JP6901657B2 - アルギン酸又はその薬学的に許容される塩及びコロイド性多糖類を含有する液状組成物 - Google Patents
アルギン酸又はその薬学的に許容される塩及びコロイド性多糖類を含有する液状組成物 Download PDFInfo
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- JP6901657B2 JP6901657B2 JP2019565475A JP2019565475A JP6901657B2 JP 6901657 B2 JP6901657 B2 JP 6901657B2 JP 2019565475 A JP2019565475 A JP 2019565475A JP 2019565475 A JP2019565475 A JP 2019565475A JP 6901657 B2 JP6901657 B2 JP 6901657B2
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- pharmaceutically acceptable
- acceptable salt
- alginic acid
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- liquid composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/145—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
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Description
0.4w/v%のヒアルロン酸ナトリウム溶液
生理食塩水(Normal Saline、NS)
粘膜隆起力評価
比較例1、比較例2、実施例1及び実施例2によって製造された試料を用いてブタ切除胃の粘膜隆起の高さを肉眼で観察した。粘膜下に試料を注入してからそれぞれ5分、10分、15分、20分、30分経過した後、図2のように粘膜隆起の高さを肉眼で観察し、その結果(それぞれ3回繰り返して測定した平均値)を表1及び図3に示した。
前記試料10mLを、内視鏡用穿刺針(針径:23G)が維持されている10mLの注射筒(ジグ)に充填し、この注射筒のピストンを0.2mm/秒の一定速度で押すことによって、前記試料を内視鏡用穿刺針の先端から排出させながらかかる力の大きさ(Kgf)を測定した。測定(小型卓上試験機:KANA、IM−010)はそれぞれ3回繰り返し、その結果を平均値として下記の表2に示した。
Claims (5)
- 内視鏡的粘膜切除術又は内視鏡的粘膜下層剥離術において粘膜下層に注入するための医療用医薬組成物であって、
重量平均分子量が10万以上15万以下であるアルギン酸又はその薬学的に許容される塩及びペクチン質又はその薬学的に許容される塩を含有し、
w/v単位を基準にして、前記アルギン酸又はその薬学的に許容される塩:前記ペクチン質又はその薬学的に許容される塩=2〜8:1である液状組成物。 - 前記組成物中のアルギン酸又はその薬学的に許容される塩の濃度が0.05w/v%以上2.0w/v%以下である、請求項1に記載の液状組成物。
- 前記ペクチン質又はその薬学的に許容される塩の濃度が0.01w/v%以上2.0w/v%以下である、請求項1に記載の液状組成物。
- 前記組成物はpH5.0〜8.0である、請求項1に記載の液状組成物。
- 前記組成物は、粘度が1.0cps〜50.0cpsである、請求項1に記載の液状組成物。
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KR10-2017-0073128 | 2017-06-12 | ||
KR1020170073128A KR101884467B1 (ko) | 2017-06-12 | 2017-06-12 | 알긴산 또는 그 약학적으로 허용되는 염과 콜로이드성 다당류를 함유하는 액상 조성물 |
PCT/KR2018/006617 WO2018230915A1 (ko) | 2017-06-12 | 2018-06-11 | 알긴산 또는 그 약학적으로 허용되는 염과 콜로이드성 다당류를 함유하는 액상 조성물 |
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EP (1) | EP3639862A4 (ja) |
JP (1) | JP6901657B2 (ja) |
KR (1) | KR101884467B1 (ja) |
CN (1) | CN110740761B (ja) |
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US11679076B2 (en) * | 2020-08-06 | 2023-06-20 | T-ACE Medical Co., Ltd. | Composition for submucosal injection and preparation method thereof |
CN114377214A (zh) * | 2022-03-01 | 2022-04-22 | 南京工业大学 | 一种辅助emr或esd手术的可注射海藻酸钠水凝胶 |
CN115003283A (zh) * | 2022-04-20 | 2022-09-02 | 江苏扬子江医疗科技股份有限公司 | 一种注射型水凝胶及其制备方法和作为内窥镜辅助治疗的粘膜下注射液的应用 |
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WO2005039672A1 (ja) * | 2003-10-23 | 2005-05-06 | Shinshu Tlo Co., Ltd. | 増粘性組成物の増粘方法、及び針装置 |
US20050208134A1 (en) * | 2004-02-25 | 2005-09-22 | Shlomo Magdassi | Biocompatible polymeric beads and use thereof |
CN101528057A (zh) * | 2006-08-24 | 2009-09-09 | 荷兰联合利华有限公司 | 液体饱腹感增强组合物 |
WO2009070793A1 (en) * | 2007-11-29 | 2009-06-04 | Pluromed, Inc. | Endoscopic mucosal resectioning using purified inverse thermosensitive polymers |
WO2013077357A1 (ja) * | 2011-11-25 | 2013-05-30 | 日本製薬株式会社 | 粘膜下膨隆剤 |
KR101436406B1 (ko) | 2011-12-29 | 2014-09-02 | 주식회사 안랩 | P2p기반 업데이트 클라이언트, 서버 장치, 시스템 및 방법 |
CN103071181B (zh) * | 2013-02-01 | 2015-04-29 | 刘昌桂 | 一种水凝胶及其制备方法和用途 |
JP6099044B2 (ja) * | 2013-03-26 | 2017-03-22 | 国立大学法人 大分大学 | 医療用組成物 |
US20160228140A1 (en) * | 2013-06-26 | 2016-08-11 | Vicut Medical Devices Ltd. | Device, kit and method for prolonged lifting of a tissue during endoscopic procedure |
KR102077158B1 (ko) | 2013-07-10 | 2020-02-13 | 삼성전자 주식회사 | 메모 기능이 연동된 메시지 기능 운용 방법 및 장치 |
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EP3096793A1 (en) * | 2013-10-07 | 2016-11-30 | Boston Scientific Scimed, Inc. | Injectable compositions |
ITMI20131924A1 (it) * | 2013-11-20 | 2015-05-21 | Cosmo Technologies Ltd | Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica |
ITMI20131927A1 (it) * | 2013-11-20 | 2015-05-21 | Cosmo Technologies Ltd | Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection. emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica |
KR20160033897A (ko) * | 2014-09-19 | 2016-03-29 | 주식회사 덱스레보 | 조직 수복용 조성물 및 이의 제조방법 |
KR20160043547A (ko) | 2014-10-13 | 2016-04-22 | (주)에코팜 | 원예작물용 천연 살균 및 살충제 제조방법 및 그로써 제조된 천연 살균 및 살충제 |
US10179190B2 (en) * | 2015-05-29 | 2019-01-15 | Boston Scientific Scimed, Inc. | Compositions and methods for treatment of tissue |
CN105251048A (zh) * | 2015-10-16 | 2016-01-20 | 山东福瑞达医药集团公司 | 一种含黄原胶的可注射型软骨组织保护及修复材料 |
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WO2018230915A1 (ko) | 2018-12-20 |
PH12019502629A1 (en) | 2020-06-08 |
US11071807B2 (en) | 2021-07-27 |
CN110740761B (zh) | 2022-10-25 |
EP3639862A1 (en) | 2020-04-22 |
EP3639862A4 (en) | 2021-04-07 |
CN110740761A (zh) | 2020-01-31 |
US20200114047A1 (en) | 2020-04-16 |
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