AU2017306038B2 - Anti-KRAS-G12D T cell receptors - Google Patents

Anti-KRAS-G12D T cell receptors Download PDF

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Publication number
AU2017306038B2
AU2017306038B2 AU2017306038A AU2017306038A AU2017306038B2 AU 2017306038 B2 AU2017306038 B2 AU 2017306038B2 AU 2017306038 A AU2017306038 A AU 2017306038A AU 2017306038 A AU2017306038 A AU 2017306038A AU 2017306038 B2 AU2017306038 B2 AU 2017306038B2
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amino acid
leu
ser
acid sequence
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AU2017306038A1 (en
Inventor
Yong-Chen LU
Anna PASETTO
Paul F. Robbins
Steven A. Rosenberg
Eric TRAN
Zhili ZHENG
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United States Department of Health and Human Services
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Government of the United States of America
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Priority to AU2023233125A priority Critical patent/AU2023233125B2/en
Priority to AU2026200276A priority patent/AU2026200276A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57557—Immunoassay; Biospecific binding assay; Materials therefor for cancer of other specific parts of the body, e.g. brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/7051—T-cell receptor (TcR)-CD3 complex

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
AU2017306038A 2016-08-02 2017-07-31 Anti-KRAS-G12D T cell receptors Active AU2017306038B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2023233125A AU2023233125B2 (en) 2016-08-02 2023-09-21 Anti-KRAS-G12D T cell receptors
AU2026200276A AU2026200276A1 (en) 2016-08-02 2026-01-15 Anti-KRAS-G12D T cell receptors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662369883P 2016-08-02 2016-08-02
US62/369,883 2016-08-02
PCT/US2017/044615 WO2018026691A1 (en) 2016-08-02 2017-07-31 Anti-kras-g12d t cell receptors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2023233125A Division AU2023233125B2 (en) 2016-08-02 2023-09-21 Anti-KRAS-G12D T cell receptors

Publications (2)

Publication Number Publication Date
AU2017306038A1 AU2017306038A1 (en) 2019-02-14
AU2017306038B2 true AU2017306038B2 (en) 2023-06-22

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AU2017306038A Active AU2017306038B2 (en) 2016-08-02 2017-07-31 Anti-KRAS-G12D T cell receptors
AU2023233125A Active AU2023233125B2 (en) 2016-08-02 2023-09-21 Anti-KRAS-G12D T cell receptors
AU2026200276A Abandoned AU2026200276A1 (en) 2016-08-02 2026-01-15 Anti-KRAS-G12D T cell receptors

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AU2026200276A Abandoned AU2026200276A1 (en) 2016-08-02 2026-01-15 Anti-KRAS-G12D T cell receptors

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US (6) US10611816B2 (enExample)
EP (2) EP3494133B1 (enExample)
JP (4) JP6993402B2 (enExample)
KR (1) KR102527052B1 (enExample)
CN (2) CN118063591A (enExample)
AU (3) AU2017306038B2 (enExample)
CY (1) CY1125601T1 (enExample)
DK (1) DK3494133T3 (enExample)
ES (1) ES2928051T3 (enExample)
HR (1) HRP20221183T1 (enExample)
HU (1) HUE060121T2 (enExample)
IL (2) IL301894B2 (enExample)
LT (1) LT3494133T (enExample)
PL (1) PL3494133T3 (enExample)
PT (1) PT3494133T (enExample)
RS (1) RS63615B1 (enExample)
SG (2) SG11201900654QA (enExample)
SI (1) SI3494133T1 (enExample)
SM (1) SMT202200379T1 (enExample)
WO (1) WO2018026691A1 (enExample)

