JP2020523388A5 - - Google Patents
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- JP2020523388A5 JP2020523388A5 JP2019569416A JP2019569416A JP2020523388A5 JP 2020523388 A5 JP2020523388 A5 JP 2020523388A5 JP 2019569416 A JP2019569416 A JP 2019569416A JP 2019569416 A JP2019569416 A JP 2019569416A JP 2020523388 A5 JP2020523388 A5 JP 2020523388A5
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- Prior art keywords
- formula
- fluorine
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- 0 CC1=C(*)N=C(C)*1 Chemical compound CC1=C(*)N=C(C)*1 0.000 description 3
- OGGHXOJOVOYBOH-ZMFCMNQTSA-N CC(C)c(cc1)ccc1-c1c(CN(C[C@H]2CC3)CC3N2C(c(nc(cc2)OC)c2F)=O)[n](cccn2)c2n1 Chemical compound CC(C)c(cc1)ccc1-c1c(CN(C[C@H]2CC3)CC3N2C(c(nc(cc2)OC)c2F)=O)[n](cccn2)c2n1 OGGHXOJOVOYBOH-ZMFCMNQTSA-N 0.000 description 1
- QQDBUSHKNJREPQ-UHFFFAOYSA-N COc(cc1)nc(C(N(CC2)C3CN(Cc4c(-c(cc5)ccc5Cl)nc5nccc[n]45)CC2C3)=O)c1F Chemical compound COc(cc1)nc(C(N(CC2)C3CN(Cc4c(-c(cc5)ccc5Cl)nc5nccc[n]45)CC2C3)=O)c1F QQDBUSHKNJREPQ-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021094338A JP2021127346A (ja) | 2017-06-14 | 2021-06-04 | ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17176046 | 2017-06-14 | ||
| EP17176046.5 | 2017-06-14 | ||
| EP17193252 | 2017-09-26 | ||
| EP17193252.8 | 2017-09-26 | ||
| PCT/EP2018/064977 WO2018228907A1 (de) | 2017-06-14 | 2018-06-07 | Diazabicyclisch substituierte imidazopyrimidine und ihre verwendung zur behandlung von atemstörungen |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021094338A Division JP2021127346A (ja) | 2017-06-14 | 2021-06-04 | ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020523388A JP2020523388A (ja) | 2020-08-06 |
| JP2020523388A5 true JP2020523388A5 (https=) | 2021-05-06 |
| JP6896113B2 JP6896113B2 (ja) | 2021-06-30 |
Family
ID=62492660
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019569416A Expired - Fee Related JP6896113B2 (ja) | 2017-06-14 | 2018-06-07 | ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用 |
| JP2021094338A Pending JP2021127346A (ja) | 2017-06-14 | 2021-06-04 | ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021094338A Pending JP2021127346A (ja) | 2017-06-14 | 2021-06-04 | ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用 |
Country Status (36)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018536693A (ja) | 2015-12-10 | 2018-12-13 | バイエル・ファルマ・アクティエンゲゼルシャフト | 睡眠関連呼吸障害を治療するためのＴＡＳＫ−１およびＴＡＳＫ−２チャネルの遮断薬としての２−フェニル−３−（ピペラジノメチル）イミダゾ［１，２−ａ］ピリジン誘導体 |
| JOP20190284A1 (ar) * | 2017-06-14 | 2019-12-11 | Bayer Pharma AG | مركبات إيميدازوبيريميدين مستبدلة بديازا ثنائي الحلقة واستخدامها للمعالجة من اضطرابات التنفس |
| WO2018227427A1 (en) | 2017-06-14 | 2018-12-20 | Bayer Aktiengesellschaft | Substituted bridged diazepane derivatives and use thereof |
| CA3139298A1 (en) | 2019-05-09 | 2020-11-12 | Bayer Aktiengesellschaft | Combination of an a2-adrenoceptor subtype c (alpha-2c) antagonists with a task1/3 channel blocker for the treatment of sleep apnea |
| TW202108139A (zh) * | 2019-05-09 | 2021-03-01 | 德商拜耳廠股份有限公司 | 用於治療睡眠呼吸中止之α２—腎上腺素受體亞型Ｃ（α—２Ｃ）拮抗劑與ＴＡＳＫ１／３通道阻斷劑之組合 |
| PE20221025A1 (es) | 2019-11-06 | 2022-06-16 | Bayer Ag | Inhibidores de los receptores a2c adrenergicos |
| WO2022008426A1 (en) * | 2020-07-06 | 2022-01-13 | Bayer Aktiengesellschaft | Combination of an alpha2-adrenoceptor subtype c (alpha-2c) antagonist with a task1/3 channel blocker for the treatment of sleep apnea |
