JP6698708B2 - 分子タグ付けのための方法、システム、組成物、キット、装置、及びコンピュータ可読媒体 - Google Patents
分子タグ付けのための方法、システム、組成物、キット、装置、及びコンピュータ可読媒体 Download PDFInfo
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- JP6698708B2 JP6698708B2 JP2017564364A JP2017564364A JP6698708B2 JP 6698708 B2 JP6698708 B2 JP 6698708B2 JP 2017564364 A JP2017564364 A JP 2017564364A JP 2017564364 A JP2017564364 A JP 2017564364A JP 6698708 B2 JP6698708 B2 JP 6698708B2
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- DHQBZROVYWZHFN-QVDQXJPCSA-N N[C@H](CCC1)CC1C1CCC1 Chemical compound N[C@H](CCC1)CC1C1CCC1 DHQBZROVYWZHFN-QVDQXJPCSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Chemical Kinetics & Catalysis (AREA)
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562172836P | 2015-06-09 | 2015-06-09 | |
| US62/172,836 | 2015-06-09 | ||
| US201562207177P | 2015-08-19 | 2015-08-19 | |
| US62/207,177 | 2015-08-19 | ||
| US201562248978P | 2015-10-30 | 2015-10-30 | |
| US62/248,978 | 2015-10-30 | ||
| US201662304530P | 2016-03-07 | 2016-03-07 | |
| US62/304,530 | 2016-03-07 | ||
| US201662310647P | 2016-03-18 | 2016-03-18 | |
| US62/310,647 | 2016-03-18 | ||
| US201662311276P | 2016-03-21 | 2016-03-21 | |
| US62/311,276 | 2016-03-21 | ||
| US201662323142P | 2016-04-15 | 2016-04-15 | |
| US62/323,142 | 2016-04-15 | ||
| PCT/US2016/036763 WO2016201142A1 (en) | 2015-06-09 | 2016-06-09 | Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018522543A JP2018522543A (ja) | 2018-08-16 |
| JP2018522543A5 JP2018522543A5 (enExample) | 2019-07-04 |
| JP6698708B2 true JP6698708B2 (ja) | 2020-05-27 |
Family
ID=56292898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017564364A Active JP6698708B2 (ja) | 2015-06-09 | 2016-06-09 | 分子タグ付けのための方法、システム、組成物、キット、装置、及びコンピュータ可読媒体 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US10344336B2 (enExample) |
| EP (2) | EP3653728B1 (enExample) |
| JP (1) | JP6698708B2 (enExample) |
| CN (1) | CN107849600A (enExample) |
| WO (1) | WO2016201142A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170009288A1 (en) | 2014-02-03 | 2017-01-12 | Thermo Fisher Scientific Baltics Uab | Method for controlled dna fragmentation |
| US11136576B2 (en) * | 2014-02-03 | 2021-10-05 | Thermo Fisher Scientific Baltics Uab | Method for controlled DNA fragmentation |
| US10196678B2 (en) | 2014-10-06 | 2019-02-05 | ALVEO Technologies Inc. | System and method for detection of nucleic acids |
| JP6698708B2 (ja) | 2015-06-09 | 2020-05-27 | ライフ テクノロジーズ コーポレーション | 分子タグ付けのための方法、システム、組成物、キット、装置、及びコンピュータ可読媒体 |
| PL3387152T3 (pl) | 2015-12-08 | 2022-05-09 | Twinstrand Biosciences, Inc. | Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego |
| CA3037494A1 (en) | 2016-09-23 | 2018-03-29 | Alveo Technologies, Inc. | Methods and compositions for detecting analytes |
| CN109790576A (zh) | 2016-09-27 | 2019-05-21 | 优比欧迈公司 | 基于crispr的文库制备和测序的方法和系统 |
| JP6941680B2 (ja) | 2016-10-24 | 2021-09-29 | ジェネインフォセック、インコーポレイテッド | 核酸内に存在する情報の秘匿化 |
| US10255990B2 (en) | 2016-11-11 | 2019-04-09 | uBiome, Inc. | Method and system for fragment assembly and sequence identification |
| CA3194557A1 (en) | 2017-01-20 | 2018-07-26 | Sequenom, Inc. | Sequencing adapter manufacture and use |
