JP6800219B2 - 特異的なインターロイキン−15(il−15)アンタゴニストポリペプチド並びに炎症疾患及び自己免疫疾患の処置のためのその使用 - Google Patents
特異的なインターロイキン−15(il−15)アンタゴニストポリペプチド並びに炎症疾患及び自己免疫疾患の処置のためのその使用 Download PDFInfo
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- JP6800219B2 JP6800219B2 JP2018514889A JP2018514889A JP6800219B2 JP 6800219 B2 JP6800219 B2 JP 6800219B2 JP 2018514889 A JP2018514889 A JP 2018514889A JP 2018514889 A JP2018514889 A JP 2018514889A JP 6800219 B2 JP6800219 B2 JP 6800219B2
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- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15306418.3 | 2015-09-16 | ||
| EP15306418 | 2015-09-16 | ||
| PCT/EP2016/071759 WO2017046200A1 (en) | 2015-09-16 | 2016-09-15 | Specific interleukin-15 (il-15) antagonist polypeptide and uses thereof for the treatment of inflammatory and auto-immune diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018527011A JP2018527011A (ja) | 2018-09-20 |
| JP2018527011A5 JP2018527011A5 (enExample) | 2019-07-18 |
| JP6800219B2 true JP6800219B2 (ja) | 2020-12-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018514889A Expired - Fee Related JP6800219B2 (ja) | 2015-09-16 | 2016-09-15 | 特異的なインターロイキン−15(il−15)アンタゴニストポリペプチド並びに炎症疾患及び自己免疫疾患の処置のためのその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10858452B2 (enExample) |
| EP (1) | EP3350205A1 (enExample) |
| JP (1) | JP6800219B2 (enExample) |
| WO (1) | WO2017046200A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015089217A2 (en) | 2013-12-10 | 2015-06-18 | Bionz, Llc | Methods of developing selective peptide antagonists |
| ES2778053T3 (es) | 2011-01-18 | 2020-08-07 | Bioniz Llc | Composiciones para modular la actividad de la citocina gamma-c |
| EP3359556B1 (en) | 2015-10-09 | 2021-05-26 | Bioniz, LLC | Modulating gamma - c -cytokine activity |
| EP3458092A1 (en) | 2016-05-18 | 2019-03-27 | Modernatx, Inc. | Mrna combination therapy for the treatment of cancer |
| US11472856B2 (en) | 2016-06-13 | 2022-10-18 | Torque Therapeutics, Inc. | Methods and compositions for promoting immune cell function |
| KR20240142577A (ko) | 2017-04-07 | 2024-09-30 | 바이오니즈 테라퓨틱스, 아이엔씨. | 감마-c-사이토카인 활성의 안정한 조절자 |
| AU2018257917B2 (en) * | 2017-04-24 | 2023-05-04 | University Of Massachusetts | Diagnosis and treatment of vitiligo |
| KR20210032924A (ko) | 2017-09-05 | 2021-03-25 | 토크 테라퓨틱스, 인코포레이티드 | 치료용 단백질 조성물 및 그의 제조 및 사용 방법 |
| CA3102821A1 (en) * | 2018-06-22 | 2019-12-26 | Cugene Inc. | Novel interleukin-15 (1l-15) fusion proteins and uses thereof |
| CN112534052B (zh) | 2018-07-25 | 2024-09-20 | 奥美药业有限公司 | 全新il-21前药及使用方法 |
| JP2022530677A (ja) * | 2019-05-03 | 2022-06-30 | バイオニズ リミテッド ライアビリティー カンパニー | 脱毛症および脱毛症関連障害の治療ための、γcサイトカインのシグナル伝達の効果の調節 |
| JP7762570B2 (ja) | 2019-05-20 | 2025-10-30 | サイチューン ファーマ | 癌又は感染性疾患を処置するためのIL-2/IL-15Rβγアゴニスト投薬レジメン |
| WO2020252264A1 (en) | 2019-06-12 | 2020-12-17 | AskGene Pharma, Inc. | Novel il-15 prodrugs and methods of use thereof |
| CN114302650B (zh) | 2019-07-03 | 2024-09-13 | 休斯敦大学体系 | Il-15抑制剂及其在治疗自身免疫/炎性病症中的用途 |
| JP7807076B2 (ja) * | 2019-12-13 | 2026-01-27 | キュージーン インコーポレイテッド | 新規インターロイキン-15(il-15)融合タンパク質およびその使用 |
| JP7767290B2 (ja) | 2020-01-11 | 2025-11-11 | アスクジーン・ファーマ・インコーポレイテッド | 新規なマスクされたサイトカインおよびその使用方法 |
| JP2023550685A (ja) | 2020-10-26 | 2023-12-05 | サイチューン ファーマ | 扁平上皮癌を治療するためのIL-2/IL-15Rβγアゴニスト |
| KR20230096047A (ko) | 2020-10-26 | 2023-06-29 | 싸이튠 파마 | 비흑색종 피부암 치료용 IL-2/IL-15Rβγ 작용제 |
| IL309522B2 (en) | 2021-06-23 | 2025-12-01 | Cytune Pharma | Interleukin 15 variants |
