JP2020523388A5 - - Google Patents
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- JP2020523388A5 JP2020523388A5 JP2019569416A JP2019569416A JP2020523388A5 JP 2020523388 A5 JP2020523388 A5 JP 2020523388A5 JP 2019569416 A JP2019569416 A JP 2019569416A JP 2019569416 A JP2019569416 A JP 2019569416A JP 2020523388 A5 JP2020523388 A5 JP 2020523388A5
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- Prior art keywords
- formula
- fluorine
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- 0 CC1=C(*)N=C(C)*1 Chemical compound CC1=C(*)N=C(C)*1 0.000 description 3
- OGGHXOJOVOYBOH-ZMFCMNQTSA-N CC(C)c(cc1)ccc1-c1c(CN(C[C@H]2CC3)CC3N2C(c(nc(cc2)OC)c2F)=O)[n](cccn2)c2n1 Chemical compound CC(C)c(cc1)ccc1-c1c(CN(C[C@H]2CC3)CC3N2C(c(nc(cc2)OC)c2F)=O)[n](cccn2)c2n1 OGGHXOJOVOYBOH-ZMFCMNQTSA-N 0.000 description 1
- QQDBUSHKNJREPQ-UHFFFAOYSA-N COc(cc1)nc(C(N(CC2)C3CN(Cc4c(-c(cc5)ccc5Cl)nc5nccc[n]45)CC2C3)=O)c1F Chemical compound COc(cc1)nc(C(N(CC2)C3CN(Cc4c(-c(cc5)ccc5Cl)nc5nccc[n]45)CC2C3)=O)c1F QQDBUSHKNJREPQ-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021094338A JP2021127346A (ja) | 2017-06-14 | 2021-06-04 | ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17176046 | 2017-06-14 | ||
| EP17176046.5 | 2017-06-14 | ||
| EP17193252.8 | 2017-09-26 | ||
| EP17193252 | 2017-09-26 | ||
| PCT/EP2018/064977 WO2018228907A1 (de) | 2017-06-14 | 2018-06-07 | Diazabicyclisch substituierte imidazopyrimidine und ihre verwendung zur behandlung von atemstörungen |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021094338A Division JP2021127346A (ja) | 2017-06-14 | 2021-06-04 | ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020523388A JP2020523388A (ja) | 2020-08-06 |
| JP2020523388A5 true JP2020523388A5 (https=) | 2021-05-06 |
| JP6896113B2 JP6896113B2 (ja) | 2021-06-30 |
Family
ID=62492660
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019569416A Expired - Fee Related JP6896113B2 (ja) | 2017-06-14 | 2018-06-07 | ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用 |
| JP2021094338A Pending JP2021127346A (ja) | 2017-06-14 | 2021-06-04 | ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021094338A Pending JP2021127346A (ja) | 2017-06-14 | 2021-06-04 | ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用 |
Country Status (36)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017097792A1 (de) | 2015-12-10 | 2017-06-15 | Bayer Pharma Aktiengesellschaft | 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridin-derivate als blocker der task-1 und task-2 kanäle zur behandlung von schlafbedingten atemstörungen |
| WO2018227427A1 (en) | 2017-06-14 | 2018-12-20 | Bayer Aktiengesellschaft | Substituted bridged diazepane derivatives and use thereof |
| JOP20190284A1 (ar) | 2017-06-14 | 2019-12-11 | Bayer Pharma AG | مركبات إيميدازوبيريميدين مستبدلة بديازا ثنائي الحلقة واستخدامها للمعالجة من اضطرابات التنفس |
| TW202108139A (zh) * | 2019-05-09 | 2021-03-01 | 德商拜耳廠股份有限公司 | 用於治療睡眠呼吸中止之α２—腎上腺素受體亞型Ｃ（α—２Ｃ）拮抗劑與ＴＡＳＫ１／３通道阻斷劑之組合 |
| US20220218695A1 (en) | 2019-05-09 | 2022-07-14 | Bayer Aktiengesellschaft | Combination of an alpha2-adrenoceptor subtype c (alpha-2c) antagonists with a task1/3 channel blocker for the treatment of sleep apnea |
| CA3160035A1 (en) | 2019-11-06 | 2021-05-14 | Bayer Aktiengesellschaft | Inhibitors of adrenoreceptor adrac2 |
| BR112022026398A2 (pt) | 2020-07-06 | 2023-01-17 | Bayer Ag | Combinação de antagonista de receptor ¿2 adrenérgico subtipo c (alfa-2c) com bloqueador de canal task1/3 para tratamento da apneia do sono |