| WO2018213235A1 (en) | 2017-05-16 | 2018-11-22 | Life Technologies Corporation | Methods for compression of molecular tagged nucleic acid sequence data |
| US12209274B2 (en) * | 2017-05-31 | 2025-01-28 | Centrillion Technology Holdings Corporation | Oligonucleotide probe array with electronic detection system |
| US11542540B2 (en) | 2017-06-16 | 2023-01-03 | Life Technologies Corporation | Control nucleic acids, and compositions, kits, and uses thereof |
| US11702654B2 (en) * | 2017-06-20 | 2023-07-18 | Illumina, Inc. | Methods and compositions for addressing inefficiencies in amplification reactions |
| CN111315895A (zh) * | 2017-09-14 | 2020-06-19 | 豪夫迈·罗氏有限公司 | 用于产生环状单链dna文库的新型方法 |
| WO2019060494A1 (en) | 2017-09-20 | 2019-03-28 | Life Technologies Corporation | METHODS OF DETECTING FUSIONS USING COMPRESSED MOLECULAR LABEL NUCLEIC ACID SEQUENCE DATA |
| US20190241982A1 (en) * | 2018-02-02 | 2019-08-08 | Apdn (B.V.I.) Inc. | Systems and methods for tracking the origin of cannabis products and cannabis derivative products |
| GB201804641D0 (en) * | 2018-03-22 | 2018-05-09 | Inivata Ltd | Methods of sequencing nucleic acids and error correction of sequence reads |
| GB201804642D0 (en) * | 2018-03-22 | 2018-05-09 | Inivata Ltd | Methods of labelling nucleic acids |
| AU2019249422B2 (en) | 2018-04-02 | 2025-09-25 | Grail, Inc. | Methylation markers and targeted methylation probe panels |
| CN108486230B (zh) * | 2018-05-18 | 2022-02-08 | 中国人民解放军陆军军医大学第一附属医院 | 用于无创检测mitf基因突变的试剂盒及其制备方法 |
| WO2019238765A1 (en) | 2018-06-12 | 2019-12-19 | Keygene N.V. | Nucleic acid amplification method |
| CN108959851B (zh) * | 2018-06-12 | 2022-03-18 | 哈尔滨工程大学 | 一种Illumina高通量测序数据误差校正方法 |
| CN112601824A (zh) | 2018-08-08 | 2021-04-02 | 英威达有限公司 | 使用可变重复多重pcr测序的方法 |
| WO2020036926A1 (en) * | 2018-08-17 | 2020-02-20 | Cellecta, Inc. | Multiplex preparation of barcoded gene specific dna fragments |
| CN120795059A (zh) | 2018-08-27 | 2025-10-17 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| IL281741B2 (en) | 2018-09-27 | 2026-04-01 | Grail Inc | Methylation markers and a targeted methylation detection panel |
| WO2020118255A1 (en) * | 2018-12-07 | 2020-06-11 | Element Biosciences, Inc. | Flow cell device and use thereof |
| BR112020026667A2 (pt) * | 2018-12-19 | 2021-07-27 | Illumina, Inc. | métodos para melhorar a prioridade de clonalidade do agrupamento de polinucleotídeo |
| US12275007B2 (en) | 2018-12-20 | 2025-04-15 | Alveo Technologies, Inc. | Handheld impedance-based diagnostic test system for detecting analytes |
| JP2022516441A (ja) * | 2018-12-20 | 2022-02-28 | アルヴェオ テクノロジーズ インコーポレイテッド | 電気的検出を伴う等温増幅 |
| US12139753B2 (en) | 2019-03-22 | 2024-11-12 | Life Technologies Corporation | Methods for partner agnostic gene fusion detection |
| EP3748014A1 (en) * | 2019-06-04 | 2020-12-09 | Sysmex Corporation | Method for analyzing nucleic acid sequence, apparatus for analyzing nucleic acid sequence, and program for analyzing nucleic acid sequence |
| EP3748013A1 (en) * | 2019-06-04 | 2020-12-09 | Sysmex Corporation | Method for analyzing a nucleic acid sequence |
| EP3748015A1 (en) * | 2019-06-04 | 2020-12-09 | Sysmex Corporation | Method for analyzing nucleic acid sequence, apparatus for analyzing nucleic acid sequence, and program for analyzing nucleic acid sequence |
