AU2016355268B2 - Combination therapy of tetracyclic quinolone analogs for treating cancer - Google Patents

Combination therapy of tetracyclic quinolone analogs for treating cancer Download PDF

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AU2016355268B2
AU2016355268B2 AU2016355268A AU2016355268A AU2016355268B2 AU 2016355268 B2 AU2016355268 B2 AU 2016355268B2 AU 2016355268 A AU2016355268 A AU 2016355268A AU 2016355268 A AU2016355268 A AU 2016355268A AU 2016355268 B2 AU2016355268 B2 AU 2016355268B2
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cancer
compound
optionally substituted
alkyl
pharmaceutically acceptable
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AU2016355268A1 (en
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John Soong
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Senhwa Biosciences Inc
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Senhwa Biosciences Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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AU2016355268A 2015-11-20 2016-11-09 Combination therapy of tetracyclic quinolone analogs for treating cancer Active AU2016355268B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021225157A AU2021225157B2 (en) 2015-11-20 2021-08-31 Combination therapy of tetracyclic quinolone analogs for treating cancer
AU2023229524A AU2023229524B2 (en) 2015-11-20 2023-09-13 Combination therapy of tetracyclic quinolone analogs for treating cancer

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562258211P 2015-11-20 2015-11-20
US62/258,211 2015-11-20
PCT/US2016/061176 WO2017087235A1 (en) 2015-11-20 2016-11-09 Combination therapy of tetracyclic quinolone analogs for treating cancer

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AU2021225157A Division AU2021225157B2 (en) 2015-11-20 2021-08-31 Combination therapy of tetracyclic quinolone analogs for treating cancer

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AU2016355268A1 AU2016355268A1 (en) 2018-06-14
AU2016355268B2 true AU2016355268B2 (en) 2021-08-19

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AU2016355268A Active AU2016355268B2 (en) 2015-11-20 2016-11-09 Combination therapy of tetracyclic quinolone analogs for treating cancer
AU2021225157A Active AU2021225157B2 (en) 2015-11-20 2021-08-31 Combination therapy of tetracyclic quinolone analogs for treating cancer
AU2023229524A Active AU2023229524B2 (en) 2015-11-20 2023-09-13 Combination therapy of tetracyclic quinolone analogs for treating cancer

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AU2021225157A Active AU2021225157B2 (en) 2015-11-20 2021-08-31 Combination therapy of tetracyclic quinolone analogs for treating cancer
AU2023229524A Active AU2023229524B2 (en) 2015-11-20 2023-09-13 Combination therapy of tetracyclic quinolone analogs for treating cancer

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US (4) US10857156B2 (cg-RX-API-DMAC7.html)
EP (1) EP3377068B1 (cg-RX-API-DMAC7.html)
JP (2) JP7017509B2 (cg-RX-API-DMAC7.html)
KR (2) KR20250065935A (cg-RX-API-DMAC7.html)
CN (2) CN108601789A (cg-RX-API-DMAC7.html)
AU (3) AU2016355268B2 (cg-RX-API-DMAC7.html)
CA (1) CA3005730A1 (cg-RX-API-DMAC7.html)
IL (1) IL259423A (cg-RX-API-DMAC7.html)
RU (1) RU2752506C2 (cg-RX-API-DMAC7.html)
TW (1) TWI730013B (cg-RX-API-DMAC7.html)
WO (1) WO2017087235A1 (cg-RX-API-DMAC7.html)

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TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
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