JP6850351B2 - 抗体のインビトロ糖鎖工学 - Google Patents

抗体のインビトロ糖鎖工学 Download PDF

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Publication number
JP6850351B2
JP6850351B2 JP2019533340A JP2019533340A JP6850351B2 JP 6850351 B2 JP6850351 B2 JP 6850351B2 JP 2019533340 A JP2019533340 A JP 2019533340A JP 2019533340 A JP2019533340 A JP 2019533340A JP 6850351 B2 JP6850351 B2 JP 6850351B2
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antibody
glycosylation
ligand
bound
antibodies
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JP2019533340A
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Japanese (ja)
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JP2020501577A5 (enExample
JP2020501577A (ja
Inventor
ローベルト ファルケンシュタイン
ローベルト ファルケンシュタイン
ハイコ ヴァルフ
ハイコ ヴァルフ
ゼバスティアン マリク
ゼバスティアン マリク
マルコ トマン
マルコ トマン
フォン ロマン マティアス フライヘル
フォン ロマン マティアス フライヘル
イングリッド グリューナート
イングリッド グリューナート
ローラント ドルン
ローラント ドルン
ミヒャエル ヒンガー
ミヒャエル ヒンガー
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2020501577A publication Critical patent/JP2020501577A/ja
Publication of JP2020501577A5 publication Critical patent/JP2020501577A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2019533340A 2016-12-21 2017-12-19 抗体のインビトロ糖鎖工学 Active JP6850351B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP16205587.5 2016-12-21
EP16205587 2016-12-21
EP17157002 2017-02-20
EP17157002.1 2017-02-20
PCT/EP2017/083429 WO2018114877A1 (en) 2016-12-21 2017-12-19 In vitro glycoengineering of antibodies

Publications (3)

Publication Number Publication Date
JP2020501577A JP2020501577A (ja) 2020-01-23
JP2020501577A5 JP2020501577A5 (enExample) 2021-01-07
JP6850351B2 true JP6850351B2 (ja) 2021-03-31

Family

ID=60997429

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019533340A Active JP6850351B2 (ja) 2016-12-21 2017-12-19 抗体のインビトロ糖鎖工学

Country Status (11)

Country Link
US (2) US20200165320A1 (enExample)
EP (1) EP3559248B2 (enExample)
JP (1) JP6850351B2 (enExample)
KR (1) KR102317884B1 (enExample)
CN (2) CN110088291A (enExample)
AU (1) AU2017384276B9 (enExample)
CA (1) CA3044920C (enExample)
IL (1) IL267351A (enExample)
MX (1) MX2019006266A (enExample)
TW (1) TWI780097B (enExample)
WO (1) WO2018114877A1 (enExample)

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* Cited by examiner, † Cited by third party
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CN117887794A (zh) * 2016-12-21 2024-04-16 豪夫迈·罗氏有限公司 用于体外糖工程化抗体的方法
JP6931058B2 (ja) 2016-12-21 2021-09-01 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 抗体のインビトロ糖鎖工学における酵素の再使用
KR102317884B1 (ko) 2016-12-21 2021-10-26 에프. 호프만-라 로슈 아게 항체의 시험관 내 당조작
US20200017600A1 (en) 2018-07-13 2020-01-16 Genmab A/S Variants of cd38 antibody and uses thereof
US20240254252A1 (en) 2018-07-13 2024-08-01 Genmab A/S Trogocytosis-mediated therapy using cd38 antibodies
US20230272105A1 (en) 2020-01-16 2023-08-31 Genmab A/S Formulations of cd38 antibodies and uses thereof
IL311141A (en) 2021-09-06 2024-04-01 Genmab As Antibodies capable of binding to CD27, their variants and uses thereof
TW202509071A (zh) 2023-05-12 2025-03-01 丹麥商珍美寶股份有限公司 能夠與ｏｘ４０結合之抗體、其變異體及其用途
WO2025049881A1 (en) * 2023-09-01 2025-03-06 Catalent Pharma Solutions, Llc Dnase co-expression in host cells

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Also Published As

Publication number Publication date
CA3044920A1 (en) 2018-06-28
EP3559248A1 (en) 2019-10-30
MX2019006266A (es) 2019-08-21
AU2017384276B2 (en) 2020-07-02
BR112019010485A2 (pt) 2019-09-10
TWI780097B (zh) 2022-10-11
TW201835333A (zh) 2018-10-01
JP2020501577A (ja) 2020-01-23
IL267351A (en) 2019-08-29
CN110088291A (zh) 2019-08-02
KR20190082942A (ko) 2019-07-10
US20240101643A1 (en) 2024-03-28
EP3559248B1 (en) 2021-11-17
CA3044920C (en) 2022-06-28
WO2018114877A1 (en) 2018-06-28
US20200165320A1 (en) 2020-05-28
KR102317884B1 (ko) 2021-10-26
AU2017384276B9 (en) 2020-11-26
EP3559248B2 (en) 2024-11-20
CN119685431A (zh) 2025-03-25
AU2017384276A1 (en) 2019-05-30

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