| CA3225815A1 (en) | 2021-08-13 | 2023-02-16 | Cytune Pharma | Il-2/il-15rbetagamma agonist combination with antibody-drug conjugates for treating cancer |
| US20230151095A1 (en) | 2021-11-12 | 2023-05-18 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and nkg2d |
| WO2024102636A1 (en) | 2022-11-07 | 2024-05-16 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and mica/b |
| EP4562059A1 (en) * | 2023-02-21 | 2025-06-04 | RemeGen Co., Ltd. | Il-15 agonists for cancer |
| WO2024215987A1 (en) | 2023-04-14 | 2024-10-17 | Sotio Biotech Inc. | IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-15/IL-15Rα CONJUGATES |
| EP4694916A1 (en) | 2023-04-14 | 2026-02-18 | SOTIO Biotech Inc. | Engineered immune cells for treating cancer in combination with il-2/il-15 receptor ?? agonists |
| US20250243279A1 (en) | 2023-10-17 | 2025-07-31 | Xencor, Inc. | Bispecific antibodies that bind to nkp46 and mica/b |
| WO2025184411A1 (en) | 2024-02-27 | 2025-09-04 | Calidi Biotherapeutics (Nevada), Inc. | Serum-resistant eev viruses and uses thereof |
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| US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
| US5278056A (en) | 1988-02-05 | 1994-01-11 | The Trustees Of Columbia University In The City Of New York | Retroviral packaging cell lines and process of using same |
| US5073627A (en) | 1989-08-22 | 1991-12-17 | Immunex Corporation | Fusion proteins comprising GM-CSF and IL-3 |
| US5108910A (en) | 1989-08-22 | 1992-04-28 | Immunex Corporation | DNA sequences encoding fusion proteins comprising GM-CSF and IL-3 |
| US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
| DE69434860T2 (de) | 1993-02-22 | 2007-03-15 | The Rockefeller University | Herstellung von helfer-freien retroviren mit hohem titer mittels transienter transfektion |
| FR2712812B1 (fr) | 1993-11-23 | 1996-02-09 | Centre Nat Rech Scient | Composition pour la production de produits thérapeutiques in vivo. |
| IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| WO2006017853A2 (en) | 2004-08-11 | 2006-02-16 | Beth Israel Deaconess Medical Center, Inc. | Mutant interleukin-15-containing compositions and suppression of an immune response |
| EP1777294A1 (en) * | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins |
| DK2160401T3 (da) | 2007-05-11 | 2014-10-20 | Altor Bioscience Corp | Fusionsmolekyler og il-15-varianter |
| EP2537933A1 (en) * | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
| KR102539359B1 (ko) | 2013-04-19 | 2023-06-02 | 싸이튠 파마 | 감소된 혈관 누출 증후군에 대한 사이토카인 유도체 치료 |
| SI3030262T1 (sl) | 2013-08-08 | 2020-03-31 | Cytune Pharma | Kombiniran farmacevtski sestavek |
| CA2919725C (en) | 2013-08-08 | 2023-04-18 | Cytune Pharma | An il-15 and il-15r.aplha. sushi domain based modulokines |
| EP2915569A1 (en) * | 2014-03-03 | 2015-09-09 | Cytune Pharma | IL-15/IL-15Ralpha based conjugates purification method |
-
2016
- 2016-09-15 JP JP2018514889A patent/JP6800219B2/ja not_active Expired - Fee Related
- 2016-09-15 WO PCT/EP2016/071759 patent/WO2017046200A1/en not_active Ceased
- 2016-09-15 EP EP16769927.1A patent/EP3350205A1/en not_active Withdrawn
- 2016-09-15 US US15/754,664 patent/US10858452B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US10858452B2 (en) | 2020-12-08 |
| EP3350205A1 (en) | 2018-07-25 |
| JP2018527011A (ja) | 2018-09-20 |
| US20180258174A1 (en) | 2018-09-13 |
| WO2017046200A1 (en) | 2017-03-23 |
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