| EP4407043A3 (en) * | 2019-08-21 | 2024-10-09 | Life Technologies Corporation | System and method for sequencing |
| WO2021042131A1 (en) * | 2019-08-30 | 2021-03-04 | Life Technologies Corporation | Compositions and methods for oncology precision assays |
| KR20220104058A (ko) * | 2019-12-30 | 2022-07-25 | 위안디안 바이오랩스 컴퍼니 리미티드 | 효소를 이용한 핵산 서열 제조 방법 |
| US20210214769A1 (en) * | 2020-01-13 | 2021-07-15 | Fluent Biosciences Inc. | Methods and systems for amplifying low concentrations of nucleic acids |
| CN115698282A (zh) | 2020-01-13 | 2023-02-03 | 福路伦特生物科学公司 | 单细胞测序 |
| US11827936B2 (en) | 2020-01-13 | 2023-11-28 | Fluent Biosciences Inc. | Methods and systems for single cell gene profiling |
| EP4090328A4 (en) | 2020-01-13 | 2024-02-14 | Fluent Biosciences Inc. | EMULSION-BASED ACTIVE SCREENING |
| CN111254198A (zh) * | 2020-03-09 | 2020-06-09 | 苏州宏元生物科技有限公司 | 一种尿路上皮癌诊断和预后评估试剂盒 |
| CA3175931A1 (en) | 2020-03-16 | 2021-09-23 | Fluent Biosciences Inc. | Multi-omic analysis in monodisperse droplets |
| CA3176859A1 (en) | 2020-03-24 | 2021-09-30 | Fluent Biosciences Inc. | Viral detection using template emulsification |
| CN111466508A (zh) * | 2020-04-10 | 2020-07-31 | 四川长虹电器股份有限公司 | 射频解冻装置、冰箱及射频解冻方法 |
| JP2023529682A (ja) | 2020-06-18 | 2023-07-11 | リゾルブ バイオサイエンシズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 試料中の異なる分析物を検出するための多重的方法 |
| WO2022015970A1 (en) | 2020-07-15 | 2022-01-20 | Fluent Biosciences Inc. | Tiered ligation oligos |
| US12472492B2 (en) | 2020-08-14 | 2025-11-18 | Alveo Technologies, Inc. | Systems and methods of sample depositing and testing |
| WO2022104138A1 (en) | 2020-11-14 | 2022-05-19 | Life Technologies Corporation | System and method for automated repeat sequencing |
| US11859241B2 (en) | 2021-06-17 | 2024-01-02 | Element Biosciences, Inc. | Compositions and methods for pairwise sequencing |
| US11535892B1 (en) | 2021-06-17 | 2022-12-27 | Element Biosciences, Inc. | Compositions and methods for pairwise sequencing |
| GB2629259B (en) | 2021-07-21 | 2025-05-28 | Element Biosciences Inc | Optical systems for nucleic acid sequencing and methods thereof |
| AU2023325064A1 (en) | 2022-08-15 | 2025-03-06 | Element Biosciences, Inc. | Spatially resolved surface capture of nucleic acids |
| US12534721B2 (en) | 2022-10-06 | 2026-01-27 | Illumina, Inc. | Quantitative detection and analysis of moleculesip |
| KR20250130601A (ko) | 2022-11-29 | 2025-09-02 | 엘리먼트 바이오사이언스, 인크. | 핵산 시퀀싱을 위한 플로우 셀 디바이스 및 광학 시스템 |
| US12605715B2 (en) * | 2022-12-02 | 2026-04-21 | Celo Biotech Inc. | Magnetic stand |
| CN118581200A (zh) * | 2023-03-01 | 2024-09-03 | 体学生物科技股份有限公司 | 核酸分子的检测方法、检测套组及检测卡匣 |
| WO2024196764A2 (en) * | 2023-03-17 | 2024-09-26 | Nanostring Technologies, Inc. | Assay for recombinase accessible chromatin and related compositions and methods |
| WO2025085618A1 (en) * | 2023-10-20 | 2025-04-24 | Illumina, Inc. | Methods for appending adaptors onto polynucleotides |
Family Cites Families (136)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5333675C1 (en) | 1986-02-25 | 2001-05-01 | Perkin Elmer Corp | Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps |
| IL86724A (en) | 1987-06-19 | 1995-01-24 | Siska Diagnostics Inc | Methods and kits for amplification and testing of nucleic acid sequences |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| CA2036946C (en) | 1990-04-06 | 2001-10-16 | Kenneth V. Deugau | Indexing linkers |
| FI941016A7 (fi) | 1990-05-07 | 1994-05-03 | Daikin Indsutries Ltd | Kaksois-D-silmukan muodostumisen diagnostiset sovellutukset |
| US5223414A (en) | 1990-05-07 | 1993-06-29 | Sri International | Process for nucleic acid hybridization and amplification |
| US5273881A (en) | 1990-05-07 | 1993-12-28 | Daikin Industries, Ltd. | Diagnostic applications of double D-loop formation |
| US5194370A (en) | 1990-05-16 | 1993-03-16 | Life Technologies, Inc. | Promoter ligation activated transcription amplification of nucleic acid sequences |
| US6261808B1 (en) | 1992-08-04 | 2001-07-17 | Replicon, Inc. | Amplification of nucleic acid molecules via circular replicons |
| US5846719A (en) | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
| US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
| US5695934A (en) | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
| US5882856A (en) | 1995-06-07 | 1999-03-16 | Genzyme Corporation | Universal primer sequence for multiplex DNA amplification |
| US6444806B1 (en) | 1996-04-30 | 2002-09-03 | Hisamitsu Pharmaceutical Co., Inc. | Conjugates and methods of forming conjugates of oligonucleotides and carbohydrates |
| EP1591541B1 (en) | 1997-04-01 | 2012-02-15 | Illumina Cambridge Limited | Method of nucleic acid sequencing |
| ES2283936T3 (es) | 1997-07-07 | 2007-11-01 | Medical Research Council | Procedimiento de clasificacion in vitro. |
| FI103809B1 (fi) | 1997-07-14 | 1999-09-30 | Finnzymes Oy | In vitro -menetelmä templaattien tuottamiseksi DNA-sekventointia varten |
| US6607878B2 (en) | 1997-10-06 | 2003-08-19 | Stratagene | Collections of uniquely tagged molecules |
| CA2342838A1 (en) | 1998-09-15 | 2000-03-23 | Yale University | Molecular cloning using rolling circle amplification |
| US6287825B1 (en) | 1998-09-18 | 2001-09-11 | Molecular Staging Inc. | Methods for reducing the complexity of DNA sequences |
| US6480791B1 (en) | 1998-10-28 | 2002-11-12 | Michael P. Strathmann | Parallel methods for genomic analysis |
| US6830884B1 (en) | 1998-12-15 | 2004-12-14 | Molecular Staging Inc. | Method of amplification |
| US6521428B1 (en) | 1999-04-21 | 2003-02-18 | Genome Technologies, Llc | Shot-gun sequencing and amplification without cloning |
| US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| US7211390B2 (en) | 1999-09-16 | 2007-05-01 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| AU2001238068A1 (en) | 2000-02-07 | 2001-08-14 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
| ATE356222T1 (de) | 2000-10-06 | 2007-03-15 | Univ Columbia | Massives parallelverfahren zur dekodierung von dna und rna |
| AR031640A1 (es) | 2000-12-08 | 2003-09-24 | Applied Research Systems | Amplificacion isotermica de acidos nucleicos en un soporte solido |
| GB2378245A (en) | 2001-08-03 | 2003-02-05 | Mats Nilsson | Nucleic acid amplification method |
| GB0127564D0 (en) | 2001-11-16 | 2002-01-09 | Medical Res Council | Emulsion compositions |
