JP6842091B2 - 水溶性分子複合体含有油剤の製造方法、及び分散液の製造方法 - Google Patents
水溶性分子複合体含有油剤の製造方法、及び分散液の製造方法 Download PDFInfo
- Publication number
- JP6842091B2 JP6842091B2 JP2018022559A JP2018022559A JP6842091B2 JP 6842091 B2 JP6842091 B2 JP 6842091B2 JP 2018022559 A JP2018022559 A JP 2018022559A JP 2018022559 A JP2018022559 A JP 2018022559A JP 6842091 B2 JP6842091 B2 JP 6842091B2
- Authority
- JP
- Japan
- Prior art keywords
- water
- soluble
- molecular complex
- molecule
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 22
- 239000006185 dispersion Substances 0.000 title claims description 10
- 102000016943 Muramidase Human genes 0.000 claims description 25
- 108010014251 Muramidase Proteins 0.000 claims description 25
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 25
- 239000004325 lysozyme Substances 0.000 claims description 25
- 229960000274 lysozyme Drugs 0.000 claims description 25
- 235000010335 lysozyme Nutrition 0.000 claims description 25
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 24
- 150000005846 sugar alcohols Polymers 0.000 claims description 23
- 239000007864 aqueous solution Substances 0.000 claims description 21
- 238000002360 preparation method Methods 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 18
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 5
- 102000004127 Cytokines Human genes 0.000 claims description 4
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 210000000130 stem cell Anatomy 0.000 claims description 4
- 239000011782 vitamin Substances 0.000 claims description 4
- 229940088594 vitamin Drugs 0.000 claims description 4
- 229930003231 vitamin Natural products 0.000 claims description 4
- 235000013343 vitamin Nutrition 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 2
- 239000006143 cell culture medium Substances 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000003921 oil Substances 0.000 description 66
- 235000019198 oils Nutrition 0.000 description 66
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 33
- 238000012360 testing method Methods 0.000 description 27
- 239000000243 solution Substances 0.000 description 26
- 239000003795 chemical substances by application Substances 0.000 description 25
- -1 sucrose fatty acid ester Chemical class 0.000 description 23
- 230000000694 effects Effects 0.000 description 18
- 230000018044 dehydration Effects 0.000 description 17
- 238000006297 dehydration reaction Methods 0.000 description 17
- 239000012488 sample solution Substances 0.000 description 14
- 235000014113 dietary fatty acids Nutrition 0.000 description 13
- 239000000194 fatty acid Substances 0.000 description 13
- 229930195729 fatty acid Natural products 0.000 description 13
- 102000004190 Enzymes Human genes 0.000 description 12
- 108090000790 Enzymes Proteins 0.000 description 12
- 229940088598 enzyme Drugs 0.000 description 12
- 239000007788 liquid Substances 0.000 description 12
- 239000003960 organic solvent Substances 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 11
- 239000003814 drug Substances 0.000 description 9
- 239000000839 emulsion Substances 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 239000002537 cosmetic Substances 0.000 description 8
- 235000013305 food Nutrition 0.000 description 8
- 210000002826 placenta Anatomy 0.000 description 8
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 7
- 230000006866 deterioration Effects 0.000 description 7
- 229920002674 hyaluronan Polymers 0.000 description 7
- 229960003160 hyaluronic acid Drugs 0.000 description 7