| GB202101734D0 (en) * | 2021-02-08 | 2021-03-24 | Cerevance Inc | Novel Compounds |
| US20250057845A1 (en) | 2021-12-22 | 2025-02-20 | Bayer Aktiengesellschaft | Combination of a task1/3 channel blocker with a p2x3 receptor antagonist for the treatment of sleep apnea |
| MX2024007764A (es) | 2021-12-22 | 2024-07-04 | Bayer Ag | Combinacion de un bloqueante de canales task1/3 con un inhibidor de la recaptacion de norepinefrina para el tratamiento de la apnea del sue?o. |
| KR20240124998A (ko) | 2021-12-22 | 2024-08-19 | 바이엘 악티엔게젤샤프트 | 수면 무호흡의 치료를 위한 task1/3 채널 차단제와 무스카린성 수용체 길항제의 조합물 |
| CN118785902A (zh) | 2022-01-07 | 2024-10-15 | 拜耳公司 | 用于治疗睡眠呼吸暂停的α2-肾上腺素受体亚型C拮抗剂 |
| KR20240132345A (ko) | 2022-01-07 | 2024-09-03 | 바이엘 악티엔게젤샤프트 | 수면 무호흡의 치료를 위한 2,3-디히드로벤조[b][1,4]디옥신-2-일메틸)피페라진-1-일 유도체 |
| AR133983A1 (es) | 2023-09-28 | 2025-11-19 | Bayer Ag | Carboxamidas heterocíclicas sustituidas y su uso |
| CN117959293B (zh) * | 2024-01-18 | 2025-05-13 | 香港大学深圳医院 | 非奈利酮在制备治疗和/或预防卵巢功能障碍疾病药物中的应用 |
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| DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
| DE19943639A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften |
| DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943634A1 (de) | 1999-09-13 | 2001-04-12 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943636A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| AU2001270297A1 (en) | 2000-06-30 | 2002-01-14 | Neurogen Corporation | 2-phenylimidazo(1,2-a)pyridine derivatives: a new class of gaba brain receptor ligands |
| GB0017256D0 (en) | 2000-07-13 | 2000-08-30 | Merck Sharp & Dohme | Therapeutic agents |
| AR031176A1 (es) | 2000-11-22 | 2003-09-10 | Bayer Ag | Nuevos derivados de pirazolpiridina sustituidos con piridina |
| SE0100568D0 (sv) | 2001-02-20 | 2001-02-20 | Astrazeneca Ab | Compounds |
| DE10110750A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE10110749A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte Aminodicarbonsäurederivate |
| DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
| DE10247269A1 (de) | 2002-10-10 | 2004-04-22 | Grünenthal GmbH | Substituierte C-Imidazo[1,2-a]pyridin-3-yl-methylamine |
| US7855194B2 (en) | 2006-03-27 | 2010-12-21 | Hoffmann-La Roche Inc. | Pyrimidine, quinazoline, pteridine and triazine derivatives |
| RU2436577C2 (ru) | 2006-04-27 | 2011-12-20 | Санофи-Авентис Дойчланд Гмбх | Ингибиторы ионных task-1 и task-3 каналов |
| CA2657623A1 (en) | 2006-07-14 | 2008-01-17 | Merck & Co., Inc. | Bridged diazepan orexin receptor antagonists |
| EP1974729A1 (en) | 2007-03-28 | 2008-10-01 | Santhera Pharmaceuticals (Schweiz) AG | Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists |
| CA2724842A1 (en) | 2008-05-19 | 2009-11-26 | Sunovion Pharmaceuticals Inc. | Imidazo[1,2-a]pyridine compounds |
| US20130178475A1 (en) | 2010-03-17 | 2013-07-11 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| SG184073A1 (en) | 2010-03-18 | 2012-10-30 | Pasteur Institut Korea | Anti-infective compounds |
| DE102010021637A1 (de) | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
| PE20130779A1 (es) | 2010-07-09 | 2013-06-21 | Bayer Ip Gmbh | Pirimidinas y triazinas condensadas y su uso |
| DE102010040233A1 (de) | 2010-09-03 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Bicyclische Aza-Heterocyclen und ihre Verwendung |
