JP6751977B2 - 線維芽細胞増殖因子受容体の阻害剤及びそれらの使用 - Google Patents
線維芽細胞増殖因子受容体の阻害剤及びそれらの使用 Download PDFInfo
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- JP6751977B2 JP6751977B2 JP2019511715A JP2019511715A JP6751977B2 JP 6751977 B2 JP6751977 B2 JP 6751977B2 JP 2019511715 A JP2019511715 A JP 2019511715A JP 2019511715 A JP2019511715 A JP 2019511715A JP 6751977 B2 JP6751977 B2 JP 6751977B2
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- 0 CCC(CCC1*C1)C*C(CC*)C1*2(C3)C1C(C(CC)CC)C3C2 Chemical compound CCC(CCC1*C1)C*C(CC*)C1*2(C3)C1C(C(CC)CC)C3C2 0.000 description 10
- CFUDIIYRXQLYDY-ROUUACIJSA-N CC(C)(C)OC(N(C1)[C@H](COC)C[C@@H]1Nc1ncc(cc(cc2)-c(c(Cl)c(cc3OC)OC)c3Cl)c2n1)=O Chemical compound CC(C)(C)OC(N(C1)[C@H](COC)C[C@@H]1Nc1ncc(cc(cc2)-c(c(Cl)c(cc3OC)OC)c3Cl)c2n1)=O CFUDIIYRXQLYDY-ROUUACIJSA-N 0.000 description 1
- SHSOJFOYXCKRGZ-HNNXBMFYSA-N COc(c(Cl)c1-c2cc3cnc(N[C@@H](CC4)CN4C(C=C)=O)nc3cc2)cc(OC)c1Cl Chemical compound COc(c(Cl)c1-c2cc3cnc(N[C@@H](CC4)CN4C(C=C)=O)nc3cc2)cc(OC)c1Cl SHSOJFOYXCKRGZ-HNNXBMFYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610802100.5 | 2016-09-01 | ||
| CN201610802100 | 2016-09-01 | ||
| CN201710351160.4 | 2017-05-18 | ||
| CN201710351160 | 2017-05-18 | ||
| PCT/CN2017/096848 WO2018040885A1 (zh) | 2016-09-01 | 2017-08-10 | 成纤维细胞生长因子受体抑制剂及其用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019529374A JP2019529374A (ja) | 2019-10-17 |
| JP6751977B2 true JP6751977B2 (ja) | 2020-09-09 |
Family
ID=61300040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019511715A Active JP6751977B2 (ja) | 2016-09-01 | 2017-08-10 | 線維芽細胞増殖因子受容体の阻害剤及びそれらの使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10744139B2 (ko) |
| EP (1) | EP3508482B1 (ko) |
| JP (1) | JP6751977B2 (ko) |
| KR (1) | KR102270620B1 (ko) |
| CN (1) | CN107793395B (ko) |
| AU (1) | AU2017317864B2 (ko) |
| ES (1) | ES2859637T3 (ko) |
| RU (1) | RU2732127C1 (ko) |
| WO (1) | WO2018040885A1 (ko) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10807951B2 (en) * | 2017-10-13 | 2020-10-20 | The Regents Of The University Of California | mTORC1 modulators |
| CN110386921A (zh) * | 2018-04-23 | 2019-10-29 | 南京药捷安康生物科技有限公司 | 成纤维细胞生长因子受体抑制剂化合物 |
| CN113474337A (zh) * | 2018-12-19 | 2021-10-01 | 奥瑞生物药品公司 | 作为fgfr抑制剂用于治疗癌症的7-((3，5-二甲氧基苯基)氨基)喹喔啉衍生物 |
| EP3898626A1 (en) * | 2018-12-19 | 2021-10-27 | Array Biopharma, Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases |
| WO2021170070A1 (zh) * | 2020-02-28 | 2021-09-02 | 南京药捷安康生物科技有限公司 | 成纤维细胞生长因子受体抑制剂的用途 |
| KR20230044483A (ko) | 2020-07-31 | 2023-04-04 | 트랜스테라 사이언시즈 (난징), 인크. | 섬유아세포증식인자수용체 억제제의 결정형 및 이의 제조방법 |
| TW202402754A (zh) | 2021-03-04 | 2024-01-16 | 美商美國禮來大藥廠 | Fgfr3抑制劑化合物 |
| US12084453B2 (en) | 2021-12-10 | 2024-09-10 | Incyte Corporation | Bicyclic amines as CDK12 inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006118256A1 (ja) * | 2005-04-28 | 2006-11-09 | Kyowa Hakko Kogyo Co., Ltd. | 2-アミノキナゾリン誘導体 |
| PT2090575E (pt) | 2005-11-15 | 2011-06-06 | Array Biopharma Inc | Inibidores de erbb |
| BR112015000653A2 (pt) * | 2012-07-11 | 2019-11-05 | Blueprint Medicines Corp | compostos inibidores do receptor de fator de crescimento de fibroblasto, sua composição farmacêutica e seus usos |
| GB201307577D0 (en) * | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
| BR112016008849B8 (pt) * | 2013-10-25 | 2022-09-06 | Blueprint Medicines Corp | Compostos ou sais farmaceuticamente aceitáveis dos mesmos, uso dos referidos compostos e composições farmacêuticas |
| US9695165B2 (en) * | 2014-01-15 | 2017-07-04 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| EP3364977A4 (en) | 2015-10-19 | 2019-09-04 | Araxes Pharma LLC | PROCESS FOR SCREENING INHIBITORS OF RAS |
-
2017
- 2017-08-10 AU AU2017317864A patent/AU2017317864B2/en active Active
- 2017-08-10 ES ES17845187T patent/ES2859637T3/es active Active
- 2017-08-10 WO PCT/CN2017/096848 patent/WO2018040885A1/zh unknown
- 2017-08-10 EP EP17845187.8A patent/EP3508482B1/en active Active
- 2017-08-10 RU RU2019107910A patent/RU2732127C1/ru active
- 2017-08-10 CN CN201710680599.1A patent/CN107793395B/zh active Active
- 2017-08-10 KR KR1020197007909A patent/KR102270620B1/ko active IP Right Grant
- 2017-08-10 US US16/328,817 patent/US10744139B2/en active Active
- 2017-08-10 JP JP2019511715A patent/JP6751977B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3508482B1 (en) | 2020-12-16 |
| CN107793395A (zh) | 2018-03-13 |
| RU2732127C1 (ru) | 2020-09-11 |
| KR102270620B1 (ko) | 2021-06-30 |
| ES2859637T3 (es) | 2021-10-04 |
| US20200108070A2 (en) | 2020-04-09 |
| EP3508482A1 (en) | 2019-07-10 |
| WO2018040885A1 (zh) | 2018-03-08 |
| JP2019529374A (ja) | 2019-10-17 |
| US20190209564A1 (en) | 2019-07-11 |
| AU2017317864B2 (en) | 2020-01-16 |
| CN107793395B (zh) | 2021-01-05 |
| KR20190039583A (ko) | 2019-04-12 |
| EP3508482A4 (en) | 2019-07-31 |
| US10744139B2 (en) | 2020-08-18 |
| AU2017317864A1 (en) | 2019-03-28 |
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