JP6918819B2 - オルトミクソウイルス感染の処置に有用な三環式化合物 - Google Patents
オルトミクソウイルス感染の処置に有用な三環式化合物 Download PDFInfo
- Publication number
- JP6918819B2 JP6918819B2 JP2018547307A JP2018547307A JP6918819B2 JP 6918819 B2 JP6918819 B2 JP 6918819B2 JP 2018547307 A JP2018547307 A JP 2018547307A JP 2018547307 A JP2018547307 A JP 2018547307A JP 6918819 B2 JP6918819 B2 JP 6918819B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- mmol
- pharmaceutically acceptable
- ring
- benzyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- AJVXSKCJVFQMBZ-RUZDIDTESA-N C=[Br]c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1OCc1ccccc1 Chemical compound C=[Br]c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1OCc1ccccc1 AJVXSKCJVFQMBZ-RUZDIDTESA-N 0.000 description 1
- PHZVOXJWCROCGO-LJQANCHMSA-N CC(OC1=C(c2ncc[n]2C[C@@H]2C(c(cc3)ccc3F)c(cc3)ccc3F)N2N=CC1=O)=O Chemical compound CC(OC1=C(c2ncc[n]2C[C@@H]2C(c(cc3)ccc3F)c(cc3)ccc3F)N2N=CC1=O)=O PHZVOXJWCROCGO-LJQANCHMSA-N 0.000 description 1
- BKJAAHYPKYYXDR-OTOKDRCRSA-N CC(c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1O)O Chemical compound CC(c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1O)O BKJAAHYPKYYXDR-OTOKDRCRSA-N 0.000 description 1
- BZNXSEXRGLMSIC-RZIURPKCSA-N CC(c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1OCc1ccccc1)O Chemical compound CC(c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1OCc1ccccc1)O BZNXSEXRGLMSIC-RZIURPKCSA-N 0.000 description 1
- SEUGYZHGQXZGJU-UHFFFAOYSA-N CCC([n]1c2ncc1)N(C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1O Chemical compound CCC([n]1c2ncc1)N(C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1O SEUGYZHGQXZGJU-UHFFFAOYSA-N 0.000 description 1
- ZTWDNXGMOKHLGO-HXUWFJFHSA-N CN(C)C(c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1O)=O Chemical compound CN(C)C(c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1O)=O ZTWDNXGMOKHLGO-HXUWFJFHSA-N 0.000 description 1
- JSZATNWYUXBKGW-HHHXNRCGSA-N CN(C)C(c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1OCc1ccccc1)=O Chemical compound CN(C)C(c1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1OCc1ccccc1)=O JSZATNWYUXBKGW-HHHXNRCGSA-N 0.000 description 1
- CYVDNIFUERLGCM-HXUWFJFHSA-N Cc1c(C)nc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1O Chemical compound Cc1c(C)nc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1O CYVDNIFUERLGCM-HXUWFJFHSA-N 0.000 description 1
- FEVGXTBZUUITCJ-AREMUKBSSA-N O=Cc1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1OCc1ccccc1 Chemical compound O=Cc1cnc2[n]1C[C@H](C(c1ccccc1)c1ccccc1)N(C=CC1=O)C2=C1OCc1ccccc1 FEVGXTBZUUITCJ-AREMUKBSSA-N 0.000 description 1
- MHWFNXWCPQNGRQ-XMMPIXPASA-N OC1=C(c2ncc(-c3ccccc3)[n]2C[C@@H]2C(c3ccccc3)c3ccccc3)N2C=CC1=O Chemical compound OC1=C(c2ncc(-c3ccccc3)[n]2C[C@@H]2C(c3ccccc3)c3ccccc3)N2C=CC1=O MHWFNXWCPQNGRQ-XMMPIXPASA-N 0.000 description 1
- AWIJSMFVNDAWRA-UHFFFAOYSA-N OC1=C(c2ncc[n]2CC2C(c3cccc(Cl)c3)c3cc(Cl)ccc3)N2N=CC1=O Chemical compound OC1=C(c2ncc[n]2CC2C(c3cccc(Cl)c3)c3cc(Cl)ccc3)N2N=CC1=O AWIJSMFVNDAWRA-UHFFFAOYSA-N 0.000 description 1
- SHISIZVWEDLGHH-QGZVFWFLSA-N OC1=C(c2ncc[n]2C[C@@H]2C(c(cc3)ccc3F)c(cc3)ccc3F)N2N=CC1=O Chemical compound OC1=C(c2ncc[n]2C[C@@H]2C(c(cc3)ccc3F)c(cc3)ccc3F)N2N=CC1=O SHISIZVWEDLGHH-QGZVFWFLSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662305392P | 2016-03-08 | 2016-03-08 | |
| US62/305,392 | 2016-03-08 | ||
| PCT/IB2017/051338 WO2017153919A1 (en) | 2016-03-08 | 2017-03-07 | Tricyclic compounds useful to treat orthomyxovirus infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019512485A JP2019512485A (ja) | 2019-05-16 |
