JP6803236B2 - アペリンポリペプチド - Google Patents

アペリンポリペプチド Download PDF

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Publication number
JP6803236B2
JP6803236B2 JP2016572433A JP2016572433A JP6803236B2 JP 6803236 B2 JP6803236 B2 JP 6803236B2 JP 2016572433 A JP2016572433 A JP 2016572433A JP 2016572433 A JP2016572433 A JP 2016572433A JP 6803236 B2 JP6803236 B2 JP 6803236B2
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JP
Japan
Prior art keywords
aperin
isolated polypeptide
polypeptide
amino acid
heart failure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016572433A
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English (en)
Japanese (ja)
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JP2017526620A5 (enExample
JP2017526620A (ja
Inventor
ジェリー ライアン ホルダー，
ジェリー ライアン ホルダー，
ガヤスリ スワミナス，
ガヤスリ スワミナス，
マイケル ジェイ． フローン，
マイケル ジェイ． フローン，
ブライアン アラン ランマン，
ブライアン アラン ランマン，
アントニー ビー． リード，
アントニー ビー． リード，
レスリー ピー． ミランダ，
レスリー ピー． ミランダ，
ジョン ゴードン アレン，
ジョン ゴードン アレン，
アレクサンダー ジェイ． ピックレル，
アレクサンダー ジェイ． ピックレル，
アーロン シー． ジークムント，
アーロン シー． ジークムント，
ルイス ディー． ペニントン，
ルイス ディー． ペニントン，
ブライアント ヤング，
ブライアント ヤング，
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Amgen Inc
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Amgen Inc
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Publication of JP2017526620A publication Critical patent/JP2017526620A/ja
Publication of JP2017526620A5 publication Critical patent/JP2017526620A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2016572433A 2014-06-10 2015-06-10 アペリンポリペプチド Active JP6803236B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462010322P 2014-06-10 2014-06-10
US62/010,322 2014-06-10
PCT/US2015/035205 WO2015191781A2 (en) 2014-06-10 2015-06-10 Apelin polypeptides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019187458A Division JP2020023539A (ja) 2014-06-10 2019-10-11 アペリンポリペプチド

Publications (3)

Publication Number Publication Date
JP2017526620A JP2017526620A (ja) 2017-09-14
JP2017526620A5 JP2017526620A5 (enExample) 2018-07-05
JP6803236B2 true JP6803236B2 (ja) 2020-12-23

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016572433A Active JP6803236B2 (ja) 2014-06-10 2015-06-10 アペリンポリペプチド
JP2019187458A Pending JP2020023539A (ja) 2014-06-10 2019-10-11 アペリンポリペプチド
JP2021200644A Withdrawn JP2022028961A (ja) 2014-06-10 2021-12-10 アペリンポリペプチド
JP2023210068A Pending JP2024026356A (ja) 2014-06-10 2023-12-13 アペリンポリペプチド

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2019187458A Pending JP2020023539A (ja) 2014-06-10 2019-10-11 アペリンポリペプチド
JP2021200644A Withdrawn JP2022028961A (ja) 2014-06-10 2021-12-10 アペリンポリペプチド
JP2023210068A Pending JP2024026356A (ja) 2014-06-10 2023-12-13 アペリンポリペプチド

Country Status (8)

Country Link
US (3) US10941182B2 (enExample)
EP (3) EP3674314B8 (enExample)
JP (4) JP6803236B2 (enExample)
AU (1) AU2015274574B2 (enExample)
CA (1) CA2951391C (enExample)
ES (1) ES2950789T3 (enExample)
MX (1) MX370689B (enExample)
WO (1) WO2015191781A2 (enExample)

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JP2025001049A (ja) * 2021-09-01 2025-01-08 積水メディカル株式会社 アルギニン誘導体
CN116554267A (zh) * 2022-01-30 2023-08-08 江苏众红生物工程创药研究院有限公司 聚乙二醇修饰的激肽或其变体和药物应用
TW202446782A (zh) * 2023-04-11 2024-12-01 美商威特拉公司 愛帕琳受體促效劑及其用途
CN119101143A (zh) * 2023-05-31 2024-12-10 浙江大学 一种G蛋白偏向的apelin-13多肽突变体及应用
WO2025092748A1 (zh) * 2023-11-01 2025-05-08 拜西欧斯（北京）生物技术有限公司 多肽衍生物、其药物组合物及其用途

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Publication number Publication date
EP3155002A2 (en) 2017-04-19
US20170107255A1 (en) 2017-04-20
EP3674314B8 (en) 2023-07-12
US20210261619A1 (en) 2021-08-26
MX370689B (es) 2019-12-19
JP2024026356A (ja) 2024-02-28
AU2015274574B2 (en) 2019-10-10
AU2015274574A1 (en) 2016-12-22
WO2015191781A2 (en) 2015-12-17
CA2951391A1 (en) 2015-12-17
ES2950789T3 (es) 2023-10-13
CA2951391C (en) 2021-11-02
JP2017526620A (ja) 2017-09-14
EP3155002B1 (en) 2019-11-27
US10941182B2 (en) 2021-03-09
WO2015191781A3 (en) 2016-07-21
JP2022028961A (ja) 2022-02-16
EP4257152A2 (en) 2023-10-11
EP3674314A2 (en) 2020-07-01
US11807693B2 (en) 2023-11-07
US20240327461A1 (en) 2024-10-03
JP2020023539A (ja) 2020-02-13
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