JP6742283B2 - 組織治癒 - Google Patents
組織治癒 Download PDFInfo
- Publication number
- JP6742283B2 JP6742283B2 JP2017174641A JP2017174641A JP6742283B2 JP 6742283 B2 JP6742283 B2 JP 6742283B2 JP 2017174641 A JP2017174641 A JP 2017174641A JP 2017174641 A JP2017174641 A JP 2017174641A JP 6742283 B2 JP6742283 B2 JP 6742283B2
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- JP
- Japan
- Prior art keywords
- wound
- layer
- dressing
- negative pressure
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
- A61F13/0253—Adhesive bandages or dressings characterised by the skin-adhering layer characterized by the adhesive material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
- A61F13/022—Adhesive bandages or dressings with fluid retention members having more than one layer with different fluid retention characteristics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
- A61F13/0223—Adhesive bandages or dressings with fluid retention members characterized by parametric properties of the fluid retention layer, e.g. absorbency, wicking capacity, liquid distribution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/023—Adhesive bandages or dressings wound covering film layers without a fluid retention layer
- A61F13/0243—Adhesive bandages or dressings wound covering film layers without a fluid retention layer characterised by the properties of the skin contacting layer, e.g. air-vapor permeability
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/05—Bandages or dressings; Absorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
- A61M1/91—Suction aspects of the dressing
- A61M1/915—Constructional details of the pressure distribution manifold
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
- A61M1/98—Containers specifically adapted for negative pressure wound therapy
- A61M1/984—Containers specifically adapted for negative pressure wound therapy portable on the body
- A61M1/985—Containers specifically adapted for negative pressure wound therapy portable on the body the dressing itself forming the collection container
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
- A61F13/0206—Adhesive bandages or dressings with fluid retention members with absorbent fibrous layers, e.g. woven or non-woven absorbent pads or island dressings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
- A61M1/91—Suction aspects of the dressing
- A61M1/916—Suction aspects of the dressing specially adapted for deep wounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
- A61M2205/7536—General characteristics of the apparatus with filters allowing gas passage, but preventing liquid passage, e.g. liquophobic, hydrophobic, water-repellent membranes
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
シリコーンと、創傷部位においてNPWTが適用されるときに、瘢痕組織形成を抑制するのに十分な量および比率の開口面積(open area)と、から構成されている創傷接触層を備える装置が提供される。
