JP6876680B2 - ネオモルフィックｓｆ３ｂ１変異体に関連するスプライスバリアント - Google Patents

ネオモルフィックｓｆ３ｂ１変異体に関連するスプライスバリアント Download PDF

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JP6876680B2
JP6876680B2 JP2018510109A JP2018510109A JP6876680B2 JP 6876680 B2 JP6876680 B2 JP 6876680B2 JP 2018510109 A JP2018510109 A JP 2018510109A JP 2018510109 A JP2018510109 A JP 2018510109A JP 6876680 B2 JP6876680 B2 JP 6876680B2
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sf3b1
cancer
splicing
seq
variants
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JP2018525994A (ja
JP2018525994A5 (cg-RX-API-DMAC7.html
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リーファ ユー，
リーファ ユー，
キアン， ヒュ リム，
キアン， ヒュ リム，
ジャコブ， ディー． フィアラ，
ジャコブ， ディー． フィアラ，
シルヴィア ブオナミーチ，
シルヴィア ブオナミーチ，
佳治 水井
佳治 水井
ピーター， ジー． スミス，
ピーター， ジー． スミス，
ピン ズー，
ピン ズー，
ユニス， サン パク，
ユニス， サン パク，
マイケル， ダブリュー． セイラー，
マイケル， ダブリュー． セイラー，
マルコ， ピーター フェッケス，
マルコ， ピーター フェッケス，
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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JP2018510109A 2015-09-01 2016-08-30 ネオモルフィックｓｆ３ｂ１変異体に関連するスプライスバリアント Active JP6876680B2 (ja)

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US201562212876P 2015-09-01 2015-09-01
US62/212,876 2015-09-01
PCT/US2016/049490 WO2017040526A2 (en) 2015-09-01 2016-08-30 Splice variants associated with neomorphic sf3b1 mutants

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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017040526A2 (en) 2015-09-01 2017-03-09 Eisai R&D Management Co., Ltd. Splice variants associated with neomorphic sf3b1 mutants
US20200190593A1 (en) * 2017-03-15 2020-06-18 Eisai R&D Management Co., Ltd. Spliceosome mutations and uses thereof
WO2019027987A2 (en) * 2017-07-31 2019-02-07 The Johns Hopkins University COMPOSITIONS AND METHODS FOR TARGETING MASAS TO TREAT CANCERS WITH SPLICE COMPLEX MUTATIONS
KR20210006907A (ko) * 2018-04-09 2021-01-19 에자이 알앤드디 매니지먼트 가부시키가이샤 플라디에놀리드 화합물 및 그의 용도
CN112367996B (zh) 2018-06-01 2024-05-24 卫材R&D管理有限公司 使用剪接调节剂的方法
IL262658A (en) * 2018-10-28 2020-04-30 Memorial Sloan Kettering Cancer Center Prevention of age related clonal hematopoiesis and diseases associated therewith
US20220073971A1 (en) * 2019-02-08 2022-03-10 Zenick Corporation Method for analyzing mrna precursor, information processing apparatus, and computer program
JP6931860B2 (ja) * 2019-02-08 2021-09-08 株式会社Ｚｅｎｉｃｋ ｍＲＮＡ前駆体の解析方法、情報処理装置、コンピュータプログラム
WO2020264177A1 (en) * 2019-06-26 2020-12-30 Fred Hutchinson Cancer Research Center Methods and compositions comprising brd9 activating therapies for treating cancers and related disorders
CN111518805A (zh) * 2020-04-30 2020-08-11 北京航空航天大学 一种可用于抑制肿瘤增殖的非编码基因及其应用
ES2891182A1 (es) * 2020-07-14 2022-01-26 Servicio Andaluz De Salud Compuestos para el tratamiento del carcinoma hepatocelular
CN116507334A (zh) * 2020-11-04 2023-07-28 卫材R&D管理有限公司 骨髓增生异常综合征（mds）的生物标记物及其使用方法
KR20230104204A (ko) 2020-11-04 2023-07-07 에자이 알앤드디 매니지먼트 가부시키가이샤 골수이형성 증후군(mds)에 대한 바이오마커 및 이를 사용하는 방법
WO2023131866A1 (en) 2022-01-05 2023-07-13 Eisai R&D Management Co., Ltd. Biomarkers for myelodysplastic syndrome (mds) and methods of using the same
WO2023209074A1 (en) * 2022-04-28 2023-11-02 Institut National de la Santé et de la Recherche Médicale Methods of restoring erythropoiesis in patients suffering from a sf3b1 mutant myelodysplastic syndrome by correcting coasy mis-splicing

