JP6711815B2 - 人工肺および人工肺の製造方法 - Google Patents
人工肺および人工肺の製造方法 Download PDFInfo
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- JP6711815B2 JP6711815B2 JP2017505333A JP2017505333A JP6711815B2 JP 6711815 B2 JP6711815 B2 JP 6711815B2 JP 2017505333 A JP2017505333 A JP 2017505333A JP 2017505333 A JP2017505333 A JP 2017505333A JP 6711815 B2 JP6711815 B2 JP 6711815B2
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- Prior art keywords
- hollow fiber
- fiber membrane
- blood
- artificial lung
- coating
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- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000007766 curtain coating Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- LSXWFXONGKSEMY-UHFFFAOYSA-N di-tert-butyl peroxide Chemical compound CC(C)(C)OOC(C)(C)C LSXWFXONGKSEMY-UHFFFAOYSA-N 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- NIYJNIFGDHAKLZ-UHFFFAOYSA-N diaminomethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC(N)N NIYJNIFGDHAKLZ-UHFFFAOYSA-N 0.000 description 1
- WAHZRYJFFZMWOU-UHFFFAOYSA-N diaminomethyl prop-2-enoate Chemical compound NC(N)OC(=O)C=C WAHZRYJFFZMWOU-UHFFFAOYSA-N 0.000 description 1
- 229940117389 dichlorobenzene Drugs 0.000 description 1
- 238000003618 dip coating Methods 0.000 description 1
- 239000002612 dispersion medium Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- WMAFNLQQGPUKCM-UHFFFAOYSA-N ethoxymethyl 2-methylprop-2-enoate Chemical compound CCOCOC(=O)C(C)=C WMAFNLQQGPUKCM-UHFFFAOYSA-N 0.000 description 1
- SZPUDSQPVUIVKC-UHFFFAOYSA-N ethoxymethyl prop-2-enoate Chemical compound CCOCOC(=O)C=C SZPUDSQPVUIVKC-UHFFFAOYSA-N 0.000 description 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 238000007756 gravure coating Methods 0.000 description 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- LNCPIMCVTKXXOY-UHFFFAOYSA-N hexyl 2-methylprop-2-enoate Chemical compound CCCCCCOC(=O)C(C)=C LNCPIMCVTKXXOY-UHFFFAOYSA-N 0.000 description 1
- LNMQRPPRQDGUDR-UHFFFAOYSA-N hexyl prop-2-enoate Chemical compound CCCCCCOC(=O)C=C LNMQRPPRQDGUDR-UHFFFAOYSA-N 0.000 description 1
- 229920006158 high molecular weight polymer Polymers 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000012690 ionic polymerization Methods 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 1
- LVQPBIMCRZQQBC-UHFFFAOYSA-N methoxymethyl 2-methylprop-2-enoate Chemical compound COCOC(=O)C(C)=C LVQPBIMCRZQQBC-UHFFFAOYSA-N 0.000 description 1
- SINFYWWJOCXYFD-UHFFFAOYSA-N methoxymethyl prop-2-enoate Chemical compound COCOC(=O)C=C SINFYWWJOCXYFD-UHFFFAOYSA-N 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
