JP6933358B2 - 美肌促進剤 - Google Patents
美肌促進剤 Download PDFInfo
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- JP6933358B2 JP6933358B2 JP2017061615A JP2017061615A JP6933358B2 JP 6933358 B2 JP6933358 B2 JP 6933358B2 JP 2017061615 A JP2017061615 A JP 2017061615A JP 2017061615 A JP2017061615 A JP 2017061615A JP 6933358 B2 JP6933358 B2 JP 6933358B2
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- skin
- strain
- beautifying
- vegetables
- lactic acid
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Description
そこで本発明は、安全な美肌促進剤および抗気逆剤と、美肌促進作用と抗気逆作用を示す経口組成物、飲食品組成物および漬物を提供することを目的とする。
以下、本発明を示す。
(i) 寄託機関の名称およびあて名
名称: 独立行政法人製品評価技術基盤機構 特許微生物寄託センター
あて名: 日本国 千葉県木更津市かずさ鎌足2−5−8
(ii) 寄託日: 2010年4月9日
(iii) 受託番号: NITE P−926
本発明に係る乳酸菌TK61406株の形態的特徴や生化学的性状などは、以下のとおりである。
(1) 被験者
医療法人メドック健康クリニックの治験ボランティアに登録された日本国籍を有する20歳以上、50歳以下の男女を候補とし、参加希望者の中から、ボディマス指数(BMI)が18.5以上30.0未満、収縮期血圧が159mmHg以下で拡張期血圧が99mmHg以下、脈拍が50〜100回/分、体温が35.5〜37.0℃であり、治療を受けていない者で、疾患を有するなど臨床研究責任医師が不適格と判断した者を除き、本人の意思により文書による同意を得られた34名を選択し、任意に本発明乳酸菌摂取群とプラセボ食群に分けた。その内、試料摂取開始前のスクリーニング期間に3名が不適格と判断され、また、試料摂取期間中に1名が疾患の治療のために離脱した。最終的にそのデータが統計解析に用いられた30名の被験者を表2に示す。
被検試料としては、Lactobacillus plantarum TK61406株の生菌25億cfuを含む発酵液2.5mLに、飲用水40mLを加えて希釈したものを用いた。
試料摂取開始前に4週間のスクリーニング期間を設けた後、12週間にわたり試料を1日一回、食後に経口摂取させた。摂取は、可能な限り同一時刻とした。次に、4週間の後観察期間を設けた。
表4と図1,2に示す結果の通り、プラセボ食群と比べ、本発明乳酸菌摂取群の摂取開始から8週後および12週後において、肉眼でも見えるような目立つ毛穴の数が有意に減少した。但し、摂取終了から4週間後においては、群間における統計上の有意差は認められなかった。よって、本発明に係るTK61406株には美肌効果があることが実証され、また、美肌促進効果を効果的に得るためにはTK61406株の継続的な摂取が有効で
あることが分かった。
上記顔肌状態の検査において、試料の摂取開始から4週間後、8週間後および12週間後、並びに試料摂取終了日から4週間後に、連続計算負荷試験を実施した。具体的には、iPad(登録商標) mini 2の連続計算用ソフトである「脳トレーニング 暗算ドリル」を用い、2桁の足し算を30問実施した際の正解数と計算時間を記録した。結果を表5と図3に示す。
上記実施例1において、試料摂取開始前、試料摂取開始から4週間後、8週間後および12週間後、並びに試料摂取終了日から4週間後に、被験者から便を採取し、便中のアンモニア濃度を測定し、試験食群とプラセボ食群との間でWilcoxon検定を行い、P値を求めた。結果を表6に示す。表6中、「*」はP<0.05で試験食群とプラセボ食群との間に有意差があったことを示す。また、摂取開始から12週間後における便のアンモニア濃度を試験食群とプラセボ食群との間で比較するグラフを図4に示す。
正常ヒト表皮角化細胞増殖用培地(「HuMedia−KG2」倉敷紡績社製)中の正常ヒト表皮角化細胞(倉敷紡績社製)を、5×103cell/wellの割合で96well plateに播種し、37℃で96時間培養した。次いで、8wellずつ、各wellにおける濃度が300μ/L、500μ/L、800μ/Lまたは1000μ/Lとなるように同培地にアンモニアを溶解した溶液を添加し、さらに37℃で96時間培養した。なお、ヒト血中のアンモニア濃度の基準値は300〜860μg/Lである。また、対照として、アンモニアを添加しないwellも8例設けた。培養後、WST−1キット(「Premix WST−1 Cell Proliferation Assay System」タカラバイオ社)を用いて細胞生存数を吸光度として測定し、対照例に対する各アンモニア濃度中の細胞生存率を求めた。また、対照例と各アンモニア濃度例との間でStudent’s−T検定を行った。結果を図5に示す。図5中、「***」はP<0.001で有意差があることを示す。
図5に示す結果の通り、培地中のアンモニア濃度が高くなるほど正常ヒト表皮角化細胞の生存率は低くなった。かかる結果の通り、アンモニアは皮膚組織の構成細胞に悪影響を与え、また、上記実施例3の結果の通り本発明に係る乳酸菌TK61406株は生体内のアンモニア量を低減することから、本発明に係る乳酸菌TK61406株の投与により、肌の状態を改善できることが示唆された。
Claims (5)
- Lactobacillus plantarum TK61406株(受託番号:NITE P−926)を含むことを特徴とする美肌促進剤。
- Lactobacillus plantarum TK61406株(受託番号:NITE P−926)を含むことを特徴とする美肌促進用経口組成物。
- Lactobacillus plantarum TK61406株(受託番号:NITE P−926)を含むことを特徴とする美肌促進用飲食品組成物。
- Lactobacillus plantarum TK61406株(受託番号:NITE P−926)を含むことを特徴とする美肌促進用漬物。
- Lactobacillus plantarum TK61406株(受託番号:NITE P−926)の生菌を含む、請求項1に記載の美肌促進剤、請求項2に記載の美肌促進用経口組成物、請求項3に記載の美肌促進用飲食品組成物、または請求項4に記載の美肌促進用漬物。
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