JP6918819B2 - オルトミクソウイルス感染の処置に有用な三環式化合物 - Google Patents
オルトミクソウイルス感染の処置に有用な三環式化合物 Download PDFInfo
- Publication number
- JP6918819B2 JP6918819B2 JP2018547307A JP2018547307A JP6918819B2 JP 6918819 B2 JP6918819 B2 JP 6918819B2 JP 2018547307 A JP2018547307 A JP 2018547307A JP 2018547307 A JP2018547307 A JP 2018547307A JP 6918819 B2 JP6918819 B2 JP 6918819B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- mmol
- pharmaceutically acceptable
- ring
- benzyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- AJVXSKCJVFQMBZ-RUZDIDTESA-N C=[Br]c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1OCc1ccccc1 Chemical compound C=[Br]c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1OCc1ccccc1 AJVXSKCJVFQMBZ-RUZDIDTESA-N 0.000 description 1
- PHZVOXJWCROCGO-LJQANCHMSA-N CC(OC1=C(c2ncc[n]2C[C@@H]2C(c(cc3)ccc3F)c(cc3)ccc3F)N2N=CC1=O)=O Chemical compound CC(OC1=C(c2ncc[n]2C[C@@H]2C(c(cc3)ccc3F)c(cc3)ccc3F)N2N=CC1=O)=O PHZVOXJWCROCGO-LJQANCHMSA-N 0.000 description 1
- BKJAAHYPKYYXDR-OTOKDRCRSA-N CC(c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1O)O Chemical compound CC(c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1O)O BKJAAHYPKYYXDR-OTOKDRCRSA-N 0.000 description 1
- BZNXSEXRGLMSIC-RZIURPKCSA-N CC(c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1OCc1ccccc1)O Chemical compound CC(c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1OCc1ccccc1)O BZNXSEXRGLMSIC-RZIURPKCSA-N 0.000 description 1
- SEUGYZHGQXZGJU-UHFFFAOYSA-N CCC([n]1c2ncc1)N(C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1O Chemical compound CCC([n]1c2ncc1)N(C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1O SEUGYZHGQXZGJU-UHFFFAOYSA-N 0.000 description 1
- ZTWDNXGMOKHLGO-HXUWFJFHSA-N CN(C)C(c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1O)=O Chemical compound CN(C)C(c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1O)=O ZTWDNXGMOKHLGO-HXUWFJFHSA-N 0.000 description 1
- JSZATNWYUXBKGW-HHHXNRCGSA-N CN(C)C(c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1OCc1ccccc1)=O Chemical compound CN(C)C(c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1OCc1ccccc1)=O JSZATNWYUXBKGW-HHHXNRCGSA-N 0.000 description 1
- CYVDNIFUERLGCM-HXUWFJFHSA-N Cc1c(C)nc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1O Chemical compound Cc1c(C)nc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1O CYVDNIFUERLGCM-HXUWFJFHSA-N 0.000 description 1
- FEVGXTBZUUITCJ-AREMUKBSSA-N O=Cc1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1OCc1ccccc1 Chemical compound O=Cc1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1OCc1ccccc1 FEVGXTBZUUITCJ-AREMUKBSSA-N 0.000 description 1
- MHWFNXWCPQNGRQ-XMMPIXPASA-N OC1=C(c2ncc(-c3ccccc3)[n]2C[C@@H]2C(c3ccccc3)c3ccccc3)N2C=CC1=O Chemical compound OC1=C(c2ncc(-c3ccccc3)[n]2C[C@@H]2C(c3ccccc3)c3ccccc3)N2C=CC1=O MHWFNXWCPQNGRQ-XMMPIXPASA-N 0.000 description 1
- AWIJSMFVNDAWRA-UHFFFAOYSA-N OC1=C(c2ncc[n]2CC2C(c3cccc(Cl)c3)c3cc(Cl)ccc3)N2N=CC1=O Chemical compound OC1=C(c2ncc[n]2CC2C(c3cccc(Cl)c3)c3cc(Cl)ccc3)N2N=CC1=O AWIJSMFVNDAWRA-UHFFFAOYSA-N 0.000 description 1
- SHISIZVWEDLGHH-QGZVFWFLSA-N OC1=C(c2ncc[n]2C[C@@H]2C(c(cc3)ccc3F)c(cc3)ccc3F)N2N=CC1=O Chemical compound OC1=C(c2ncc[n]2C[C@@H]2C(c(cc3)ccc3F)c(cc3)ccc3F)N2N=CC1=O SHISIZVWEDLGHH-QGZVFWFLSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662305392P | 2016-03-08 | 2016-03-08 | |
| US62/305,392 | 2016-03-08 | ||
| PCT/IB2017/051338 WO2017153919A1 (en) | 2016-03-08 | 2017-03-07 | Tricyclic compounds useful to treat orthomyxovirus infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019512485A JP2019512485A (ja) | 2019-05-16 |
