JP6993402B2 - 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体 - Google Patents

抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体 Download PDF

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JP6993402B2
JP6993402B2 JP2019505220A JP2019505220A JP6993402B2 JP 6993402 B2 JP6993402 B2 JP 6993402B2 JP 2019505220 A JP2019505220 A JP 2019505220A JP 2019505220 A JP2019505220 A JP 2019505220A JP 6993402 B2 JP6993402 B2 JP 6993402B2
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amino acid
acid sequence
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amino acids
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JP2019527555A (ja
JP2019527555A5 (enExample
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トラン、エリック
ルー、ヨン－チェン
パセット、アンナ
エフ． ロビンズ、ポール
エイ． ローゼンバーグ、スティーヴン
チェン、ジリ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/7051—T-cell receptor (TcR)-CD3 complex

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
JP2019505220A 2016-08-02 2017-07-31 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体 Active JP6993402B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021199878A JP7413338B2 (ja) 2016-08-02 2021-12-09 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体
JP2023221526A JP7649370B2 (ja) 2016-08-02 2023-12-27 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体
JP2025036871A JP2025090690A (ja) 2016-08-02 2025-03-07 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体

Applications Claiming Priority (3)

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US201662369883P 2016-08-02 2016-08-02
US62/369,883 2016-08-02
PCT/US2017/044615 WO2018026691A1 (en) 2016-08-02 2017-07-31 Anti-kras-g12d t cell receptors

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JP2019527555A JP2019527555A (ja) 2019-10-03
JP2019527555A5 JP2019527555A5 (enExample) 2020-09-10
JP6993402B2 true JP6993402B2 (ja) 2022-02-03

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JP2021199878A Active JP7413338B2 (ja) 2016-08-02 2021-12-09 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体
JP2023221526A Active JP7649370B2 (ja) 2016-08-02 2023-12-27 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体
JP2025036871A Pending JP2025090690A (ja) 2016-08-02 2025-03-07 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体

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JP2023221526A Active JP7649370B2 (ja) 2016-08-02 2023-12-27 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体
JP2025036871A Pending JP2025090690A (ja) 2016-08-02 2025-03-07 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体

