JP6872501B2 - 化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム - Google Patents

化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム Download PDF

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JP6872501B2
JP6872501B2 JP2017562972A JP2017562972A JP6872501B2 JP 6872501 B2 JP6872501 B2 JP 6872501B2 JP 2017562972 A JP2017562972 A JP 2017562972A JP 2017562972 A JP2017562972 A JP 2017562972A JP 6872501 B2 JP6872501 B2 JP 6872501B2
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fine particles
ligand
linker
nucleic acid
solid support
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JP2018505700A (ja
JP2018505700A5 (https=
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ベルリン，ジェイコブ
コープランド，グレゴリー
エリソン，キャスリーン
ムラディアン，ヒュリック
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City of Hope
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City of Hope
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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Structural Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Signal Processing For Digital Recording And Reproducing (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2017562972A 2015-02-24 2016-02-24 化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム Active JP6872501B2 (ja)

Priority Applications (1)

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JP2021068860A JP7109618B6 (ja) 2015-02-24 2021-04-15 化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム

Applications Claiming Priority (3)

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US201562120262P 2015-02-24 2015-02-24
US62/120,262 2015-02-24
PCT/US2016/019426 WO2016138184A1 (en) 2015-02-24 2016-02-24 Chemically encoded spatially addressed library screening platforms

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JP2018505700A5 JP2018505700A5 (https=) 2019-09-12
JP6872501B2 true JP6872501B2 (ja) 2021-05-19

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JP2021068860A Active JP7109618B6 (ja) 2015-02-24 2021-04-15 化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム

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US (6) US10760181B2 (https=)
EP (4) EP4276059A3 (https=)
JP (2) JP6872501B2 (https=)
AU (2) AU2016222755B2 (https=)
CA (1) CA2976946C (https=)
CY (1) CY1124954T1 (https=)
DK (3) DK3650459T5 (https=)
ES (3) ES2965764T3 (https=)
FI (2) FI3650458T3 (https=)
HR (3) HRP20231536T1 (https=)
HU (3) HUE058813T2 (https=)
LT (3) LT3650458T (https=)
NZ (1) NZ734644A (https=)
PL (3) PL3650458T3 (https=)
PT (3) PT3650458T (https=)
RS (3) RS64567B1 (https=)
SI (3) SI3262059T1 (https=)
SM (3) SMT202200039T1 (https=)
WO (1) WO2016138184A1 (https=)

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DK3650459T3 (da) 2023-12-11
EP3262059B1 (en) 2022-01-05
RS64899B1 (sr) 2023-12-29
PT3650459T (pt) 2023-12-06
SMT202200039T1 (it) 2022-03-21
NZ772386A (en) 2024-10-25
JP2021106607A (ja) 2021-07-29
DK3262059T3 (da) 2022-01-31
JP7109618B6 (ja) 2022-08-22
HRP20231536T1 (hr) 2024-03-15
RS64567B1 (sr) 2023-10-31
CA2976946A1 (en) 2016-09-01
AU2021200399A1 (en) 2021-03-18
HUE058813T2 (hu) 2022-09-28
US11015266B2 (en) 2021-05-25
JP2018505700A (ja) 2018-03-01
PL3650459T3 (pl) 2024-02-26
DK3650458T3 (da) 2023-09-04
FI3650459T3 (fi) 2023-11-28
HRP20220093T1 (hr) 2022-04-15
CY1124954T1 (el) 2023-01-05
RS62847B1 (sr) 2022-02-28
SI3262059T1 (sl) 2022-04-29
SMT202300430T1 (it) 2024-01-10
AU2016222755A1 (en) 2017-08-31
US20190390367A1 (en) 2019-12-26
US11015265B2 (en) 2021-05-25
ES2904997T3 (es) 2022-04-06
ES2954467T3 (es) 2023-11-22
LT3650458T (lt) 2023-10-10
EP3650458B1 (en) 2023-08-09
EP4276059A3 (en) 2024-05-01
AU2016222755B2 (en) 2021-02-18
US20200378031A1 (en) 2020-12-03
EP3650459A1 (en) 2020-05-13
PT3650458T (pt) 2023-08-31
FI3650458T3 (fi) 2023-08-21
US20210324538A1 (en) 2021-10-21
CA2976946C (en) 2023-09-19
PT3262059T (pt) 2022-01-27
US20200378032A1 (en) 2020-12-03
AU2021200399B2 (en) 2023-04-20
EP3650458A1 (en) 2020-05-13
DK3650459T5 (da) 2024-08-26
US20220341059A1 (en) 2022-10-27
US10767278B2 (en) 2020-09-08
ES2965764T3 (es) 2024-04-16
HRP20230928T1 (hr) 2023-11-24
EP3650459B1 (en) 2023-09-06
HUE063406T2 (hu) 2024-01-28
NZ734644A (en) 2023-02-24
EP3262059A1 (en) 2018-01-03
SMT202300275T1 (it) 2023-11-13
PL3650458T3 (pl) 2023-11-06
WO2016138184A1 (en) 2016-09-01
SI3650459T1 (sl) 2024-04-30
EP4276059A2 (en) 2023-11-15
SI3650458T1 (sl) 2023-11-30
US20180245241A1 (en) 2018-08-30
EP3262059A4 (en) 2018-12-05
JP7109618B2 (ja) 2022-07-29
US10760181B2 (en) 2020-09-01
PL3262059T3 (pl) 2022-02-21
DK3650458T5 (da) 2024-08-26
HUE064689T2 (hu) 2024-04-28
LT3650459T (lt) 2023-12-27
LT3262059T (lt) 2022-02-25

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