| GB0129012D0 (en) | 2001-12-04 | 2002-01-23 | Solexa Ltd | Labelled nucleotides |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| WO2003050304A1 (en) | 2001-12-08 | 2003-06-19 | Seegene, Inc | Annealing control primer system for regulating primer annealing specificity and its applications |
| US20030175749A1 (en) | 2001-12-08 | 2003-09-18 | Jong-Yoon Chun | Annealing control primer and its uses |
| EP1319718A1 (en) | 2001-12-14 | 2003-06-18 | Keygene N.V. | High throughput analysis and detection of multiple target sequences |
| US7399590B2 (en) | 2002-02-21 | 2008-07-15 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| CA2476481C (en) | 2002-02-21 | 2016-01-26 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| US8030000B2 (en) | 2002-02-21 | 2011-10-04 | Alere San Diego, Inc. | Recombinase polymerase amplification |
| GB0208768D0 (en) | 2002-04-17 | 2002-05-29 | Univ Newcastle | DNA polymerases |
| EP2607369B1 (en) | 2002-08-23 | 2015-09-23 | Illumina Cambridge Limited | Modified nucleotides for polynucleotide sequencing |
| US7414116B2 (en) | 2002-08-23 | 2008-08-19 | Illumina Cambridge Limited | Labelled nucleotides |
| US20040038331A1 (en) | 2002-08-23 | 2004-02-26 | Reddy M. Parameswara | Solid phase synthesis of biomolecule conjugates |
| CA2513889A1 (en) | 2003-01-29 | 2004-08-19 | 454 Corporation | Double ended sequencing |
| CA2552858A1 (en) | 2004-01-23 | 2005-08-04 | Lingvitae As | Improving polynucleotide ligation reactions |
| EP2272983A1 (en) | 2005-02-01 | 2011-01-12 | AB Advanced Genetic Analysis Corporation | Reagents, methods and libraries for bead-based sequencing |
| US7393665B2 (en) | 2005-02-10 | 2008-07-01 | Population Genetics Technologies Ltd | Methods and compositions for tagging and identifying polynucleotides |
| ATE474937T1 (de) | 2005-04-29 | 2010-08-15 | Synthetic Genomics Inc | Amplifikation und klonierung einzelner dna- moleküle mittels rolling-circle-amplifikation |
| US20060263789A1 (en) | 2005-05-19 | 2006-11-23 | Robert Kincaid | Unique identifiers for indicating properties associated with entities to which they are attached, and methods for using |
| CN105039313B (zh) | 2005-06-23 | 2018-10-23 | 科因股份有限公司 | 用于多态性的高通量鉴定和检测的策略 |
| US20070020640A1 (en) | 2005-07-21 | 2007-01-25 | Mccloskey Megan L | Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis |
| EP1929049B1 (en) | 2005-07-25 | 2013-04-10 | Alere San Diego, Inc. | Methods for multiplexing recombinase polymerase amplification |
| ATE510930T1 (de) | 2005-08-02 | 2011-06-15 | Rubicon Genomics Inc | Zusammensetzungen und verfahren zur bearbeitung und amplifikation von dna mit verwendung mehrerer enzyme in einer einzigen reaktion |
| GB0517097D0 (en) | 2005-08-19 | 2005-09-28 | Solexa Ltd | Modified nucleosides and nucleotides and uses thereof |
| CA2910861C (en) | 2005-09-29 | 2018-08-07 | Michael Josephus Theresia Van Eijk | High throughput screening of mutagenized populations |
| US7405281B2 (en) | 2005-09-29 | 2008-07-29 | Pacific Biosciences Of California, Inc. | Fluorescent nucleotide analogs and uses therefor |
| GB0522310D0 (en) | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
| WO2007087312A2 (en) | 2006-01-23 | 2007-08-02 | Population Genetics Technologies Ltd. | Molecular counting |
| US20070231823A1 (en) | 2006-03-23 | 2007-10-04 | Mckernan Kevin J | Directed enrichment of genomic DNA for high-throughput sequencing |