シリコーンと、組織部位においてNPTが適用されるときに、瘢痕組織を低減するのに十分な量および比率の開口面積と、から構成されている組織接触層であって、前記瘢痕組織が、線維性疾患に関連する、組織接触層を備える、装置が提供される。
組織部位に創傷被覆材を位置付けるステップであって、創傷被覆材が、組織接触層を備え、組織接触層が、シリコーンと、組織部位においてNPTが適用されるときに、瘢痕組織を低減するのに十分な量および比率の開口面積と、から構成されている、ステップと、
創傷被覆材を介して組織部位にNPTを適用するステップと、
組織部位において瘢痕組織を少なくとも低減させるステップと、
を備える、方法が提供される。
シリコーン創傷接触層および水蒸気透過性のカバー層を備える創傷被覆材を提供するステップと、
被覆材を創傷部位の上方に位置付けて、創傷部位の上方に密封された空洞を形成するステップと、
創傷部位から密封された空洞の中へ流体を吸い込むために、創傷部位に陰圧を適用するステップと、
を備える方法が提供される。
[実施例1]
陰圧創傷療法(NPWT)が適用される創傷部位において、瘢痕のない創傷の治癒を促進する装置であって、前記装置は、
シリコーンと、前記創傷部位においてNPWTが適用されるときに、瘢痕組織形成を抑制するのに十分な量および比率の開口面積と、から構成されている創傷接触層を備える装置。
[実施例2]
前記装置は、複数の貫通穴を備える前記創傷接触層をさらに備え、前記貫通穴の組合せ面積が、前記開口面積を構成し、かつ前記開口面積が、前記創傷接触層の全体面積の約20%以下を構成する実施例1に記載の装置。
[実施例3]
スリット、および/または、スロット、および/または、円形の穴、および/または、四角形の穴、および/または、多角形の穴、および/または、楕円形の穴を備える前記貫通穴をさらに備える実施例2に記載の装置。
[実施例4]
シリコーン接着層を備える前記創傷接触層をさらに備える実施例1から3のいずれか一項に記載の装置。
[実施例5]
前記創傷部位から前記開口面積を介して除去される滲出液を保持するために、前記創傷接触層に対して近位に位置する少なくとも1つの滲出液吸収層をさらに備える実施例1から4のいずれか一項に記載の装置。
[実施例6]
前記滲出液吸収層によって保持される滲出液が、NPWTの間に、前記創傷のために湿潤環境を提供する液体を構成することをさらに備える、実施例5に記載の装置。
[実施例7]
前記滲出液吸収層によって保持される滲出液が、治癒剤を備え、前記創傷の治癒を促進するために、前記創傷が治癒するときに、前記創傷部位に提供される実施例5または実施例6に記載の装置。
[実施例8]
前記滲出液吸収層が、3Dニット層と、高吸収体を含有する層と、を備える実施例5から7のいずれか一項に記載の装置。
[実施例9]
陰圧創傷療法(NPWT)が適用される創傷部位において、瘢痕のない創傷の治癒を促進する装置であって、前記装置は、
シリコーンベースの接着剤を備える創傷接触層であって、シリコーンが、前記創傷部位にNPWTが適用されるときに、瘢痕組織形成を抑制するのに十分な量および比率で存在する創傷接触層を備える装置。
[実施例10]
前記シリコーンが、ポリシロキサン、または、ポリオルガノシロキサン、または、ポリジメチルシロキサンを備えることをさらに備える実施例1から9のいずれか一項に記載の装置。
瘢痕組織形成の抑制が、完全なまたは部分的な瘢痕化の防止または低減を含むことをさらに備える実施例1から10のいずれか一項に記載の装置。
[実施例12]
瘢痕化が、創傷の治癒から結果として生じる瘢痕化であることをさらに含む実施例1から11のいずれか一項に記載の装置。
[実施例13]
瘢痕化が、皮膚、腱、靱帯または筋肉、腹腔、骨盤腔、および、胸腔などからなる群から選択された組織において生じることをさらに含む実施例12に記載の装置。
[実施例14]
陰圧療法(NPT)が適用される組織部位において、瘢痕のない治癒を促進する装置であって、前記装置は、
シリコーンと、前記組織部位にNPTが適用されるときに、瘢痕組織を低減するのに十分な量および比率の開口面積と、から構成されている組織接触層であって、前記瘢痕組織が線維性疾患に関連する、組織接触層を備える装置。
[実施例15]
前記線維性疾患が、皮膚線維症、筋肉線維症、および、腹部、骨盤、脊柱、または腱において生じるものなどのような癒着などからなる群から選択されたことをさらに含む実施例14に記載の装置。
[実施例16]
創傷部位に連結可能な陰圧供給源であって、前記陰圧供給源が、連続的および/または間欠的な陰圧を提供するように適合されている、陰圧供給源をさらに備える、実施例1から15のいずれか一項に記載の装置。
[実施例17]
前記陰圧供給源が、約−20mmHgから−200mmHgの間の範囲にある陰圧を提供することをさらに備える実施例16に記載の装置。
[実施例18]
前記陰圧供給源が、約−50mmHgから−150mmHgの間の範囲にある陰圧を提供することをさらに備える実施例17に記載の装置。
[実施例19]
創傷接触層を備える創傷被覆材とともに行う陰圧創傷療法(NPWT)の使用であって、前記創傷接触層は、シリコーンと、前記創傷接触層の全体面積の約20%以下の開口面積と、から構成され、それによって実質的に瘢痕のない切開創傷の治癒を促進する使用。
[実施例20]
局所的に制御された薬剤送出システムであって、前記薬剤送出システムは、シリコーンまたはその薬学的に許容可能な均等物の有効な1日用量を備え、抗瘢痕化の治療において、創傷を患うホストに対して陰圧創傷療法(NPWT)を適用することと組み合わせられた局所的な投与によって、局所的にシリコーンを保持するジェル被覆材の形態の従来の創傷被覆材治療と比べて、瘢痕化のレベルの低減が、前記ホストによって経験される、薬剤送出システム。
陰圧療法(NPT)が適用される組織部位において、瘢痕のない治癒を促進する方法であって、前記方法は、
組織部位に創傷被覆材を位置付けるステップであって、前記創傷被覆材が、組織接触層を備え、前記組織接触層が、シリコーンと、前記組織部位にNPTが適用されるときに、瘢痕組織を低減するのに十分な量および比率の開口面積と、から構成されている、ステップと、
前記創傷被覆材を介して前記組織部位にNPTを適用するステップと、
前記組織部位において瘢痕組織を少なくとも低減させるステップと、
