JP6052721B2 - 新規乳酸菌 - Google Patents
新規乳酸菌 Download PDFInfo
- Publication number
- JP6052721B2 JP6052721B2 JP2012145915A JP2012145915A JP6052721B2 JP 6052721 B2 JP6052721 B2 JP 6052721B2 JP 2012145915 A JP2012145915 A JP 2012145915A JP 2012145915 A JP2012145915 A JP 2012145915A JP 6052721 B2 JP6052721 B2 JP 6052721B2
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- Prior art keywords
- lactic acid
- present
- strain
- acid bacteria
- bacteria
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Landscapes
- Preparation Of Fruits And Vegetables (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
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Description
(i) 寄託機関の名称およびあて名
名称: 独立行政法人製品評価技術基盤機構 特許微生物寄託センター
あて名: 日本国 千葉県木更津市かずさ鎌足2−5−8
(ii) 寄託日: 2010年4月9日
(iii) 受託番号: NITE P−926
(1) 本発明に係る乳酸菌の単離と実験動物への投与
本願出願人が製造した漬物製品からLb.plantarum TK61406株を単離した。
本発明乳酸菌投与群では、馴化飼育後から0日目、3日目および7日目に糞便を回収した。得られた糞便をTK61406株用選択培地(ソルビトールと5%NaClを含む)に塗布し、30℃で48時間培養した。1匹当たり5株のシングルコロニーを採取し、プラスミドDNAのバンドパターンを解析し、また、糖類に対する資化性を試験した。7日目の糞便から培養された菌のプラスミドDNAのバンドパターンを図1に示す。なお、比較のために、分子量マーカーと共に、TK61406株自体のバンドパターンを同時に示す。また、レーン数の関係から、各ラットから採取したシングルコロニーから1コロニーまたは2コロニーを任意に選択して試験した。
乳酸菌用培地であるGYP培地のグルコース(1質量%)を表3に示すプレバイオティクスに置換した液体培地を用いてTK61406株を30℃で24時間培養した。また、比較のため、糖類を含まないGYP培地と、D−グルコースを含む通常のGYP培地を用い、同様に培養した。
体重90〜110g、5週齢の雄性Wistar系ラット12匹を6匹ずつTK61406株投与群とTK61406株+フラクトオリゴ糖投与群とに任意に分けた。TK61406株投与群用の餌としては、米国国立栄養研究所標準準精製飼料(AIN-76 semi-purified-diet)に107/gの菌数割合でTK61406株を添加したものを用いた。また、TK61406株+フラクトオリゴ糖投与群には、さらに3質量%の割合でフラクトオリゴ糖(明治フードマテリア社製,メイオリゴ(登録商標)P)を混合した餌を与えた。各群ラットを、水と上記餌を自由摂取させつつ14日間飼育した。その後、ラットを屠殺して盲腸を取り出し、その内容物重量、組織重量、pH、免疫グロブリンA(IgA)量を測定し、また、上記実施例2と同様にHPLCにて有機酸量を測定した。得られた測定値につき、二元配置分散分析およびチューキーの全群比較検定で有意差検定を行った。結果を表4に示す。なお、表4中、「*」はp<0.01で有意差があることを示す。
上記実施例3の結果のとおり、本発明に係るTK61406株をフラクトオリゴ糖と併用することにより、腸内の免疫グロブリンAの量が顕著に増加することが明らかとなった。そこで、TK61406株自体による免疫賦活化効果を確認した。
Claims (5)
- Lactobacillus plantarum TK61406株(受託番号:NITE P−926)。
- Lactobacillus plantarum TK61406株(受託番号:NITE P−926)を含むことを特徴とするプロバイオティクス製品。
- 免疫賦活作用を有するものである請求項2に記載のプロバイオティクス製品。
- さらにフラクトオリゴ糖および/またはセロオリゴ糖を含む請求項2または3に記載のプロバイオティクス製品。
- 漬物製品である請求項2〜4のいずれかに記載のプロバイオティクス製品。
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JP6052721B2 true JP6052721B2 (ja) | 2016-12-27 |
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Families Citing this family (3)
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JP6933358B2 (ja) * | 2016-04-06 | 2021-09-08 | 東海漬物株式会社 | 美肌促進剤 |
JP7267536B2 (ja) * | 2017-10-11 | 2023-05-02 | 株式会社ゲノム創薬研究所 | 乳酸醗酵ニンジンの製造方法 |
AR115757A1 (es) * | 2018-07-13 | 2021-02-24 | Cj Cheiljedang Corp | Composición que comprende la cepa cjlp475 de lactobacillus plantarum y la cepa cjlp17 de lactobacillus plantarum y el uso de la misma |
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JP2006180836A (ja) * | 2004-12-28 | 2006-07-13 | Marudai Food Co Ltd | 食中毒菌感染を抑制する乳酸菌、ならびにそれを含む発酵物、食品および医薬組成物 |
JP2009082126A (ja) * | 2007-09-14 | 2009-04-23 | Kikkoman Corp | 新規な乳酸菌、それを用いた乳酸発酵物及び乳酸発酵物含有飲食品 |
JP4791429B2 (ja) * | 2007-10-05 | 2011-10-12 | 旭化成ケミカルズ株式会社 | オリゴ糖および植物性乳酸菌を含有する発酵乳および乳酸菌飲料 |
KR101178217B1 (ko) * | 2009-10-28 | 2012-09-07 | 씨제이제일제당 (주) | 신규한 락토바실러스 플란타룸 및 이를 포함하는 조성물 |
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