JP6986445B2 - １５−ｈｅｐｅを含む組成物、およびそれを用いて線維症を処置または防止する方法 - Google Patents

１５−ｈｅｐｅを含む組成物、およびそれを用いて線維症を処置または防止する方法 Download PDF

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JP6986445B2
JP6986445B2 JP2017527848A JP2017527848A JP6986445B2 JP 6986445 B2 JP6986445 B2 JP 6986445B2 JP 2017527848 A JP2017527848 A JP 2017527848A JP 2017527848 A JP2017527848 A JP 2017527848A JP 6986445 B2 JP6986445 B2 JP 6986445B2
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hepe
fibrosis
pharmaceutical composition
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composition
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JP2017536380A (ja
JP2017536380A5 (enExample
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ロウエ ジョナサン
ダッフィ ケビン
クリマク ジョン
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アフィミューン リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017527848A 2014-12-02 2015-12-02 １５−ｈｅｐｅを含む組成物、およびそれを用いて線維症を処置または防止する方法 Expired - Fee Related JP6986445B2 (ja)

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JP2021192836A JP2022031813A (ja) 2014-12-02 2021-11-29 １５－ｈｅｐｅを含む組成物、およびそれを用いて線維症を処置または防止する方法

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US201462086535P 2014-12-02 2014-12-02
US62/086,535 2014-12-02
PCT/US2015/063488 WO2016090030A1 (en) 2014-12-02 2015-12-02 Compositions comprising 15-hepe and methods of treating or preventing fibrosis using same

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JP2021192836A Division JP2022031813A (ja) 2014-12-02 2021-11-29 １５－ｈｅｐｅを含む組成物、およびそれを用いて線維症を処置または防止する方法

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JP2017536380A JP2017536380A (ja) 2017-12-07
JP2017536380A5 JP2017536380A5 (enExample) 2019-01-24
JP6986445B2 true JP6986445B2 (ja) 2021-12-22

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JP2017527848A Expired - Fee Related JP6986445B2 (ja) 2014-12-02 2015-12-02 １５−ｈｅｐｅを含む組成物、およびそれを用いて線維症を処置または防止する方法
JP2021192836A Pending JP2022031813A (ja) 2014-12-02 2021-11-29 １５－ｈｅｐｅを含む組成物、およびそれを用いて線維症を処置または防止する方法

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US (1) US10363235B2 (enExample)
EP (2) EP3988101A1 (enExample)
JP (2) JP6986445B2 (enExample)
KR (1) KR20170102879A (enExample)
CN (2) CN112245419A (enExample)
AU (2) AU2015358512B2 (enExample)
BR (1) BR112017011685A2 (enExample)
CA (1) CA2968980A1 (enExample)
ES (1) ES2900593T3 (enExample)
IL (2) IL252431B (enExample)
MA (1) MA41120A (enExample)
MX (2) MX382116B (enExample)
PH (1) PH12017501022B1 (enExample)
RU (2) RU2020115523A (enExample)
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WO (1) WO2016090030A1 (enExample)
ZA (2) ZA201704463B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
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GB201301626D0 (en) * 2013-01-30 2013-03-13 Dignity Sciences Ltd Composition comprising 15-OHEPA and methods of using the same
CN105899485B (zh) 2013-11-15 2018-10-19 尊严科学有限公司 多不饱和羟基脂肪酸的药学上可接受的盐
WO2015106215A2 (en) * 2014-01-10 2015-07-16 Mehar Manku Pharmaceutical compositions comprising 15-hepe and methods of treating asthma and lung disorders using same
EP3247348A1 (en) * 2015-01-16 2017-11-29 Afimmune Limited Compositions comprising 15-hepe and methods of using the same
JP2018524274A (ja) 2015-05-13 2018-08-30 ディーエス バイオファーマ リミテッド １５−オキソ−ｅｐａまたは１５−オキソ−ｄｇｌａを含む組成物、ならびにその作製及び使用方法
JP2018537513A (ja) 2015-12-18 2018-12-20 アフィミューン リミテッド １５−ｈｅｐｅを含む組成物及びその使用方法
US20210315851A1 (en) 2020-04-03 2021-10-14 Afimmune Limited Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases

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US6180671B1 (en) * 1998-03-10 2001-01-30 Beth Israel Deaconess Medical Center, Inc. Methods for treating disorders in which docosahexaenoic acid (DHA) levels are affected
JP2000191525A (ja) 1998-12-25 2000-07-11 Nof Corp 皮膚外用剤組成物
AU2634101A (en) * 2000-01-06 2001-07-16 Martek Biosciences Corporation Therapeutic preparations of highly unsaturated fatty acids
DE60144401D1 (de) 2000-02-16 2011-05-19 Brigham & Womens Hospital Aspirin-ausgelöste Lipidmediatoren
JP2005179211A (ja) 2003-12-17 2005-07-07 Idemitsu Kosan Co Ltd 皮膚外用剤組成物
WO2005063231A2 (en) 2003-12-31 2005-07-14 Igennus Limited Formulation containing an eicosapentaenoic acid or an ester thereof and a triterpene or esther thereof
US20050239889A1 (en) 2004-04-26 2005-10-27 Jean Gosselin In vivo release of endogenous anti-microbial mediators by leukotriene B4 (LTB4) administration
CA2662987A1 (en) * 2006-08-08 2008-02-21 Tethys Bioscience, Inc. Markers of non-alcoholic fatty liver disease (nafld) and non-alcoholic steatohepatitis (nash) and methods of use thereof
US8042070B2 (en) * 2007-10-23 2011-10-18 International Business Machines Corporation Methods and system for analysis and management of parametric yield
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PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
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WO2010120880A1 (en) * 2009-04-14 2010-10-21 Vertex Pharmaceuticals Incorporated Treatment of liver diseases with a caspase inhibitor
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JP2014530841A (ja) 2011-10-19 2014-11-20 ディグニティサイエンシスリミテッド Ｄｇｌａおよび／または１５−ｈｅｔｒｅを含む医薬組成物、ならびにその使用方法
US8293790B2 (en) 2011-10-19 2012-10-23 Dignity Sciences Limited Pharmaceutical compositions comprising DGLA and benzoyl peroxide and methods of use thereof
RU2014126356A (ru) 2011-11-29 2016-01-27 Дигнити Сайенсиз Лимитед Композиции, содержащие жирные кислоты с цепью из 20 атомов углерода, и способы их получения и применения
JP2015504870A (ja) * 2011-12-16 2015-02-16 タリックス ファーマシューティカルズ リミテッド 線維症を処置するためのアンジオテンシン
US20120264705A1 (en) 2012-01-26 2012-10-18 Dignity Sciences Limited Antimicrobial compositions comprising 15-hetre and methods of use thereof
US20130267598A1 (en) 2012-02-23 2013-10-10 Dignity Sciences Limited Pharmaceutical compositions comprising dgla, 15-ohepa, and/or 15-hetre and methods of reducing sebum production using same
CN110478342A (zh) 2012-05-10 2019-11-22 索卢泰克斯Na有限责任公司 含有天然专门促消退介质及其前体的具有抗炎活性的油
GB201301626D0 (en) * 2013-01-30 2013-03-13 Dignity Sciences Ltd Composition comprising 15-OHEPA and methods of using the same
TWI742541B (zh) * 2013-03-15 2021-10-11 英商邊緣生物科技有限公司 用於治療肺纖維化、肝纖維化、皮膚纖維化及心臟纖維化之經取代之芳族化合物
JP2018537513A (ja) 2015-12-18 2018-12-20 アフィミューン リミテッド １５−ｈｅｐｅを含む組成物及びその使用方法

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KR20170102879A (ko) 2017-09-12
IL252431B (en) 2021-12-01
CN112245419A (zh) 2021-01-22
ZA201704463B (en) 2018-11-28
RU2721555C2 (ru) 2020-05-20
EP3226873A4 (en) 2018-08-08
MX2017007000A (es) 2017-12-07
IL252431A0 (en) 2017-07-31
US10363235B2 (en) 2019-07-30
AU2021203189A1 (en) 2021-06-10
RU2020115523A (ru) 2021-01-27
JP2017536380A (ja) 2017-12-07
EP3226873B1 (en) 2021-10-27
CA2968980A1 (en) 2016-06-09
BR112017011685A2 (pt) 2018-01-02
CN107206008A (zh) 2017-09-26
SG11201704495VA (en) 2017-06-29
MX382116B (es) 2025-03-13
RU2017122758A (ru) 2019-01-09
EP3226873A1 (en) 2017-10-11
HK1245101A1 (zh) 2018-08-24
MA41120A (fr) 2017-10-10
PH12017501022A1 (en) 2017-11-27
ES2900593T3 (es) 2022-03-17
WO2016090030A1 (en) 2016-06-09
IL287983A (en) 2022-01-01
PH12017501022B1 (en) 2022-02-16
SG10202010594WA (en) 2020-12-30
EP3988101A1 (en) 2022-04-27
RU2017122758A3 (enExample) 2019-06-13
AU2015358512A1 (en) 2017-07-20
ZA201804380B (en) 2021-03-31
MX2021005080A (es) 2021-06-15
US20160184252A1 (en) 2016-06-30
JP2022031813A (ja) 2022-02-22
AU2015358512B2 (en) 2021-02-18

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