| JP2019512485A5 JP2019512485A5 (enExample) | 2020-05-28 |
| JP6918819B2 true JP6918819B2 (ja) | 2021-08-11 |
Family
ID=58347733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018547307A Active JP6918819B2 (ja) | 2016-03-08 | 2017-03-07 | オルトミクソウイルス感染の処置に有用な三環式化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10858366B2 (enExample) |
| EP (1) | EP3426656B1 (enExample) |
| JP (1) | JP6918819B2 (enExample) |
| CN (1) | CN108699059B (enExample) |
| ES (1) | ES2881776T3 (enExample) |
| WO (1) | WO2017153919A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107709321A (zh) | 2015-04-28 | 2018-02-16 | 盐野义制药株式会社 | 经取代的多环性吡啶酮衍生物及其前药 |
| HK1254961A1 (en) | 2015-12-15 | 2019-08-02 | Shionogi & Co., Ltd. | Medicine for treating influenza characterized by comprising combination of cap-dependent endonuclease inhibitor with anti-influenza drug |
| KR102398439B1 (ko) | 2016-03-07 | 2022-05-16 | 이난타 파마슈티칼스, 인코포레이티드 | B형 간염 항바이러스제 |
| ES2881776T3 (es) | 2016-03-08 | 2021-11-30 | Novartis Ag | Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus |
| US10759814B2 (en) | 2016-08-10 | 2020-09-01 | Shionogi & Co., Ltd. | Pharmaceutical compositions containing substituted polycyclic pyridone derivatives and prodrug thereof |
| JOP20170169A1 (ar) | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
| SG11202001685TA (en) | 2017-08-28 | 2020-03-30 | Enanta Pharm Inc | Hepatitis b antiviral agents |
| US11058678B2 (en) | 2018-01-22 | 2021-07-13 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| HUE069183T2 (hu) * | 2018-02-28 | 2025-02-28 | Novartis Ag | 10-(di(fenil)metil)-4-hidroxi-8,9,9a,10-tetrahidro-7H--pirrolo[1',2':4,5]pirazino[1,2-b]piridazin-3,5-dion származékok és kapcsolódó vegyületek mint orthomyxovírus repikáció gátlók influenza kezelésére |
| TW202024093A (zh) | 2018-09-21 | 2020-07-01 | 美商安塔製藥公司 | 作為抗病毒劑之官能化雜環 |
| EP3883570A4 (en) | 2018-11-21 | 2022-07-13 | Enanta Pharmaceuticals, Inc. | FUNCTIONALIZED HETEROCYCLES AS ANTIVIRAL AGENTS |
| CN111410661B (zh) * | 2019-01-04 | 2023-05-05 | 周雨恬 | 帽依赖性内切核酸酶抑制剂及其用途 |
| CN109912624B (zh) * | 2019-04-11 | 2021-05-11 | 杭州科巢生物科技有限公司 | 一种巴洛沙韦酯关键母核中间体的合成方法 |
| CN111909174B (zh) | 2019-05-08 | 2022-01-21 | 江西彩石医药科技有限公司 | 吡啶酮衍生物的晶型及制备方法和应用 |
| WO2020247444A1 (en) | 2019-06-03 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| US11472808B2 (en) | 2019-06-04 | 2022-10-18 | Enanta Pharmaceuticals, Inc. | Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents |
| WO2020247561A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| WO2021007488A1 (en) | 2019-07-11 | 2021-01-14 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| WO2021055425A2 (en) | 2019-09-17 | 2021-03-25 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| US11802125B2 (en) | 2020-03-16 | 2023-10-31 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8501542D0 (en) | 1985-01-22 | 1985-02-20 | Erba Farmitalia | 4 5 6 7-tetrahydro-imidazo(4 5-clpyridine derivatives |
| ATE530520T1 (de) * | 2001-08-10 | 2011-11-15 | Shionogi & Co | Antivirales mittel |
| WO2004078163A2 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| TW200526635A (en) * | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
| AU2005221864A1 (en) | 2004-03-09 | 2005-09-22 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | HIV integrase inhibitors |
| FR2901795A1 (fr) * | 2006-05-30 | 2007-12-07 | Fourtillan Snc | Derives de pyrimidino[1',6'-1,2]pyrido[3,4-b]indoles et leur utilisation en therapeutique |
| EA019520B1 (ru) | 2008-10-31 | 2014-04-30 | Сионоги Энд Ко., Лтд. | Цефалоспорины, содержащие катехольную группу |
