JP7007381B2 - 細胞外クエン酸の取込みの阻害剤としてのスルホンアミド - Google Patents

細胞外クエン酸の取込みの阻害剤としてのスルホンアミド Download PDF

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JP7007381B2
JP7007381B2 JP2019530714A JP2019530714A JP7007381B2 JP 7007381 B2 JP7007381 B2 JP 7007381B2 JP 2019530714 A JP2019530714 A JP 2019530714A JP 2019530714 A JP2019530714 A JP 2019530714A JP 7007381 B2 JP7007381 B2 JP 7007381B2
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compound
group
citric acid
substituted
formula
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JP2020500907A (ja
JP2020500907A5 (https=
Inventor
ヨルク クレイ
シュテファン カウシュケ
アレクサンダー パウチ
ディーター ヴィーデンマイヤー
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
JP2019530714A 2016-12-09 2017-12-04 細胞外クエン酸の取込みの阻害剤としてのスルホンアミド Active JP7007381B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16203086 2016-12-09
EP16203086.0 2016-12-09
PCT/EP2017/081359 WO2018104220A1 (en) 2016-12-09 2017-12-04 Sulfonamides as inhibitors of the uptake of extracellular citrate

Publications (3)

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JP2020500907A JP2020500907A (ja) 2020-01-16
JP2020500907A5 JP2020500907A5 (https=) 2021-01-21
JP7007381B2 true JP7007381B2 (ja) 2022-01-24

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ID=57539116

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JP2019530714A Active JP7007381B2 (ja) 2016-12-09 2017-12-04 細胞外クエン酸の取込みの阻害剤としてのスルホンアミド

Country Status (5)

Country Link
US (1) US10793522B2 (https=)
EP (1) EP3551618B1 (https=)
JP (1) JP7007381B2 (https=)
CN (1) CN110325527B (https=)
WO (1) WO2018104220A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018104220A1 (en) 2016-12-09 2018-06-14 Boehringer Ingelheim International Gmbh Sulfonamides as inhibitors of the uptake of extracellular citrate
GB2560713A (en) * 2017-03-20 2018-09-26 Eternygen Gmbh Inhibitor of citrate transporter
GB201918410D0 (en) * 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of alpha1-antitrypsin deficiency

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009518451A (ja) 2005-12-12 2009-05-07 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ キナーゼ阻害薬として活性な置換ピラゾロ［４，３−ｃ］ピリジン誘導体
WO2010080183A1 (en) 2009-01-08 2010-07-15 The Trustees Of Columbia University In The City Of New York Potent non-urea inhibitors of soluble epoxide hydrolase
JP2013504533A (ja) 2009-09-11 2013-02-07 エフ．ホフマン−ラ ロシュ アーゲー 糖尿病の処置に有用なｈｓｌインヒビター

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100286145A1 (en) 2007-07-26 2010-11-11 Comentis, Inc. Isophthalamide derivatives inhibiting beta-secretase activity
BR112014004569A2 (pt) 2011-09-01 2017-06-13 F. Hoffmann-La Roche Ag composto da fórmula i, métodos para tratar condição inflamatória, artrite reumatoide, asma e distúrbio imune, composição farmacêutica e uso do composto
HK1222658A1 (zh) 2013-07-17 2017-07-07 Otsuka Pharmaceutical Co., Ltd. 氰基三唑化合物
WO2018104220A1 (en) 2016-12-09 2018-06-14 Boehringer Ingelheim International Gmbh Sulfonamides as inhibitors of the uptake of extracellular citrate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009518451A (ja) 2005-12-12 2009-05-07 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ キナーゼ阻害薬として活性な置換ピラゾロ［４，３−ｃ］ピリジン誘導体
WO2010080183A1 (en) 2009-01-08 2010-07-15 The Trustees Of Columbia University In The City Of New York Potent non-urea inhibitors of soluble epoxide hydrolase
JP2013504533A (ja) 2009-09-11 2013-02-07 エフ．ホフマン−ラ ロシュ アーゲー 糖尿病の処置に有用なｈｓｌインヒビター

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HUARD, K. et al.，Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family，Journal of Medicinal Chemistry，2016年，59(3)，pp. 1165-1175

Also Published As

Publication number Publication date
JP2020500907A (ja) 2020-01-16
US10793522B2 (en) 2020-10-06
CN110325527A (zh) 2019-10-11
EP3551618B1 (en) 2020-09-16
US20200062708A1 (en) 2020-02-27
CN110325527B (zh) 2022-08-09
WO2018104220A1 (en) 2018-06-14
EP3551618A1 (en) 2019-10-16

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