| GB202101734D0 (en) * | 2021-02-08 | 2021-03-24 | Cerevance Inc | Novel Compounds |
| CN118434415A (zh) | 2021-12-22 | 2024-08-02 | 拜耳公司 | 用于治疗睡眠呼吸暂停的task1/3通道阻断剂与毒蕈碱型受体拮抗剂的结合物 |
| US20250057845A1 (en) | 2021-12-22 | 2025-02-20 | Bayer Aktiengesellschaft | Combination of a task1/3 channel blocker with a p2x3 receptor antagonist for the treatment of sleep apnea |
| JP2024545289A (ja) | 2021-12-22 | 2024-12-05 | バイエル・アクチエンゲゼルシヤフト | 睡眠時無呼吸の治療のためのｔａｓｋ１／３チャネル遮断薬とノルエピネフリン再取込み阻害薬との組合せ |
| EP4460307A1 (en) | 2022-01-07 | 2024-11-13 | Bayer Aktiengesellschaft | 2,3-dihydrobenzo [b][1, 4]dioxin-2-ylmethyl)piperazin-1-yl derivates for the treatment of sleep apnea |
| EP4460298A1 (en) | 2022-01-07 | 2024-11-13 | Bayer Aktiengesellschaft | Alpha2-ADRENOCEPTOR SUBTYPE C ANTAGONISTS FOR THE TREATMENT OF SLEEP APNEA |
| WO2025068514A1 (en) | 2023-09-28 | 2025-04-03 | Bayer Aktiengesellschaft | Substituted heterocyclic carboxamindes and use thereof |
| CN117959293B (zh) * | 2024-01-18 | 2025-05-13 | 香港大学深圳医院 | 非奈利酮在制备治疗和/或预防卵巢功能障碍疾病药物中的应用 |
Family Cites Families (51)
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| DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
| DE19943636A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943639A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften |
| DE19943634A1 (de) | 1999-09-13 | 2001-04-12 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| MY125533A (en) * | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| WO2002002557A2 (en) | 2000-06-30 | 2002-01-10 | Neurogen Corporation | 2-phenylimidazo[1,2-a]pyridine derivatives: a new class of gaba brain receptor ligands |
| GB0017256D0 (en) | 2000-07-13 | 2000-08-30 | Merck Sharp & Dohme | Therapeutic agents |
| AR031176A1 (es) | 2000-11-22 | 2003-09-10 | Bayer Ag | Nuevos derivados de pirazolpiridina sustituidos con piridina |
| SE0100568D0 (sv) | 2001-02-20 | 2001-02-20 | Astrazeneca Ab | Compounds |
| DE10110749A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte Aminodicarbonsäurederivate |
| DE10110750A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
| DE10247269A1 (de) | 2002-10-10 | 2004-04-22 | Grünenthal GmbH | Substituierte C-Imidazo[1,2-a]pyridin-3-yl-methylamine |
| US7855194B2 (en) * | 2006-03-27 | 2010-12-21 | Hoffmann-La Roche Inc. | Pyrimidine, quinazoline, pteridine and triazine derivatives |
| BRPI0710946A2 (pt) | 2006-04-27 | 2012-03-06 | Sanofi-Aventis Deutschland Gmbh | inibidores dos canais de Íon task-1 e task-3 |
| EP2049110B1 (en) | 2006-07-14 | 2014-08-20 | Merck Sharp & Dohme Corp. | Bridged diazepan orexin receptor antagonists |
| EP1974729A1 (en) | 2007-03-28 | 2008-10-01 | Santhera Pharmaceuticals (Schweiz) AG | Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists |
| CA2724842A1 (en) | 2008-05-19 | 2009-11-26 | Sunovion Pharmaceuticals Inc. | Imidazo[1,2-a]pyridine compounds |
| WO2011115804A1 (en) | 2010-03-17 | 2011-09-22 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| CA2793086C (en) | 2010-03-18 | 2018-08-21 | Institut Pasteur Korea | Substituted imidazo[1,2-a]pyridine compounds and their use in the treatment of bacterial infections |
| DE102010021637A1 (de) | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
| EA201390060A1 (ru) | 2010-07-09 | 2013-07-30 | Байер Интеллектуэль Проперти Гмбх | Аннелированные пиримидины и триазины и их применение для лечения и/или профилактики сердечно-сосудистых заболеваний |
