JP6697386B2 - 改変された高親和性ヒトｔ細胞受容体 - Google Patents

改変された高親和性ヒトｔ細胞受容体 Download PDF

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Publication number
JP6697386B2
JP6697386B2 JP2016533163A JP2016533163A JP6697386B2 JP 6697386 B2 JP6697386 B2 JP 6697386B2 JP 2016533163 A JP2016533163 A JP 2016533163A JP 2016533163 A JP2016533163 A JP 2016533163A JP 6697386 B2 JP6697386 B2 JP 6697386B2
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tcr
cell
modified
cell receptor
cells
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Expired - Fee Related
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JP2016533163A
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JP2017501130A (ja
JP2017501130A5 (enExample
Inventor
シーナ エヌ． スミス，
シーナ エヌ． スミス，
ダニエル ティー． ハリス，
ダニエル ティー． ハリス，
デイビッド エム． クランツ，
デイビッド エム． クランツ，
トーマス エム． シュミット，
トーマス エム． シュミット，
フィリップ ディー． グリーンバーグ，
フィリップ ディー． グリーンバーグ，
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University of Illinois System
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University of Illinois System
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Priority to JP2019190139A priority Critical patent/JP6970724B2/ja
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Publication of JP6697386B2 publication Critical patent/JP6697386B2/ja
Priority to JP2021178468A priority patent/JP2022023196A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2016533163A 2013-11-22 2014-11-21 改変された高親和性ヒトｔ細胞受容体 Expired - Fee Related JP6697386B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2019190139A JP6970724B2 (ja) 2013-11-22 2019-10-17 改変された高親和性ヒトｔ細胞受容体
JP2021178468A JP2022023196A (ja) 2013-11-22 2021-11-01 改変された高親和性ヒトｔ細胞受容体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361907887P 2013-11-22 2013-11-22
US61/907,887 2013-11-22
PCT/US2014/066903 WO2015077615A1 (en) 2013-11-22 2014-11-21 Engineered high-affinity human t cell receptors

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JP2019190139A Division JP6970724B2 (ja) 2013-11-22 2019-10-17 改変された高親和性ヒトｔ細胞受容体

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JP2017501130A JP2017501130A (ja) 2017-01-12
JP2017501130A5 JP2017501130A5 (enExample) 2017-12-21
JP6697386B2 true JP6697386B2 (ja) 2020-05-20

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JP2016533163A Expired - Fee Related JP6697386B2 (ja) 2013-11-22 2014-11-21 改変された高親和性ヒトｔ細胞受容体
JP2016533150A Active JP6476182B2 (ja) 2013-11-22 2014-11-21 改変された高親和性ヒトｔ細胞受容体
JP2019190139A Expired - Fee Related JP6970724B2 (ja) 2013-11-22 2019-10-17 改変された高親和性ヒトｔ細胞受容体
JP2021178468A Pending JP2022023196A (ja) 2013-11-22 2021-11-01 改変された高親和性ヒトｔ細胞受容体

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JP2016533150A Active JP6476182B2 (ja) 2013-11-22 2014-11-21 改変された高親和性ヒトｔ細胞受容体
JP2019190139A Expired - Fee Related JP6970724B2 (ja) 2013-11-22 2019-10-17 改変された高親和性ヒトｔ細胞受容体
JP2021178468A Pending JP2022023196A (ja) 2013-11-22 2021-11-01 改変された高親和性ヒトｔ細胞受容体

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US (4) US10023625B2 (enExample)
EP (2) EP3071593B1 (enExample)
JP (4) JP6697386B2 (enExample)
KR (2) KR102415259B1 (enExample)
CN (2) CN105899530B (enExample)
AU (4) AU2014352826B2 (enExample)
BR (1) BR112016011567A2 (enExample)
CA (2) CA2930847A1 (enExample)
DK (1) DK3071593T3 (enExample)
ES (1) ES2729406T3 (enExample)
IL (2) IL245468B (enExample)
MX (3) MX383471B (enExample)
PL (1) PL3071593T3 (enExample)
PT (1) PT3071593T (enExample)
RU (2) RU2740648C2 (enExample)
SA (1) SA516371174B1 (enExample)
SG (2) SG10201804330YA (enExample)
TR (1) TR201908404T4 (enExample)
WO (2) WO2015077615A1 (enExample)
ZA (2) ZA201603116B (enExample)

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PL3071593T3 (pl) 2019-11-29
AU2019272003A1 (en) 2019-12-19
ZA201603169B (en) 2020-05-27
JP2017501130A (ja) 2017-01-12
MX2016006620A (es) 2017-05-11
BR112016011583A2 (pt) 2017-09-26
KR20160087866A (ko) 2016-07-22
ES2729406T3 (es) 2019-11-04
MX2021006932A (es) 2021-07-07
US20160280755A1 (en) 2016-09-29
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JP2022023196A (ja) 2022-02-07
RU2016124179A (ru) 2017-12-27
CA2930852A1 (en) 2015-05-28
US20220396606A1 (en) 2022-12-15
EP3071593A1 (en) 2016-09-28
US20190055298A1 (en) 2019-02-21
NZ719707A (en) 2020-09-25
TR201908404T4 (tr) 2019-07-22
SG10201804330YA (en) 2018-07-30
CN105899530A (zh) 2016-08-24
US10344075B2 (en) 2019-07-09
IL245468A0 (en) 2016-06-30
WO2015077607A1 (en) 2015-05-28
ZA201603116B (en) 2018-12-19
RU2729383C2 (ru) 2020-08-06
AU2014352834B2 (en) 2019-08-29
IL245467A0 (en) 2016-06-30
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AU2019272003B2 (en) 2021-05-06
BR112016011567A2 (pt) 2017-10-24
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IL245468B (en) 2020-10-29
AU2021202274A1 (en) 2021-05-06
RU2016124163A (ru) 2017-12-27
CA2930847A1 (en) 2015-05-28
AU2014352834A1 (en) 2016-05-26
EP3071593A4 (en) 2017-05-03
MX371202B (es) 2020-01-22
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IL245467B (en) 2020-04-30
JP2020007374A (ja) 2020-01-16
EP3071593B1 (en) 2019-03-13
MX383471B (es) 2025-03-14
SG10201804335QA (en) 2018-06-28
CN105873945A (zh) 2016-08-17
EP3071594A1 (en) 2016-09-28
US10023625B2 (en) 2018-07-17
CA2930852C (en) 2024-01-23
JP2017501129A (ja) 2017-01-12
PT3071593T (pt) 2019-06-27
KR20160085345A (ko) 2016-07-15
KR102415259B1 (ko) 2022-06-30
EP3071594A4 (en) 2017-05-03
MX2016006625A (es) 2016-12-02
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AU2014352826A1 (en) 2016-05-26

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