| US8835461B2 (en) * | 2009-03-26 | 2014-09-16 | Shionogi & Co., Ltd. | Substituted 3-hydroxy-4-pyridone derivative |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| JP5737691B2 (ja) * | 2009-06-15 | 2015-06-17 | 塩野義製薬株式会社 | 置換された多環性カルバモイルピリドン誘導体 |
| TW201201813A (en) * | 2010-03-31 | 2012-01-16 | Arqule Inc | Substituted benzo-pyrido-triazolo-diazepine compounds |
| US20120195857A1 (en) | 2010-08-12 | 2012-08-02 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| LT2620436T (lt) | 2010-09-24 | 2018-08-10 | Shionogi & Co., Ltd. | Pakeistojo policiklinio karbamoilpiridono darinio provaistas |
| WO2012151567A1 (en) * | 2011-05-05 | 2012-11-08 | St. Jude Children's Research Hospital | Pyrimidinone compounds and methods for preventing and treating influenza |
| AU2012321762A1 (en) | 2011-10-12 | 2014-04-17 | Shionogi & Co., Ltd. | Polycyclic pyridone derivative having integrase-inhibiting activity |
| US9278996B2 (en) | 2012-09-20 | 2016-03-08 | Celltrion, Inc. | Dolastatin-10 derivative, method of producing the same and anticancer drug composition containing the same |
| EA201591291A1 (ru) * | 2013-01-08 | 2015-12-30 | Савира Фармасьютикалз Гмбх | Производные пиримидона и их применение в лечении, облегчении или профилактике вирусного заболевания |
| CA2921294C (en) | 2013-08-21 | 2023-05-16 | Alios Biopharma, Inc. | Antiviral compounds |
| CN105530946A (zh) | 2013-09-11 | 2016-04-27 | 南加利福尼亚大学 | 具有高度表达的fas配体的干细胞组合物 |
| AU2014318837B2 (en) | 2013-09-12 | 2019-05-30 | Janssen Biopharma, Inc. | Pyridazinone compounds and uses thereof |
| CN105764904B (zh) | 2013-09-12 | 2020-02-11 | 詹森生物制药有限公司 | 氮杂-吡啶酮化合物及其用途 |
| CA2953862A1 (en) | 2014-07-07 | 2016-01-14 | F. Hoffmann-La Roche Ag | Dihydropyridopyrazine-1,8-diones and their use in the treatment, amelioration or prevention of viral diseases |
| WO2016145103A1 (en) | 2015-03-11 | 2016-09-15 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| ES2881776T3 (es) * | 2016-03-08 | 2021-11-30 | Novartis Ag | Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus |
| US10759814B2 (en) | 2016-08-10 | 2020-09-01 | Shionogi & Co., Ltd. | Pharmaceutical compositions containing substituted polycyclic pyridone derivatives and prodrug thereof |
| JOP20170169A1 (ar) | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
| CN111848615B (zh) | 2018-01-17 | 2022-05-17 | 江西彩石医药科技有限公司 | 吡啶酮衍生物及包含其的抗流感病毒药物组合物 |
| HUE069183T2 (hu) | 2018-02-28 | 2025-02-28 | Novartis Ag | 10-(di(fenil)metil)-4-hidroxi-8,9,9a,10-tetrahidro-7H--pirrolo[1',2':4,5]pirazino[1,2-b]piridazin-3,5-dion származékok és kapcsolódó vegyületek mint orthomyxovírus repikáció gátlók influenza kezelésére |
-
2017
- 2017-03-07 ES ES17711349T patent/ES2881776T3/es active Active
- 2017-03-07 US US16/083,089 patent/US10858366B2/en active Active
- 2017-03-07 WO PCT/IB2017/051338 patent/WO2017153919A1/en not_active Ceased
- 2017-03-07 JP JP2018547307A patent/JP6918819B2/ja active Active
- 2017-03-07 CN CN201780015673.6A patent/CN108699059B/zh active Active
- 2017-03-07 EP EP17711349.5A patent/EP3426656B1/en active Active
-
2020
- 2020-07-20 US US16/933,000 patent/US11453677B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017153919A1 (en) | 2017-09-14 |
| US11453677B2 (en) | 2022-09-27 |
| US20190092780A1 (en) | 2019-03-28 |
| EP3426656B1 (en) | 2021-05-12 |
| JP2019512485A (ja) | 2019-05-16 |
| CN108699059A (zh) | 2018-10-23 |
| EP3426656A1 (en) | 2019-01-16 |
| US10858366B2 (en) | 2020-12-08 |
| CN108699059B (zh) | 2021-06-18 |
| US20200347072A1 (en) | 2020-11-05 |
| ES2881776T3 (es) | 2021-11-30 |
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| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |