology, Llc Treating MUC1-expressing cancers with combination therapies
US9415118B2 (en) 2013-03-13 2016-08-16 Novartis Ag Antibody drug conjugates
WO2014209804A1 (en) * 2013-06-24 2014-12-31 Biomed Valley Discoveries, Inc. Bispecific antibodies
ES2754207T3 (es) 2013-11-28 2020-04-16 Tel Hashomer Medical Res Infrastructure & Services Ltd Inhibidores de la ARN polimerasa I y usos de los mismos
PL3134123T3 (pl) 2014-02-21 2021-07-12 Nektar Therapeutics (India) Pvt. Ltd. Agoniści selektywni względem IL-2Rbeta w kombinacji z przeciwciałem anty-CTLA-4 lub z przeciwciałem anty-PD-1
KR20250065935A (ko) 2015-11-20 2025-05-13 센화 바이오사이언시즈 인코포레이티드 암을 치료하기 위한 테트라사이클릭 퀴놀론 유사체의 병행 요법
US9957282B2 (en) 2015-12-14 2018-05-01 Senhwa Biosciences, Inc. Crystalline forms of quinolone analogs and their salts
JP7445597B2 (ja) 2018-02-15 2024-03-07 センワ バイオサイエンシズ インコーポレイテッド キノロン類似体及びそれらの塩、組成物、ならびにそれらの使用方法
WO2021030686A1 (en) 2019-08-14 2021-02-18 Senhwa Biosciences, Inc. Crystalline forms of quinoline analogs and salts thereof, compositions, and their methods for use
EP4013421A4 (en) 2019-08-14 2023-08-23 Senhwa Biosciences, Inc. Tetracyclic compounds and their salts, compositions, and methods for their use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006519827A (ja) 2003-03-12 2006-08-31 クドス ファーマシューティカルズ リミテッド フタラジノン誘導体
JP2007537291A (ja) 2004-05-13 2007-12-20 イコス・コーポレイション ヒトホスファチジルイノシトール３−キナーゼデルタの阻害剤としてのキナゾリノン
JP2010540663A (ja) 2007-10-05 2010-12-24 サイリーン ファーマシューティカルズ インコーポレーティッド キノロン類似体およびそれに関連する方法
JP2015518826A (ja) 2012-05-15 2015-07-06 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔ Ｐｄ−１／ｐｄ−ｌ１シグナル伝達を破壊することによる癌免疫療法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CANCER DISCOVERY，2015年10月21日，(2016)vol. 6，pp.59-70
Oncotarget，2015年06月05日，Vol. 6, No. 20，pp. 18094-18104
Oncotarget，2015年10月12日，Vol. 6, No. 33，pp. 34846-34858

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