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6372431B1 (en) * 1999-11-19 2002-04-16 Incyte Genomics, Inc. Mammalian toxicological response markers
CA2400666C (fr) 2000-02-18 2011-01-18 Gencell S.A. Procede de preparation de polyalkylenimines fonctionnalises, compositions les contenant et leurs utilisations
US6436703B1 (en) 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
TWI311558B (en) 2001-02-01 2009-07-01 Mercian Corporatio Novel physiologically active substance
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
US20070015271A1 (en) * 2002-04-04 2007-01-18 Rosen Craig A Human secreted proteins
TWI334866B (en) 2002-05-29 2010-12-21 Mercian Corp Novel physiologically active substances
JP4459051B2 (ja) 2002-07-31 2010-04-28 メルシャン株式会社 新規生理活性物質
KR101285695B1 (ko) 2002-07-31 2013-07-12 에자이 알앤드디 매니지먼트 가부시키가이샤 신규한 생리 활성 물질
CA2507641A1 (en) 2002-11-29 2004-06-17 Mercian Corporation Method of producing macrolide compound
CA2546614A1 (en) 2003-11-27 2005-06-09 Mercian Corporation Dna participating in hydroxylation of macrolide compound
CN1977046A (zh) 2004-07-20 2007-06-06 卫材R&D管理有限公司 编码参与普拉地内酯生物合成的多肽的dna
CN101282967B (zh) 2005-10-13 2011-01-26 卫材R&D管理有限公司 普拉二烯内酯b和普拉二烯内酯d的全合成
EP2136209A4 (en) * 2007-03-05 2010-10-27 Eisai R&D Man Co Ltd METHOD FOR EXAMINING AN ACTION OF AN ANTI-CANCER AGENT USING A SPLICE DEFECT AS A MEASUREMENT
US20080312317A1 (en) 2007-04-12 2008-12-18 Eisai R&D Management Co., Ltd. 12 membered-ring macrolactam derivatives
JP5836803B2 (ja) 2008-08-14 2015-12-24 ナノストリング テクノロジーズ， インコーポレイテッド 安定したナノレポーター
WO2011129427A1 (ja) * 2010-04-16 2011-10-20 第一三共株式会社 癌の診断剤および治療剤
WO2013070521A1 (en) 2011-11-08 2013-05-16 Genomic Health, Inc. Method of predicting breast cancer prognosis
WO2013086464A1 (en) * 2011-12-07 2013-06-13 The Broad Institute, Inc. Markers associated with chronic lymphocytic leukemia prognosis and progression
JP6057408B2 (ja) 2012-03-05 2017-01-11 国立大学法人 千葉大学 癌の予防剤および／または治療剤
US20140275010A1 (en) 2013-03-12 2014-09-18 Guo Zhu Zheng Quaternary salts
WO2014165753A1 (en) * 2013-04-05 2014-10-09 The Wistar Institute Of Anatomy And Biology Methods and compositions for diagnosis of glioblastoma or a subtype thereof
MY195081A (en) 2014-05-15 2023-01-09 Eisai R&D Man Co Ltd Pladienolide Pyridine Compounds and Methods of use
WO2017040526A2 (en) 2015-09-01 2017-03-09 Eisai R&D Management Co., Ltd. Splice variants associated with neomorphic sf3b1 mutants

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EP3910073A1 (en) 2021-11-17
ES2887201T3 (es) 2021-12-22
US10889866B2 (en) 2021-01-12
US20180318312A1 (en) 2018-11-08
EP3344780B1 (en) 2021-06-23
JP7256840B2 (ja) 2023-04-12
EP3344780A2 (en) 2018-07-11
US11761045B2 (en) 2023-09-19
WO2017040526A2 (en) 2017-03-09
JP2018525994A (ja) 2018-09-13
JP2021106615A (ja) 2021-07-29
US20210130909A1 (en) 2021-05-06
WO2017040526A3 (en) 2017-04-20
EP3910073B1 (en) 2024-03-06

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