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US (6) US10611816B2 (enExample)
EP (2) EP3494133B1 (enExample)
JP (4) JP6993402B2 (enExample)
KR (1) KR102527052B1 (enExample)
CN (2) CN118063591A (enExample)
AU (2) AU2017306038B2 (enExample)
CA (1) CA3032870A1 (enExample)
DK (1) DK3494133T3 (enExample)
ES (1) ES2928051T3 (enExample)
HR (1) HRP20221183T1 (enExample)
HU (1) HUE060121T2 (enExample)
IL (2) IL301894B2 (enExample)
LT (1) LT3494133T (enExample)
PL (1) PL3494133T3 (enExample)
PT (1) PT3494133T (enExample)
RS (1) RS63615B1 (enExample)
SG (2) SG11201900654QA (enExample)
SI (1) SI3494133T1 (enExample)
SM (1) SMT202200379T1 (enExample)
WO (1) WO2018026691A1 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3494133T (lt) * 2016-08-02 2022-12-12 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Anti-kras-g12d t ląstelės receptoriai
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
SG11202002425PA (en) 2017-09-20 2020-04-29 The United States Of America As Represented By The Secretary Hla class ii-restricted t cell receptors against mutated ras
AU2018345400B2 (en) 2017-10-05 2024-06-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for selectively expanding cells expressing a TCR with a murine constant region
CA3103983A1 (en) 2018-06-19 2019-12-26 Biontech Us Inc. Neoantigens and uses thereof
US20220088190A1 (en) * 2019-01-25 2022-03-24 The Trustees Of The University Of Pennsylvania Compositions and Methods for Targeting Mutant RAS
GB2596461B (en) * 2019-02-20 2023-09-27 Fred Hutchinson Cancer Center Binding proteins specific for RAS neoantigens and uses thereof
CN110172089B (zh) * 2019-06-11 2020-01-07 北京鼎成肽源生物技术有限公司 一种kras突变多抗原组合、靶向kras突变肿瘤ctl及其应用
CN112110995A (zh) * 2019-06-19 2020-12-22 上海交通大学医学院 肿瘤新抗原多肽及其用途
CN112760290A (zh) * 2019-10-21 2021-05-07 郑州大学 携带突变的肿瘤驱动基因的干细胞及其用途
CN112759641B (zh) * 2019-11-01 2023-01-20 香雪生命科学技术（广东）有限公司 一种识别Kras G12V的高亲和力TCR
US20220409711A1 (en) * 2019-11-05 2022-12-29 Board Of Regents, The University Of Texas System Hla restricted hormad1 t cell receptors and uses thereof
WO2021123832A1 (en) 2019-12-20 2021-06-24 Instil Bio (Uk) Limited Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof
WO2021135178A1 (zh) * 2019-12-30 2021-07-08 华夏英泰（北京）生物技术有限公司 一种增强型t细胞受体star及其应用
US20230272038A1 (en) * 2020-07-13 2023-08-31 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Hla class ii-restricted drb t cell receptors against ras with g12d mutation
AU2021351710A1 (en) * 2020-10-02 2023-06-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla class ii-restricted dq t cell receptors against ras with g13d mutation
JP2023551204A (ja) * 2020-11-20 2023-12-07 シンク・セラピューティクス・インコーポレイテッド 最適化ペプチドワクチンの組成物および方法
JP2023551819A (ja) * 2020-11-25 2023-12-13 ジーニアス・バイオテクノロジー・インコーポレイテッド 抗原特異的ｔ細胞並びにその作製及び使用方法
US20240175047A1 (en) 2021-02-25 2024-05-30 Alaunos Therapeutics, Inc. Recombinant Vectors Comprising Polycistronic Expression Cassettes and Methods of Use Thereof
BR112023022765A2 (pt) 2021-05-05 2024-01-02 Immatics Biotechnologies Gmbh Proteínas de ligação ao antígeno que ligam especificamente o prame
US20250145950A1 (en) 2022-02-01 2025-05-08 Alaunos Therapeutics, Inc. Methods for Activation and Expansion of T Cells
CN114920823B (zh) * 2022-05-27 2023-10-17 重庆医科大学 Tcr或其抗原结合片段及其应用
JP2025524005A (ja) * 2022-07-22 2025-07-25 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 養子免疫療法のための亢進された機能を有するｃｄ３発現ナチュラルキラー細胞
CN115850444B (zh) * 2022-09-15 2025-01-28 重庆医科大学 Tcr或其抗原结合片段及其应用
CN117777270B (zh) * 2022-09-29 2025-04-25 广州医科大学 一种t细胞受体(tcr)及其用途
CN120693174A (zh) * 2022-12-13 2025-09-23 百欧恩泰美国公司 T细胞受体构建体及其用途
WO2025006196A1 (en) 2023-06-28 2025-01-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors targeting ras with g12d, g12r, or g12v mutation
CN120157754A (zh) * 2023-12-14 2025-06-17 新景智源生物科技(苏州)有限公司 Kras_g12d突变抗原特异性tcr及其与cd8共表达重定向cd4 t细胞

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013541332A (ja) 2010-09-20 2013-11-14 ビオエンテッヒ・アクチェンゲゼルシャフト 抗原特異的ｔ細胞受容体およびｔ細胞エピトープ
JP2014528714A (ja) 2011-09-15 2014-10-30 アメリカ合衆国 Ｈｌａ−ａ１−又はｈｌａ−ｃｗ７−拘束性ｍａｇｅを認識するｔ細胞受容体
WO2015022520A1 (en) 2013-08-12 2015-02-19 Immunocore Limited T cell receptors
JP2018535647A (ja) 2015-09-15 2018-12-06 アメリカ合衆国 Ｈｌａ−ｃｗ８拘束性の変異ｋｒａｓを認識するｔ細胞受容体

