JP6936937B2 - 細胞および／または細胞生成物の製造システム、製造装置および製造方法 - Google Patents

細胞および／または細胞生成物の製造システム、製造装置および製造方法 Download PDF

Info

Publication number
JP6936937B2
JP6936937B2 JP2017559911A JP2017559911A JP6936937B2 JP 6936937 B2 JP6936937 B2 JP 6936937B2 JP 2017559911 A JP2017559911 A JP 2017559911A JP 2017559911 A JP2017559911 A JP 2017559911A JP 6936937 B2 JP6936937 B2 JP 6936937B2
Authority
JP
Japan
Prior art keywords
bioreactor
less
unit
cell
medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017559911A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018504931A (ja
JP2018504931A5 (enExample
Inventor
カスティーヨ，ホセ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Univercells Technologies SA
Original Assignee
Univercells Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from BE2015/5064A external-priority patent/BE1022269B1/fr
Application filed by Univercells Technologies SA filed Critical Univercells Technologies SA
Publication of JP2018504931A publication Critical patent/JP2018504931A/ja
Publication of JP2018504931A5 publication Critical patent/JP2018504931A5/ja
Application granted granted Critical
Publication of JP6936937B2 publication Critical patent/JP6936937B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/40—Manifolds; Distribution pieces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/50—Means for positioning or orientating the apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/54—Constructional details, e.g. recesses, hinges hand portable
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/10—Rotating vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/16—Sterilization

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Computer Hardware Design (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2017559911A 2015-02-09 2016-02-08 細胞および／または細胞生成物の製造システム、製造装置および製造方法 Active JP6936937B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
BE2015/5064A BE1022269B1 (fr) 2015-02-09 2015-02-09 Système, appareil et procédé pour la production de cellules et/ou de produits cellulaires
EP2015052633 2015-02-09
EPPCT/EP2015/052633 2015-02-09
BEBE2015/5064 2015-02-09
PCT/EP2016/052644 WO2016128361A1 (en) 2015-02-09 2016-02-08 System, apparatus and method for the production of cells and/or cell products

Publications (3)

Publication Number Publication Date
JP2018504931A JP2018504931A (ja) 2018-02-22
JP2018504931A5 JP2018504931A5 (enExample) 2019-05-30
JP6936937B2 true JP6936937B2 (ja) 2021-09-22

Family

ID=55310830

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017559911A Active JP6936937B2 (ja) 2015-02-09 2016-02-08 細胞および／または細胞生成物の製造システム、製造装置および製造方法

Country Status (8)

Country Link
US (2) US20180030398A1 (enExample)
EP (1) EP3256565A1 (enExample)
JP (1) JP6936937B2 (enExample)
CN (1) CN107532132A (enExample)
AU (1) AU2016218037B2 (enExample)
BR (1) BR112017016986A2 (enExample)
MX (1) MX2017010217A (enExample)
WO (1) WO2016128361A1 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012048275A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
EP3068866B1 (en) 2013-11-16 2018-04-25 Terumo BCT, Inc. Expanding cells in a bioreactor
EP3105311A1 (en) * 2014-02-10 2016-12-21 Univercells NV System, apparatus and method for biomolecules production
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
US20160090569A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled Feed
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
EP3464565A4 (en) 2016-05-25 2020-01-01 Terumo BCT, Inc. CELL EXPANSION
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
BE1024230B1 (fr) 2016-11-08 2017-12-20 Univercells Sa Production contenue de cellules et/ou de produits cellulaires
CN110612344B (zh) 2017-03-31 2023-09-12 泰尔茂比司特公司 细胞扩增
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
RU2020114891A (ru) 2017-09-27 2021-10-27 Юниверселлс С.А. Система и способ получения биомолекул, таких как вирусные вакцины
JP7057148B2 (ja) * 2018-01-31 2022-04-19 株式会社熊谷組 微細藻類培養装置
CN110317832B (zh) * 2018-03-28 2022-07-05 西比曼生物科技（香港）有限公司 Gmp级规模化制备重组慢病毒载体的纯化制剂的方法
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
CN112424337A (zh) * 2018-05-31 2021-02-26 维格希公司 用于分离和纯化多核苷酸的溶胞线圈设备及其用途
GB201810772D0 (en) 2018-06-29 2018-08-15 Ge Healthcare Bio Sciences Ab Method in bioprocess purification system
GB201814233D0 (en) 2018-08-31 2018-10-17 Ge Healthcare Bio Sciences Ab Method for optimization of a bioprocessing system
WO2020051042A1 (en) * 2018-09-06 2020-03-12 Momenta Pharmaceuticals, Inc. Methods of continuous cell culture
JP7430717B2 (ja) * 2018-10-10 2024-02-13 シュタム ヴェーグ コーポレーション 連続流マイクロバイオリアクター
AU2020204794A1 (en) * 2019-01-04 2021-08-12 Oribiotech Ltd Cell processing device cell processing system and methods of use thereof
US20240093153A1 (en) * 2019-12-02 2024-03-21 Avant Meats Company Limited Methods of meat production by in vitro cell cultivation
CN112430540A (zh) * 2020-10-21 2021-03-02 英诺维尔智能科技（苏州）有限公司 一种可置于生物培养箱内的紧凑型反应器
WO2022109071A1 (en) * 2020-11-18 2022-05-27 Xibus Systems, Inc. Particle-based detection of analytes
GB2619893A (en) 2021-03-23 2023-12-20 Terumo Bct Inc Cell capture and expansion
WO2022202734A1 (ja) * 2021-03-26 2022-09-29 テルモ株式会社 細胞培養システム
KR102870031B1 (ko) * 2021-09-16 2025-11-03 주식회사 아모그린텍 포터블 바이오리액터
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device
US12330149B2 (en) * 2023-10-03 2025-06-17 Ark Biotech Inc. Mobile bioreactor service system
DE102023130768A1 (de) * 2023-11-07 2025-05-08 KyooBe Tech GmbH Werkzeugprozesseinheit
DE102023130775A1 (de) * 2023-11-07 2025-05-08 KyooBe Tech GmbH System und Verfahren zum Rüsten und/oder zum Aufbereiten von Prozesseinheiten zur Herstellung eines Produkts