| JP2019512485A5 JP2019512485A5 (enExample) | 2020-05-28 |
| JP6918819B2 true JP6918819B2 (ja) | 2021-08-11 |
Family
ID=58347733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018547307A Active JP6918819B2 (ja) | 2016-03-08 | 2017-03-07 | オルトミクソウイルス感染の処置に有用な三環式化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10858366B2 (enExample) |
| EP (1) | EP3426656B1 (enExample) |
| JP (1) | JP6918819B2 (enExample) |
| CN (1) | CN108699059B (enExample) |
| ES (1) | ES2881776T3 (enExample) |
| WO (1) | WO2017153919A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK4219508T3 (da) | 2015-04-28 | 2024-08-05 | Shionogi & Co | Substitueret polycyklisk pyridonderivat og prodrug deraf |
| JP6323860B2 (ja) | 2015-12-15 | 2018-05-16 | 塩野義製薬株式会社 | キャップ依存的エンドヌクレアーゼ阻害剤及び抗インフルエンザ薬を組み合わせることを特徴とするインフルエンザ治療用医薬 |
| KR102398439B1 (ko) | 2016-03-07 | 2022-05-16 | 이난타 파마슈티칼스, 인코포레이티드 | B형 간염 항바이러스제 |
| ES2881776T3 (es) * | 2016-03-08 | 2021-11-30 | Novartis Ag | Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus |
| AU2017310774B2 (en) | 2016-08-10 | 2023-01-19 | Shionogi & Co., Ltd. | Substituted polycyclic pyridone derivative and pharmaceutical composition containing prodrug thereof |
| JOP20170169A1 (ar) | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
| EA202090514A1 (ru) | 2017-08-28 | 2020-06-24 | Энанта Фармасьютикалс, Инк. | Противовирусное средство против гепатита в |
| WO2019143902A2 (en) | 2018-01-22 | 2019-07-25 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| EA202091696A1 (ru) * | 2018-02-28 | 2021-01-27 | Новартис Аг | ПРОИЗВОДНЫЕ 10-(ДИ(ФЕНИЛ)МЕТИЛ)-4-ГИДРОКСИ-8,9,9a,10-ТЕТРАГИДРО-7H-ПИРРОЛО[1',2':4,5]ПИРАЗИНО[1,2-b]ПИРИДАЗИН-3,5-ДИОНА И РОДСТВЕННЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ РЕПЛИКАЦИИ ОРТОМИКСОВИРУСА ДЛЯ ЛЕЧЕНИЯ ГРИППА |
| CA3113235A1 (en) | 2018-09-21 | 2020-03-26 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| IL283190B2 (en) * | 2018-11-21 | 2025-08-01 | Enanta Pharm Inc | Functionalized heterocycles as antiviral agents |
| CN111410661B (zh) * | 2019-01-04 | 2023-05-05 | 周雨恬 | 帽依赖性内切核酸酶抑制剂及其用途 |
| CN109912624B (zh) * | 2019-04-11 | 2021-05-11 | 杭州科巢生物科技有限公司 | 一种巴洛沙韦酯关键母核中间体的合成方法 |
| CN111909174B (zh) | 2019-05-08 | 2022-01-21 | 江西彩石医药科技有限公司 | 吡啶酮衍生物的晶型及制备方法和应用 |
| US11236111B2 (en) | 2019-06-03 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2020247575A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2020247561A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| WO2021007488A1 (en) | 2019-07-11 | 2021-01-14 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| US11236108B2 (en) | 2019-09-17 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| US11802125B2 (en) | 2020-03-16 | 2023-10-31 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8501542D0 (en) | 1985-01-22 | 1985-02-20 | Erba Farmitalia | 4 5 6 7-tetrahydro-imidazo(4 5-clpyridine derivatives |
| DK3042894T1 (da) | 2001-08-10 | 2016-11-07 | Shionogi & Co | Antiviralt middel |
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| TW200526635A (en) * | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
| CA2557926A1 (en) | 2004-03-09 | 2005-09-22 | Monica Donghi | Hiv integrase inhibitors |
| FR2901795A1 (fr) * | 2006-05-30 | 2007-12-07 | Fourtillan Snc | Derives de pyrimidino[1',6'-1,2]pyrido[3,4-b]indoles et leur utilisation en therapeutique |
| MX2011004636A (es) | 2008-10-31 | 2011-06-20 | Shionogi & Co | Cefarosporinas que tienen un grupo catecol. |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| WO2010110231A1 (ja) * | 2009-03-26 | 2010-09-30 | 塩野義製薬株式会社 | 置換された３－ヒドロキシ－４－ピリドン誘導体 |