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776459A (en) * 1989-07-19 1998-07-07 Connetics Corporation TCR V beta 5 peptides
US20020150891A1 (en) * 1994-09-19 2002-10-17 Leroy E. Hood Diagnostic and therapeutic compositions and methods which utilize the t cell receptor beta gene region
US7709002B1 (en) 1996-04-19 2010-05-04 The United States Of America As Represented By The Department Of Health And Human Services Mutated ras peptides for generation of CD8+Cytotoxic T lymphocytes
GB2328689A (en) 1997-08-27 1999-03-03 Norsk Hydro As Peptides based on the p21 ras proto-oncogene protein for the treatment of cancer
DK1545204T3 (en) 2002-09-06 2016-11-14 The Government Of The Us Secretary Dept Of Health And Human Services Immunotherapy with in vitro selected antigen-specific lymphocytes following non-myeloablative lymphodepletive chemotherapy
WO2008089053A2 (en) 2007-01-12 2008-07-24 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Gp100-specific t cell receptors and related materials and methods of use
US8383099B2 (en) 2009-08-28 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adoptive cell therapy with young T cells
US20120244133A1 (en) 2011-03-22 2012-09-27 The United States of America, as represented by the Secretary, Department of Health and Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
EP2749642A4 (en) * 2011-11-30 2015-03-04 Nat Cancer Ct INDUCED MALIGNE STEM CELLS
KR20160013049A (ko) * 2013-06-03 2016-02-03 노파르티스 아게 항-pd-l1 항체 및 mek 억제제 및/또는 braf 억제제의 조합물
GB201313377D0 (en) * 2013-07-26 2013-09-11 Adaptimmune Ltd T cell receptors
PL3223850T3 (pl) 2014-11-26 2020-08-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Receptory limfocytów t przeciwko zmutowanemu kras
LT3494133T (lt) * 2016-08-02 2022-12-12 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Anti-kras-g12d t ląstelės receptoriai
WO2025006196A1 (en) 2023-06-28 2025-01-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors targeting ras with g12d, g12r, or g12v mutation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013541332A (ja) 2010-09-20 2013-11-14 ビオエンテッヒ・アクチェンゲゼルシャフト 抗原特異的ｔ細胞受容体およびｔ細胞エピトープ
JP2014528714A (ja) 2011-09-15 2014-10-30 アメリカ合衆国 Ｈｌａ−ａ１−又はｈｌａ−ｃｗ７−拘束性ｍａｇｅを認識するｔ細胞受容体
WO2015022520A1 (en) 2013-08-12 2015-02-19 Immunocore Limited T cell receptors
JP2018535647A (ja) 2015-09-15 2018-12-06 アメリカ合衆国 Ｈｌａ−ｃｗ８拘束性の変異ｋｒａｓを認識するｔ細胞受容体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PNAS，2015年01月20日，Vol.112, No.3，pp.779-784

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US20190177395A1 (en) 2019-06-13
ES2928051T3 (es) 2022-11-15
JP2019527555A (ja) 2019-10-03
LT3494133T (lt) 2022-12-12
US20210300988A1 (en) 2021-09-30
US11208456B2 (en) 2021-12-28
HUE060121T2 (hu) 2023-01-28
AU2017306038A1 (en) 2019-02-14
JP7413338B2 (ja) 2024-01-15
JP2024045139A (ja) 2024-04-02
DK3494133T3 (da) 2022-09-19
EP4159751A1 (en) 2023-04-05
KR20190064566A (ko) 2019-06-10
CN109790211A (zh) 2019-05-21
US20250340611A1 (en) 2025-11-06
IL301894A (en) 2023-06-01
EP3494133B1 (en) 2022-07-06
CN118063591A (zh) 2024-05-24
AU2023233125A1 (en) 2023-10-12
SG11201900654QA (en) 2019-02-27
JP2025090690A (ja) 2025-06-17
WO2018026691A1 (en) 2018-02-08
JP7649370B2 (ja) 2025-03-19
PL3494133T3 (pl) 2022-11-21
SMT202200379T1 (it) 2022-11-18
RS63615B1 (sr) 2022-10-31
IL264425B1 (en) 2023-05-01
US20200247869A1 (en) 2020-08-06
US10611816B2 (en) 2020-04-07
CN109790211B (zh) 2024-03-26
SG10201913959WA (en) 2020-03-30
US12391742B2 (en) 2025-08-19
IL301894B1 (en) 2024-10-01
IL264425B2 (en) 2023-09-01
PT3494133T (pt) 2022-09-28
EP3494133A1 (en) 2019-06-12
US11897933B2 (en) 2024-02-13
AU2017306038B2 (en) 2023-06-22
CA3032870A1 (en) 2018-02-08
HRP20221183T1 (hr) 2022-12-09
US20240209059A1 (en) 2024-06-27
IL301894B2 (en) 2025-02-01
SI3494133T1 (sl) 2022-11-30
IL264425A (enExample) 2019-03-31
JP2022050400A (ja) 2022-03-30
KR102527052B1 (ko) 2023-04-27
US20220089677A1 (en) 2022-03-24
US11840561B2 (en) 2023-12-12
AU2023233125B2 (en) 2025-10-16

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