| DE102010043379A1 (de) | 2010-11-04 | 2012-05-10 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung |
| US9000186B2 (en) | 2011-02-01 | 2015-04-07 | Kyowa Hakko Kirin Co., Ltd. | Ring-fused heterocyclic derivative |
| CA2831356A1 (en) | 2011-03-31 | 2012-10-04 | Emblem Technology Transfer Gmbh | Imidazo [1,2-a]pyridine_compounds for use in therapy |
| KR20140093610A (ko) | 2011-04-21 | 2014-07-28 | 재단법인 한국파스퇴르연구소 | 소염 화합물 |
| MX2014002968A (es) | 2011-09-12 | 2014-07-09 | Sanofi Sa | 4,5,6,7 - tetrahidro - 1h - pirazolo [4,3 -c] piridinas sustituidas con indanilo, su uso como medicamento, y preparaciones farmaceuticas que las comprenden. |
| MX2014003181A (es) * | 2011-09-16 | 2015-08-05 | Sanofi Sa | 4,5,6,7-tetrahidro-1h-pirazolo [4,3-c] piridinas sustituidas, su uso como medicamento y preparaciones farmacéuticas que las comprenden. |
| AU2011376721B2 (en) | 2011-09-16 | 2017-06-08 | Sanofi | Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them |
| UY34610A (es) | 2012-02-03 | 2013-09-30 | Sanofi Sa | Pirroldicarboxamidas condensadas y su uso como agentes farmacéuticos. |
| EP3004088A1 (en) * | 2013-05-24 | 2016-04-13 | Iomet Pharma Ltd. | Slc2a transporter inhibitors |
| CN106103446B (zh) | 2014-03-26 | 2019-07-30 | 豪夫迈·罗氏有限公司 | 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的二环化合物 |
| TWI585785B (zh) | 2014-11-26 | 2017-06-01 | Murata Manufacturing Co | Electronic parts manufacturing methods, electronic components and electronic devices |
| JP2018012645A (ja) | 2014-11-26 | 2018-01-25 | 持田製薬株式会社 | 新規ジアザビシクロ誘導体 |
| WO2016085784A1 (en) | 2014-11-26 | 2016-06-02 | Merck Sharp & Dohme Corp. | Methyl diazepane orexin receptor antagonists |
| US9994570B2 (en) * | 2014-11-26 | 2018-06-12 | Merck Sharp & Dohme Corp. | Bridged diazepane orexin receptor antagonists |
| JP2018016544A (ja) | 2014-12-03 | 2018-02-01 | 持田製薬株式会社 | 新規ジアザビシクロ［２．２．２］オクタン誘導体 |
| KR20180054830A (ko) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 오토탁신(atx) 억제제로서의 이환형 화합물 |
| WO2017097792A1 (de) | 2015-12-10 | 2017-06-15 | Bayer Pharma Aktiengesellschaft | 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridin-derivate als blocker der task-1 und task-2 kanäle zur behandlung von schlafbedingten atemstörungen |
| US10414765B2 (en) | 2015-12-10 | 2019-09-17 | Bayer Pharma Aktiengesellschaft | Substituted perhydropyrrolo[3,4-c]pyrrole derivatives and the use of same |
| JOP20190005A1 (ar) | 2016-07-20 | 2019-01-20 | Bayer Ag | مركبات ديازاهيترو ثنائية الحلقة مستبدلة واستخداماتها |
| JOP20190148A1 (ar) | 2016-12-21 | 2019-06-18 | Bayer Pharma AG | أشكال جرعات صيدلية تحتوي على مثبطات قنوات task-1 و task-3 واستخدامها لمعالجة الاضطرابات التنفسية |
| JOP20190141A1 (ar) | 2016-12-21 | 2019-06-12 | Bayer Pharma AG | أشكال جرعات صيدلية تحتوي على مثبطات لقناة task-1 و task-3 واستخدامها في معالجة اضطراب تنفسي |
| WO2018227427A1 (en) | 2017-06-14 | 2018-12-20 | Bayer Aktiengesellschaft | Substituted bridged diazepane derivatives and use thereof |
| JOP20190284A1 (ar) | 2017-06-14 | 2019-12-11 | Bayer Pharma AG | مركبات إيميدازوبيريميدين مستبدلة بديازا ثنائي الحلقة واستخدامها للمعالجة من اضطرابات التنفس |
| PE20211285A1 (es) | 2018-11-27 | 2021-07-19 | Bayer Ag | Proceso para la produccion de formas farmaceuticas que contienen inhibidores de los canales task-1 y task-3 y su uso para la terapia de trastornos respiratorios |
| US20220218695A1 (en) | 2019-05-09 | 2022-07-14 | Bayer Aktiengesellschaft | Combination of an alpha2-adrenoceptor subtype c (alpha-2c) antagonists with a task1/3 channel blocker for the treatment of sleep apnea |
