US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
WO1988001649A1
(fr)
|
1986-09-02 |
1988-03-10 |
Genex Corporation |
Molecules de liaison de chaines de polypeptide simples
|
HUT53672A
(en)
|
1988-02-25 |
1990-11-28 |
Gen Hospital Corp |
Quick immunoselective cloning process
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
US6172197B1
(en)
|
1991-07-10 |
2001-01-09 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
EP0551301A1
(fr)
|
1990-07-13 |
1993-07-21 |
The General Hospital Corporation |
Antigene de surface de cellule cd53 et son utilisation
|
US5932448A
(en)
|
1991-11-29 |
1999-08-03 |
Protein Design Labs., Inc. |
Bispecific antibody heterodimers
|
ATE408012T1
(de)
|
1991-12-02 |
2008-09-15 |
Medical Res Council |
Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
|
ATE199392T1
(de)
|
1992-12-04 |
2001-03-15 |
Medical Res Council |
Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
|
WO1994017184A1
(fr)
|
1993-01-29 |
1994-08-04 |
Schering Corporation |
Modulation de la reponse physiologique de lymphocytes par les molecules cd38 ou leurs anti-corps
|
GB9424449D0
(en)
|
1994-12-02 |
1995-01-18 |
Wellcome Found |
Antibodies
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
AUPO591797A0
(en)
|
1997-03-27 |
1997-04-24 |
Commonwealth Scientific And Industrial Research Organisation |
High avidity polyvalent and polyspecific reagents
|
WO1998016245A1
(fr)
|
1996-10-15 |
1998-04-23 |
Shionogi & Co., Ltd. |
Procede de determination d'un auto-anticorps
|
DE69719529T2
(de)
|
1996-10-17 |
2003-12-11 |
Immunomedics, Inc. |
Nichtantigenes toxinkonjugat und fusionsprotein eines internalisierendes rezeptorsystems
|
WO2000006194A2
(fr)
|
1997-02-05 |
2000-02-10 |
Biotransplant, Inc. |
Depletion de cellules responsables du rejet d'une greffe induit par des anticorps
|
JP3835827B2
(ja)
|
1997-05-02 |
2006-10-18 |
ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ,アズ リプレゼンティッド バイ ザ セクレタリーオブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ |
悪性細胞に対する、oncタンパク質を含む、免疫毒素
|
WO1999062526A2
(fr)
|
1998-06-05 |
1999-12-09 |
Mayo Foundation For Medical Education And Research |
Traitement du myelome multiple au moyen d'anticorps du cd38 obtenus par genie genetique
|
US6838283B2
(en)
|
1998-09-29 |
2005-01-04 |
Isis Pharmaceuticals Inc. |
Antisense modulation of survivin expression
|
US6335194B1
(en)
|
1998-09-29 |
2002-01-01 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of survivin expression
|
US7223397B1
(en)
|
1999-01-07 |
2007-05-29 |
Research Development Foundation |
Potentiation of anti-CD38-Immunotoxin cytotoxicity
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
US6608108B2
(en)
|
1999-10-15 |
2003-08-19 |
Johns Hopkins University |
Method for treatment of tumors using nordihydroguaiaretic acid derivatives
|
US7829693B2
(en)
|
1999-11-24 |
2010-11-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a target gene
|
AU2001232286A1
(en)
|
2000-02-15 |
2001-08-27 |
Yamanouchi Pharmaceutical Co..Ltd. |
Fused imidazolium derivatives
|
FR2807767B1
(fr)
|
2000-04-12 |
2005-01-14 |
Lab Francais Du Fractionnement |
Anticorps monoclonaux anti-d
|
EP1292334A4
(fr)
|
2000-06-22 |
2003-11-19 |
Idec Pharma Corp |
Proteine de fusion bispecifique et son procede d'utilisation permettant d'ameliorer l'action tueuse de cellules effectives sur des cellules cibles
|
EP1174440A1
(fr)
|
2000-07-19 |
2002-01-23 |
U-BISys B.V. |
Un épitope exprimé sélectivement sur la molécule humaine CD38 et détecté par un fragment d'un anticorps humain de forme scFv dérivé d'une librairie "phage display"
|
US20070042436A1
(en)
|
2000-10-17 |
2007-02-22 |
Lund Frances E |
CD38 modulated chemotaxis
|
EP1326998A4
(fr)
|
2000-10-17 |
2005-05-11 |
Trudeau Inst Inc |
Chimiotaxie modulee du gene cd38
|
US6833441B2
(en)
|
2001-08-01 |
2004-12-21 |
Abmaxis, Inc. |
Compositions and methods for generating chimeric heteromultimers
|
US20040166490A1
(en)
|
2002-12-17 |
2004-08-26 |
Morris David W. |
Novel therapeutic targets in cancer
|
US7550140B2
(en)
|
2002-06-13 |
2009-06-23 |
Crucell Holland B.V. |
Antibody to the human OX40 receptor
|
ES2335005T5
(es)
*
|
2003-03-05 |
2013-04-17 |
Halozyme, Inc. |
Glicoproteína hialuronidasa soluble (shasegp), proceso para prepararla, usos y composiciones farmacéuticas que la comprenden
|
WO2004092160A1
(fr)
|
2003-04-15 |
2004-10-28 |
Astellas Pharma Inc. |
Bromure et cristal de bromure
|
MXPA05012723A
(es)
|
2003-05-30 |
2006-02-08 |
Genentech Inc |
Tratamiento con anticuerpos anti-vgf.
|
US8597911B2
(en)
|
2003-06-11 |
2013-12-03 |
Chugai Seiyaku Kabushiki Kaisha |
Process for producing antibodies
|
US7902338B2
(en)
|
2003-07-31 |
2011-03-08 |
Immunomedics, Inc. |
Anti-CD19 antibodies
|
EP1689435A4
(fr)
|
2003-10-22 |
2007-10-03 |
Univ Rochester |
Antiserum anti-thymocyte et son utilisation pour declencher l'apoptose des cellules b
|
PL1684805T3
(pl)
|
2003-11-04 |
2010-12-31 |
Novartis Vaccines & Diagnostics Inc |
Sposoby leczenia szpiczaka mnogiego z zastosowaniem antagonistycznych monoklonalnych przeciwciał przeciwko CD40
|
ES2378767T3
(es)
|
2003-12-23 |
2012-04-17 |
Crucell Holland B.V. |
Molécula de unión humana contra CD1a
|
US8263746B2
(en)
|
2004-02-06 |
2012-09-11 |
Morphosys Ag |
Anti-CD38 human antibodies and uses thereof
|
ES2541489T3
(es)
|
2004-02-06 |
2015-07-21 |
Morphosys Ag |
Anticuerpos humanos anti-CD38 y usos para ellos
|
WO2006125640A2
(fr)
|
2005-05-24 |
2006-11-30 |
Morphosys Ag |
Production et profilage d'anticorps therapeutiques entierement humains hucal gold®; propres a la molecule cd38 humaine
|
CN101218256B
(zh)
|
2005-03-23 |
2017-04-19 |
根马布股份公司 |
用于治疗多发性骨髓瘤的cd38抗体
|
WO2006106905A1
(fr)
|
2005-03-31 |
2006-10-12 |
Chugai Seiyaku Kabushiki Kaisha |
Procede pour la production de polypeptide au moyen de la regulation d’un ensemble
|
KR101472250B1
(ko)
*
|
2005-10-12 |
2014-12-11 |
모르포시스 아게 |
인간 cd38에 특이적인 완전 인간 hucal gold-유도 치료 항체들의 생성 및 프로파일링
|
JP2009518441A
(ja)
|
2005-12-09 |
2009-05-07 |
シアトル ジェネティクス,インコーポレーテッド |
Cd40結合剤の使用方法
|
WO2007110205A2
(fr)
|
2006-03-24 |
2007-10-04 |
Merck Patent Gmbh |
Domaines de proteine heterodimerique d'ingenierie
|
US20090182127A1
(en)
|
2006-06-22 |
2009-07-16 |
Novo Nordisk A/S |
Production of Bispecific Antibodies
|
WO2008016702A2
(fr)
|
2006-08-02 |
2008-02-07 |
Sunesis Pharmaceuticals, Inc. |
Procédés d'utilisation d'acide (+)-1,4-dihydro-7-[(3s,4s)-3-méthoxy-4-(méthylamino)-1-pyrrolidinyl]-4-oxo-1(2-thiazolyl)-1,8-naphtyridine-3-carboxylique pour traiter certains troubles hématologiques
|
WO2008073160A2
(fr)
|
2006-08-17 |
2008-06-19 |
The Trustees Of Columbia University In The City Of New York |
Procédés de conversion ou d'induction d'une immunité protectrice
|
US9040050B2
(en)
|
2006-09-26 |
2015-05-26 |
Genmab A/S |
Combination treatment of CD38-expressing tumors
|
EP1914242A1
(fr)
|
2006-10-19 |
2008-04-23 |
Sanofi-Aventis |
Nouveau anticorps Anti-CD38 pour le traitement du cancer
|
US20080226635A1
(en)
|
2006-12-22 |
2008-09-18 |
Hans Koll |
Antibodies against insulin-like growth factor I receptor and uses thereof
|
US7618992B2
(en)
|
2006-12-29 |
2009-11-17 |
Astellas Pharma Inc. |
Method of treating cancer by co-administration of anticancer agents
|
CN104497143B
(zh)
|
2007-03-29 |
2020-08-25 |
健玛保 |
双特异性抗体及其制造方法
|
WO2008150530A2
(fr)
|
2007-06-01 |
2008-12-11 |
Biogen Idec Ma Inc. |
Molécules de liaison de cripto
|
US20090076249A1
(en)
|
2007-09-19 |
2009-03-19 |
Michel De Weers |
Antibodies against CD38 for treatment of multiple myeloma
|
WO2009044793A1
(fr)
|
2007-10-02 |
2009-04-09 |
Alphagen Co., Ltd. |
ARNsi CIBLANT UN ONCOGÈNE
|
WO2009062054A1
(fr)
|
2007-11-09 |
2009-05-14 |
Novartis Ag |
Utilisation d'anticorps anti-cd40
|
WO2009074807A2
(fr)
|
2007-12-12 |
2009-06-18 |
Imperial Innovations Limited |
Procédés
|
ES2564523T3
(es)
|
2007-12-19 |
2016-03-23 |
Janssen Biotech, Inc. |
Diseño y generación de bibliotecas de presentación en fago por pIX de novo humanas mediante fusión con pIX o pVII, vectores, anticuerpos y métodos
|
EP2235064B1
(fr)
|
2008-01-07 |
2015-11-25 |
Amgen Inc. |
Méthode de fabrication de molécules hétérodimères fc d'anticorps utilisant les effets de conduite électrostatique
|
AU2009221916A1
(en)
|
2008-03-03 |
2009-09-11 |
Dyax Corp. |
Metalloproteinase 9 and metalloproteinase 2 binding proteins
|
US20110053862A1
(en)
|
2008-03-12 |
2011-03-03 |
Intradigm Corporation |
Compositions comprising survivin sirna and methods of use thereof
|
AR072947A1
(es)
|
2008-03-25 |
2010-10-06 |
Glycart Biotechnology Ag |
Terapia de combinacion de un anticuerpo anti-cd20 de tipo ii con citotoxicidad, celular dependiente de anticuerpos (ccda) aumentada, composicion farmaceutica, anticuerpo anti-cd20 de tipo ii
|
CA2721229C
(fr)
|
2008-04-14 |
2022-08-23 |
Halozyme, Inc. |
Hyaluronidases modifiees et utilisations pour traiter des maladies et des pathologies associees a l'acide hyaluronique
|
KR20110014607A
(ko)
|
2008-04-29 |
2011-02-11 |
아보트 러보러터리즈 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
WO2010052014A1
(fr)
|
2008-11-07 |
2010-05-14 |
Micromet Ag |
Traitement de la leucémie lymphoblastique aiguë
|
EP2191843A1
(fr)
|
2008-11-28 |
2010-06-02 |
Sanofi-Aventis |
Combinaisons antitumorales contenant des anticorps reconnaissant spécifiquement les CD38 et cyclophosphamide
|
EP2191842A1
(fr)
|
2008-11-28 |
2010-06-02 |
Sanofi-Aventis |
Combinaisons antitumorales contenant des anticorps reconnaissant spécifiquement les CD38 et cytarabine
|
EP2191840A1
(fr)
|
2008-11-28 |
2010-06-02 |
Sanofi-Aventis |
Combinaisons antitumorales contenant des anticorps reconnaissant spécifiquement les CD38 et melphalan
|
EP2191841A1
(fr)
|
2008-11-28 |
2010-06-02 |
Sanofi-Aventis |
Combinaisons antitumorales contenant des anticorps reconnaissant spécifiquement les CD38 et vincristine
|
US8710068B2
(en)
|
2009-01-19 |
2014-04-29 |
The Trustees Of The University Of Pennsylvania |
Method of treating cancer using a survivin inhibitor
|
ES2708124T3
(es)
|
2009-04-27 |
2019-04-08 |
Oncomed Pharm Inc |
Procedimiento para preparar moléculas heteromultiméricas
|
US8865710B2
(en)
|
2009-05-14 |
2014-10-21 |
Ambit Biosciences Corporation |
Methods of treating proliferative diseases
|
US9345661B2
(en)
*
|
2009-07-31 |
2016-05-24 |
Genentech, Inc. |
Subcutaneous anti-HER2 antibody formulations and uses thereof
|
JP5734985B2
(ja)
|
2009-09-17 |
2015-06-17 |
バクスター・ヘルスケヤー・ソシエテ・アノニムBaxter Healthcare SA |
ヒアルロニダーゼおよび免疫グロブリンの安定な共製剤およびそれらの使用方法
|
US9096877B2
(en)
|
2009-10-07 |
2015-08-04 |
Macrogenics, Inc. |
Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use
|
EP2327725A1
(fr)
|
2009-11-26 |
2011-06-01 |
InflaRx GmbH |
Groupes caractéristiques à liaison anti-C5a avec une activité à blocage élevé
|
GB201003701D0
(en)
|
2010-03-05 |
2010-04-21 |
