JP6727285B2 - 免疫応答ならびに皮膚および/または粘膜バリア機能を改善するための材料および方法 - Google Patents

免疫応答ならびに皮膚および/または粘膜バリア機能を改善するための材料および方法 Download PDF

Info

Publication number
JP6727285B2
JP6727285B2 JP2018502770A JP2018502770A JP6727285B2 JP 6727285 B2 JP6727285 B2 JP 6727285B2 JP 2018502770 A JP2018502770 A JP 2018502770A JP 2018502770 A JP2018502770 A JP 2018502770A JP 6727285 B2 JP6727285 B2 JP 6727285B2
Authority
JP
Japan
Prior art keywords
biofilm
skin
composition
extract
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018502770A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018527322A (ja
JP2018527322A5 (https=
Inventor
エヴァ エイ. バーケス
エヴァ エイ. バーケス
ニコラス ティー. モンスル
ニコラス ティー. モンスル
フレデリック ティー. ベーム
フレデリック ティー. ベーム
Original Assignee
クオラム イノベーションズ リミテッド ライアビリティ カンパニー
クオラム イノベーションズ リミテッド ライアビリティ カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by クオラム イノベーションズ リミテッド ライアビリティ カンパニー, クオラム イノベーションズ リミテッド ライアビリティ カンパニー filed Critical クオラム イノベーションズ リミテッド ライアビリティ カンパニー
Publication of JP2018527322A publication Critical patent/JP2018527322A/ja
Publication of JP2018527322A5 publication Critical patent/JP2018527322A5/ja
Application granted granted Critical
Publication of JP6727285B2 publication Critical patent/JP6727285B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747Lactobacilli, e.g. L. acidophilus or L. brevis
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/20Bacteria; Substances produced thereby or obtained therefrom
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135Bacteria or derivatives thereof, e.g. probiotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00Lactic or propionic acid bacteria
    • A23V2400/11Lactobacillus
    • A23V2400/143Fermentum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225Lactobacillus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
JP2018502770A 2015-07-20 2016-07-19 免疫応答ならびに皮膚および/または粘膜バリア機能を改善するための材料および方法 Active JP6727285B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562194630P 2015-07-20 2015-07-20
US62/194,630 2015-07-20
PCT/US2016/042939 WO2017015275A1 (en) 2015-07-20 2016-07-19 Materials and methods for improving immune responses and the skin and/or mucosal barrier function

Publications (3)

Publication Number Publication Date
JP2018527322A JP2018527322A (ja) 2018-09-20
JP2018527322A5 JP2018527322A5 (https=) 2018-11-01
JP6727285B2 true JP6727285B2 (ja) 2020-07-22

Family

ID=57835147

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018502770A Active JP6727285B2 (ja) 2015-07-20 2016-07-19 免疫応答ならびに皮膚および/または粘膜バリア機能を改善するための材料および方法

Country Status (17)