- 230000003110 anti-inflammatory effect Effects 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000000523 sample Substances 0.000 description 6
- 238000005259 measurement Methods 0.000 description 5
- 239000007962 solid dispersion Substances 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 229920002385 Sodium hyaluronate Polymers 0.000 description 4
- 235000002597 Solanum melongena Nutrition 0.000 description 4
- 238000012790 confirmation Methods 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 4
- 239000008055 phosphate buffer solution Substances 0.000 description 4
- 230000000717 retained effect Effects 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 229940010747 sodium hyaluronate Drugs 0.000 description 4
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
- 239000012085 test solution Substances 0.000 description 4
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 3
- 150000005215 alkyl ethers Chemical class 0.000 description 3
- 239000004359 castor oil Substances 0.000 description 3
- 235000019438 castor oil Nutrition 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 210000000245 forearm Anatomy 0.000 description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
- 229940014041 hyaluronate Drugs 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 239000011259 mixed solution Substances 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000004006 olive oil Substances 0.000 description 3
- 235000008390 olive oil Nutrition 0.000 description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 230000001687 destabilization Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000011737 fluorine Substances 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
- 150000002894 organic compounds Chemical class 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229940032094 squalane Drugs 0.000 description 2
- 239000012086 standard solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000003960 Ligases Human genes 0.000 description 1
- 108090000364 Ligases Proteins 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 238000011481 absorbance measurement Methods 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 239000003405 delayed action preparation Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000003631 expected effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000002657 hormone replacement therapy Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 150000002433 hydrophilic molecules Chemical class 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 150000004072 triols Chemical class 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
まず、水溶性分子として塩化リゾチームを用い、本実施形態に係る水溶性分子複合体の調製を行った。
本試験では、塩化リゾチームの活性の経時変化を、本実施形態に係る水溶性分子複合体とした場合としていない場合とで比較することにより、経時的な活性低下が少ないほど立体構造が保持されているものとして、立体構造保持状態の確認試験を行った。
本品1g中のリゾチームの量[mg(力価)]
=MS/(MT×10) × ( Ab+Ax−At ) / (Ab−As)
MS:乾燥物に換算したリゾチーム標準品の秤取量(mg)
MT:本品の秤取量(g)
本試験では、多価アルコールが配合された本実施形態に係る水溶性分子複合体と、多価アルコールを配合していない比較用の製剤とについて抗炎症効果を検討することで、多価アルコールの有無による効果の違いについて確認を行った。
まず、水溶性分子としてプラセンタを用い、本実施形態に係る水溶性分子複合体の調製を行った。
肌への保湿効果を有するヒアルロン酸ナトリウム、アセチルヒアルロン酸ナトリウムおよび加水分解ヒアルロン酸を混合した混合液を、〔4.各種水溶性分子を用いた水溶性分子複合体含有油剤の調製〕により調製した場合には、水溶性分子複合体含有油剤としない通常のヒアルロン酸混合液と比較して、肌に塗布した場合の保湿感が向上することが示された。
Claims (4)
- 両親媒性分子により構成され油中に分散して存在する親水部会合構造に内包させた水溶性分子の水溶液を沸騰させつつ脱水して水溶性分子複合体が油中に分散した水溶性分子複合体含有油剤を製造するにあたり、予め前記水溶液に多価アルコールを添加しておくことで前記水溶性分子の立体配座を維持することを特徴とする水溶性分子複合体含有油剤の製造方法。
- 前記水溶性分子が塩化リゾチーム、水溶性サイトカイン、水溶性ビタミン類(その塩や誘導体を含む)、幹細胞培養液から選ばれる少なくとも何れか1つであることを特徴とする請求項1に記載の水溶性分子複合体含有油剤の製造方法。
- 前記多価アルコールがポリエチレングリコール、グリセリン、プロピレングリコールから選ばれる少なくとも何れか1つであることを特徴とする請求項1又は請求項2に記載の水溶性分子複合体含有油剤の製造方法。
