JP6961236B2 - 神経成長因子発現促進用組成物 - Google Patents
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Description
上記神経成長因子促進用組成物において、前記藻体は、原始紅藻綱チノリモ目チノリモ属、緑藻綱ヨコワミドロ目デスモデスムス属、藍藻綱スチゴネマ目ノストコプシス属、藍藻綱ネンジュモ目ネンジュモ属に属する藻体であることが好ましい。
NGF促進用組成物に含有される特定藻体の抽出物、又は特定藻体のジメチルスルホキシド可溶性成分は、生体内におけるNGFの発現を促進する作用を有する。
(1)NGF促進用組成物は、特定藻体の抽出物、又は特定藻体のジメチルスルホキシド可溶性成分を有効成分として含有する。
(2)特定藻体は、原始紅藻綱チノリモ目チノリモ属、緑藻綱ヨコワミドロ目デスモデスムス属、藍藻綱スチゴネマ目ノストコプシス属、藍藻綱ネンジュモ目ネンジュモ属に属する藻体であることが好ましい。
なお、本実施形態は、以下のように変更して実施することができる。本実施形態及び以下の変更例は、技術的に矛盾しない範囲で互いに組み合わせて実施することができる。
・NGF促進用組成物の摂取量及び摂取期間は、特に限定されず、摂取者の身体機能の状態、年齢、性別、及びその他の条件を考慮し、適宜、決定される。
次に、上記実施形態及び変更例から把握できる技術的思想について記載する。
表1の藻体欄に示す各藻体の乾燥粉体0.0106gにジメチルスルホキシド1000μlを添加し、5分間、ボルテックスミキサーで撹拌した後、遠心分離処理(3000rpm、5分間)を行った。処理後の上清を0.22μmのフィルターを用いて濾過滅菌し、これを各試験例の藻体試料液とした。
マウス由来3T3−L1(マウス線維芽細胞JCRB9014)細胞を、0.5%牛血清アルブミン(プロテアーゼフリー)を含んだダルベッコ変法イーグル培地を用いて培養した。24時間後、培地交換を行うとともに試験例の藻体試料液を5μl/mlの濃度となるように培地中に添加し、培養を継続した。24時間後、培地を回収し、遠心分離処理(5200×g、15分間)を行った。処理後の上清を回収した。
対照例2として、試験例の藻体試料液に代えて、NGFの発現を促進する既知物質であるエピネフリンを30μg/mlの濃度となるように培地中に添加して同様の処理を行い、上清を回収した。
Claims (3)
- 神経成長因子の発現を促進する神経成長因子発現促進用組成物であって、
プレウロクリシス・カルテラエ(Pleurochrysis carterae)、ポルフィリディウム・プルプレウム(Porphyridium purpureum)、ノストコプシス・ロバツス(Nostochopsis lobatus)、ノストック・コミューネ(Nostoc commune)、ノストック・フラジリフォルメ(Nostoc flagelliforme)から選ばれる藻体の抽出物を有効成分として含有することを特徴とする神経成長因子発現促進用組成物。 - 前記抽出物は、有機溶媒、又は有機溶媒と水との混合溶媒を抽出溶媒とする抽出物であることを特徴とする請求項1に記載の神経成長因子発現促進用組成物。
- 前記藻体は、ポルフィリディウム・プルプレウム(Porphyridium purpureum)、ノストコプシス・ロバツス(Nostochopsis lobatus)、ノストック・コミューネ(Nostoc commune)、ノストック・フラジリフォルメ(Nostoc flagelliforme)から選ばれる藻体であることを特徴とする請求項1又は請求項2に記載の神経成長因子発現促進用組成物。
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