Country Link
US (6) US9706778B2 (https=)
EP (1) EP3324986B1 (https=)
JP (1) JP6727285B2 (https=)
KR (1) KR102258415B1 (https=)
CN (1) CN108135947B (https=)
AU (1) AU2016297539B9 (https=)
BR (1) BR112018001187B1 (https=)
CA (1) CA2991990C (https=)
DK (1) DK3324986T3 (https=)
ES (1) ES2904555T3 (https=)
HU (1) HUE057494T2 (https=)
IL (1) IL256973B (https=)
MX (1) MX395076B (https=)
PL (1) PL3324986T3 (https=)
PT (1) PT3324986T (https=)
WO (1) WO2017015275A1 (https=)
ZA (1) ZA201800209B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5548121B2 (ja) 2007-05-14 2014-07-16 リサーチ ファウンデーション オブ ステイト ユニバーシティ オブ ニューヨーク バイオフィルム中の細菌細胞における生理学的分散応答の誘導
DK3324986T3 (da) * 2015-07-20 2022-01-31 Quorum Innovations Llc Materialer og fremgangsmåder til forbedring af immunreaktioner og hud- og/eller slimhindebarrierefunktion
WO2018146550A1 (en) 2017-02-10 2018-08-16 De Maio Domingos Mauricio Methods and systems for preventing, correcting, transforming, and modifying facial, aesthetics, and consulting patients regarding the same
US11253454B2 (en) * 2017-03-10 2022-02-22 Johnson & Johnson Consumer Inc. Method for affecting touch
GB201807576D0 (en) 2018-05-09 2018-06-20 Skinbiotherapeutics Plc Compositions and uses thereof
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
EP3685669A1 (en) * 2019-01-23 2020-07-29 Chrisal NV Composition for the decontamination and inoculation of surfaces
EP3741398A1 (en) * 2019-05-20 2020-11-25 Medizinische Hochschule Hannover Method for coating a medical device and coated medical device
MX2022006163A (es) * 2019-11-26 2022-06-17 Quorum Innovations Llc Nuevas composiciones de barrera protectora y usos de las mismas.
CA3176797A1 (en) * 2020-05-06 2021-11-11 Nicholas T. Monsul Novel protein, and therapeutic and cosmetic uses thereof
KR102167387B1 (ko) * 2020-05-14 2020-10-19 코스맥스 주식회사 피부 장벽 강화, 피부 보습 또는 항노화를 위한 조성물
EP4161558A4 (en) * 2020-06-06 2024-06-19 Quorum Innovations, LLC Materials and methods for inhibiting a viral infection, including a coronavirus infection
CA3193765A1 (en) * 2020-09-29 2022-04-07 Anindya Dasgupta A personal care composition comprising amino acids
KR102573754B1 (ko) * 2021-02-25 2023-09-01 주식회사 차메디텍 신규의 펩타이드 및 이를 포함하는 피부장벽 강화 또는 피부가려움증 억제를 위한 화장료 조성물
KR102389749B1 (ko) * 2021-05-14 2022-04-22 주식회사 세바바이오텍 피부장벽강화 및 항주름 활성을 갖는 피부 유래 락토바실러스 퍼멘텀 아종 세바­101 균주 및 이의 용도
CN113832050B (zh) * 2021-08-13 2022-10-21 广东省科学院微生物研究所(广东省微生物分析检测中心) 一株高效合成烟酰胺、抗光老化的发酵乳杆菌xjc60及其应用
CN114717162A (zh) * 2022-05-17 2022-07-08 廖梅香 发酵乳杆菌及其应用
CN118126875B (zh) * 2024-02-05 2024-11-05 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) 一株表皮葡萄球菌及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPS057102A0 (en) * 2002-02-15 2002-03-07 Vri Biomedical Ltd Compositions and methods for treatment of skin disorders
US20050014729A1 (en) * 2003-07-16 2005-01-20 Pharmacia Corporation Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith
EP1736537A1 (en) * 2005-06-22 2006-12-27 OrganoBalance GmbH Methods and means for protecting the skin against pathogenic microorganisms
JP2007284360A (ja) * 2006-04-13 2007-11-01 Mitsukan Group Honsha:Kk 乳酸菌由来のppar依存的遺伝子転写活性化組成物
RU2009125184A (ru) * 2006-12-01 2011-01-10 Органобэлэнс Гмбх (De) Композиции, наборы и их применения для защиты кожи от патогенных микроорганизмов
EP2227239A2 (en) * 2007-12-06 2010-09-15 Arla Foods Amba Probiotic bacteria and regulation of fat storage
CZ2009724A3 (cs) * 2009-11-04 2011-02-09 Bio Agens Research And Development - Bard, S.R.O. Protiplísnová smes s houbovým organismem Pythium oligandrum
AU2011241175A1 (en) * 2010-04-16 2012-11-29 Davos Life Science Pte. Ltd. Synergistic interaction of at least one Vitamin E component and tyrosinase inhibitors for dermatological applications
CN103415531B (zh) * 2011-02-09 2016-10-26 器官平衡有限责任公司 用于治疗皮肤病症的肽
CN103687604A (zh) 2011-03-01 2014-03-26 群体创新有限责任公司 用于治疗与致病生物膜相关之病症的材料和方法
CN102226157B (zh) * 2011-05-06 2013-01-09 北京龙科方舟生物工程技术有限公司 一株发酵乳杆菌及其应用
KR20150000867A (ko) 2011-12-07 2015-01-05 칼피스가부시키가이샤 유산균 또는 그 처리물을 포함한 지질대사 및/또는 당대사 개선제
DK3324986T3 (da) * 2015-07-20 2022-01-31 Quorum Innovations Llc Materialer og fremgangsmåder til forbedring af immunreaktioner og hud- og/eller slimhindebarrierefunktion