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- QRWZCJXEAOZAAW-UHFFFAOYSA-N n,n,2-trimethylprop-2-enamide Chemical compound CN(C)C(=O)C(C)=C QRWZCJXEAOZAAW-UHFFFAOYSA-N 0.000 description 1
- JMCVCHBBHPFWBF-UHFFFAOYSA-N n,n-diethyl-2-methylprop-2-enamide Chemical compound CCN(CC)C(=O)C(C)=C JMCVCHBBHPFWBF-UHFFFAOYSA-N 0.000 description 1
- OVHHHVAVHBHXAK-UHFFFAOYSA-N n,n-diethylprop-2-enamide Chemical compound CCN(CC)C(=O)C=C OVHHHVAVHBHXAK-UHFFFAOYSA-N 0.000 description 1
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 description 1
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 1
- QYZFTMMPKCOTAN-UHFFFAOYSA-N n-[2-(2-hydroxyethylamino)ethyl]-2-[[1-[2-(2-hydroxyethylamino)ethylamino]-2-methyl-1-oxopropan-2-yl]diazenyl]-2-methylpropanamide Chemical compound OCCNCCNC(=O)C(C)(C)N=NC(C)(C)C(=O)NCCNCCO QYZFTMMPKCOTAN-UHFFFAOYSA-N 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L persulfate group Chemical group S(=O)(=O)([O-])OOS(=O)(=O)[O-] JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
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- 230000000379 polymerizing effect Effects 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- YOHLNKAKHLQGPN-UHFFFAOYSA-N propoxymethyl 2-methylprop-2-enoate Chemical compound CCCOCOC(=O)C(C)=C YOHLNKAKHLQGPN-UHFFFAOYSA-N 0.000 description 1
- RPGBCXPLDSDRMQ-UHFFFAOYSA-N propoxymethyl prop-2-enoate Chemical compound CCCOCOC(=O)C=C RPGBCXPLDSDRMQ-UHFFFAOYSA-N 0.000 description 1
- NHARPDSAXCBDDR-UHFFFAOYSA-N propyl 2-methylprop-2-enoate Chemical compound CCCOC(=O)C(C)=C NHARPDSAXCBDDR-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- PNXMTCDJUBJHQJ-UHFFFAOYSA-N propyl prop-2-enoate Chemical compound CCCOC(=O)C=C PNXMTCDJUBJHQJ-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000012966 redox initiator Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000000790 scattering method Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000005549 size reduction Methods 0.000 description 1
- 229940079827 sodium hydrogen sulfite Drugs 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- CHQMHPLRPQMAMX-UHFFFAOYSA-L sodium persulfate Substances [Na+].[Na+].[O-]S(=O)(=O)OOS([O-])(=O)=O CHQMHPLRPQMAMX-UHFFFAOYSA-L 0.000 description 1
- 229940001482 sodium sulfite Drugs 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 238000004528 spin coating Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- OPQYOFWUFGEMRZ-UHFFFAOYSA-N tert-butyl 2,2-dimethylpropaneperoxoate Chemical compound CC(C)(C)OOC(=O)C(C)(C)C OPQYOFWUFGEMRZ-UHFFFAOYSA-N 0.000 description 1
- NMOALOSNPWTWRH-UHFFFAOYSA-N tert-butyl 7,7-dimethyloctaneperoxoate Chemical compound CC(C)(C)CCCCCC(=O)OOC(C)(C)C NMOALOSNPWTWRH-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
