JP2019510066A5 - - Google Patents
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- JP2019510066A5 JP2019510066A5 JP2018551358A JP2018551358A JP2019510066A5 JP 2019510066 A5 JP2019510066 A5 JP 2019510066A5 JP 2018551358 A JP2018551358 A JP 2018551358A JP 2018551358 A JP2018551358 A JP 2018551358A JP 2019510066 A5 JP2019510066 A5 JP 2019510066A5
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- 125000000217 alkyl group Chemical group 0.000 claims description 56
- 206010028980 Neoplasm Diseases 0.000 claims description 55
- 201000011510 cancer Diseases 0.000 claims description 53
- 238000000034 method Methods 0.000 claims description 46
- 230000035772 mutation Effects 0.000 claims description 41
- 239000008194 pharmaceutical composition Substances 0.000 claims description 37
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims description 23
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims description 23
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 18
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 18
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- 102000015735 Beta-catenin Human genes 0.000 claims description 14
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- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 14
- -1 aminopurine compound Chemical class 0.000 claims description 14
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 14
- 229910052736 halogen Inorganic materials 0.000 claims description 14
- 125000005843 halogen group Chemical group 0.000 claims description 14
- 230000003287 optical effect Effects 0.000 claims description 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 14
- 125000001424 substituent group Chemical group 0.000 claims description 14
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- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 8
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- 101000813745 Homo sapiens ETS translocation variant 5 Proteins 0.000 claims description 4
- 101000877379 Homo sapiens ETS-related transcription factor Elf-3 Proteins 0.000 claims description 4
- 101001049697 Homo sapiens Early growth response protein 1 Proteins 0.000 claims description 4
- 101001002170 Homo sapiens Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial Proteins 0.000 claims description 4
- 101001069921 Homo sapiens Growth-regulated alpha protein Proteins 0.000 claims description 4
- 101000861454 Homo sapiens Protein c-Fos Proteins 0.000 claims description 4
- 101000702384 Homo sapiens Protein sprouty homolog 2 Proteins 0.000 claims description 4
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- 101000944909 Homo sapiens Ribosomal protein S6 kinase alpha-1 Proteins 0.000 claims description 4
- 101000843556 Homo sapiens Transcription factor HES-1 Proteins 0.000 claims description 4
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- 108090000320 Hyaluronan Synthases Proteins 0.000 claims description 4
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- 108090001007 Interleukin-8 Proteins 0.000 claims description 4
- 102000004890 Interleukin-8 Human genes 0.000 claims description 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 4
- 102100027584 Protein c-Fos Human genes 0.000 claims description 4
- 102100030400 Protein sprouty homolog 2 Human genes 0.000 claims description 4
- 102100026845 Protein sprouty homolog 4 Human genes 0.000 claims description 4
- 102100020949 Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial Human genes 0.000 claims description 4
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- 102100033536 Ribosomal protein S6 kinase alpha-1 Human genes 0.000 claims description 4
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- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims description 2
- 102000007665 Extracellular Signal-Regulated MAP Kinases Human genes 0.000 claims description 2
- 108010007457 Extracellular Signal-Regulated MAP Kinases Proteins 0.000 claims description 2
- 102100021337 Gap junction alpha-1 protein Human genes 0.000 claims description 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims description 2
- 208000032612 Glial tumor Diseases 0.000 claims description 2
- 206010018338 Glioma Diseases 0.000 claims description 2
- 101000894966 Homo sapiens Gap junction alpha-1 protein Proteins 0.000 claims description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
