JP6791875B2 - ｍｉＲＮＡをブロックするための方法 - Google Patents

ｍｉＲＮＡをブロックするための方法 Download PDF

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JP6791875B2
JP6791875B2 JP2017553115A JP2017553115A JP6791875B2 JP 6791875 B2 JP6791875 B2 JP 6791875B2 JP 2017553115 A JP2017553115 A JP 2017553115A JP 2017553115 A JP2017553115 A JP 2017553115A JP 6791875 B2 JP6791875 B2 JP 6791875B2
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blocking
mirna
nucleic acid
mir
rna
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JP2018513685A5 (https=
JP2018513685A (ja
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マイヤーズ，リチャード・エム
ロバーツ，ブライアン・エス
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ハドソン アルファ インスティテュート フォー バイオテクノロジー
ハドソン アルファ インスティテュート フォー バイオテクノロジー
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    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
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    • C12Q2521/501—Ligase
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    • C12Q2525/10—Modifications characterised by
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    • C12Q2525/207—Modifications characterised by siRNA, miRNA
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
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    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/163—Reactions characterised by the reaction format or use of a specific feature the purpose or use of blocking probe

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JP2017553115A 2015-04-10 2016-04-10 ｍｉＲＮＡをブロックするための方法 Active JP6791875B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562146015P 2015-04-10 2015-04-10
US62/146,015 2015-04-10
PCT/US2016/026846 WO2016164866A1 (en) 2015-04-10 2016-04-10 METHOD FOR BLOCKING miRNA

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JP2018513685A JP2018513685A (ja) 2018-05-31
JP2018513685A5 JP2018513685A5 (https=) 2020-07-02
JP6791875B2 true JP6791875B2 (ja) 2020-11-25

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US (2) US10480023B2 (https=)
EP (1) EP3280805B1 (https=)
JP (1) JP6791875B2 (https=)
AU (1) AU2016246820B2 (https=)
CA (1) CA2982369A1 (https=)
IL (1) IL254972B (https=)
MX (1) MX386064B (https=)
WO (1) WO2016164866A1 (https=)

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US20160319278A1 (en) 2015-04-03 2016-11-03 University Of Massachusetts Fully stabilized asymmetric sirna
US11396650B2 (en) 2015-06-02 2022-07-26 Children's Medical Center Corporation Nucleic acid complexes for screening barcoded compounds
US12077807B2 (en) 2015-06-27 2024-09-03 The Research Foundation For The State University Of New York Compositions and methods for analyte detection using nanoswitches
WO2017030973A1 (en) 2015-08-14 2017-02-23 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
US10478503B2 (en) 2016-01-31 2019-11-19 University Of Massachusetts Branched oligonucleotides
US10287625B2 (en) * 2016-03-18 2019-05-14 Norgen Biotek Corp. Methods and kits for separating nucleic acids by size
US12123869B2 (en) 2016-03-23 2024-10-22 Children's Medical Center Corporation Rapid and sensitive detection and quantification of analytes in complex samples using polymer-based methods
CA3033368A1 (en) 2016-08-12 2018-02-15 University Of Massachusetts Conjugated oligonucleotides
US12252507B2 (en) 2016-12-05 2025-03-18 Children's Medical Center Corporation Nucleic acid nanoswitch construction methods
WO2018157100A1 (en) * 2017-02-27 2018-08-30 Bioo Scientific Corporation Methods and kits for depleting undesired nucleic acids
JP7406793B2 (ja) 2017-06-23 2023-12-28 ユニバーシティー オブ マサチューセッツ ２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法
EP3681895A4 (en) * 2017-09-13 2021-05-26 Becton, Dickinson and Company METHODS AND COMPOSITIONS FOR EXTRACTION OF NUCLEIC ACIDS USING FERROUS PARTICLES
US11591636B2 (en) 2017-11-20 2023-02-28 Children's Medical Center Corporation Force-controlled nanoswitch assays for single-molecule detection in complex biological fluids
CN108676846B (zh) * 2018-05-25 2022-04-01 艾吉泰康生物科技(北京)有限公司 一种桥式寡核苷酸在文库目标区域捕获中的应用
WO2020033899A1 (en) 2018-08-10 2020-02-13 University Of Massachusetts Modified oligonucleotides targeting snps
US11279930B2 (en) 2018-08-23 2022-03-22 University Of Massachusetts O-methyl rich fully stabilized oligonucleotides
CN113614232A (zh) * 2019-01-18 2021-11-05 马萨诸塞大学 动态药代动力学修饰锚
KR20220047989A (ko) 2019-08-09 2022-04-19 유니버시티 오브 매사추세츠 Snp를 표적화하는 화학적으로 변형된 올리고뉴클레오타이드
US12365894B2 (en) 2019-09-16 2025-07-22 University Of Massachusetts Branched lipid conjugates of siRNA for specific tissue delivery
WO2021174071A1 (en) 2020-02-29 2021-09-02 President And Fellows Of Harvard College Nanoswitch caliper trains for high-throughput, high-resolution structural analysis of biomolecules
WO2021242883A1 (en) 2020-05-26 2021-12-02 University Of Massachusetts Synthetic oligonucleotides having regions of block and cluster modifications
CN117677699A (zh) 2021-06-23 2024-03-08 马萨诸塞大学 用于治疗先兆子痫和其他血管生成病症的优化抗flt1寡核苷酸化合物
CN118139978A (zh) * 2021-10-22 2024-06-04 蜂鸟诊断有限责任公司 使用反义寡核苷酸靶向抑制逆转录
US20230323341A1 (en) * 2022-03-25 2023-10-12 Bioo Scientific Corporation Methods, compositions, and kits for inhibiting formation of adapter dimers

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EP1253205A1 (en) 2001-04-24 2002-10-30 LION Bioscience AG Method of blocking amplification of selected sequences
US20030211483A1 (en) * 2002-05-09 2003-11-13 Schroeder Benjamin G. Methods for the enrichment of low-abundance polynucleotides
EP1924713B1 (en) 2005-08-24 2011-11-09 Life Technologies Corporation A method to quantify sirnas, mirnas and polymorphic mirnas
WO2010126913A1 (en) 2009-04-27 2010-11-04 Gen-Probe Incorporated Methods and kits for use in the selective amplification of target sequences
CA2779689A1 (en) * 2009-11-06 2011-05-12 Enzymatics, Inc. Composition and method for synthesizing a deoxyribonucleotide chain using a double stranded nucleic acid complex with a thermostable polymerase
EP2542696B1 (en) * 2010-03-01 2016-09-28 Caris Life Sciences Switzerland Holdings GmbH Biomarkers for theranostics
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EP3280805A1 (en) 2018-02-14
CA2982369A1 (en) 2016-10-13
EP3280805B1 (en) 2020-12-16
IL254972A0 (en) 2017-12-31
IL254972B (en) 2021-05-31
BR112017021854A2 (pt) 2018-07-10
EP3280805A4 (en) 2019-03-13
MX386064B (es) 2025-03-18
US10480023B2 (en) 2019-11-19
US20180073066A1 (en) 2018-03-15
US20200024652A1 (en) 2020-01-23
JP2018513685A (ja) 2018-05-31
MX2017013022A (es) 2018-03-15
US11781176B2 (en) 2023-10-10
AU2016246820B2 (en) 2021-08-12
WO2016164866A1 (en) 2016-10-13
AU2016246820A1 (en) 2017-11-30

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