| DK2444400T3 (en) | 2009-06-15 | 2018-06-18 | Shionogi & Co | SUBSTITUTED POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE |
| US8541407B2 (en) * | 2010-03-31 | 2013-09-24 | Arqule, Inc. | Substituted benzo-pyrido-triazolo-diazepine compounds |
| US20120195857A1 (en) | 2010-08-12 | 2012-08-02 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| CA2812363C (en) | 2010-09-24 | 2019-04-02 | Shionogi & Co., Ltd. | Substituted polycyclic carbamoyl pyridone derivative prodrug |
| WO2012151567A1 (en) * | 2011-05-05 | 2012-11-08 | St. Jude Children's Research Hospital | Pyrimidinone compounds and methods for preventing and treating influenza |
| CA2851218A1 (en) | 2011-10-12 | 2013-04-18 | Shionogi & Co., Ltd. | Polycyclic pyridone derivative having integrase-inhibiting activity |
| ES2604766T3 (es) | 2012-09-20 | 2017-03-09 | Celltrion, Inc. | Derivado de dolastatina-10, procedimiento de producción del mismo y composición de fármaco anticanceroso que contiene el mismo |
| PE20151722A1 (es) * | 2013-01-08 | 2015-11-19 | European Molecular Biology Lab Embl | Derivados de pirimidona y su uso en el tratamiento, mejora o prevencion de una enfermedad viral |
| PH12021550330A1 (en) | 2013-08-21 | 2022-09-28 | Janssen Biopharma Inc | Antiviral compounds |
| WO2015038665A1 (en) | 2013-09-11 | 2015-03-19 | University Of Southern California | A composition of stem cells having highly expressed fas ligand |
| LT3030549T (lt) | 2013-09-12 | 2019-06-25 | Janssen Biopharma, Inc. | Piridazinono junginiai ir jų panaudojimas |
| KR102323515B1 (ko) * | 2013-09-12 | 2021-11-05 | 얀센 바이오파마, 인코퍼레이트. | 아자-피리돈 화합물 및 이의 용도 |
| JP2017521424A (ja) | 2014-07-07 | 2017-08-03 | ザヴィラ ファーマシューティカルズ ゲーエムベーハー | ウイルス疾患の治療、改善又は予防におけるジヒドロピリドピラジン−１，８−ジオン及びそれらの使用 |
| EA036776B1 (ru) | 2015-03-11 | 2020-12-21 | Янссен Байофарма, Инк. | Соединения азапиридона и способы их применения |
| ES2881776T3 (es) | 2016-03-08 | 2021-11-30 | Novartis Ag | Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus |
| AU2017310774B2 (en) | 2016-08-10 | 2023-01-19 | Shionogi & Co., Ltd. | Substituted polycyclic pyridone derivative and pharmaceutical composition containing prodrug thereof |
| JOP20170169A1 (ar) | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
| CN111848616B (zh) | 2018-01-17 | 2021-11-23 | 江西彩石医药科技有限公司 | 吡啶酮衍生物及其用于制备抗流感病毒药物的用途 |
| EA202091696A1 (ru) | 2018-02-28 | 2021-01-27 | Новартис Аг | ПРОИЗВОДНЫЕ 10-(ДИ(ФЕНИЛ)МЕТИЛ)-4-ГИДРОКСИ-8,9,9a,10-ТЕТРАГИДРО-7H-ПИРРОЛО[1',2':4,5]ПИРАЗИНО[1,2-b]ПИРИДАЗИН-3,5-ДИОНА И РОДСТВЕННЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ РЕПЛИКАЦИИ ОРТОМИКСОВИРУСА ДЛЯ ЛЕЧЕНИЯ ГРИППА |
-
2017
- 2017-03-07 ES ES17711349T patent/ES2881776T3/es active Active
- 2017-03-07 WO PCT/IB2017/051338 patent/WO2017153919A1/en not_active Ceased
- 2017-03-07 CN CN201780015673.6A patent/CN108699059B/zh active Active
- 2017-03-07 EP EP17711349.5A patent/EP3426656B1/en active Active
- 2017-03-07 JP JP2018547307A patent/JP6918819B2/ja active Active
- 2017-03-07 US US16/083,089 patent/US10858366B2/en active Active
-
2020
- 2020-07-20 US US16/933,000 patent/US11453677B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3426656A1 (en) | 2019-01-16 |
| CN108699059A (zh) | 2018-10-23 |
| US20200347072A1 (en) | 2020-11-05 |
| ES2881776T3 (es) | 2021-11-30 |
| WO2017153919A1 (en) | 2017-09-14 |
| JP2019512485A (ja) | 2019-05-16 |
| US10858366B2 (en) | 2020-12-08 |
| EP3426656B1 (en) | 2021-05-12 |
| US20190092780A1 (en) | 2019-03-28 |
| CN108699059B (zh) | 2021-06-18 |
| US11453677B2 (en) | 2022-09-27 |
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