| TW202108139A (zh) | 2019-05-09 | 2021-03-01 | 德商拜耳廠股份有限公司 | 用於治療睡眠呼吸中止之α２—腎上腺素受體亞型Ｃ（α—２Ｃ）拮抗劑與ＴＡＳＫ１／３通道阻斷劑之組合 |
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2017
- 2017-06-16 JO JOP/2019/0284A patent/JOP20190284A1/ar unknown
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2018
- 2018-06-07 CR CR20190563A patent/CR20190563A/es unknown
- 2018-06-07 PE PE2019002541A patent/PE20200016A1/es unknown
- 2018-06-07 CN CN202211200547.7A patent/CN115554300B/zh active Active
- 2018-06-07 HU HUE18728646A patent/HUE066512T2/hu unknown
- 2018-06-07 RS RS20240581A patent/RS65543B1/sr unknown
- 2018-06-07 GE GEAP202115256A patent/GEAP202115256A/en unknown
- 2018-06-07 MY MYPI2019007414A patent/MY204293A/en unknown
- 2018-06-07 SG SG11201911508XA patent/SG11201911508XA/en unknown
- 2018-06-07 ES ES18728646T patent/ES2985167T3/es active Active
- 2018-06-07 BR BR112019026450-7A patent/BR112019026450A2/pt not_active Application Discontinuation
- 2018-06-07 UA UAA202000222A patent/UA125186C2/uk unknown
- 2018-06-07 PL PL18728646.3T patent/PL3638675T3/pl unknown
- 2018-06-07 WO PCT/EP2018/064977 patent/WO2018228907A1/de not_active Ceased
- 2018-06-07 EA EA202090043A patent/EA202090043A1/ru unknown
- 2018-06-07 KR KR1020207000676A patent/KR102364134B1/ko active Active
- 2018-06-07 HR HRP20240678TT patent/HRP20240678T1/hr unknown
- 2018-06-07 GE GEAP201815256A patent/GEP20227366B/en unknown
- 2018-06-07 AU AU2018283331A patent/AU2018283331B2/en not_active Ceased
- 2018-06-07 MX MX2019014983A patent/MX2019014983A/es unknown
- 2018-06-07 CN CN202211199746.0A patent/CN115554299A/zh active Pending
- 2018-06-07 US US16/622,233 patent/US11098063B2/en active Active
- 2018-06-07 CN CN201880039548.3A patent/CN110719911B/zh active Active
- 2018-06-07 NZ NZ758821A patent/NZ758821A/en unknown
- 2018-06-07 EP EP18728646.3A patent/EP3638675B1/de active Active
- 2018-06-07 CN CN202211200627.2A patent/CN115583959B/zh active Active
- 2018-06-07 CU CU2019000101A patent/CU24603B1/es unknown
- 2018-06-07 JP JP2019569416A patent/JP6896113B2/ja not_active Expired - Fee Related
- 2018-06-07 MA MA49368A patent/MA49368B1/fr unknown
- 2018-06-07 CA CA3066942A patent/CA3066942A1/en active Pending
- 2018-06-12 TW TW107120117A patent/TWI801388B/zh active
- 2018-06-13 AR ARP180101619A patent/AR112099A1/es not_active Application Discontinuation
- 2018-06-14 UY UY0001037773A patent/UY37773A/es not_active Application Discontinuation
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2019
- 2019-12-02 IL IL271117A patent/IL271117B/en unknown
- 2019-12-11 MX MX2022012716A patent/MX2022012716A/es unknown
- 2019-12-12 CL CL2019003650A patent/CL2019003650A1/es unknown
- 2019-12-12 CO CONC2019/0014047A patent/CO2019014047A2/es unknown
- 2019-12-12 EC ECSENADI201988492A patent/ECSP19088492A/es unknown
- 2019-12-12 NI NI201900126A patent/NI201900126A/es unknown
- 2019-12-13 PH PH12019502828A patent/PH12019502828A1/en unknown
- 2019-12-13 DO DO2019000308A patent/DOP2019000308A/es unknown
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2021
- 2021-06-04 JP JP2021094338A patent/JP2021127346A/ja active Pending
- 2021-07-16 US US17/305,927 patent/US12180227B2/en active Active
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2024
- 2024-11-21 US US18/955,853 patent/US20250154175A1/en active Pending
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