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58155087A (ja) * 1982-03-12 1983-09-14 Olympus Optical Co Ltd 細胞の自動培養装置
US5409841A (en) * 1991-03-14 1995-04-25 Chow; Timothy Ultraviolet light sterilized sampling device and method of sampling
US5882918A (en) * 1995-08-08 1999-03-16 Genespan Corporation Cell culture incubator
JPH07236468A (ja) * 1994-02-28 1995-09-12 Mitsubishi Heavy Ind Ltd 培養装置
US8026096B1 (en) * 1998-10-08 2011-09-27 Protein Sciences Corporation In vivo active erythropoietin produced in insect cells
US6214221B1 (en) * 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances
US8507253B2 (en) * 2002-05-13 2013-08-13 Algae Systems, LLC Photobioreactor cell culture systems, methods for preconditioning photosynthetic organisms, and cultures of photosynthetic organisms produced thereby
JP2004016194A (ja) * 2002-06-20 2004-01-22 Hitachi Medical Corp 細胞培養装置
US7670839B2 (en) * 2002-12-23 2010-03-02 Fuji Film Manufacturing Europe B.V. Process for coating cell-culture support
US8513848B2 (en) * 2003-10-09 2013-08-20 Mag Life, Llc Aquarium having improved filtration system with neutral buoyancy substrate, pump and sediment removal system
AU2005209751A1 (en) * 2004-02-03 2005-08-18 Xcellerex, Inc. System and method for manufacturing
SI1720972T1 (sl) * 2004-03-05 2014-06-30 Dsm Ip Assets B.V. Postopek kultiviranja celic s kontinuiranim škropljenjem in spreminjanjem tangencialnega toka
AU2013203461B2 (en) * 2004-03-05 2016-03-17 Patheon Holdings I B.V. Process for cell culturing by continuous perfusion and alternating tangential flow
JP2006174828A (ja) * 2004-11-29 2006-07-06 Olympus Corp 生体試料培養観察システム、インキュベータボックス、供給手段、および培養容器
ES2657055T3 (es) * 2007-08-09 2018-03-01 Wyeth Llc Uso de perfusión para mejorar la producción de un cultivo de células alimentado por lotes en biorreactores
US20090233334A1 (en) * 2008-03-11 2009-09-17 Excellgene Sa Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale
CN101821378B (zh) * 2008-06-16 2015-07-08 浙江金仪盛世生物工程有限公司 生物反应器
JP5341434B2 (ja) * 2008-08-26 2013-11-13 パナソニックヘルスケア株式会社 培養装置
CN201825955U (zh) * 2009-07-10 2011-05-11 杭州安普生物工程有限公司 一种细胞培养装置
CN101603006B (zh) * 2009-07-10 2012-10-10 杭州安普生物工程有限公司 一种细胞培养装置
KR20110073949A (ko) * 2009-12-24 2011-06-30 연세대학교 산학협력단 튜브형 생체조직 또는 생체기관 재생을 위한 세포배양방법 및 세포배양장치
CN102296029B (zh) * 2010-06-28 2013-01-30 裴国献 灌注式生物反应器系统
CN201915101U (zh) * 2010-12-20 2011-08-03 北京清大天一科技有限公司 一种动物细胞培养生物反应器
JP5714316B2 (ja) * 2010-12-22 2015-05-07 株式会社日立製作所 細胞培養装置
US9469671B2 (en) * 2011-09-03 2016-10-18 Therapeutic Proteins International, LLC Closed bioreactor
SG11201401135XA (en) * 2011-10-07 2014-10-30 Pall Technology Uk Ltd Fluid processing control system and related methods
DE102012200938B4 (de) * 2012-01-23 2016-08-18 Alpha Plan Gmbh Bio- und medizintechnisches Baukastensystem
EP2639294A1 (fr) * 2012-03-15 2013-09-18 CellProthera Automate et procédé automatisé de culture cellulaire
ES2435092B1 (es) * 2012-06-14 2014-09-09 Aglaris Cell S.L. Método y sistema de cultivo celular
CN103194390B (zh) * 2013-04-19 2014-08-06 南方医科大学南方医院 双环路振荡灌注式生物反应系统
CN103480276B (zh) * 2013-09-06 2015-09-02 北京科兴生物制品有限公司 一种封闭式超滤管道系统及其应用
CN103525699B (zh) * 2013-10-22 2015-03-04 中国人民解放军第二一〇医院 一种细胞暴露特定气体精确控制装置
CN104017727B (zh) * 2014-06-04 2016-03-30 奥星制药设备（石家庄）有限公司 一次性无菌细胞培养袋配套细胞培养系统
CN107043701A (zh) * 2017-05-26 2017-08-15 奥凯（苏州）生物技术有限公司 一种提高细胞接种分散性的细胞扩增系统