- 請求項1〜3いずれか1項に記載の水溶性分子複合体含有油剤の製造方法にて製造した水溶性分子複合体含有油剤を両親媒性分子を含む水溶液に分散させた分散液の製造方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2017022952 | 2017-02-10 | ||
JP2017022952 | 2017-02-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2018127453A JP2018127453A (ja) | 2018-08-16 |
JP6842091B2 true JP6842091B2 (ja) | 2021-03-17 |
Family
ID=63172159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018022559A Active JP6842091B2 (ja) | 2017-02-10 | 2018-02-09 | 水溶性分子複合体含有油剤の製造方法、及び分散液の製造方法 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP6842091B2 (ja) |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69841984D1 (de) * | 1997-09-05 | 2010-12-16 | Maruho K K | Zusammensetzung aus nanokapseln zur behandlung von intraarticulaeren erkrankungen |
JP2002255728A (ja) * | 2001-02-27 | 2002-09-11 | Kansai Koso Kk | 肌荒れ防止剤及び化粧料 |
JP4426749B2 (ja) * | 2002-07-11 | 2010-03-03 | 株式会社産学連携機構九州 | O/w型エマルション製剤 |
EP1785131A4 (en) * | 2004-08-31 | 2009-03-11 | Aspion Co Ltd | EXTERNAL PREPARATION OF TYPE S / O |
JP5028564B2 (ja) * | 2005-10-31 | 2012-09-19 | 宮崎県 | 肝疾患治療用又は予防用の血中滞留型多相エマルション製剤及びその製造方法 |
JP2016027032A (ja) * | 2014-07-02 | 2016-02-18 | 日本新薬株式会社 | 慢性閉塞性肺疾患治療剤 |
-
2018
- 2018-02-09 JP JP2018022559A patent/JP6842091B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
JP2018127453A (ja) | 2018-08-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Rapalli et al. | Curcumin loaded nanostructured lipid carriers for enhanced skin retained topical delivery: optimization, scale-up, in-vitro characterization and assessment of ex-vivo skin deposition | |
WO2005090534A1 (ja) | 油溶性物質含有カルシウム成分粉末の製造方法 | |
US10166187B2 (en) | Curcumin solid lipid particles and methods for their preparation and use | |
KR20140121835A (ko) | 피부 외용제 및 정상 피부세포 부활화제 | |
JPH11188256A (ja) | 油性組成物及びその製造方法 | |
JP6632837B2 (ja) | 乳化組成物 | |
JP6842091B2 (ja) | 水溶性分子複合体含有油剤の製造方法、及び分散液の製造方法 | |
JP2000026283A (ja) | 油性組成物を含有した粉末組成物 | |
JP6234112B2 (ja) | W/o/w型乳化組成物 | |
JP2009120555A (ja) | 殺菌剤を内包した水分散可能なナノ粒子 | |
JP2000157168A (ja) | 油性組成物及びその製造方法 | |
KR101623375B1 (ko) | 키토산 및 디카르복실산을 포함하는 주사 질환의 치료용 조성물 | |
JP5706223B2 (ja) | W/o/w型乳化組成物 | |
JP2006306793A (ja) | 乳化型化粧料 | |
JP2010168335A (ja) | おむつかぶれ改善剤 | |
WO2020158881A1 (ja) | 皮膚又は粘膜の外用剤及びその製造方法、並びに皮膚又は粘膜の外用剤の基剤 | |
WO2013031949A1 (ja) | ソフトカプセル製剤、ソフトカプセル製剤用組成物、及びソフトカプセル製剤の製造方法 | |
JP2008297239A (ja) | 油中水剤形の皮膚外用剤 | |
JP2000159656A (ja) | コラーゲン合成促進剤 | |
JP2003212750A (ja) | ゲル組成物および乳化組成物 | |
KR101845517B1 (ko) | 폴리감마글루탐산과 감마올리고펩타이드를 함유하는 리포좀 복합체를 포함하는 화장료 조성물 | |
JP3712673B2 (ja) | ゲル組成物および水中油(o/w)型組成物 | |
US20090274639A1 (en) | Composition for hair | |
CN110652460B (zh) | 含有亚油酸的组合物 | |
JP7499024B2 (ja) | 外用組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AA64 | Notification of invalidation of claim of internal priority (with term) |
Free format text: JAPANESE INTERMEDIATE CODE: A241764 Effective date: 20180306 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180416 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190905 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20200731 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200818 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20201016 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20201217 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20210105 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20210203 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6842091 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |