JP6816036B2 - ヒストン脱アセチル化阻害剤の結晶形態 - Google Patents

ヒストン脱アセチル化阻害剤の結晶形態 Download PDF

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Publication number
JP6816036B2
JP6816036B2 JP2017563542A JP2017563542A JP6816036B2 JP 6816036 B2 JP6816036 B2 JP 6816036B2 JP 2017563542 A JP2017563542 A JP 2017563542A JP 2017563542 A JP2017563542 A JP 2017563542A JP 6816036 B2 JP6816036 B2 JP 6816036B2
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pattern
oxoheptyl
hydroxyamino
carboxamide
chlorophenyl
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JP2018516946A5 (enExample
JP2018516946A (ja
Inventor
ジョン・エイチ・ヴァン・ドゥーザー
ファルザネー・セイエディ
グイ・リュウ
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Acetylon Pharmaceuticals Inc
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Acetylon Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2017563542A 2015-06-08 2016-06-08 ヒストン脱アセチル化阻害剤の結晶形態 Expired - Fee Related JP6816036B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562172629P 2015-06-08 2015-06-08
US62/172,629 2015-06-08
PCT/US2016/036422 WO2016200919A1 (en) 2015-06-08 2016-06-08 Crystalline forms of a histone deacetylase inhibitor

Publications (3)

Publication Number Publication Date
JP2018516946A JP2018516946A (ja) 2018-06-28
JP2018516946A5 JP2018516946A5 (enExample) 2019-07-04
JP6816036B2 true JP6816036B2 (ja) 2021-01-20

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JP2017563542A Expired - Fee Related JP6816036B2 (ja) 2015-06-08 2016-06-08 ヒストン脱アセチル化阻害剤の結晶形態

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Country Link
US (1) US10464906B2 (enExample)
EP (1) EP3303306B1 (enExample)
JP (1) JP6816036B2 (enExample)
AR (1) AR104935A1 (enExample)
TW (1) TW201718516A (enExample)
WO (1) WO2016200919A1 (enExample)

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WO2013158984A1 (en) 2012-04-19 2013-10-24 Acetylon Pharmaceuticals, Inc. Biomarkers to identify patients that will respond to treatment and treating such patients
CA2988594C (en) 2015-06-08 2023-08-15 Acetylon Pharmaceuticals, Inc. Methods of making protein deacetylase inhibitors
EP3468559B1 (en) * 2016-06-09 2023-11-22 Dana Farber Cancer Institute, Inc. Methods of use and pharmaceutical combinations of hdac inhibitors with bet inhibitors
JP7100018B2 (ja) 2016-08-08 2022-07-12 アセチロン ファーマシューティカルズ インコーポレイテッド ヒストンデアセチラーゼ６阻害剤及びｃｄ２０阻害抗体の薬学的組み合わせならびにその使用
US11497746B2 (en) 2016-11-23 2022-11-15 Acetylon Pharmaceuticals, Inc. Pharmaceutical combinations comprising a histone deacetylase inhibitor and a programmed death-ligand 1 (PD-L1) inhibitor and methods of use thereof

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JP7017309B2 (ja) 2013-12-20 2022-02-08 アセチロン ファーマシューティカルズ インコーポレイテッド 多発性骨髄腫におけるヒストン脱アセチル化酵素６（ｈｄａｃ６）バイオマーカー
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Also Published As

Publication number Publication date
AR104935A1 (es) 2017-08-23
EP3303306B1 (en) 2020-02-12
WO2016200919A1 (en) 2016-12-15
US10464906B2 (en) 2019-11-05
TW201718516A (zh) 2017-06-01
US20170001965A1 (en) 2017-01-05
JP2018516946A (ja) 2018-06-28
EP3303306A1 (en) 2018-04-11

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