JP7014731B2 - 置換アミノプリン化合物、その組成物、及びそれらを用いた治療方法 - Google Patents
置換アミノプリン化合物、その組成物、及びそれらを用いた治療方法 Download PDFInfo
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- JP7014731B2 JP7014731B2 JP2018551358A JP2018551358A JP7014731B2 JP 7014731 B2 JP7014731 B2 JP 7014731B2 JP 2018551358 A JP2018551358 A JP 2018551358A JP 2018551358 A JP2018551358 A JP 2018551358A JP 7014731 B2 JP7014731 B2 JP 7014731B2
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- Prior art keywords
- purine
- cyclohexanecarboxamide
- ylamino
- chloro
- difluorophenylamino
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
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| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| IL288519B2 (en) | 2015-11-02 | 2023-09-01 | Blueprint Medicines Corp | inhibitors of ret |
| US10913716B2 (en) | 2016-03-31 | 2021-02-09 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| KR102359743B1 (ko) | 2016-03-31 | 2022-02-07 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서의 치환 인돌 유도체 |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JP6995058B2 (ja) | 2016-04-01 | 2022-02-21 | シグナル ファーマシューティカルズ，エルエルシー | （１ｓ，４ｓ）－４－（２－（（（３ｓ，４ｒ）－３－フルオロテトラヒドロ－２ｈ－ピラン－４－イル）アミノ）－８－（（２，４，６－トリクロロフェニル）アミノ）－９ｈ－プリン－９－イル）－１－メチルクロロヘキサン－１－カルボキサミドの固体形態及びその使用方法 |
| CA3013408A1 (en) | 2016-04-01 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indole compound derivatives as dengue viral replication inhibitors |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CN110753682B (zh) | 2017-05-22 | 2023-06-30 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物 |
| CA3060583C (en) | 2017-05-22 | 2024-06-04 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| US10543214B2 (en) | 2017-10-04 | 2020-01-28 | Celgene Corporation | Compositions and methods of use of cis-4-[2-{[(3S,4R)-3-fluorooxan-4-yl]amino}-8-(2,4,6-trichloroanilino)-9H-purin-9-yl]-1-methylcyclohexane-1-carboxamide |
| HRP20240124T1 (hr) | 2018-04-03 | 2024-04-12 | Blueprint Medicines Corporation | Inhibitori za ret za uporabu u liječenju raka koji ima ret alteraciju |
| JP7490635B2 (ja) * | 2018-08-10 | 2024-05-27 | ブループリント メディシンズ コーポレイション | Ｅｇｆｒ変異がんの処置 |
| KR20220016456A (ko) * | 2019-04-16 | 2022-02-09 | 비바체 테라퓨틱스, 인크. | 바이사이클릭 화합물 |
| US12122787B2 (en) | 2019-09-20 | 2024-10-22 | Shanghai Jemincare Pharmaceuticals Co., Ltd | Fused pyridone compound, and preparation method therefor and use thereof |
| CN115279368B (zh) * | 2019-11-20 | 2024-05-24 | 维瓦斯治疗公司 | 杂芳基化合物 |
| US12448366B2 (en) | 2020-05-29 | 2025-10-21 | Rigel Pharmaceuticals, Inc. | Solid forms of pralsetinib |
| CN115916747A (zh) * | 2020-07-01 | 2023-04-04 | 四川海思科制药有限公司 | 一种并环杂环衍生物及其在医药上的应用 |
| KR102664454B1 (ko) * | 2021-08-03 | 2024-05-09 | 한국생명공학연구원 | 젬시타빈에 대한 민감성 향상을 위한 신규 표적 및 이의 활용 |
| CN114681456A (zh) * | 2022-02-23 | 2022-07-01 | 中山大学附属第六医院 | Plx3397在结直肠癌的治疗中的用途 |
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| JP2008526989A (ja) | 2005-01-13 | 2008-07-24 | シグナル ファーマシューティカルズ，エルエルシー | ハロアリール置換アミノプリン、その組成物、およびそれによる治療の方法 |
| JP2009535346A (ja) | 2006-04-26 | 2009-10-01 | シグナル ファーマシューティカルズ，エルエルシー | ハロアリール置換アミノプリン、その組成物及びそれによる治療方法 |
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| SG11201808388QA (en) | 2018-10-30 |
| AU2017241837B2 (en) | 2021-07-22 |
| NZ746554A (en) | 2023-03-31 |
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| KR102356433B1 (ko) | 2022-01-27 |
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| CA3018986A1 (en) | 2017-10-05 |
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| EP3436018A1 (en) | 2019-02-06 |
| US20170281633A1 (en) | 2017-10-05 |
| SG10202009589UA (en) | 2020-10-29 |
| EA201892229A1 (ru) | 2019-03-29 |
| EA039392B1 (ru) | 2022-01-21 |
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| IL262007B2 (en) | 2023-04-01 |
| KR20180126497A (ko) | 2018-11-27 |
| BR112018070163A2 (pt) | 2019-01-29 |
| US10576085B2 (en) | 2020-03-03 |
| JP2019510066A (ja) | 2019-04-11 |
| EP3436018A4 (en) | 2019-11-13 |
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