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CN112110995A (zh) * 2019-06-19 2020-12-22 上海交通大学医学院 肿瘤新抗原多肽及其用途
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CN112760290A (zh) * 2019-10-21 2021-05-07 郑州大学 携带突变的肿瘤驱动基因的干细胞及其用途
CN112759641B (zh) * 2019-11-01 2023-01-20 香雪生命科学技术（广东）有限公司 一种识别Kras G12V的高亲和力TCR
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JP2023507432A (ja) 2019-12-20 2023-02-22 インスティル バイオ （ユーケイ） リミテッド 腫瘍浸潤リンパ球を単離するためのデバイスおよび方法ならびにそれらの使用
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CA3168015A1 (en) * 2020-02-12 2021-08-19 Noam LEVIN Hla class i-restricted t cell receptors against ras with g12d mutation
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CA3185241A1 (en) 2020-07-13 2022-01-20 Noam LEVIN Hla class ii?restricted drb t cell receptors against ras with g12d mutation
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AU2021351710A1 (en) * 2020-10-02 2023-06-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla class ii-restricted dq t cell receptors against ras with g13d mutation
JP7829242B2 (ja) * 2020-11-20 2026-03-13 シンク・セラピューティクス・インコーポレイテッド 最適化ペプチドワクチンの組成物および方法
EP4251177A4 (en) * 2020-11-25 2025-01-08 Geneius Biotechnology, Inc. Antigen specific t cells and methods of making and using same
JP2024507929A (ja) 2021-02-25 2024-02-21 アラウノス セラピューティクス インコーポレイテッド 多シストロン性発現カセットを含む組換えベクター及びそれらの使用方法
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CN115850444B (zh) * 2022-09-15 2025-01-28 重庆医科大学 Tcr或其抗原结合片段及其应用
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Publication number Publication date
US20200247869A1 (en) 2020-08-06
SG10201913959WA (en) 2020-03-30
EP4159751A1 (en) 2023-04-05
JP2025090690A (ja) 2025-06-17
US11208456B2 (en) 2021-12-28
WO2018026691A1 (en) 2018-02-08
EP3494133A1 (en) 2019-06-12
SI3494133T1 (sl) 2022-11-30
EP3494133B1 (en) 2022-07-06
IL301894B1 (en) 2024-10-01
IL264425B1 (en) 2023-05-01
JP2022050400A (ja) 2022-03-30
US11840561B2 (en) 2023-12-12
CA3032870A1 (en) 2018-02-08
HRP20221183T1 (hr) 2022-12-09
IL301894A (en) 2023-06-01
IL264425B2 (en) 2023-09-01
KR102527052B1 (ko) 2023-04-27
EP4159751B1 (en) 2026-07-08
AU2023233125B2 (en) 2025-10-16
US20210300988A1 (en) 2021-09-30
US20220089677A1 (en) 2022-03-24
US20190177395A1 (en) 2019-06-13
JP7413338B2 (ja) 2024-01-15
PT3494133T (pt) 2022-09-28
JP2024045139A (ja) 2024-04-02
US20250340611A1 (en) 2025-11-06
AU2023233125A1 (en) 2023-10-12
IL301894B2 (en) 2025-02-01
KR20190064566A (ko) 2019-06-10
US10611816B2 (en) 2020-04-07
IL264425A (enExample) 2019-03-31
HUE060121T2 (hu) 2023-01-28
US12391742B2 (en) 2025-08-19
CN109790211B (zh) 2024-03-26
AU2017306038A1 (en) 2019-02-14
AU2026200276A1 (en) 2026-02-19
CN109790211A (zh) 2019-05-21
RS63615B1 (sr) 2022-10-31
CY1125601T1 (el) 2026-02-25
DK3494133T3 (da) 2022-09-19
CN118063591A (zh) 2024-05-24
US20240209059A1 (en) 2024-06-27
US11897933B2 (en) 2024-02-13
JP7649370B2 (ja) 2025-03-19
SMT202200379T1 (it) 2022-11-18
PL3494133T3 (pl) 2022-11-21
JP2019527555A (ja) 2019-10-03
JP6993402B2 (ja) 2022-02-03
SG11201900654QA (en) 2019-02-27
LT3494133T (lt) 2022-12-12
ES2928051T3 (es) 2022-11-15

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