Cilian Ag |
System for the expression of a protein
|
US20130137134A1
(en)
|
2010-03-29 |
2013-05-30 |
Ben Gurion University Of The Negev Research And Development Authority |
Method and system for detecting and monitoring hematological cancer
|
CN103097417B
(zh)
|
2010-04-20 |
2019-04-09 |
根马布股份公司 |
含异二聚体抗体fc的蛋白及其制备方法
|
JP6022444B2
(ja)
|
2010-05-14 |
2016-11-09 |
ライナット ニューロサイエンス コーポレイション |
ヘテロ二量体タンパク質ならびにそれを生産および精製するための方法
|
WO2011154453A1
(fr)
|
2010-06-09 |
2011-12-15 |
Genmab A/S |
Anticorps dirigés contre le cd38 humain
|
EP2420253A1
(fr)
|
2010-08-20 |
2012-02-22 |
Leadartis, S.L. |
Synthèse de molécules polyvalentes et multifonctionnelles avec un domaine de trimérisation de collagène XV
|
BR112013006769B1
(pt)
|
2010-09-27 |
2021-02-02 |
Morphosys Ag |
combinação sinérgica
|
AU2011325833C1
(en)
|
2010-11-05 |
2017-07-13 |
Zymeworks Bc Inc. |
Stable heterodimeric antibody design with mutations in the Fc domain
|
KR20200059320A
(ko)
*
|
2010-11-08 |
2020-05-28 |
제넨테크, 인크. |
피하 투여용 항―il―6 수용체 항체
|
US9358233B2
(en)
|
2010-11-29 |
2016-06-07 |
Boehringer Ingelheim International Gmbh |
Method for treating acute myeloid leukemia
|
UA112170C2
(uk)
|
2010-12-10 |
2016-08-10 |
Санофі |
Протипухлинна комбінація, що містить антитіло, яке специфічно розпізнає cd38, і бортезоміб
|
JOP20210044A1
(ar)
|
2010-12-30 |
2017-06-16 |
Takeda Pharmaceuticals Co |
الأجسام المضادة لـ cd38
|
CL2013001944A1
(es)
|
2010-12-30 |
2014-09-12 |
Takeda Pharmaceutical |
Anticuerpo aislado que se une especificamente a cd38 humana y cd38 de cinomolgo; acido nucleico que lo codifica; celula huesped; metodo de produccion; y su uso para tratar una enfermedad autoinmune.
|
WO2012129344A1
(fr)
|
2011-03-23 |
2012-09-27 |
Amgen Inc. |
Doubles inhibiteurs tricycliques fusionnés de cdk 4/6 et de flt3
|
EP2561868A1
(fr)
|
2011-08-24 |
2013-02-27 |
Anton Bernhard Van Oosten |
Compositions pharmaceutiques comportant de l'hydroxychloroquine (HCQ), curcuma, pipérine/BioPérine et utilisations associées dans le domaine médical
|
KR102096224B1
(ko)
|
2011-10-28 |
2020-04-03 |
테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 |
폴리펩티드 구축물 및 이의 용도
|
AU2013243873B2
(en)
|
2012-04-04 |
2016-08-25 |
Halozyme, Inc. |
Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane
|
SG11201407190TA
(en)
|
2012-05-15 |
2014-12-30 |
Bristol Myers Squibb Co |
Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
|
US9682143B2
(en)
|
2012-08-14 |
2017-06-20 |
Ibc Pharmaceuticals, Inc. |
Combination therapy for inducing immune response to disease
|
LT2900232T
(lt)
|
2012-09-25 |
2018-02-26 |
Morphosys Ag |
Deriniai ir jų panaudojimas
|
WO2014068114A1
(fr)
|
2012-11-05 |
2014-05-08 |
Morphosys Ag |
Anticorps radiomarqué et ses utilisations
|
UA118255C2
(uk)
|
2012-12-07 |
2018-12-26 |
Санофі |
Композиція, яка містить антитіло до cd38 і леналідомід
|
WO2014142220A1
(fr)
|
2013-03-13 |
2014-09-18 |
アステラス製薬株式会社 |
Agent antitumoral
|
US20140271644A1
(en)
|
2013-03-15 |
2014-09-18 |
Memorial Sloan-Kettering Cancer Center |
Combination/adjuvant therapy for wt-1-positive disease
|
DK3677591T5
(da)
|
2013-04-29 |
2024-08-26 |