を備える方法。
[実施例22]
前記組織部位が、創傷部位を備え、前記方法が、
前記NPTを適用するステップが、前記組織部位に陰圧創傷療法(NPWT)を適用するステップを備え、
前記瘢痕組織を少なくとも低減させるステップが、前記創傷部位において瘢痕組織形成を抑制するステップを備えることをさらに備える実施例21に記載の方法。
[実施例23]
前記方法が、瘢痕組織形成を抑制する美容的な方法を備えることをさらに備える実施例21または実施例22に記載の方法。
[実施例24]
陰圧療法(NPT)が適用される組織部位において、瘢痕のない治癒を促進する装置であって、前記装置は、
実質的に水蒸気不透過性の層と、
限定された開口面積から構成されている層であって、前記水蒸気不透過性の層の水蒸気透過性、および前記開口面積が、前記組織部位においてNPTが適用されるときに、瘢痕組織形成を抑制するのに十分な量および比率である層と、
を備える装置。
[実施例25]
前記水蒸気不透過性の層が、組織接触層である実施例24に記載の装置。
[実施例26]
前記水蒸気不透過性の層が、組織接触層の上方の層である実施例24に記載の装置。
[実施例27]
前記層が、組織接触層を備える実施例24に記載の装置。
[実施例28]
前記水蒸気不透過性の層および前記層が、単一の共通の層である実施例24に記載の装置。
[実施例29]
前記単一の共通の層が、穿孔された層を備える実施例28に記載の装置。
[実施例30]
前記穿孔が、複数の穴、スリット、またはスロットなどを備える実施例29に記載の装置。
前記穿孔された層が、穿孔されたシリコーン接着層を備える実施例29に記載の装置。
[実施例32]
前記組織部位が、創傷部位を含み、かつ前記NPTが、陰圧創傷療法(NPWT)を含む実施例24に記載の装置。
[実施例33]
実質的に、本明細書において添付の図面を参照して説明したような方法。
[実施例34]
実質的に、添付の図面を参照して上記に説明したように構成されるとともに配置された装置。
[実施例35]
創傷の治療のための方法であって、前記方法は、
シリコーン創傷接触層および水蒸気透過性のカバー層を備える創傷被覆材を提供するステップと、
前記創傷被覆材を創傷部位の上方に位置付けて、前記創傷部位の上方に密封された空洞を形成させるステップと、
前記創傷部位から前記密封された空洞の中へ流体を吸い込むために、前記創傷部位に陰圧を適用するステップと、
を備える方法。
[実施例36]
前記創傷被覆材が、それ自身を通して創傷滲出液を導くように構成された透過層と、創傷滲出液を吸収する吸収層と、をさらに備える実施例35に記載の方法。
[実施例37]
前記密封された空洞の中に前記創傷部位からの流体を含有するステップをさらに備える実施例35または36に記載の方法。
[実施例38]
前記シリコーン創傷接触層のない創傷被覆材を使用して生じることとなる瘢痕組織形成と比較して、前記創傷部位において、瘢痕組織形成を低減させるステップをさらに備える、実施例35から37のいずれか一項に記載の方法。
[実施例39]
前記瘢痕組織形成が、バンクーバー瘢痕スケールまたはマンチェスター瘢痕スケールによると、少なくとも1ポイント低減させられる実施例38に記載の方法。
[実施例40]
創傷接触層から前記創傷部位へ、瘢痕組織形成を低減させるのに十分な量だけ、シリコーンを漏れさせるステップをさらに備える実施例35から39のいずれか一項に記載の方法。
101 下面
102 創傷接触層
104 開口部、穿孔
105 透過層
110 吸収層
500 上面
502 下面
503 繊維
700 接触範囲
701 消散範囲
1001 上面
1002 下面
c 圧縮距離
r 分離距離
x 非圧縮された厚さ
y 圧縮された距離
Claims (4)
- 陰圧創傷療法(NPWT)が適用される創傷部位において、瘢痕のない創傷の治癒を促進する創傷被覆材装置であって、前記装置は、
シリコーンと、開口領域と、を備える創傷接触層と、
前記創傷部位から前記開口領域を介して除去される滲出液を保持するために、前記創傷接触層に対して近位に位置する滲出液吸収層と、
陰圧を加えることを可能にするオリフィスが設けられたカバー層と、
を備え、
前記オリフィスの下方の前記滲出液吸収層に開口部が設けられており、
三次元構造を有する多孔性材料の層が前記創傷接触層と前記滲出液吸収層との間に位置しており、
前記三次元構造を有する前記多孔性材料は編まれるかまたは織られたスペーサ布であり、
前記カバー層は、前記創傷被覆材装置の周囲の境界領域内に前記創傷接触層に対して密封される、創傷被覆材装置。 - 水蒸気不透過性の層が、前記創傷接触層の上方に設けられている請求項1に記載の創傷被覆材装置。
- 前記開口領域が複数の貫通穴で構成されている請求項1又は2に記載の創傷被覆材装置。
- 前記開口領域が、複数の穴、スリット、またはスロットを備える請求項1〜3の何れか一項に記載の創傷被覆材装置。
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GB201108229D0 (en) | 2011-06-29 |
JP5940650B2 (ja) | 2016-06-29 |
BR112013029271A2 (pt) | 2017-01-31 |
CN103841935B (zh) | 2021-04-13 |
EP4159170A1 (en) | 2023-04-05 |
US20220192886A1 (en) | 2022-06-23 |
AU2011368647C1 (en) | 2017-04-06 |
JP2014518711A (ja) | 2014-08-07 |
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WO2012156655A8 (en) | 2013-11-21 |
AU2016273884B2 (en) | 2018-08-09 |
CO6930321A2 (es) | 2014-04-28 |
CA2835360C (en) | 2021-10-05 |
US20140350494A1 (en) | 2014-11-27 |
MX354375B (es) | 2018-02-28 |
EP2712312A1 (en) | 2014-04-02 |
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