BR112017016986A2 - sistema, aparelho e método para a produção de células e/ou produtos de célula - Google Patents

sistema, aparelho e método para a produção de células e/ou produtos de célula

Info

Publication number
BR112017016986A2
BR112017016986A2 BR112017016986A BR112017016986A BR112017016986A2 BR 112017016986 A2 BR112017016986 A2 BR 112017016986A2 BR 112017016986 A BR112017016986 A BR 112017016986A BR 112017016986 A BR112017016986 A BR 112017016986A BR 112017016986 A2 BR112017016986 A2 BR 112017016986A2
Authority
BR
Brazil
Prior art keywords
cell
unit
cell culture
cells
production
Prior art date
Application number
BR112017016986A
Other languages
English (en)
Inventor
Castillo José
Original Assignee
Univercells Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from BE2015/5064A external-priority patent/BE1022269B1/fr
Application filed by Univercells Nv filed Critical Univercells Nv
Publication of BR112017016986A2 publication Critical patent/BR112017016986A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/40—Manifolds; Distribution pieces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/50—Means for positioning or orientating the apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/54—Constructional details, e.g. recesses, hinges hand portable
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/10—Rotating vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/16—Sterilization

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Computer Hardware Design (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

a presente invenção provê um sistema e um método para a produção de células e/ou produtos de célula. o sistema compreende pelo menos uma unidade de cultura de célula que compreende pelo menos um biorreator para cultivar células, pelo menos uma unidade de controle técnico para controlar os parâmetros de crescimento de uma célula, a dita unidade de controle técnico está pelo menos fluidamente conectada à unidade de cultura de célula, e pelo menos uma unidade de tratamento de ar para tratar o ar ambiente, a dita unidade de tratamento de ar está fluidamente conectada à unidade de cultura de célula. o sistema está caracterizado pelo fato de que o sistema é autônomo e o volume total de biorreator é no máximo 1000 l.
BR112017016986A 2015-02-09 2016-02-08 sistema, aparelho e método para a produção de células e/ou produtos de célula BR112017016986A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2015052633 2015-02-09
BE2015/5064A BE1022269B1 (fr) 2015-02-09 2015-02-09 Système, appareil et procédé pour la production de cellules et/ou de produits cellulaires
PCT/EP2016/052644 WO2016128361A1 (en) 2015-02-09 2016-02-08 System, apparatus and method for the production of cells and/or cell products

Publications (1)

Publication Number Publication Date
BR112017016986A2 true BR112017016986A2 (pt) 2018-04-03

Family

ID=55310830

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017016986A BR112017016986A2 (pt) 2015-02-09 2016-02-08 sistema, aparelho e método para a produção de células e/ou produtos de célula

Country Status (8)

Country Link
US (2) US20180030398A1 (pt)
EP (1) EP3256565A1 (pt)
JP (1) JP6936937B2 (pt)
CN (1) CN107532132A (pt)
AU (1) AU2016218037B2 (pt)
BR (1) BR112017016986A2 (pt)
MX (1) MX2017010217A (pt)
WO (1) WO2016128361A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2625577B1 (en) 2010-10-08 2019-06-26 Terumo BCT, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
JP6633522B2 (ja) 2013-11-16 2020-01-22 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
EP3105311A1 (en) * 2014-02-10 2016-12-21 Univercells NV System, apparatus and method for biomolecules production
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
BE1024230B1 (fr) 2016-11-08 2017-12-20 Univercells Sa Production contenue de cellules et/ou de produits cellulaires
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
EP3656841A1 (en) 2017-03-31 2020-05-27 Terumo BCT, Inc. Cell expansion
JP7057148B2 (ja) * 2018-01-31 2022-04-19 株式会社熊谷組 微細藻類培養装置
CN110317832B (zh) * 2018-03-28 2022-07-05 西比曼生物科技（香港）有限公司 Gmp级规模化制备重组慢病毒载体的纯化制剂的方法
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
CN112424337A (zh) * 2018-05-31 2021-02-26 维格希公司 用于分离和纯化多核苷酸的溶胞线圈设备及其用途
GB201810772D0 (en) * 2018-06-29 2018-08-15 Ge Healthcare Bio Sciences Ab Method in bioprocess purification system
GB201814233D0 (en) * 2018-08-31 2018-10-17 Ge Healthcare Bio Sciences Ab Method for optimization of a bioprocessing system
MX2021004099A (es) * 2018-10-10 2021-08-11 Stamm Vegh Corp Microbioreactor de flujo continuo.
EP3906295A1 (en) * 2019-01-04 2021-11-10 Oribiotech Ltd Cell processing unit, cell processing system and methods of use thereof
WO2021111196A1 (en) 2019-12-02 2021-06-10 Avant Meats Company Limited Methods of meat production by in vitro cell cultivation
CN112430540A (zh) * 2020-10-21 2021-03-02 英诺维尔智能科技（苏州）有限公司 一种可置于生物培养箱内的紧凑型反应器
US20240003890A1 (en) * 2020-11-18 2024-01-04 Xibus Systems, Inc. Particle-based detection of analytes
US12043823B2 (en) 2021-03-23 2024-07-23 Terumo Bct, Inc. Cell capture and expansion
WO2022202734A1 (ja) * 2021-03-26 2022-09-29 テルモ株式会社 細胞培養システム
KR20230040774A (ko) * 2021-09-16 2023-03-23 주식회사 아모그린텍 포터블 바이오리액터