Also Published As

Publication number Publication date
AU2016218037B2 (en) 2020-12-17
MX2017010217A (es) 2017-11-10
US20220017850A1 (en) 2022-01-20
CN107532132A (zh) 2018-01-02
JP2018504931A (ja) 2018-02-22
AU2016218037A1 (en) 2017-09-21
BR112017016986A2 (pt) 2018-04-03
EP3256565A1 (en) 2017-12-20
US20180030398A1 (en) 2018-02-01
WO2016128361A1 (en) 2016-08-18

Similar Documents

Publication Publication Date Title
JP6936937B2 (ja) 細胞および／または細胞生成物の製造システム、製造装置および製造方法
US10494421B2 (en) System, apparatus and method for biomolecules production
US20250145935A1 (en) System and method for the production of biomolecules such as viral vaccines
ES2864721T3 (es) Disposición y proceso continuo de un biorreactor para la producción y captura de un biopolímero
US9732313B2 (en) Method and apparatus for virus and vaccine production
WO2015118148A1 (en) System, apparatus and method for biomolecules production
US20130115588A1 (en) Integrated bioreactor and separation system and methods of use therof
WO2015118149A1 (en) System, apparatus and method for anti-rsv antibodies and formulations
JP2018504931A5 (enExample)
WO2012171030A2 (en) Method and apparatus for antibody production and purification
CN108260347A (zh) Cff/tff单次使用流路径中的再循环回路
JP2022519950A (ja) 組換えタンパク質の連続的生産
CN107109322B (zh) 从消毒处理容器一体化连续分离流体流
JP6758194B2 (ja) 高細胞密度フィル・アンド・ドロー発酵プロセス
BE1022269B1 (fr) Système, appareil et procédé pour la production de cellules et/ou de produits cellulaires
HK40055464B (zh) 从消毒处理容器一体化连续分离流体流
EP4347778A1 (en) Integrated continuous bioprocess production platform
TW202415759A (zh) 用於細胞培養之系統、設備及方法
HK40055464A (en) Integrated continuous isolation of fluid streams from sterile process vessels

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190201

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190422

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20191016

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20191210

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200929

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201224

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20210525

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210624

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20210706

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20210706

R150 Certificate of patent or registration of utility model

Ref document number: 6936937

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250