JP6743051B2 - Cd1dを標的とする単一ドメイン抗体 - Google Patents
Cd1dを標的とする単一ドメイン抗体 Download PDFInfo
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- JP6743051B2 JP6743051B2 JP2017557264A JP2017557264A JP6743051B2 JP 6743051 B2 JP6743051 B2 JP 6743051B2 JP 2017557264 A JP2017557264 A JP 2017557264A JP 2017557264 A JP2017557264 A JP 2017557264A JP 6743051 B2 JP6743051 B2 JP 6743051B2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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| AU2012323781B8 (en) * | 2011-10-14 | 2015-05-14 | Teva Pharmaceuticals Australia Pty Ltd. | Antibodies to CD1d |
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| CN104334741B (zh) | 2012-03-28 | 2018-08-17 | 歌德塔有限公司 | 组合的γ9δ2T细胞受体链交换 |
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| WO2014210522A1 (en) | 2013-06-28 | 2014-12-31 | The Scripps Research Institute | Nkt cell ligands and methods of use |
| WO2015121383A1 (en) | 2014-02-12 | 2015-08-20 | Michael Uhlin | Bispecific antibodies for use in stem cell transplantation |
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| JP6894702B2 (ja) | 2014-05-13 | 2021-06-30 | 中外製薬株式会社 | 免疫抑制機能を有する細胞に対するt細胞リダイレクト抗原結合分子 |
| CA2988504A1 (en) | 2014-07-02 | 2016-01-07 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods for diagnosing and treating cd1d restricted gamma/delta t cell lymphomas |
| WO2016081518A2 (en) | 2014-11-17 | 2016-05-26 | Adicet Bio, Inc. | Engineered gamma delta t-cells |
| KR102574729B1 (ko) | 2015-01-27 | 2023-09-04 | 라바 테라퓨틱스 엔.브이. | Cd1d를 표적화하는 단일 도메인 항체 |
| CN104829730A (zh) | 2015-04-14 | 2015-08-12 | 苏静 | 一种能联合免疫细胞增强肿瘤杀伤能力的双特异性抗体及其制备方法和应用 |
| US11000603B2 (en) | 2015-04-14 | 2021-05-11 | Benhealth Biopharmaceutic (Shenzhen) Co., Ltd. | Multi-specific binding conjugate, related pharmaceutical compositions and use |
| JP6931329B2 (ja) | 2015-11-18 | 2021-09-01 | 中外製薬株式会社 | 免疫抑制機能を有する細胞に対するt細胞リダイレクト抗原結合分子を用いた併用療法 |
| CN109195992A (zh) | 2016-04-29 | 2019-01-11 | 本康生物制药(深圳)有限公司 | 多特异性结合偶联物、相关的药物组合物及应用 |
| US20180028566A1 (en) | 2016-07-29 | 2018-02-01 | New York University | Gamma delta t cells as a target for treatment of solid tumors |
| CA3049791A1 (en) | 2017-01-27 | 2018-08-02 | Silverback Therapeutics, Inc. | Tumor targeting conjugates and methods of use thereof |
| WO2018229163A1 (en) | 2017-06-14 | 2018-12-20 | King's College London | Methods of activating v delta 2 negative gamma delta t cells |
| TWI687227B (zh) | 2017-10-03 | 2020-03-11 | 生倍科技股份有限公司 | 用於t細胞免疫療法之組合及其用途 |
| US20210163620A1 (en) | 2018-04-05 | 2021-06-03 | Brian Granda | Trispecific binding molecules against cancers and uses thereof |
| CN112955465A (zh) | 2018-07-03 | 2021-06-11 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| JP2022521751A (ja) | 2019-02-21 | 2022-04-12 | マレンゴ・セラピューティクス,インコーポレーテッド | 抗tcr抗体分子およびその使用 |
| AU2020267504A1 (en) | 2019-05-08 | 2021-12-02 | Janssen Biotech, Inc. | Materials and methods for modulating T cell mediated immunity |
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| UY39127A (es) | 2020-03-13 | 2021-09-30 | Janssen Biotech Inc | Materiales y métodos para modular la inmunidad mediada por cadena delta |
| CN116390950A (zh) | 2020-10-28 | 2023-07-04 | 詹森生物科技公司 | 用于调节δγ链介导的免疫的组合物和方法 |
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| MX2017009680A (es) | 2018-04-13 |
| US20240425592A1 (en) | 2024-12-26 |
| AU2016212777B2 (en) | 2021-11-18 |
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| CN107531787A (zh) | 2018-01-02 |
| HK1247937A1 (en) | 2018-10-05 |
| US12110328B2 (en) | 2024-10-08 |
| US20240067726A1 (en) | 2024-02-29 |
| US20180142020A1 (en) | 2018-05-24 |
| CA2975078A1 (en) | 2016-08-04 |
| KR20170128254A (ko) | 2017-11-22 |
| AU2016212777A1 (en) | 2017-08-17 |
| KR20230132604A (ko) | 2023-09-15 |
| CN114504645A (zh) | 2022-05-17 |
| WO2016122320A1 (en) | 2016-08-04 |
| JP2018508229A (ja) | 2018-03-29 |
| KR102574729B1 (ko) | 2023-09-04 |
| MX386714B (es) | 2025-03-11 |
| JP7165701B2 (ja) | 2022-11-04 |
| US20200115450A1 (en) | 2020-04-16 |
| CN107531787B (zh) | 2022-01-18 |
| US11591394B2 (en) | 2023-02-28 |
| SG11201706128PA (en) | 2017-08-30 |
| EA201791691A1 (ru) | 2018-01-31 |
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