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58155087A (ja) * 1982-03-12 1983-09-14 Olympus Optical Co Ltd 細胞の自動培養装置
US5409841A (en) * 1991-03-14 1995-04-25 Chow; Timothy Ultraviolet light sterilized sampling device and method of sampling
US5882918A (en) * 1995-08-08 1999-03-16 Genespan Corporation Cell culture incubator
JPH07236468A (ja) * 1994-02-28 1995-09-12 Mitsubishi Heavy Ind Ltd 培養装置
US8026096B1 (en) * 1998-10-08 2011-09-27 Protein Sciences Corporation In vivo active erythropoietin produced in insect cells
US6214221B1 (en) * 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances
US8507253B2 (en) * 2002-05-13 2013-08-13 Algae Systems, LLC Photobioreactor cell culture systems, methods for preconditioning photosynthetic organisms, and cultures of photosynthetic organisms produced thereby
JP2004016194A (ja) * 2002-06-20 2004-01-22 Hitachi Medical Corp 細胞培養装置
WO2004056976A2 (en) * 2002-12-23 2004-07-08 Fuji Photo Film B.V. Process for coating cell-culture support
US8513848B2 (en) * 2003-10-09 2013-08-20 Mag Life, Llc Aquarium having improved filtration system with neutral buoyancy substrate, pump and sediment removal system
AU2005209751A1 (en) * 2004-02-03 2005-08-18 Xcellerex, Inc. System and method for manufacturing
CN1930281A (zh) * 2004-03-05 2007-03-14 帝斯曼知识产权资产管理有限公司 用于通过连续灌注和交互切向流来培养细胞的方法
AU2013203461B2 (en) * 2004-03-05 2016-03-17 Patheon Holdings I B.V. Process for cell culturing by continuous perfusion and alternating tangential flow
JP2006174828A (ja) * 2004-11-29 2006-07-06 Olympus Corp 生体試料培養観察システム、インキュベータボックス、供給手段、および培養容器
US20090042253A1 (en) * 2007-08-09 2009-02-12 Wyeth Use of perfusion to enhance production of fed-batch cell culture in bioreactors
US20090233334A1 (en) * 2008-03-11 2009-09-17 Excellgene Sa Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale
US20100076380A1 (en) * 2008-06-16 2010-03-25 Amprotein Corporation Bioreactors
JP5341434B2 (ja) * 2008-08-26 2013-11-13 パナソニックヘルスケア株式会社 培養装置
CN201825955U (zh) * 2009-07-10 2011-05-11 杭州安普生物工程有限公司 一种细胞培养装置
CN101603006B (zh) * 2009-07-10 2012-10-10 杭州安普生物工程有限公司 一种细胞培养装置
KR20110073949A (ko) * 2009-12-24 2011-06-30 연세대학교 산학협력단 튜브형 생체조직 또는 생체기관 재생을 위한 세포배양방법 및 세포배양장치
CN102296029B (zh) * 2010-06-28 2013-01-30 裴国献 灌注式生物反应器系统
CN201915101U (zh) * 2010-12-20 2011-08-03 北京清大天一科技有限公司 一种动物细胞培养生物反应器
JP5714316B2 (ja) * 2010-12-22 2015-05-07 株式会社日立製作所 細胞培養装置
US9469671B2 (en) * 2011-09-03 2016-10-18 Therapeutic Proteins International, LLC Closed bioreactor
WO2013052836A1 (en) * 2011-10-07 2013-04-11 Atmi Packaging, Inc. Fluid processing control system and related methods
DE102012200938B4 (de) * 2012-01-23 2016-08-18 Alpha Plan Gmbh Bio- und medizintechnisches Baukastensystem
EP2639294A1 (fr) * 2012-03-15 2013-09-18 CellProthera Automate et procédé automatisé de culture cellulaire
ES2435092B1 (es) * 2012-06-14 2014-09-09 Aglaris Cell S.L. Método y sistema de cultivo celular
CN103194390B (zh) * 2013-04-19 2014-08-06 南方医科大学南方医院 双环路振荡灌注式生物反应系统
CN103480276B (zh) * 2013-09-06 2015-09-02 北京科兴生物制品有限公司 一种封闭式超滤管道系统及其应用
CN103525699B (zh) * 2013-10-22 2015-03-04 中国人民解放军第二一〇医院 一种细胞暴露特定气体精确控制装置
CN104017727B (zh) * 2014-06-04 2016-03-30 奥星制药设备（石家庄）有限公司 一次性无菌细胞培养袋配套细胞培养系统
CN107043701A (zh) * 2017-05-26 2017-08-15 奥凯（苏州）生物技术有限公司 一种提高细胞接种分散性的细胞扩增系统

Also Published As

Publication number Publication date
AU2016218037A1 (en) 2017-09-21
CN107532132A (zh) 2018-01-02
JP6936937B2 (ja) 2021-09-22
AU2016218037B2 (en) 2020-12-17
US20220017850A1 (en) 2022-01-20
JP2018504931A (ja) 2018-02-22
WO2016128361A1 (en) 2016-08-18
MX2017010217A (es) 2017-11-10
EP3256565A1 (en) 2017-12-20
US20180030398A1 (en) 2018-02-01

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