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- 206010029260 Neuroblastoma Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims description 2
- 208000008385 Urogenital Neoplasms Diseases 0.000 claims description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims description 2
- 206010047741 Vulval cancer Diseases 0.000 claims description 2
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
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- 0 CC(CC1)(CCC1[n]1c(N)nc2cnc(N*)nc12)C(N)=O Chemical compound CC(CC1)(CCC1[n]1c(N)nc2cnc(N*)nc12)C(N)=O 0.000 description 9
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662317412P | 2016-04-01 | 2016-04-01 | |
| US62/317,412 | 2016-04-01 | ||
| PCT/US2017/025252 WO2017173206A1 (en) | 2016-04-01 | 2017-03-31 | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510066A JP2019510066A (ja) | 2019-04-11 |
| JP2019510066A5 true JP2019510066A5 (cg-RX-API-DMAC7.html) | 2020-05-07 |
| JP7014731B2 JP7014731B2 (ja) | 2022-02-01 |
Family
ID=59959573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018551358A Active JP7014731B2 (ja) | 2016-04-01 | 2017-03-31 | 置換アミノプリン化合物、その組成物、及びそれらを用いた治療方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10576085B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3436018A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7014731B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102356433B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN109069512B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017241837B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112018070163A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3018986A1 (cg-RX-API-DMAC7.html) |
| CL (1) | CL2018002787A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA039392B1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL262007B2 (cg-RX-API-DMAC7.html) |
| MX (1) | MX379513B (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ746554A (cg-RX-API-DMAC7.html) |
| SG (2) | SG10202009589UA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017173206A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| IL288519B2 (en) | 2015-11-02 | 2023-09-01 | Blueprint Medicines Corp | inhibitors of ret |
| US10913716B2 (en) | 2016-03-31 | 2021-02-09 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| KR102359743B1 (ko) | 2016-03-31 | 2022-02-07 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서의 치환 인돌 유도체 |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JP6995058B2 (ja) | 2016-04-01 | 2022-02-21 | シグナル ファーマシューティカルズ，エルエルシー | （１ｓ，４ｓ）－４－（２－（（（３ｓ，４ｒ）－３－フルオロテトラヒドロ－２ｈ－ピラン－４－イル）アミノ）－８－（（２，４，６－トリクロロフェニル）アミノ）－９ｈ－プリン－９－イル）－１－メチルクロロヘキサン－１－カルボキサミドの固体形態及びその使用方法 |
| CA3013408A1 (en) | 2016-04-01 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indole compound derivatives as dengue viral replication inhibitors |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CN110753682B (zh) | 2017-05-22 | 2023-06-30 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物 |
| CA3060583C (en) | 2017-05-22 | 2024-06-04 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| US10543214B2 (en) | 2017-10-04 | 2020-01-28 | Celgene Corporation | Compositions and methods of use of cis-4-[2-{[(3S,4R)-3-fluorooxan-4-yl]amino}-8-(2,4,6-trichloroanilino)-9H-purin-9-yl]-1-methylcyclohexane-1-carboxamide |
| HRP20240124T1 (hr) | 2018-04-03 | 2024-04-12 | Blueprint Medicines Corporation | Inhibitori za ret za uporabu u liječenju raka koji ima ret alteraciju |
| JP7490635B2 (ja) * | 2018-08-10 | 2024-05-27 | ブループリント メディシンズ コーポレイション | Ｅｇｆｒ変異がんの処置 |
| KR20220016456A (ko) * | 2019-04-16 | 2022-02-09 | 비바체 테라퓨틱스, 인크. | 바이사이클릭 화합물 |
| US12122787B2 (en) | 2019-09-20 | 2024-10-22 | Shanghai Jemincare Pharmaceuticals Co., Ltd | Fused pyridone compound, and preparation method therefor and use thereof |
| CN115279368B (zh) * | 2019-11-20 | 2024-05-24 | 维瓦斯治疗公司 | 杂芳基化合物 |
| US12448366B2 (en) | 2020-05-29 | 2025-10-21 | Rigel Pharmaceuticals, Inc. | Solid forms of pralsetinib |
| CN115916747A (zh) * | 2020-07-01 | 2023-04-04 | 四川海思科制药有限公司 | 一种并环杂环衍生物及其在医药上的应用 |
| KR102664454B1 (ko) * | 2021-08-03 | 2024-05-09 | 한국생명공학연구원 | 젬시타빈에 대한 민감성 향상을 위한 신규 표적 및 이의 활용 |
| CN114681456A (zh) * | 2022-02-23 | 2022-07-01 | 中山大学附属第六医院 | Plx3397在结直肠癌的治疗中的用途 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5391485A (en) | 1985-08-06 | 1995-02-21 | Immunex Corporation | DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues |
| JPS63500636A (ja) | 1985-08-23 | 1988-03-10 | 麒麟麦酒株式会社 | 多分化能性顆粒球コロニー刺激因子をコードするｄｎａ |
| US4810643A (en) | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| IL99699A (en) | 1990-10-10 | 2002-04-21 | Autoimmune Inc | Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes |
| FI109088B (fi) | 1997-09-19 | 2002-05-31 | Leiras Oy | Tabletti ja menetelmä sen valmistamiseksi |
| JP2007517052A (ja) * | 2003-12-23 | 2007-06-28 | ノバルティス アクチエンゲゼルシャフト | 二環式ヘテロ環式ｐ−３８キナーゼ阻害剤 |
| US7521446B2 (en) | 2005-01-13 | 2009-04-21 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
| US7723340B2 (en) * | 2005-01-13 | 2010-05-25 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
| US7759342B2 (en) | 2005-01-13 | 2010-07-20 | Signal Pharmaceuticals, Llc | Methods of treatment and prevention using haloaryl substituted aminopurines |
| WO2007030438A2 (en) * | 2005-09-06 | 2007-03-15 | Pharmacopeia, Inc. | Aminopurine derivatives for treating neurodegenerative diseases |
| JP2009516707A (ja) | 2005-11-18 | 2009-04-23 | アストラゼネカ・アクチエボラーグ | 固形製剤 |
| NZ572600A (en) * | 2006-05-12 | 2011-08-26 | Myrexis Inc | 6-Amino-purine derivatives for the treatment of cancer and fibrogenetic disorders |
| JO3235B1 (ar) | 2006-05-26 | 2018-03-08 | Astex Therapeutics Ltd | مركبات بيررولوبيريميدين و استعمالاتها |
| KR20150028857A (ko) | 2006-10-27 | 2015-03-16 | 시그날 파마소티칼 엘엘씨 | 4-[9-(테트라하이드로-퓨란-3-일)-8-(2,4,6-트리플루오로-페닐아미노)-9ｈ-퓨린-2-일아미노]-사이클로헥산-1-올을포함하는 고체 형태들, 이들의 조성물들 및 이들의 용도 |
| WO2009130342A1 (es) | 2008-04-23 | 2009-10-29 | Farmasierra Manufacturing, S.L. | Formulación farmacéutica mejorada a base de ibuprofeno y codeína |
| US20130034495A1 (en) | 2009-12-09 | 2013-02-07 | Marie Georges Beauchamps | Isotopologues of 4-[9-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phenylamino)-9h-purin-2-ylamino]-cyclohexan-1-ol |
| US8603527B2 (en) | 2010-10-25 | 2013-12-10 | Signal Pharmaceuticals, Llc | Pharmaceutical formulations of a substituted diaminopurine |
| US8680076B2 (en) | 2010-10-25 | 2014-03-25 | Signal Pharmaceuticals, Llc | Methods of treatment, improvement and prevention using haloaryl substituted aminopurines |
| US9466042B2 (en) | 2012-01-24 | 2016-10-11 | International Business Machines Corporation | Facilitating the design of information technology solutions |
| US20160082015A1 (en) | 2013-04-18 | 2016-03-24 | President And Fellows Of Harvard College | Methods, compositions and kits for promoting motor neuron survival and treating and diagnosing neurodegenerative disorders |
| GB201321737D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
| SG11201702759XA (en) | 2014-10-06 | 2017-05-30 | Signal Pharm Llc | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith |
| CN105184228A (zh) * | 2015-08-13 | 2015-12-23 | 小米科技有限责任公司 | 移动设备及其屏幕模组、指纹采集方法、装置及电子设备 |
| JP6995058B2 (ja) * | 2016-04-01 | 2022-02-21 | シグナル ファーマシューティカルズ，エルエルシー | （１ｓ，４ｓ）－４－（２－（（（３ｓ，４ｒ）－３－フルオロテトラヒドロ－２ｈ－ピラン－４－イル）アミノ）－８－（（２，４，６－トリクロロフェニル）アミノ）－９ｈ－プリン－９－イル）－１－メチルクロロヘキサン－１－カルボキサミドの固体形態及びその使用方法 |
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2017
- 2017-03-31 NZ NZ746554A patent/NZ746554A/en unknown
- 2017-03-31 KR KR1020187028514A patent/KR102356433B1/ko active Active
- 2017-03-31 EP EP17776735.7A patent/EP3436018A4/en not_active Withdrawn
- 2017-03-31 IL IL262007A patent/IL262007B2/en unknown
- 2017-03-31 AU AU2017241837A patent/AU2017241837B2/en active Active
- 2017-03-31 MX MX2018011992A patent/MX379513B/es unknown
- 2017-03-31 BR BR112018070163A patent/BR112018070163A2/pt not_active Application Discontinuation
- 2017-03-31 WO PCT/US2017/025252 patent/WO2017173206A1/en not_active Ceased
- 2017-03-31 SG SG10202009589UA patent/SG10202009589UA/en unknown
- 2017-03-31 JP JP2018551358A patent/JP7014731B2/ja active Active
- 2017-03-31 US US15/475,899 patent/US10576085B2/en active Active
- 2017-03-31 CA CA3018986A patent/CA3018986A1/en not_active Abandoned
- 2017-03-31 SG SG11201808388QA patent/SG11201808388QA/en unknown
- 2017-03-31 CN CN201780021651.0A patent/CN109069512B/zh active Active
- 2017-03-31 EA EA201892229A patent/EA039392B1/ru unknown
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2018
- 2018-09-28 CL CL2018002787A patent/CL2018002787A1/es unknown
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