ES2843586T3 - Anticuerpos dirigidos contra CSF1R para tratar la SVNP - Google Patents

Anticuerpos dirigidos contra CSF1R para tratar la SVNP Download PDF

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Publication number
ES2843586T3
ES2843586T3 ES15823889T ES15823889T ES2843586T3 ES 2843586 T3 ES2843586 T3 ES 2843586T3 ES 15823889 T ES15823889 T ES 15823889T ES 15823889 T ES15823889 T ES 15823889T ES 2843586 T3 ES2843586 T3 ES 2843586T3
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ES
Spain
Prior art keywords
antibody
csf1r
dose
sequence
seq
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Active
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ES15823889T
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English (en)
Spanish (es)
Inventor
Robert Sikorski
Julie Hambleton
Nilacantan Sankar
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Five Prime Therapeutics Inc
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Five Prime Therapeutics Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES15823889T 2014-12-22 2015-12-21 Anticuerpos dirigidos contra CSF1R para tratar la SVNP Active ES2843586T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462095297P 2014-12-22 2014-12-22
US201562163251P 2015-05-18 2015-05-18
PCT/US2015/067012 WO2016106180A1 (en) 2014-12-22 2015-12-21 Anti-csf1r antibodies for treating pvns

Publications (1)

Publication Number Publication Date
ES2843586T3 true ES2843586T3 (es) 2021-07-19

Family

ID=55135539

Family Applications (1)

Application Number Title Priority Date Filing Date
ES15823889T Active ES2843586T3 (es) 2014-12-22 2015-12-21 Anticuerpos dirigidos contra CSF1R para tratar la SVNP

Country Status (16)

Country Link
US (3) US10040858B2 (cg-RX-API-DMAC7.html)
EP (1) EP3237447B1 (cg-RX-API-DMAC7.html)
JP (1) JP6797801B2 (cg-RX-API-DMAC7.html)
KR (1) KR20170096187A (cg-RX-API-DMAC7.html)
CN (1) CN107257806B (cg-RX-API-DMAC7.html)
AU (1) AU2015369854B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017013111A2 (cg-RX-API-DMAC7.html)
CA (1) CA2969341C (cg-RX-API-DMAC7.html)
EA (1) EA201791421A1 (cg-RX-API-DMAC7.html)
ES (1) ES2843586T3 (cg-RX-API-DMAC7.html)
HK (1) HK1245804A1 (cg-RX-API-DMAC7.html)
IL (1) IL252716A0 (cg-RX-API-DMAC7.html)
MX (1) MX2017008218A (cg-RX-API-DMAC7.html)
SG (1) SG11201704792UA (cg-RX-API-DMAC7.html)
TW (1) TW201630937A (cg-RX-API-DMAC7.html)
WO (1) WO2016106180A1 (cg-RX-API-DMAC7.html)

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CN109053887B (zh) * 2018-07-18 2019-07-23 博奥信生物技术(南京)有限公司 一种抗人csf-1r单克隆抗体及用途
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TW202112812A (zh) 2019-05-24 2021-04-01 香港商安立璽榮生醫(香港)有限公司 Csf1r抗體、il10融合蛋白及其用途
US11419822B2 (en) * 2020-12-14 2022-08-23 AmMax Bio, Inc. High concentration formulations of anti-CSF1 and anti-CSF1R antibodies
WO2024059508A2 (en) * 2022-09-12 2024-03-21 AmMax Bio, Inc. Treatment of tenosynovial giant cell tumor
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof
CN118593504B (zh) * 2024-06-03 2025-03-18 北京大学第三医院(北京大学第三临床医学院) 氘可来昔替尼或其盐在制备pvns药物方面的新用途
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Also Published As

Publication number Publication date
JP2018501254A (ja) 2018-01-18
AU2015369854A1 (en) 2017-06-15
CA2969341C (en) 2023-07-04
BR112017013111A2 (pt) 2018-05-15
KR20170096187A (ko) 2017-08-23
CN107257806A (zh) 2017-10-17
IL252716A0 (en) 2017-08-31
US20190119390A1 (en) 2019-04-25
EA201791421A1 (ru) 2017-10-31
MX2017008218A (es) 2017-10-18
CN107257806B (zh) 2021-08-10
TW201630937A (zh) 2016-09-01
US20210009700A1 (en) 2021-01-14
AU2015369854B2 (en) 2021-07-01
WO2016106180A1 (en) 2016-06-30
US10730949B2 (en) 2020-08-04
CA2969341A1 (en) 2016-06-30
EP3237447A1 (en) 2017-11-01
EP3237447B1 (en) 2020-12-02
JP6797801B2 (ja) 2020-12-09
HK1245804A1 (zh) 2018-08-31
SG11201704792UA (en) 2017-07-28
US20160185869A1 (en) 2016-06-30
US10040858B2 (en) 2018-08-07

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