CN110088291A - 用于体外糖工程化抗体的方法 - Google Patents

用于体外糖工程化抗体的方法 Download PDF

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Publication number
CN110088291A
CN110088291A CN201780079057.7A CN201780079057A CN110088291A CN 110088291 A CN110088291 A CN 110088291A CN 201780079057 A CN201780079057 A CN 201780079057A CN 110088291 A CN110088291 A CN 110088291A
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CN
China
Prior art keywords
antibody
glycosylation
antibodies
ligand
modified
Prior art date
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Pending
Application number
CN201780079057.7A
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English (en)
Chinese (zh)
Inventor
R·法尔肯施泰因
H·沃尔克
S·马利克
M·托曼
M·弗赖赫尔范罗曼
I·格伦特
R·多恩
M·欣加尔
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60997429&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN110088291(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority to CN202411870260.4A priority Critical patent/CN119685431A/zh
Publication of CN110088291A publication Critical patent/CN110088291A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201780079057.7A 2016-12-21 2017-12-19 用于体外糖工程化抗体的方法 Pending CN110088291A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202411870260.4A CN119685431A (zh) 2016-12-21 2017-12-19 用于体外糖工程化抗体的方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP16205587.5 2016-12-21
EP16205587 2016-12-21
EP17157002 2017-02-20
EP17157002.1 2017-02-20
PCT/EP2017/083429 WO2018114877A1 (en) 2016-12-21 2017-12-19 In vitro glycoengineering of antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202411870260.4A Division CN119685431A (zh) 2016-12-21 2017-12-19 用于体外糖工程化抗体的方法

Publications (1)

Publication Number Publication Date
CN110088291A true CN110088291A (zh) 2019-08-02

Family

ID=60997429

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201780079057.7A Pending CN110088291A (zh) 2016-12-21 2017-12-19 用于体外糖工程化抗体的方法
CN202411870260.4A Pending CN119685431A (zh) 2016-12-21 2017-12-19 用于体外糖工程化抗体的方法

Family Applications After (1)

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CN202411870260.4A Pending CN119685431A (zh) 2016-12-21 2017-12-19 用于体外糖工程化抗体的方法

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US (2) US20200165320A1 (enExample)
EP (1) EP3559248B2 (enExample)
JP (1) JP6850351B2 (enExample)
KR (1) KR102317884B1 (enExample)
CN (2) CN110088291A (enExample)
AU (1) AU2017384276B9 (enExample)
CA (1) CA3044920C (enExample)
IL (1) IL267351A (enExample)
MX (1) MX2019006266A (enExample)
TW (1) TWI780097B (enExample)
WO (1) WO2018114877A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117887794A (zh) * 2016-12-21 2024-04-16 豪夫迈·罗氏有限公司 用于体外糖工程化抗体的方法
JP6931058B2 (ja) 2016-12-21 2021-09-01 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 抗体のインビトロ糖鎖工学における酵素の再使用
KR102317884B1 (ko) 2016-12-21 2021-10-26 에프. 호프만-라 로슈 아게 항체의 시험관 내 당조작
US20200017600A1 (en) 2018-07-13 2020-01-16 Genmab A/S Variants of cd38 antibody and uses thereof
US20240254252A1 (en) 2018-07-13 2024-08-01 Genmab A/S Trogocytosis-mediated therapy using cd38 antibodies
US20230272105A1 (en) 2020-01-16 2023-08-31 Genmab A/S Formulations of cd38 antibodies and uses thereof
IL311141A (en) 2021-09-06 2024-04-01 Genmab As Antibodies capable of binding to CD27, their variants and uses thereof
TW202509071A (zh) 2023-05-12 2025-03-01 丹麥商珍美寶股份有限公司 能夠與ｏｘ４０結合之抗體、其變異體及其用途
WO2025049881A1 (en) * 2023-09-01 2025-03-06 Catalent Pharma Solutions, Llc Dnase co-expression in host cells

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Also Published As

Publication number Publication date
CA3044920A1 (en) 2018-06-28
EP3559248A1 (en) 2019-10-30
JP6850351B2 (ja) 2021-03-31
MX2019006266A (es) 2019-08-21
AU2017384276B2 (en) 2020-07-02
BR112019010485A2 (pt) 2019-09-10
TWI780097B (zh) 2022-10-11
TW201835333A (zh) 2018-10-01
JP2020501577A (ja) 2020-01-23
IL267351A (en) 2019-08-29
KR20190082942A (ko) 2019-07-10
US20240101643A1 (en) 2024-03-28
EP3559248B1 (en) 2021-11-17
CA3044920C (en) 2022-06-28
WO2018114877A1 (en) 2018-06-28
US20200165320A1 (en) 2020-05-28
KR102317884B1 (ko) 2021-10-26
AU2017384276B9 (en) 2020-11-26
EP3559248B2 (en) 2024-11-20
CN119685431A (zh) 2025-03-25
AU2017384276A1 (en) 2019-05-30

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