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- A—HUMAN NECESSITIES
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- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/064—Use of macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3623—Means for actively controlling temperature of blood
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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Description
本発明の人工肺を、図面を参照しながら以下で説明する。
本発明において、中空糸膜の外表面(または内表面)を被覆するために用いられる抗血栓性材料は、上記の通り、高分子を主成分として含む。ここで、「高分子を主成分とする抗血栓性材料」とは、抗血栓性材料の全量に対して、高分子が90重量%以上含まれることを意味する。したがって製造上含まれてしまう不純成分が抗血栓性材料中に微量含まれていても良い。なお、生産性や抗血栓性を十分に発揮させるという観点から、抗血栓性材料は、高分子を95重量%以上含んでいるとより好ましく、100重量%であると特に好ましい。なお、抗血栓性材料が高分子を90重量%以上含むことは、NMR、GPC等を用いた分析により確認される。
本発明の人工肺では、中空糸膜の外表面または内表面が上記したような抗血栓性材料および溶媒を含むコロイド溶液で被覆され、当該溶液中のコロイドの平均粒子径は、中空糸膜の開口部の直径の1.5倍以上である。以下では、本発明の人工肺の製造方法の好ましい形態について説明する。なお、本発明は、上記コロイド溶液で中空糸膜の外表面または内表面を被覆する以外は、下記好ましい形態に限定されない。
まず、中空糸膜の外表面または内表面を被覆するための、コロイド溶液を調製する。なお、抗血栓性材料として用いられる高分子の製造方法は上記した通りであるため、その詳細は省略する。
(a)コロイドの粒子径の変動係数(CV)が30%以下である;
(b)コロイドの平均粒子径(μ)−標準偏差(σ)≧1.05×中空糸膜の開口部の直径。
次に、上記の通り調製した抗血栓性材料のコロイド溶液を用いて、中空糸膜の外表面または内表面を被覆する。具体的には、人工肺(例えば、図1または図3のような構造のもの)を組み立てた後、上記工程(1)において調製したコロイド溶液を接触させる(または流通させる)ことによって、中空糸膜の外表面または内表面(すなわち、血液接触部)に抗血栓性材料を被覆する。また、コロイド溶液による中空糸膜の被覆は、人工肺組立前に行ってもよい。
製造例1:重量平均分子量25万のPMEAの合成
2−メトキシエチルアクリレート(MEA)15g(0.115mol)をメタノール40gに溶解し、四ツ口フラスコに入れ、50℃でN2バブリングを1時間行い、モノマー溶液(1)を調製した。別途、2,2’−アゾビス(4−メトキシ−2,4−ジメチルバレロニトリル)(V−70、和光純薬工業(株)製)0.015gをメタノール5gに溶解して、重合開始剤溶液(1)を調製した。次に、この重合開始剤溶液(1)をモノマー溶液(1)に添加し、50℃で5時間重合反応を行った。所定時間重合後、重合溶液をエタノールに滴下し、析出した重合体(PMEA(1))を回収した。なお、回収した重合体(PMEA(1))の重量平均分子量を測定したところ、250,000であった。
2−メトキシエチルアクリレート(MEA)60g(0.46mol)をメタノール135gに溶解し、四ツ口フラスコに入れ、50℃でN2バブリングを1時間行い、モノマー溶液(2)を調製した。別途、2,2’−アゾビス(4−メトキシ−2,4−ジメチルバレロニトリル)(V−70、和光純薬工業(株)製)0.06gをメタノール5gに溶解して、重合開始剤溶液(2)を調製した。次に、この重合開始剤溶液(2)をモノマー溶液(2)に添加し、50℃で5時間重合反応を行った。所定時間重合後、重合溶液をエタノールに滴下し、析出した重合体(PMEA(2))を回収した。なお、回収した重合体(PMEA(2))の重量平均分子量を測定したところ、310,000であった。
2−メトキシエチルアクリレート(MEA)80g(0.61mol)をメタノール115gに溶解し、四ツ口フラスコに入れ、50℃でN2バブリングを1時間行い、モノマー溶液(3)を調製した。別途、2,2’−アゾビス(4−メトキシ−2,4−ジメチルバレロニトリル)(V−70、和光純薬工業(株)製)0.08gをメタノール5gに溶解して、重合開始剤溶液(3)を調製した。次に、この重合開始剤溶液(3)をモノマー溶液(3)に添加し、50℃で5時間重合反応を行った。所定時間重合後、重合溶液をエタノールに滴下し、析出した重合体(PMEA(3))を回収した。なお、回収した重合体(PMEA(3))の重量平均分子量を測定したところ、420,000であった。
2−メトキシエチルアクリレート(MEA)100g(0.77mol)をメタノール95gに溶解し、四ツ口フラスコに入れ、50℃でN2バブリングを1時間行い、モノマー溶液(4)を調製した。別途、2,2’−アゾビス(4−メトキシ−2,4−ジメチルバレロニトリル)(V−70、和光純薬工業(株)製)0.1gをメタノール5gに溶解して、重合開始剤溶液(4)を調製した。次に、この重合開始剤溶液(4)をモノマー溶液(4)に添加し、50℃で5時間重合反応を行った。所定時間重合後、重合溶液をエタノールに滴下し、析出した重合体(PMEA(4))を回収した。なお、回収した重合体(PMEA(4))の重量平均分子量を測定したところ、800,000であった。