| JP2009535053A (ja) | 2006-05-04 | 2009-10-01 | エーエスエム サイエンティフィック, インコーポレイテッド | レコンビナーゼポリメラーゼ増幅 |
| US8644588B2 (en) | 2006-09-20 | 2014-02-04 | Luminescent Technologies, Inc. | Photo-mask and wafer image reconstruction |
| US8399188B2 (en) | 2006-09-28 | 2013-03-19 | Illumina, Inc. | Compositions and methods for nucleotide sequencing |
| DE112007002932B4 (de) | 2006-12-01 | 2015-08-06 | The Trustees Of Columbia University In The City Of New York | Vierfarben DNA-Sequenzierung mittels Synthese unter Verwendung von abspaltbaren, reversiblen, fluoreszierenden Nucleotidterminatoren |
| US8349167B2 (en) | 2006-12-14 | 2013-01-08 | Life Technologies Corporation | Methods and apparatus for detecting molecular interactions using FET arrays |
| EP2639578B1 (en) | 2006-12-14 | 2016-09-14 | Life Technologies Corporation | Apparatus for measuring analytes using large scale fet arrays |
| US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| US7932034B2 (en) | 2006-12-20 | 2011-04-26 | The Board Of Trustees Of The Leland Stanford Junior University | Heat and pH measurement for sequencing of DNA |
| WO2008093098A2 (en) | 2007-02-02 | 2008-08-07 | Illumina Cambridge Limited | Methods for indexing samples and sequencing multiple nucleotide templates |
| CA2679586A1 (en) | 2007-02-27 | 2008-10-23 | Northwestern University | Molecule attachment to nanoparticles |
| US8003330B2 (en) | 2007-09-28 | 2011-08-23 | Pacific Biosciences Of California, Inc. | Error-free amplification of DNA for clonal sequencing |
| EP3269824A1 (en) | 2008-03-28 | 2018-01-17 | Pacific Biosciences Of California, Inc. | Compositions and methods for nucleic acid sequencing |
| US8271206B2 (en) * | 2008-04-21 | 2012-09-18 | Softgenetics Llc | DNA sequence assembly methods of short reads |
| US8029993B2 (en) | 2008-04-30 | 2011-10-04 | Population Genetics Technologies Ltd. | Asymmetric adapter library construction |
| GB2461127B (en) | 2008-06-25 | 2010-07-14 | Ion Torrent Systems Inc | Methods and apparatus for measuring analytes using large scale FET arrays |
| US8383345B2 (en) | 2008-09-12 | 2013-02-26 | University Of Washington | Sequence tag directed subassembly of short sequencing reads into long sequencing reads |
| US8546128B2 (en) | 2008-10-22 | 2013-10-01 | Life Technologies Corporation | Fluidics system for sequential delivery of reagents |
| US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
| US20100301398A1 (en) | 2009-05-29 | 2010-12-02 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
| US9080211B2 (en) | 2008-10-24 | 2015-07-14 | Epicentre Technologies Corporation | Transposon end compositions and methods for modifying nucleic acids |
| US9394567B2 (en) * | 2008-11-07 | 2016-07-19 | Adaptive Biotechnologies Corporation | Detection and quantification of sample contamination in immune repertoire analysis |
| AU2009316660B2 (en) | 2008-11-19 | 2015-01-29 | Amrys, Inc. | Compositions and methods for the assembly of polynucleotides |
| WO2010127186A1 (en) | 2009-04-30 | 2010-11-04 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
| US9309557B2 (en) | 2010-12-17 | 2016-04-12 | Life Technologies Corporation | Nucleic acid amplification |
