JP6797801B2 - Ｐｖｎｓを治療するための抗ｃｓｆ１ｒ抗体 - Google Patents

Ｐｖｎｓを治療するための抗ｃｓｆ１ｒ抗体 Download PDF

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JP6797801B2
JP6797801B2 JP2017533421A JP2017533421A JP6797801B2 JP 6797801 B2 JP6797801 B2 JP 6797801B2 JP 2017533421 A JP2017533421 A JP 2017533421A JP 2017533421 A JP2017533421 A JP 2017533421A JP 6797801 B2 JP6797801 B2 JP 6797801B2
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antibody
csf1r
seq
sequence
doses
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JP2018501254A (ja
JP2018501254A5 (cg-RX-API-DMAC7.html
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ロバート シコルスキ，
ロバート シコルスキ，
ジュリー ハンブルトン，
ジュリー ハンブルトン，
ニラカンタン サンカール，
ニラカンタン サンカール，
Original Assignee
ファイヴ プライム セラピューティクス インク
ファイヴ プライム セラピューティクス インク
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2017533421A 2014-12-22 2015-12-21 Ｐｖｎｓを治療するための抗ｃｓｆ１ｒ抗体 Active JP6797801B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462095297P 2014-12-22 2014-12-22
US62/095,297 2014-12-22
US201562163251P 2015-05-18 2015-05-18
US62/163,251 2015-05-18
PCT/US2015/067012 WO2016106180A1 (en) 2014-12-22 2015-12-21 Anti-csf1r antibodies for treating pvns

Publications (3)

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JP2018501254A JP2018501254A (ja) 2018-01-18
JP2018501254A5 JP2018501254A5 (cg-RX-API-DMAC7.html) 2019-03-07
JP6797801B2 true JP6797801B2 (ja) 2020-12-09

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JP2017533421A Active JP6797801B2 (ja) 2014-12-22 2015-12-21 Ｐｖｎｓを治療するための抗ｃｓｆ１ｒ抗体

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Country Link
US (3) US10040858B2 (cg-RX-API-DMAC7.html)
EP (1) EP3237447B1 (cg-RX-API-DMAC7.html)
JP (1) JP6797801B2 (cg-RX-API-DMAC7.html)
KR (1) KR20170096187A (cg-RX-API-DMAC7.html)
CN (1) CN107257806B (cg-RX-API-DMAC7.html)
AU (1) AU2015369854B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017013111A2 (cg-RX-API-DMAC7.html)
CA (1) CA2969341C (cg-RX-API-DMAC7.html)
EA (1) EA201791421A1 (cg-RX-API-DMAC7.html)
ES (1) ES2843586T3 (cg-RX-API-DMAC7.html)
HK (1) HK1245804A1 (cg-RX-API-DMAC7.html)
IL (1) IL252716A0 (cg-RX-API-DMAC7.html)
MX (1) MX2017008218A (cg-RX-API-DMAC7.html)
SG (1) SG11201704792UA (cg-RX-API-DMAC7.html)
TW (1) TW201630937A (cg-RX-API-DMAC7.html)
WO (1) WO2016106180A1 (cg-RX-API-DMAC7.html)

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CN109053887B (zh) * 2018-07-18 2019-07-23 博奥信生物技术（南京）有限公司 一种抗人csf-1r单克隆抗体及用途
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TW202112812A (zh) 2019-05-24 2021-04-01 香港商安立璽榮生醫(香港)有限公司 Csf1r抗體、il10融合蛋白及其用途
US11419822B2 (en) * 2020-12-14 2022-08-23 AmMax Bio, Inc. High concentration formulations of anti-CSF1 and anti-CSF1R antibodies
WO2024059508A2 (en) * 2022-09-12 2024-03-21 AmMax Bio, Inc. Treatment of tenosynovial giant cell tumor
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CN118593504B (zh) * 2024-06-03 2025-03-18 北京大学第三医院（北京大学第三临床医学院） 氘可来昔替尼或其盐在制备pvns药物方面的新用途
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JP2018501254A (ja) 2018-01-18
ES2843586T3 (es) 2021-07-19
AU2015369854A1 (en) 2017-06-15
CA2969341C (en) 2023-07-04
BR112017013111A2 (pt) 2018-05-15
KR20170096187A (ko) 2017-08-23
CN107257806A (zh) 2017-10-17
IL252716A0 (en) 2017-08-31
US20190119390A1 (en) 2019-04-25
EA201791421A1 (ru) 2017-10-31
MX2017008218A (es) 2017-10-18
CN107257806B (zh) 2021-08-10
TW201630937A (zh) 2016-09-01
US20210009700A1 (en) 2021-01-14
AU2015369854B2 (en) 2021-07-01
WO2016106180A1 (en) 2016-06-30
US10730949B2 (en) 2020-08-04
CA2969341A1 (en) 2016-06-30
EP3237447A1 (en) 2017-11-01
EP3237447B1 (en) 2020-12-02
HK1245804A1 (zh) 2018-08-31
SG11201704792UA (en) 2017-07-28
US20160185869A1 (en) 2016-06-30
US10040858B2 (en) 2018-08-07

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