JP6835590B2 - インスリン様成長因子−１および上皮増殖因子を含む融合タンパク質およびそのバリアントならびにその使用 - Google Patents
インスリン様成長因子−１および上皮増殖因子を含む融合タンパク質およびそのバリアントならびにその使用 Download PDFInfo
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
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- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
Landscapes
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- Chemical & Material Sciences (AREA)
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| PCT/US2015/011066 WO2015106224A2 (en) | 2014-01-12 | 2015-01-12 | Fusion proteins containing insulin-like growth factor-1 and epidermal growth factor and variants thereof and uses thereof |
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| CA2800173C (en) | 2010-05-21 | 2019-05-14 | Ulrik Nielsen | Bi-specific fusion proteins |
| US10040840B2 (en) | 2015-10-02 | 2018-08-07 | Silver Creek Pharmaceuticals, Inc. | Bi-specific annexin A5/IGF-1 proteins and methods of use thereof to promote regeneration and survival of tissue |
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| EP3630195A4 (en) * | 2017-05-21 | 2021-03-24 | IGF Oncology, LLC | INSULIN-LIKE GROWTH FACTOR CONJUGATE - CHEMOTHERAPEUTIC PRODUCT FOR THE TREATMENT OF MYELODYSPLASIC SYNDROME |
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| US4876242A (en) | 1987-09-21 | 1989-10-24 | Merck & Co., Inc. | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
| FI890312A7 (fi) * | 1988-01-25 | 1989-07-26 | Oncogen | Amfireguliini: uusi bifunktionaalinen kasvua moduloiva glykoproteiini |
| IL89220A (en) | 1988-02-11 | 1994-02-27 | Bristol Myers Squibb Co | Anthracycline immunoconjugates, their production and pharmaceutical compositions containing them |
| CA2016584C (en) | 1989-05-17 | 1999-06-29 | Robert S. Greenfield | Anthracycline conjugates having a novel linker and methods for their production |
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| US20100197890A1 (en) * | 2009-01-31 | 2010-08-05 | Mctavish Hugh | Anti-cancer protein-platinum conjugates |
| US8986956B2 (en) * | 2010-11-04 | 2015-03-24 | Korea Research Institute Of Bioscience And Biotechnology | Method for producing human epidermal growth factor in large volume from yeast |
| US20160122411A1 (en) * | 2013-03-29 | 2016-05-05 | Merrimack Pharmaceuticals, Inc. | Cartilage-binding fusion proteins |
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- 2015-01-12 US US14/594,980 patent/US9675671B2/en active Active
- 2015-01-12 CA CA2936675A patent/CA2936675C/en active Active
- 2015-01-12 WO PCT/US2015/011066 patent/WO2015106224A2/en not_active Ceased
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| WO2015106224A2 (en) | 2015-07-16 |
| US10967049B2 (en) | 2021-04-06 |
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| AU2015204540B2 (en) | 2020-03-19 |
| US9675671B2 (en) | 2017-06-13 |
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| US20150196656A1 (en) | 2015-07-16 |
| JP2017503862A (ja) | 2017-02-02 |
| CA2936675C (en) | 2023-06-27 |
| CA2936675A1 (en) | 2015-07-16 |
| EP3094339B1 (en) | 2019-12-11 |
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| EP3094339A2 (en) | 2016-11-23 |
| EP3094339A4 (en) | 2017-06-07 |
| US9801923B2 (en) | 2017-10-31 |
| WO2015106224A3 (en) | 2015-11-12 |
| US10391147B2 (en) | 2019-08-27 |
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