JP6907227B2 - Ｐｃｖ２ウイルス及びマイコプラズマ・ハイオニューモニエ感染症に対する混合ワクチン - Google Patents
Ｐｃｖ２ウイルス及びマイコプラズマ・ハイオニューモニエ感染症に対する混合ワクチン Download PDFInfo
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- JP6907227B2 JP6907227B2 JP2018549447A JP2018549447A JP6907227B2 JP 6907227 B2 JP6907227 B2 JP 6907227B2 JP 2018549447 A JP2018549447 A JP 2018549447A JP 2018549447 A JP2018549447 A JP 2018549447A JP 6907227 B2 JP6907227 B2 JP 6907227B2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16161997 | 2016-03-23 | ||
| EP16161997.8 | 2016-03-23 | ||
| PCT/EP2017/056831 WO2017162741A1 (en) | 2016-03-23 | 2017-03-22 | A combination vaccine against pcv2 virus and mycoplasma hyopneumoniae infection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019509300A JP2019509300A (ja) | 2019-04-04 |
| JP2019509300A5 JP2019509300A5 (https=) | 2020-03-12 |
| JP6907227B2 true JP6907227B2 (ja) | 2021-07-21 |
Family
ID=55589754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018549447A Expired - Fee Related JP6907227B2 (ja) | 2016-03-23 | 2017-03-22 | Ｐｃｖ２ウイルス及びマイコプラズマ・ハイオニューモニエ感染症に対する混合ワクチン |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20190105385A1 (https=) |
| EP (1) | EP3432919A1 (https=) |
| JP (1) | JP6907227B2 (https=) |
| CN (1) | CN108697782A (https=) |
| BR (1) | BR112018069100A2 (https=) |
| RU (1) | RU2018137034A (https=) |
| WO (1) | WO2017162741A1 (https=) |
Families Citing this family (7)
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| BR112020011044A2 (pt) * | 2017-12-04 | 2020-11-17 | Intervet International B.V. | vacinação com partículas de replicon e adjuvante de óleo |
| JP7510874B2 (ja) * | 2017-12-22 | 2024-07-04 | ヒプラ シエンティフィック エセ．エレ．ウ． | マイコプラズマ及びブタサーコウイルスに対する皮内混合ワクチン |
| US20220323567A1 (en) * | 2019-09-12 | 2022-10-13 | Intervet Inc. | Combination vaccine for intradermal administration |
| KR20230004654A (ko) * | 2020-04-20 | 2023-01-06 | 인터벳 인터내셔널 비.브이. | 마이코플라즈마 하이오뉴모니아에로부터 방어하기 위한 백신 |
| CA3176154A1 (en) | 2020-04-20 | 2021-10-28 | Maarten Hendrik Witvliet | A combination of vaccines to prophylactically treat a pig |
| CN115887636A (zh) * | 2022-01-18 | 2023-04-04 | 武汉科前生物股份有限公司 | 猪圆环病毒2型、猪肺炎支原体、猪链球菌三联灭活疫苗及其制备方法 |
| WO2025132513A1 (en) | 2023-12-19 | 2025-06-26 | Intervet International B.V. | Low-energy electron irradiation-inactivated mollicutes |
Family Cites Families (18)
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| HU212924B (en) * | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| SI1651265T1 (sl) * | 2003-07-24 | 2008-10-31 | Merial Ltd | Formulacije cepiva, ki obsegajo emulzijo olje v vodi |
| AU2005230708B2 (en) * | 2004-04-05 | 2009-01-15 | Zoetis Services Llc | Microfluidized oil-in-water emulsions and vaccine compositions |
| RU2007130801A (ru) | 2005-01-13 | 2009-02-20 | Берингер Ингельхайм Ветмедика Гмбх (De) | Улучшенные вакцины против репродуктивно-респираторного синдрома свиней (prrs) |
| US8834891B2 (en) * | 2005-03-14 | 2014-09-16 | Boehringer Ingelheim Vetmedica, Inc. | Immunogenic compositions comprising Lawsonia intracellularis |
| AR054822A1 (es) * | 2005-07-07 | 2007-07-18 | Sanofi Pasteur | Emulsion inmuno adyuvante |
| ES2425228T3 (es) | 2005-09-09 | 2013-10-14 | Intervet International B.V. | Vacuna contra el PCV-2 |
| DK3766518T3 (da) | 2005-12-29 | 2026-04-13 | Boehringer Ingelheim Animal Health Usa Inc | Immunogen pcv2-sammensætning til mindskelse af kliniske symptomer hos grise |
| PT2094872T (pt) | 2006-12-15 | 2017-04-27 | Boehringer Ingelheim Vetmedica Inc | Tratamento de porcos seropositivos para o anticorpo anti-pcv2 com antigénio de pcv2 |
| TWI449533B (zh) * | 2008-04-18 | 2014-08-21 | Intervet Int Bv | 防備胞內勞森菌（Ｌａｗｓｏｎｉａ ｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）、豬肺炎黴漿菌（Ｍｙｃｏｐｌａｓｍａ ｈｙｏｐｎｅｕｍｏｎｉａｅ）及豬環狀病毒（Ｐｏｒｃｉｎｅ ｃｉｒｃｏ ｖｉｒｕｓ）用疫苗 |
| US8728487B2 (en) | 2011-01-20 | 2014-05-20 | Hua Wu | Attenuated live vaccine for prevention of porcine reproductive and respiratory syndrome |
| JP6460792B2 (ja) * | 2011-09-09 | 2019-01-30 | ナノバイオ コーポレーション | ナノエマルション呼吸器合胞体ウイルス（ｒｓｖ）サブユニットワクチン |
| UA114503C2 (uk) * | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv та mycoplasma hyopneumoniae |
| UA114504C2 (uk) * | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
| US9457073B2 (en) | 2012-09-26 | 2016-10-04 | University Of Manitoba | Live attenuated replication-competent arteriviruses having decreased dub/deisgylating activity |
| CN104043118A (zh) * | 2013-03-11 | 2014-09-17 | 普莱柯生物工程股份有限公司 | 猪prrsv、猪肺炎支原体和pvc-2抗原在制备疫苗中的应用 |
| CN103263666B (zh) * | 2013-05-24 | 2019-07-16 | 北京大北农科技集团股份有限公司动物医学研究中心 | 猪圆环病毒2型、猪支原体肺炎二联灭活疫苗及其制备方法 |
| KR102547168B1 (ko) * | 2013-12-03 | 2023-06-22 | 인터벳 인터내셔널 비.브이. | 로소니아 인트라셀룰라리스 및 돼지 써코바이러스 2에 대한 백신 |
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2017
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- 2017-03-22 CN CN201780014561.9A patent/CN108697782A/zh active Pending
- 2017-03-22 RU RU2018137034A patent/RU2018137034A/ru unknown
- 2017-03-22 US US16/086,690 patent/US20190105385A1/en not_active Abandoned
- 2017-03-22 BR BR112018069100-3A patent/BR112018069100A2/pt unknown
- 2017-03-22 WO PCT/EP2017/056831 patent/WO2017162741A1/en not_active Ceased
- 2017-03-22 EP EP17711241.4A patent/EP3432919A1/en active Pending
Also Published As
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|---|---|
| JP2019509300A (ja) | 2019-04-04 |
| RU2018137034A3 (https=) | 2020-06-26 |
| EP3432919A1 (en) | 2019-01-30 |
| BR112018069100A2 (pt) | 2019-01-29 |
| WO2017162741A1 (en) | 2017-09-28 |
| RU2018137034A (ru) | 2020-04-23 |
| CN108697782A (zh) | 2018-10-23 |
| US20190105385A1 (en) | 2019-04-11 |
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