| DE102010040233A1 (de) | 2010-09-03 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Bicyclische Aza-Heterocyclen und ihre Verwendung |
| DE102010043379A1 (de) | 2010-11-04 | 2012-05-10 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung |
| TW201242965A (en) | 2011-02-01 | 2012-11-01 | Kyowa Hakko Kirin Co Ltd | Ring-fused heterocyclic derivative |
| EP2691392A1 (en) | 2011-03-31 | 2014-02-05 | EMBLEM Technology Transfer GmbH | Imidazo [1,2-a]pyridine compounds for use in therapy |
| KR102104125B1 (ko) | 2011-04-21 | 2020-05-29 | 재단법인 한국파스퇴르연구소 | 소염 화합물 |
| MX2014002968A (es) | 2011-09-12 | 2014-07-09 | Sanofi Sa | 4,5,6,7 - tetrahidro - 1h - pirazolo [4,3 -c] piridinas sustituidas con indanilo, su uso como medicamento, y preparaciones farmaceuticas que las comprenden. |
| AU2011376721B2 (en) | 2011-09-16 | 2017-06-08 | Sanofi | Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them |
| BR112014006180A2 (pt) * | 2011-09-16 | 2017-04-11 | Sanofi Sa | 4, 5, 6, 7-tetraidro-1h-pirazol [4, 3-c] piridinas substituídas, seu uso como medicamento e preparações farmacêuticas que compreendem as mesmas |
| JP6126135B2 (ja) | 2012-02-03 | 2017-05-10 | サノフイ | 縮合ピロールカルボキサミド及びその医薬としてのその使用 |
| SG11201509650YA (en) * | 2013-05-24 | 2015-12-30 | Iomet Pharma Ltd | Slc2a transporter inhibitors |
| CA2937616A1 (en) | 2014-03-26 | 2015-10-01 | F. Hoffmann-La Roche Ag | Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| TWI585785B (zh) * | 2014-11-26 | 2017-06-01 | Murata Manufacturing Co | Electronic parts manufacturing methods, electronic components and electronic devices |
| JP2018012645A (ja) | 2014-11-26 | 2018-01-25 | 持田製薬株式会社 | 新規ジアザビシクロ誘導体 |
| US9994570B2 (en) * | 2014-11-26 | 2018-06-12 | Merck Sharp & Dohme Corp. | Bridged diazepane orexin receptor antagonists |
| US10000499B2 (en) | 2014-11-26 | 2018-06-19 | Merck Sharp & Dohme Corp. | Methyl diazepane orexin receptor antagonists |
| JP2018016544A (ja) | 2014-12-03 | 2018-02-01 | 持田製薬株式会社 | 新規ジアザビシクロ［２．２．２］オクタン誘導体 |
| WO2017050732A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
| WO2017097671A1 (de) | 2015-12-10 | 2017-06-15 | Bayer Pharma Aktiengesellschaft | Substituierte perhydropyrrolo[3,4-c]pyrrol-derivate und ihre verwendung |
| JP2018536693A (ja) | 2015-12-10 | 2018-12-13 | バイエル・ファルマ・アクティエンゲゼルシャフト | 睡眠関連呼吸障害を治療するためのＴＡＳＫ−１およびＴＡＳＫ−２チャネルの遮断薬としての２−フェニル−３−（ピペラジノメチル）イミダゾ［１，２−ａ］ピリジン誘導体 |
| JOP20190005A1 (ar) | 2016-07-20 | 2019-01-20 | Bayer Ag | مركبات ديازاهيترو ثنائية الحلقة مستبدلة واستخداماتها |
| JOP20190141A1 (ar) | 2016-12-21 | 2019-06-12 | Bayer Pharma AG | أشكال جرعات صيدلية تحتوي على مثبطات لقناة task-1 و task-3 واستخدامها في معالجة اضطراب تنفسي |
| JOP20190148A1 (ar) | 2016-12-21 | 2019-06-18 | Bayer Pharma AG | أشكال جرعات صيدلية تحتوي على مثبطات قنوات task-1 و task-3 واستخدامها لمعالجة الاضطرابات التنفسية |
| JOP20190284A1 (ar) | 2017-06-14 | 2019-12-11 | Bayer Pharma AG | مركبات إيميدازوبيريميدين مستبدلة بديازا ثنائي الحلقة واستخدامها للمعالجة من اضطرابات التنفس |
| WO2018227427A1 (en) | 2017-06-14 | 2018-12-20 | Bayer Aktiengesellschaft | Substituted bridged diazepane derivatives and use thereof |
| PE20211285A1 (es) | 2018-11-27 | 2021-07-19 | Bayer Ag | Proceso para la produccion de formas farmaceuticas que contienen inhibidores de los canales task-1 y task-3 y su uso para la terapia de trastornos respiratorios |
| TW202108139A (zh) | 2019-05-09 | 2021-03-01 | 德商拜耳廠股份有限公司 | 用於治療睡眠呼吸中止之α２—腎上腺素受體亞型Ｃ（α—２Ｃ）拮抗劑與ＴＡＳＫ１／３通道阻斷劑之組合 |
| CA3139298A1 (en) | 2019-05-09 | 2020-11-12 | Bayer Aktiengesellschaft | Combination of an a2-adrenoceptor subtype c (alpha-2c) antagonists with a task1/3 channel blocker for the treatment of sleep apnea |
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2017
- 2017-06-16 JO JOP/2019/0284A patent/JOP20190284A1/ar unknown
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2018
- 2018-06-07 MY MYPI2019007414A patent/MY204293A/en unknown
- 2018-06-07 JP JP2019569416A patent/JP6896113B2/ja not_active Expired - Fee Related
- 2018-06-07 CN CN202211200627.2A patent/CN115583959B/zh active Active
- 2018-06-07 US US16/622,233 patent/US11098063B2/en active Active
- 2018-06-07 BR BR112019026450-7A patent/BR112019026450A2/pt not_active Application Discontinuation
- 2018-06-07 CN CN202211199746.0A patent/CN115554299A/zh active Pending
- 2018-06-07 GE GEAP202115256A patent/GEAP202115256A/en unknown
- 2018-06-07 KR KR1020207000676A patent/KR102364134B1/ko active Active
- 2018-06-07 CA CA3066942A patent/CA3066942A1/en active Pending
- 2018-06-07 EA EA202090043A patent/EA202090043A1/ru unknown
- 2018-06-07 CU CU2019000101A patent/CU24603B1/es unknown
- 2018-06-07 HR HRP20240678TT patent/HRP20240678T1/hr unknown
- 2018-06-07 CR CR20190563A patent/CR20190563A/es unknown
- 2018-06-07 HU HUE18728646A patent/HUE066512T2/hu unknown
- 2018-06-07 UA UAA202000222A patent/UA125186C2/uk unknown
- 2018-06-07 CN CN201880039548.3A patent/CN110719911B/zh active Active
- 2018-06-07 WO PCT/EP2018/064977 patent/WO2018228907A1/de not_active Ceased
- 2018-06-07 MX MX2019014983A patent/MX2019014983A/es unknown
- 2018-06-07 GE GEAP201815256A patent/GEP20227366B/en unknown
- 2018-06-07 RS RS20240581A patent/RS65543B1/sr unknown
- 2018-06-07 AU AU2018283331A patent/AU2018283331B2/en not_active Ceased
- 2018-06-07 PE PE2019002541A patent/PE20200016A1/es unknown
- 2018-06-07 SG SG11201911508XA patent/SG11201911508XA/en unknown
- 2018-06-07 CN CN202211200547.7A patent/CN115554300B/zh active Active
- 2018-06-07 PL PL18728646.3T patent/PL3638675T3/pl unknown
- 2018-06-07 EP EP18728646.3A patent/EP3638675B1/de active Active
- 2018-06-07 NZ NZ758821A patent/NZ758821A/en unknown
- 2018-06-07 MA MA49368A patent/MA49368B1/fr unknown
- 2018-06-07 ES ES18728646T patent/ES2985167T3/es active Active
- 2018-06-12 TW TW107120117A patent/TWI801388B/zh active
- 2018-06-13 AR ARP180101619A patent/AR112099A1/es not_active Application Discontinuation
- 2018-06-14 UY UY0001037773A patent/UY37773A/es not_active Application Discontinuation
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2019
- 2019-12-02 IL IL271117A patent/IL271117B/en unknown
- 2019-12-11 MX MX2022012716A patent/MX2022012716A/es unknown
- 2019-12-12 CO CONC2019/0014047A patent/CO2019014047A2/es unknown
- 2019-12-12 CL CL2019003650A patent/CL2019003650A1/es unknown
- 2019-12-12 NI NI201900126A patent/NI201900126A/es unknown
- 2019-12-12 EC ECSENADI201988492A patent/ECSP19088492A/es unknown
- 2019-12-13 DO DO2019000308A patent/DOP2019000308A/es unknown
- 2019-12-13 PH PH12019502828A patent/PH12019502828A1/en unknown
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2021
- 2021-06-04 JP JP2021094338A patent/JP2021127346A/ja active Pending
- 2021-07-16 US US17/305,927 patent/US12180227B2/en active Active
-
2024
- 2024-11-21 US US18/955,853 patent/US20250154175A1/en active Pending
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