JP6816038B2 - 抗cd38抗体及びサバイビン阻害剤による血液悪性疾患の併用療法 - Google Patents

抗cd38抗体及びサバイビン阻害剤による血液悪性疾患の併用療法 Download PDF

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JP6816038B2
JP6816038B2 JP2017566284A JP2017566284A JP6816038B2 JP 6816038 B2 JP6816038 B2 JP 6816038B2 JP 2017566284 A JP2017566284 A JP 2017566284A JP 2017566284 A JP2017566284 A JP 2017566284A JP 6816038 B2 JP6816038 B2 JP 6816038B2
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antibody
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JP2018522857A (ja
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ドーシ,パルル
ロクホースト,ヘンク,エム.
ムティス,テュナ
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ヤンセン バイオテツク,インコーポレーテツド
ヤンセン バイオテツク,インコーポレーテツド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01035Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
JP2017566284A 2015-06-22 2016-06-22 抗cd38抗体及びサバイビン阻害剤による血液悪性疾患の併用療法 Active JP6816038B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562182699P 2015-06-22 2015-06-22
US62/182,699 2015-06-22
US201662319036P 2016-04-06 2016-04-06
US62/319,036 2016-04-06
PCT/US2016/038702 WO2016209921A1 (en) 2015-06-22 2016-06-22 Combination therapies for heme malignancies with anti-cd38 antibodies and survivin inhibitors

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JP2018522857A JP2018522857A (ja) 2018-08-16
JP6816038B2 true JP6816038B2 (ja) 2021-01-20

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US (1) US10668149B2 (de)
EP (1) EP3310386B1 (de)
JP (1) JP6816038B2 (de)
KR (1) KR102601550B1 (de)
CN (1) CN107708734B (de)
AU (1) AU2016282674B2 (de)
BR (1) BR112017027724A2 (de)
CA (1) CA2990406A1 (de)
CL (1) CL2017003255A1 (de)
CO (1) CO2017013331A2 (de)
CR (1) CR20170587A (de)
DO (1) DOP2018000181A (de)
EA (1) EA036789B1 (de)
EC (1) ECSP17084270A (de)
ES (1) ES2890783T3 (de)
GT (1) GT201700284A (de)
HK (2) HK1250666A1 (de)
IL (1) IL256242A (de)
MA (1) MA46315A (de)
MX (1) MX2018000265A (de)
MY (1) MY192978A (de)
NI (1) NI201700167A (de)
PE (1) PE20181323A1 (de)
PH (1) PH12017502342A1 (de)
SV (1) SV2017005606A (de)
UA (1) UA125115C2 (de)
WO (1) WO2016209921A1 (de)
ZA (1) ZA201800403B (de)

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