JP7008023B2 - 低減されたポリソルベート分解を有する製剤 - Google Patents

低減されたポリソルベート分解を有する製剤 Download PDF

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Publication number
JP7008023B2
JP7008023B2 JP2018534668A JP2018534668A JP7008023B2 JP 7008023 B2 JP7008023 B2 JP 7008023B2 JP 2018534668 A JP2018534668 A JP 2018534668A JP 2018534668 A JP2018534668 A JP 2018534668A JP 7008023 B2 JP7008023 B2 JP 7008023B2
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polysorbate
antibody
months
preparation
cyclodextrin
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JP2019504056A5 (enExample
JP2019504056A (ja
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ブライアン コノリー，
リディア ハンバーグ，
エミリー ホルツ，
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Genentech Inc
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Genentech Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2018534668A 2015-12-30 2016-12-28 低減されたポリソルベート分解を有する製剤 Active JP7008023B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021188331A JP2022036977A (ja) 2015-12-30 2021-11-19 低減されたポリソルベート分解を有する製剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562272965P 2015-12-30 2015-12-30
US62/272,965 2015-12-30
PCT/US2016/069046 WO2017117311A1 (en) 2015-12-30 2016-12-28 Formulations with reduced degradation of polysorbate

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JP2021188331A Division JP2022036977A (ja) 2015-12-30 2021-11-19 低減されたポリソルベート分解を有する製剤

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JP2019504056A JP2019504056A (ja) 2019-02-14
JP2019504056A5 JP2019504056A5 (enExample) 2020-02-13
JP7008023B2 true JP7008023B2 (ja) 2022-01-25

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JP2021188331A Withdrawn JP2022036977A (ja) 2015-12-30 2021-11-19 低減されたポリソルベート分解を有する製剤

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US (3) US10525137B2 (enExample)
EP (1) EP3397287B8 (enExample)
JP (2) JP7008023B2 (enExample)
KR (2) KR20250052501A (enExample)
CN (2) CN108472379B (enExample)
AU (2) AU2016380988B2 (enExample)
BR (1) BR112018010945A2 (enExample)
CA (1) CA3007419A1 (enExample)
ES (1) ES3038408T3 (enExample)
HR (1) HRP20250951T1 (enExample)
HU (1) HUE072357T2 (enExample)
IL (2) IL299759A (enExample)
PL (1) PL3397287T3 (enExample)
SG (1) SG11201804961UA (enExample)
WO (1) WO2017117311A1 (enExample)

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AU2016380988B2 (en) 2015-12-30 2022-07-21 Genentech, Inc. Formulations with reduced degradation of polysorbate
IL277215B2 (en) 2018-03-14 2025-10-01 Boehringer Ingelheim Int Use of anti-IL-36R antibodies for the treatment of generalized pustular psoriasis
EP3560945A1 (en) 2018-04-27 2019-10-30 F. Hoffmann-La Roche AG Methods for purification of polypeptides using polysorbates
EP3934620A1 (en) 2019-03-05 2022-01-12 Regeneron Pharmaceuticals, Inc. Human serum albumin in formulations
EP3962924A1 (en) * 2019-05-03 2022-03-09 Genentech, Inc. Methods of reducing the enzymatic hydrolysis activity rate in a composition obtained from a purification platform
BR112021025558A2 (pt) 2019-06-17 2022-03-03 Intas Pharmaceuticals Ltd Formulação estável de cetrorelix e processo para a preparação de uma formulação estável
KR20220027940A (ko) * 2019-06-28 2022-03-08 제넨테크, 인크. 액체 단백질 제제의 안정화를 위한 조성물 및 방법
KR20220157386A (ko) * 2020-03-20 2022-11-29 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 폴리소르베이트의 검출 방법
AU2022420630A1 (en) 2021-12-20 2024-05-02 Boehringer Ingelheim International Gmbh Method for determining the degree of oxidative degradation of polysorbate 20 in aqueous formulations

Citations (3)

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JP2006008684A (ja) 2004-06-22 2006-01-12 Ibsa Inst Biochimique Sa ジクロフェナクナトリウムとβ−シクロデキストリンとを有する注入可能薬学組成物
JP2009526858A (ja) 2006-02-15 2009-07-23 ティカ レーケメデル アーベー コルチコステロイド溶液を製造する方法
JP2015509526A (ja) 2012-03-07 2015-03-30 カディラ ヘルスケア リミティド 医薬製剤

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