実施例1−1
上記製造例1で合成したPMEA(1)(重量平均分子量=25万)0.4gを、20gのメタノールに溶解した。別の容器に蒸留水380gを添加し、スターラーで撹拌しながら、上記PMEA(1)のメタノール溶液を20g/minの添加速度で添加した。その後、25℃で10分間撹拌し、白濁したコート液(1)を得た。コート液(1)は、PMEAのコロイドが分散されたコロイド溶液であった。(このとき、コート液(1)の溶媒は、水:メタノールの混合比=95:5(体積比)であり、PMEA(1)の濃度0.1重量%である。)
上記コート液(1)について、コロイド平均粒子径をマルバーン社製ゼータサイザーナノZS90で測定したところ、PMEA高分子コロイドの平均粒子径は、160nmであった。
上記実施例1−1において、用いたPMEAを、製造例2で合成したPMEA(2)(重量平均分子量=31万)に変更したことを除いては、実施例1−1と同様にしてコート液(2)を得た。コート液(2)は、PMEAのコロイドが分散されたコロイド溶液であった。
上記実施例1−1において、用いたPMEAを、製造例3で合成したPMEA(3)(重量平均分子量=42万)に変更したことを除いては、実施例1−1と同様にしてコート液(3)を得た。コート液(3)は、PMEAのコロイドが分散されたコロイド溶液であった。
上記製造例2で合成したPMEA(重量平均分子量=31万)を、PMEA濃度が0.1重量%となるように、水とメタノールとエタノールの混合溶媒(水:メタノール:エタノールの混合比=60:10:30(体積比))に分散させて比較コート液(1)を調製した。なお、上記比較コート液(1)は、コロイド溶液とならず、均一な溶液であった。
上記製造例4で合成したPMEA(4)(重量平均分子量=80万)0.4gを、20gのメタノールに溶解した。別の容器に蒸留水380gを添加し、スターラーで撹拌しながら、上記PMEA(4)のメタノール溶液を20g/minの添加速度で添加した。このとき、容器の壁面にポリマー凝集物の付着が著しく、人工肺の作製に使用可能なコート液を得ることができなかった。
実施例2−1
内径が195μm、外径が295μm、肉厚が50μm、空孔率が約35体積%、外表面の孔径(すなわち、開口部の平均直径)が80nmの多孔質ポリプロピレン製のガス交換用多孔質中空糸膜が約20,000本をハウジングに収納し、膜面積が1.8m2である特開平11−114056号公報(米国特許第6495101号明細書に相当または欧州特許第0908191号明細書に相当)の図1に記載される血液外部灌流型中空糸膜人工肺(a)を作製した。
上記実施例2−1において、ガス交換用多孔質中空糸膜の肉厚を25μmとしたこと以外は、上記実施例2−1と同様にして血液外部灌流型中空糸膜人工肺(2)を製造した。なお、このようにして得られた血液外部灌流型中空糸膜人工肺(2)を人工肺(2)とも称する。
内径が195μm、外径が295μm、肉厚が25μm、空孔率が約35体積%、外表面の孔径(すなわち、開口部の平均直径)が80nmの多孔質ポリプロピレン製のガス交換用多孔質中空糸膜が約20,000本をハウジングに収納し、膜面積が1.8m2である特開平11−114056号公報(米国特許第6495101号明細書に相当または欧州特許第0908191号明細書に相当)の図1に記載される血液外部灌流型中空糸膜人工肺(b)を作製した。
上記実施例2−1において、用いたコート液を、比較例1−1において調製した比較PMEA高分子溶液(1)に変更したことを除いては、実施例2−1と同様にして比較血液外部灌流型中空糸膜人工肺(1)を製造した。なお、このようにして得られた比較血液外部灌流型中空糸膜人工肺(1)を比較人工肺(1)とも称する。
上記実施例2−1〜2−3の人工肺(1)〜(3)および比較例2−1の比較人工肺(1)について、下記方法によって、耐血漿リーク性能を評価した。結果を下記表2に示す。
Claims (7)
- 外表面と、内腔を形成する内表面と、前記外表面と前記内表面とを連通する開口部と、を備えた複数のガス交換用多孔質中空糸膜を有する人工肺の製造方法であって、
高分子を主成分とする抗血栓性材料のコロイド溶液を調製し、前記コロイド溶液を前記中空糸膜の前記外表面および前記内表面のいずれか一方に塗布する工程を含み、
前記コロイド溶液中の前記コロイドの平均粒子径は、前記中空糸膜の開口部の直径の1.5倍以上であり、
前記中空糸膜が、酸素含有ガスが流れる前記内腔を形成する前記内表面と、血液と接触する前記外表面と、を有し、前記外表面に、前記コロイド溶液を塗布する、または
前記中空糸膜が、血液が流れる前記内腔を形成する前記内表面と、酸素含有ガスと接触する前記外表面と、を有し、前記内表面に、前記コロイド溶液を塗布する、人工肺の製造方法。 - 前記中空糸膜が、酸素含有ガスが流れる前記内腔を形成する前記内表面と、血液と接触する前記外表面と、を有し、
前記外表面に、前記コロイド溶液を塗布する、請求項1に記載の人工肺の製造方法。 - 前記コロイドの平均粒子径は、140nm以上である、請求項1または2に記載の人工肺の製造方法。
- 前記高分子は、下記式(I):
で示されるアルコキシアルキル(メタ)アクリレート由来の構成単位を有する、請求項1〜3のいずれか1項に記載の人工肺の製造方法。 - 前記高分子の重量平均分子量は、200,000を超えて800,000未満である、請求項1〜4のいずれか1項に記載の人工肺の製造方法。
- 前記コロイド溶液の溶媒は、6〜32:1の混合比(体積比)で水およびメタノールから構成される、請求項1〜5のいずれか1項に記載の人工肺の製造方法。
- 前記コロイド溶液は、下記(a)および(b)の少なくとも一方を満たす、請求項1〜6のいずれか1項に記載の人工肺の製造方法:
(a)コロイドの粒子径の変動係数(CV)が30%以下である;
(b)コロイドの平均粒子径(μ)−標準偏差(σ)≧1.05×前記中空糸膜の開口部の直径。
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