| US9334531B2 (en) | 2010-12-17 | 2016-05-10 | Life Technologies Corporation | Nucleic acid amplification |
| US9309566B2 (en) | 2010-12-17 | 2016-04-12 | Life Technologies Corporation | Methods, compositions, systems, apparatuses and kits for nucleic acid amplification |
| US8673627B2 (en) | 2009-05-29 | 2014-03-18 | Life Technologies Corporation | Apparatus and methods for performing electrochemical reactions |
| US8776573B2 (en) | 2009-05-29 | 2014-07-15 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
| EP3360974B1 (en) | 2009-06-05 | 2025-04-09 | Abbott Diagnostics Scarborough, Inc. | Recombinase polymerase amplification reagents |
| US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20120045368A1 (en) | 2010-08-18 | 2012-02-23 | Life Technologies Corporation | Chemical Coating of Microwell for Electrochemical Detection Device |
| EP2619327B1 (en) | 2010-09-21 | 2014-10-22 | Population Genetics Technologies LTD. | Increasing confidence of allele calls with molecular counting |
| EP3141614B1 (en) | 2010-10-27 | 2018-11-28 | Life Technologies Corporation | Predictive model for use in sequencing-by-synthesis |
| CN110079588B (zh) | 2010-12-17 | 2024-03-15 | 生命技术公司 | 用于核酸扩增的方法、组合物、系统、仪器和试剂盒 |
| KR20140024270A (ko) | 2010-12-30 | 2014-02-28 | 파운데이션 메디신 인코포레이티드 | 종양 샘플의 다유전자 분석의 최적화 |
| US20130090860A1 (en) | 2010-12-30 | 2013-04-11 | Life Technologies Corporation | Methods, systems, and computer readable media for making base calls in nucleic acid sequencing |
| US20130060482A1 (en) | 2010-12-30 | 2013-03-07 | Life Technologies Corporation | Methods, systems, and computer readable media for making base calls in nucleic acid sequencing |
| WO2012103545A1 (en) | 2011-01-28 | 2012-08-02 | Illumina, Inc. | Oligonucleotide replacement for di-tagged and directional libraries |
| WO2012129363A2 (en) | 2011-03-24 | 2012-09-27 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
| EP3978620A1 (en) | 2011-04-07 | 2022-04-06 | Abbott Diagnostics Scarborough, Inc. | Monitoring recombinase polymerase amplification mixtures |
| US9617296B2 (en) | 2011-04-08 | 2017-04-11 | Life Technologies Corporation | Methods and kits for breaking emulsions |
| AU2012242847B2 (en) | 2011-04-15 | 2017-01-19 | The Johns Hopkins University | Safe sequencing system |
| US9809904B2 (en) * | 2011-04-21 | 2017-11-07 | University Of Washington Through Its Center For Commercialization | Methods for retrieval of sequence-verified DNA constructs |
| CN103827318B (zh) | 2011-05-27 | 2018-05-08 | 生命技术公司 | 用于操作生物分子的方法 |
| US20130017978A1 (en) | 2011-07-11 | 2013-01-17 | Finnzymes Oy | Methods and transposon nucleic acids for generating a dna library |
| US9145623B2 (en) | 2011-07-20 | 2015-09-29 | Thermo Fisher Scientific Oy | Transposon nucleic acids comprising a calibration sequence for DNA sequencing |
| US11177020B2 (en) * | 2012-02-27 | 2021-11-16 | The University Of North Carolina At Chapel Hill | Methods and uses for molecular tags |
| CA2865575C (en) * | 2012-02-27 | 2024-01-16 | Cellular Research, Inc. | Compositions and kits for molecular counting |
| EP2825675B1 (en) * | 2012-03-13 | 2017-12-27 | Patel, Abhijit Ajit | Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing |
| ES2828661T3 (es) * | 2012-03-20 | 2021-05-27 | Univ Washington Through Its Center For Commercialization | Métodos para reducir la tasa de error de la secuenciación de ADN masiva en paralelo mediante el uso de la secuenciación de secuencia consenso bicatenaria |
| CA2872141C (en) | 2012-05-31 | 2016-01-19 | Board Of Regents, The University Of Texas System | Method for accurate sequencing of dna |
| JP2015521472A (ja) | 2012-06-14 | 2015-07-30 | フレッド ハチンソン キャンサー リサーチ センター | 核酸分子における高感度変異検出のための組成物および方法 |
| US8895249B2 (en) | 2012-06-15 | 2014-11-25 | Illumina, Inc. | Kinetic exclusion amplification of nucleic acid libraries |
| US20160115532A1 (en) | 2012-08-10 | 2016-04-28 | Sequenta, Inc. | High sensitivity mutation detection using sequence tags |
| US20140066317A1 (en) * | 2012-09-04 | 2014-03-06 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| DE202013012824U1 (de) * | 2012-09-04 | 2020-03-10 | Guardant Health, Inc. | Systeme zum Erfassen von seltenen Mutationen und einer Kopienzahlvariation |
| CN103045726B (zh) * | 2012-11-20 | 2015-11-25 | 南方科技大学 | 对多个混合dna或rna序列进行基因测序的方法及装置 |
| EP3561072A1 (en) | 2012-12-10 | 2019-10-30 | Resolution Bioscience, Inc. | Methods for targeted genomic analysis |
| EP2959016A4 (en) * | 2013-02-21 | 2016-10-12 | Toma Biosciences Inc | METHOD, COMPOSITIONS AND NUCLEIC ACID ANALYSIS KITS |
| US20140255929A1 (en) | 2013-03-11 | 2014-09-11 | Sequenta, Inc. | Mosaic tags for labeling templates in large-scale amplifications |
| EP3249057B1 (en) | 2013-03-14 | 2019-05-01 | Life Technologies Corporation | Matrix arrays and methods for making same |
| ITMI20130496A1 (it) | 2013-03-29 | 2014-09-30 | Atlas Copco Blm Srl | Gruppo e disposizione di montaggio di una spina di un connettore circolare a baionetta su un pannello o una parete, in particolare un pannello o una parete di un corpo scatolare di contenimento di un dispositivo elettrico o elettronico |
| US20140357499A1 (en) * | 2013-05-30 | 2014-12-04 | Washington University | METHODS OF LOW ERROR AMPLICON SEQUENCING (LEA-Seq) AND THE USE THEREOF |
| WO2015031559A1 (en) | 2013-08-30 | 2015-03-05 | Tensor Surgical, Inc | Passive retrieving interosseous suture passing device |
| GB2518668B (en) | 2013-09-28 | 2017-07-12 | Design Blue Ltd | Flexible pads and shield systems |
| US9476853B2 (en) | 2013-12-10 | 2016-10-25 | Life Technologies Corporation | System and method for forming microwells |
| ES2660989T3 (es) | 2013-12-28 | 2018-03-27 | Guardant Health, Inc. | Métodos y sistemas para detectar variantes genéticas |
| WO2015108663A1 (en) | 2014-01-16 | 2015-07-23 | Illumina, Inc. | Amplicon preparation and sequencing on solid supports |
| US20170009288A1 (en) | 2014-02-03 | 2017-01-12 | Thermo Fisher Scientific Baltics Uab | Method for controlled dna fragmentation |
| JP6794350B2 (ja) | 2014-07-02 | 2020-12-02 | ライフ テクノロジーズ コーポレーション | 半導体センサの表面処理 |
| EP3626834B1 (en) | 2014-07-15 | 2022-09-21 | Qiagen Sciences, LLC | Semi-random barcodes for nucleic acid analysis |
| JP6698708B2 (ja) | 2015-06-09 | 2020-05-27 | ライフ テクノロジーズ コーポレーション | 分子タグ付けのための方法、システム、組成物、キット、装置、及びコンピュータ可読媒体 |
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| EP3307908B1 (en) | 2019-09-11 |
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