Teva Pharmaceuticals Australia Pty Ltd |
Anti-CD38 antistoffer og fusioner til svækket interferon alpha-2b
|
US20140356318A1
(en)
|
2013-05-28 |
2014-12-04 |
Israel Barken |
Adoptive cell therapy with specific regulatory lymphocytes
|
EP3021866A4
(fr)
|
2013-07-15 |
2017-02-22 |
The Board of Trustees of the Leland Stanford Junior University |
Utilisations médicales d'agonistes de cd38
|
TW201522378A
(zh)
|
2013-10-31 |
2015-06-16 |
Sanofi Sa |
用於治療人類癌症的特異性抗cd38抗體
|
JP2016536361A
(ja)
|
2013-11-06 |
2016-11-24 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Cd33抗体及び脱メチル剤を含む医薬配合物
|
US9732154B2
(en)
|
2014-02-28 |
2017-08-15 |
Janssen Biotech, Inc. |
Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
|
US9603927B2
(en)
|
2014-02-28 |
2017-03-28 |
Janssen Biotech, Inc. |
Combination therapies with anti-CD38 antibodies
|
WO2015195556A1
(fr)
|
2014-06-16 |
2015-12-23 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Blocage de cd38 à l'aide de f(ab')2 anti-cd38 pour protéger les cellules nk
|
WO2015195555A1
(fr)
|
2014-06-16 |
2015-12-23 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Blocage de cd38 à l'aide d'anticorps anti-cd38 conjugué à la protéine g pour protéger des cellules nk
|
US9499514B2
(en)
|
2014-07-11 |
2016-11-22 |
Celgene Corporation |
Antiproliferative compounds and methods of use thereof
|
SG11201701867SA
(en)
|
2014-09-09 |
2017-04-27 |
Janssen Biotech Inc |
Combination therapies with anti-cd38 antibodies
|
IL307913A
(en)
|
2014-12-04 |
2023-12-01 |
Janssen Biotech Inc |
Anti-CD38 antibodies for the treatment of acute myeloid leukemia
|
BR112017024877A2
(pt)
|
2015-05-20 |
2019-09-17 |
Janssen Biotech, Inc. |
anticorpo anti-cd38 e seu uso no tratamento de amiloidose de cadeia leve e outras malignidades hematológicas positivas para cd38
|
WO2016209921A1
(fr)
|
2015-06-22 |
2016-12-29 |
Janssen Biotech, Inc. |
Polythérapies pour malignités hématologiques avec des anticorps anti-cd38 et des inhibiteurs de la survivine
|
PL3313441T3
(pl)
|
2015-06-24 |
2024-08-19 |
Janssen Biotech, Inc. |
Immunomodulacja i leczenie guzów litych przeciwciałami swoiście wiążącymi cd38
|
US20170044265A1
(en)
|
2015-06-24 |
2017-02-16 |
Janssen Biotech, Inc. |
Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38
|
US10781261B2
(en)
|
2015-11-03 |
2020-09-22 |
Janssen Biotech, Inc. |
Subcutaneous formulations of anti-CD38 antibodies and their uses
|
MA43187B1
(fr)
|
2015-11-03 |
2021-02-26 |
Janssen Biotech Inc |
Formulations sous-cutanée d'anticorps anti-cd38 et leurs utilisations
|
US20170121417A1
(en)
|
2015-11-03 |
2017-05-04 |
Janssen Biotech, Inc. |
Subcutaneous Formulations of Anti-CD38 Antibodies and Their Uses
|
US20190233533A1
(en)
|
2016-06-28 |
2019-08-01 |
Umc Utrecht Holding B.V. |
Treatment Of IgE-Mediated Diseases With Antibodies That Specifically Bind CD38
|
US20180117150A1
(en)
|
2016-11-01 |
2018-05-03 |
Janssen Biotech, Inc. |
Combination Therapies for CD38-Positive Hematological Malignances with ANTI-CD38 Antibodies and Cyclophosphamide
|
US11618787B2
(en)
|
2017-10-31 |
2023-04-04 |
Janssen Biotech, Inc. |
Methods of treating high risk multiple myeloma
|