JP6896113B2 - ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用 - Google Patents

ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用 Download PDF

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JP6896113B2
JP6896113B2 JP2019569416A JP2019569416A JP6896113B2 JP 6896113 B2 JP6896113 B2 JP 6896113B2 JP 2019569416 A JP2019569416 A JP 2019569416A JP 2019569416 A JP2019569416 A JP 2019569416A JP 6896113 B2 JP6896113 B2 JP 6896113B2
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formula
fluorine
compound
methyl
group
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JP2020523388A (ja
JP2020523388A5 (https=
Inventor
マルティナ・デルベック
ミヒャエル・ハーン
トーマス・ミュラー
クレメンス・ルスティヒ
カール・コリンズ
ニールス・リントナー
ヤニーネ・ニコライ
モリッツ・ベック−ブロイヒシッター
ウドー・アルバス
ドリス・ゲーリング
ビョルン・ローゼンシュタイン
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Bayer AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019569416A 2017-06-14 2018-06-07 ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用 Expired - Fee Related JP6896113B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021094338A JP2021127346A (ja) 2017-06-14 2021-06-04 ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP17176046 2017-06-14
EP17176046.5 2017-06-14
EP17193252.8 2017-09-26
EP17193252 2017-09-26
PCT/EP2018/064977 WO2018228907A1 (de) 2017-06-14 2018-06-07 Diazabicyclisch substituierte imidazopyrimidine und ihre verwendung zur behandlung von atemstörungen

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JP2021094338A Division JP2021127346A (ja) 2017-06-14 2021-06-04 ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用

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JP2020523388A JP2020523388A (ja) 2020-08-06
JP2020523388A5 JP2020523388A5 (https=) 2021-05-06
JP6896113B2 true JP6896113B2 (ja) 2021-06-30

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JP2021094338A Pending JP2021127346A (ja) 2017-06-14 2021-06-04 ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用

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US (3) US11098063B2 (https=)
EP (1) EP3638675B1 (https=)
JP (2) JP6896113B2 (https=)
KR (1) KR102364134B1 (https=)
CN (4) CN115554300B (https=)
AR (1) AR112099A1 (https=)
AU (1) AU2018283331B2 (https=)
BR (1) BR112019026450A2 (https=)
CA (1) CA3066942A1 (https=)
CL (1) CL2019003650A1 (https=)
CO (1) CO2019014047A2 (https=)
CR (1) CR20190563A (https=)
CU (1) CU24603B1 (https=)
DO (1) DOP2019000308A (https=)
EA (1) EA202090043A1 (https=)
EC (1) ECSP19088492A (https=)
ES (1) ES2985167T3 (https=)
GE (2) GEAP202115256A (https=)
HR (1) HRP20240678T1 (https=)
HU (1) HUE066512T2 (https=)
IL (1) IL271117B (https=)
JO (1) JOP20190284A1 (https=)
MA (1) MA49368B1 (https=)
MX (2) MX2019014983A (https=)
MY (1) MY204293A (https=)
NI (1) NI201900126A (https=)
NZ (1) NZ758821A (https=)
PE (1) PE20200016A1 (https=)
PH (1) PH12019502828A1 (https=)
PL (1) PL3638675T3 (https=)
RS (1) RS65543B1 (https=)
SG (1) SG11201911508XA (https=)
TW (1) TWI801388B (https=)
UA (1) UA125186C2 (https=)
UY (1) UY37773A (https=)
WO (1) WO2018228907A1 (https=)

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JP2021127346A (ja) * 2017-06-14 2021-09-02 バイエル アクチェンゲゼルシャフトBayer Aktiengesellschaft ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用

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US20220218695A1 (en) 2019-05-09 2022-07-14 Bayer Aktiengesellschaft Combination of an alpha2-adrenoceptor subtype c (alpha-2c) antagonists with a task1/3 channel blocker for the treatment of sleep apnea
TW202108139A (zh) 2019-05-09 2021-03-01 德商拜耳廠股份有限公司 用於治療睡眠呼吸中止之α２—腎上腺素受體亞型Ｃ（α—２Ｃ）拮抗劑與ＴＡＳＫ１／３通道阻斷劑之組合

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021127346A (ja) * 2017-06-14 2021-09-02 バイエル アクチェンゲゼルシャフトBayer Aktiengesellschaft ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用
US12180227B2 (en) 2017-06-14 2024-12-31 Bayer Aktiengesellschaft Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders

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