Also Published As

Publication number Publication date
MX2018000870A (es) 2018-05-15
HUE057494T2 (hu) 2022-05-28
PL3324986T3 (pl) 2022-04-04
IL256973A (en) 2018-03-29
DK3324986T3 (da) 2022-01-31
US20230165915A1 (en) 2023-06-01
KR102258415B1 (ko) 2021-05-28
US20170020139A1 (en) 2017-01-26
US10617726B2 (en) 2020-04-14
US10004772B2 (en) 2018-06-26
CN108135947A (zh) 2018-06-08
MX395076B (es) 2025-03-24
US12440521B2 (en) 2025-10-14
KR20180023012A (ko) 2018-03-06
EP3324986A4 (en) 2019-01-09
US20260034184A1 (en) 2026-02-05
HK1253067A1 (zh) 2019-06-06
CN108135947B (zh) 2022-06-14
CA2991990C (en) 2024-04-16
AU2016297539B9 (en) 2019-11-28
EP3324986B1 (en) 2021-11-24
US20200215130A1 (en) 2020-07-09
US20170224748A1 (en) 2017-08-10
IL256973B (en) 2020-06-30
JP2018527322A (ja) 2018-09-20
EP3324986A1 (en) 2018-05-30
US11564957B2 (en) 2023-01-31
CA2991990A1 (en) 2017-01-26
US20170296599A1 (en) 2017-10-19
ZA201800209B (en) 2018-12-19
AU2016297539B2 (en) 2019-10-31
BR112018001187B1 (pt) 2022-02-15
PT3324986T (pt) 2022-01-26
BR112018001187A2 (pt) 2018-09-11
US9706778B2 (en) 2017-07-18
AU2016297539A1 (en) 2018-02-08
WO2017015275A1 (en) 2017-01-26
ES2904555T3 (es) 2022-04-05

Similar Documents

Publication Publication Date Title
JP6727285B2 (ja) 免疫応答ならびに皮膚および/または粘膜バリア機能を改善するための材料および方法
JP7610630B2 (ja) プロピオニバクテリウム・アクネス(Propionibacterium acnes)による感染症、特にざ瘡の処置に使用するための乳酸菌の組成物
JP6505594B2 (ja) プロバイオティクス細菌
US10449222B2 (en) Method for preventing and/or treating infections, colonisations, or illnesses related to Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pyogenes, Enterococcus faecium, Enterobacter cloacae, Proteus mirabilis, Bacteroides fragilis, Staphylococcus epidermidis, Propionibacterium acnes, Candida albicans and/or Malassezia furfur
KR101885403B1 (ko) 신규 락트산 박테리아 및 그를 함유하는 조성물
EP2583684B1 (en) Peptide having antimicrobial or anti-inflammatory activity and pharmaceutical composition containing same as an active ingredient
CN111511379A (zh) 基于益生菌的组合物及其应用
JP2018527322A5 (https=)
JP7189024B2 (ja) 組成物およびその使用
JP2002212100A (ja) ニキビ予防及び治療用スフィンゴ脂質組成物
CN119923265A (zh) 用于治疗痤疮的具核梭杆菌
HK1253067B (en) Materials and methods for improving immune responses and the skin and/or mucosal barrier function

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180205

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180921

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20180921

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181005

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190829

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20191127

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200228

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20200603

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20200630

R150 Certificate of patent or registration of utility model

Ref document number: 6727285

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250